Report Card - Murray-Darling Basin - 2001

Ongoing deterioration of the riverine environments of the Murray-Darling Basin led the Murray-Darling Basin Ministerial Council to introduce a Cap in 1995 to halt the growth in diversions of water for consumptive use. This initiative recognised the finite nature of water resources in the Basin and sought to introduce a balance between off-stream use of water and protection of the riverine environment. But the cap is only one step, albeit a fundamental one, in restoring the Basin's rivers - it is a “stake in the ground”. Parties to the Murray-Darling Basin Initiative recognise the need to reverse decades of creeping decline if the Basin's rivers and riverine environments are to return to a more ecologically sustainable condition. In the last 12 months, Council and Commission have taken far-reaching decisions designed to restore the Basin's Rivers. Many of these decisions, even 10 years ago, would have been unimaginable. The Report Card will explain the need for a number of recent decisions that will impact on the future of the Basin's rivers. For example, Council's decision to establish an Environmental Manager function in the Office of the Commission was made in the context of the recently agreed Integrated Catchment Management (ICM) Policy, and supporting Sustainable Rivers Audit. The role of targets and accountabilities under the ICM Policy will also be discussed. The Report Card will also present a snapshot of the state of the Basin's rivers and the actions being taken at a range of scales and locations in response to identified problems. Because some of the key initiatives are still in development, this Report Card will set the scene by describing where our attention is being focused and why.

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Murray-Darling Basin Commission: a case study in integrated catchment management

Water Science & Technology ◽

10.2166/wst.1995.0548 ◽

1995 ◽

Vol 32 (5-6) ◽

pp. 15-25 ◽

Cited By ~ 6

Author(s):

D. J. Blackmore

Keyword(s):

Natural Resources ◽

Community Action ◽

Catchment Management ◽

State Governments ◽

Integrated Catchment Management ◽

Murray Darling Basin ◽

Murray River ◽

Common Interests ◽

Basin Water

This paper describes the Australian Murray-Darling basin experience in integrated catchment management, what has been achieved and what remains to be done. The basin water is shared by three states, but falls under the jurisdiction of four governments, that of the Commonwealth as well as the State governments. The critical development in recent years at the political and bureaucratic level was the establishment of a three-tier management structure that allows common interests to be developed, discussed, resolved and implemented. Two main problems had to be resolved before significant co-operative action could take place, namely the issues of water sharing between the states and the sharing of costs associated with Murray River salinity. A framework Salinity and Drainage Strategy was developed to address this, and is described. This paper also describes the Natural Resources Management Strategy, the cornerstone of efforts to sustain the natural resources of the basin. The strategy emphasises community participation and empowerment. The problems identified, strategic aims to address these problems and the role of community action are detailed.

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ASPECTS IN BUILDING A COMPANY WEB-SITE AND ITS ROLE FOR THE DEVELOPMENT OF BUSINESS

International Conference on Technics Technologies and Education ◽

10.15547/ictte.04.001 ◽

2018 ◽

pp. 117-124

Author(s):

Petar Halachev ◽

Victoria Radeva ◽

Albena Nikiforova ◽

Miglena Veneva

Keyword(s):

Life Cycle ◽

Web Site ◽

The Internet ◽

A Company ◽

The Web ◽

Design Construction ◽

Made In ◽

Site Types

This report is dedicated to the role of the web site as an important tool for presenting business on the Internet. Classification of site types has been made in terms of their application in the business and the types of structures in their construction. The Models of the Life Cycle for designing business websites are analyzed and are outlined their strengths and weaknesses. The stages in the design, construction, commissioning, and maintenance of a business website are distinguished and the activities and requirements of each stage are specified.

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Aboutness

10.23943/princeton/9780691144955.001.0001 ◽

2014 ◽

Cited By ~ 7

Author(s):

Stephen Yablo

Keyword(s):

Subject Matter ◽

Philosophy Of Language ◽

Mental States ◽

Library Science ◽

Philosophical Methodology ◽

Major Advance ◽

Truth Conditions ◽

Ways Of Being ◽

Made In

Aboutness has been studied from any number of angles. Brentano made it the defining feature of the mental. Phenomenologists try to pin down the aboutness features of particular mental states. Materialists sometimes claim to have grounded aboutness in natural regularities. Attempts have even been made, in library science and information theory, to operationalize the notion. However, it has played no real role in philosophical semantics, which is surprising. This is the first book to examine through a philosophical lens the role of subject matter in meaning. A long-standing tradition sees meaning as truth conditions, to be specified by listing the scenarios in which a sentence is true. Nothing is said about the principle of selection—about what in a scenario gets it onto the list. Subject matter is the missing link here. A sentence is true because of how matters stand where its subject matter is concerned. This book maintains that this is not just a feature of subject matter, but its essence. One indicates what a sentence is about by mapping out logical space according to its changing ways of being true or false. The notion of content that results—directed content—is brought to bear on a range of philosophical topics, including ontology, verisimilitude, knowledge, loose talk, assertive content, and philosophical methodology. The book represents a major advance in semantics and the philosophy of language.

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Mechanisms of ATP to cAMP Conversion Catalyzed by the Mammalian Adenylyl Cyclase: A Role of Magnesium Coordination Shells and Proton Wires

10.26434/chemrxiv.9209180 ◽

2019 ◽

Author(s):

Bella Grigorenko ◽

Igor Polyakov ◽

Alexander Nemukhin

Keyword(s):

Adenylyl Cyclase ◽

Bond Cleavage ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Md Simulations ◽

Coordination Shell ◽

Energy Profile ◽

One Step ◽

Type V

We report a mechanism of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP) conversion by the mammalian type V adenylyl cyclase revealed in molecular dynamics (MD) and quantum mechanics/molecular mechanics (QM/MM) simulations. We characterize a set of computationally derived enzyme-substrate (ES) structures showing an important role of coordination shells of magnesium ions in the solvent accessible active site. Several stable six-fold coordination shells of MgA2+ are observed in MD simulations of ES complexes. In the lowest energy ES conformation, the coordination shell of MgA2+ does not include the Oδ1 atom of the conserved Asp440 residue. Starting from this conformation, a one-step reaction mechanism is characterized which includes proton transfer from the ribose O3'H3' group in ATP to Asp440 via a shuttling water molecule and PA-O3A bond cleavage and O3'-PA bond formation. The energy profile of this route is consistent with the observed reaction kinetics. In a higher energy ES conformation, MgA2+ is bound to the Oδ1(Asp440) atom as suggested in the relevant crystal structure of the protein with a substrate analog. The computed energy profile initiated by this ES is characterized by higher energy expenses to complete the reaction. Consistently with experimental data, we show that the Asp440Ala mutant of the enzyme should exhibit a reduced but retained activity. All considered reaction pathways include proton wires from the O3'H3' group via shuttling water molecules.

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Август и Агриппа: развитие системы соправления с 29 по 18 г. до н. э.

Istoricheskii vestnik ◽

10.35549/hr.2017.2017.34958 ◽

2017 ◽

pp. 126-169

Author(s):

S.E. Tariverdieva

Keyword(s):

Political Life ◽

The Political ◽

State Administration ◽

Inheritance System ◽

The Future ◽

One Step ◽

Formal Equality ◽

Different Parts

The article deals with the development of the coregency system of Augustus and Agrippa from 29 to 18 BC: from formal and actual disparity of the coregents to their formal equality with the dominance of the princeps auctoritas. Particular attention is paid to the earlier stages of this development and to the crisis of 23 BC. The coregency system created by Augustus is often regarded by modern historians as means of ensuring uninterrupted succession of power. Agrippa as his coregent often is thought to have assumed the role of the regent who temporally replaces the princeps, just as it was in formal monarchies, or that of the tutor of the future rulers. However, the Roman system of state administration did not allow such type of regency. The princeps coregent, who was his equal in formal credentials but his inferior in terms of auctoritas, in case of the princeps death had to become the next princeps as his immediate successor. It is unlikely that later he was expected to voluntarily give up his power in favour of younger heir and to vanish from the political life altogether. The inheritance system under Augustus was like a ladder with the princeps at the top, the coregent who was also the immediate successor one step below, heirs of the next degree further down. In case of death of one of them, successors shifted one step up. The coregency had one more function: geographically it allowed Augustus and Agrippa to rule jointly the empire while staying in different parts of it.В статье исследуется развитие системы соправления Августа и Агриппы с 29 по 12 гг. до н. э.: от формального и фактического неравенства соправителей до их формального равенства при преобладании auctoritas принцепса, причём особое внимание уделяется раннему этапу этого развития и кризису 23 г. до н. э. Институт соправления, созданный Августом, часто рассматривается, как средство обеспечения бесперебойного перехода власти, причем Агриппе, как соправителю, НЕРЕДКО отводится роль регента, временно замещающего принцепса или воспитателя будущих правителей. Однако римская система государственного управления не предполагала регентства. Соправитель принцепса, равный ему по формальным полномочиям, но уступавший по auctoritas, в случае его смерти должен был СТАТЬ следующим принцепсом, ближайшим его наследником. Вряд ли предполагалось, что в будущем он должен добровольно уступить власть более молодому наследнику и исчезнуть из политической жизни. Система наследования при Августе представляла собой нечто вроде лестницы, на вершине которой стоял принцепс, на следующей ступени соправитель, он же избранный преемник, ниже наследники следующей очереди в случае смерти когото из них происходило продвижение наследников по ступеням вверх. Кроме того, соправление имело и иное значение позволяло Августу и Агриппе совместно управлять империей, находясь в разных ее частях.

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The Role of the Endothelium in Premature Atherosclerosis: Molecular Mechanisms

Current Medicinal Chemistry ◽

10.2174/0929867326666190911141951 ◽

2020 ◽

Vol 27 (7) ◽

pp. 1041-1051 ◽

Cited By ~ 1

Author(s):

Michael Spartalis ◽

Eleftherios Spartalis ◽

Antonios Athanasiou ◽

Stavroula A. Paschou ◽

Christos Kontogiannis ◽

...

Keyword(s):

Molecular Mechanisms ◽

Low Density Lipoprotein ◽

Critical Role ◽

Density Lipoprotein ◽

Number Of Genes ◽

Causes Of Mortality ◽

Artery Disease ◽

Genetic And Environmental Factors ◽

Made In

Atherosclerotic disease is still one of the leading causes of mortality. Atherosclerosis is a complex progressive and systematic artery disease that involves the intima of the large and middle artery vessels. The inflammation has a key role in the pathophysiological process of the disease and the infiltration of the intima from monocytes, macrophages and T-lymphocytes combined with endothelial dysfunction and accumulated oxidized low-density lipoprotein (LDL) are the main findings of atherogenesis. The development of atherosclerosis involves multiple genetic and environmental factors. Although a large number of genes, genetic polymorphisms, and susceptible loci have been identified in chromosomal regions associated with atherosclerosis, it is the epigenetic process that regulates the chromosomal organization and genetic expression that plays a critical role in the pathogenesis of atherosclerosis. Despite the positive progress made in understanding the pathogenesis of atherosclerosis, the knowledge about the disease remains scarce.

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Conclusions

10.1093/oso/9780198826248.003.0010 ◽

2018 ◽

Author(s):

Amy Strecker

Keyword(s):

International Law ◽

Eu Law ◽

World Heritage Convention ◽

State Practice ◽

The World ◽

State Obligations ◽

Made In ◽

Landscape Protection

The final chapter of this book advances four main conclusions on the role of international law in landscape protection. These relate to state obligations regarding landscape protection, the influence of the World Heritage Convention and the European Landscape Convention, the substantive and procedural nature of landscape rights, and the role of EU law. It is argued that, although state practice is lagging behind the normative developments made in the field of international landscape protection, landscape has contributed positively to the corpus of international cultural heritage law and indeed has emerged as a nascent field of international law in its own right.

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Simultaneity and Precise Time in Rotation

Universe ◽

10.3390/universe5120226 ◽

2019 ◽

Vol 5 (12) ◽

pp. 226 ◽

Cited By ~ 2

Author(s):

Don Koks

Keyword(s):

Time Coordinate ◽

Near Future ◽

Precise Time ◽

Made In

I analyse the role of simultaneity in relativistic rotation by building incrementally on its role in simpler scenarios. Historically, rotation has been analysed in 1 + 1 dimensions; but my stance is that a 2 + 1 -dimensional treatment is necessary. This treatment requires a discussion of what constitutes a frame, how coordinate choices differ from frame choices, and how poor coordinates can be misleading. I determine how precisely we are able to define a meaningful time coordinate on a gravity-free rotating Earth, and discuss complications due to gravity on our real Earth. I end with a critique of several statements made in relativistic precision-timing literature, that I maintain contradict the tenets of relativity. Those statements tend to be made in the context of satellite-based navigation; but they are independent of that technology, and hence are not validated by its success. I suggest that if relativistic precision-timing adheres to such analyses, our civilian timing is likely to suffer in the near future as clocks become ever more precise.

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The Role of Histones and Heparin in Sepsis: A Review

Journal of Intensive Care Medicine ◽

10.1177/0885066621992320 ◽

2021 ◽

pp. 088506662199232

Author(s):

Xiaojuan Zhang ◽

Xin Li

Keyword(s):

Septic Shock ◽

Multiple Organ ◽

Clinical Settings ◽

The Past ◽

Life Saving ◽

Extracellular Histones ◽

Sepsis And Septic Shock ◽

Development And Management ◽

Made In

Septic shock with multiple organ failure is a devastating situation in clinical settings. Through the past decades, much progress has been made in the management of sepsis and its underlying pathogenesis, but a highly effective therapeutic has not been developed. Recently, macromolecules such as histones have been targeted in the treatment of sepsis. Histones primarily function as chromosomal organizers to pack DNA and regulate its transcription through epigenetic mechanisms. However, a growing body of research has shown that histone family members can also exert cellular toxicity once they relocate from the nucleus into the extracellular space. Heparin, a commonly used anti-coagulant, has been shown to possess life-saving capabilities for septic patients, but the potential interplay between heparin and extracellular histones has not been investigated. In this review, we summarize the pathogenic roles of extracellular histones and the therapeutic roles of heparin in the development and management of sepsis and septic shock.

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Microbial-Driven Stabilisation of Archaeological Iron Artefacts

Corrosion and Materials Degradation ◽

10.3390/cmd2020015 ◽

2021 ◽

Vol 2 (2) ◽

pp. 274-292

Author(s):

Sarah James ◽

Edith Joseph

Keyword(s):

Health And Safety ◽

Chloride Content ◽

Key Factors ◽

Passivation Layers ◽

Archaeological Iron ◽

Initial Results ◽

Sulphur Species ◽

Partial Success ◽

Made In

The instability of iron artefacts is rooted in salt contamination during burial and damages associated with exposure to alternative oxygen levels and high relative humidity once excavated. While a combination of chemical and mechanical treatments is utilised to remove the harmful ions (chlorides, sulphur species) and excess bulky corrosion products, these methods can be hazardous for conservation staff’s health, have limited success, or require extensive treatment times. Bio-based treatments provide a potentially greener alternative for removing damaging corrosion and creating biogenic mineral passivation layers, thus remediating concerns over costs, duration, and health and safety. Pseudomonas putida mt-2 (KT2440) is capable of utilising iron under certain conditions and for phosphating mild steel; however, applications have not been made in the cultural heritage sector. To address the potential of using bacteria for conservation purposes, Pseudomonas was assessed for both the bioremediation of salt contaminates and the production of a passivation layer suitable for iron artefacts, with specific conservation concerns in mind. Key factors for optimisation include the role of agitation, chloride content, and oxygen content on bacterial growth and biomineralisation. The initial results indicate a growth preference, not reliance, for NaCl and agitation with partial success of bioconversion of a mineral source.

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