scholarly journals Effects of Cardiac Hemodynamics on Agreement in the pH, HCO3- and Lactate Levels between Arterial and Venous Blood Samples in Patients with Known or Suspected Chronic Heart Failure

2015 ◽  
Vol 54 (15) ◽  
pp. 1841-1847 ◽  
Author(s):  
Satoshi Kurisu ◽  
Noriaki Watanabe ◽  
Hiroki Ikenaga ◽  
Tadanao Higaki ◽  
Takashi Shimonaga ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Venous Blood ◽  
Blood Samples ◽  
Cardiac Hemodynamics ◽  
Lactate Levels

scholarly journals Monocyte subpopulations of blood and bone marrow in patients with chronic heart failure

2018 ◽  
Vol 17 (4) ◽  
pp. 16-22
Author(s):  
M. V. Vins ◽  
S. P. Chumakova ◽  
O. I. Urazova ◽  
D. A. Azarova ◽  
V. M. Shipulin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Bone Marrow ◽  
Chronic Heart Failure ◽  
Ischemic Cardiomyopathy ◽  
Venous Blood ◽  
Relative Content ◽  
Red Bone Marrow ◽  
Healthy Donors ◽  
Monocyte Subpopulations ◽  
Classical Monocytes

The aim of the investigationwas to evaluate the ratio of classical (CD14++CD16-), intermediate (CD14++CD16+), nonclassical (CD14+CD16+) and transient (CD14+CD16–) monocytes in the blood and bone marrow in patients with chronic heart failure (CHF) against ischemic cardiomyopathy (ICMP).Materials and methods. 17 patients with ICMP and 14 practically healthy donors were observed. The material of the study was venous blood (in patients and healthy donors) and red bone marrow (in patients). In the materials the relative content of different monocytes subpopulations was determined by flow cytometry. The obtained results were analyzed by statistical methods.Results. It is shown that in the blood of patients the proportion of monocytes with the phenotype CD14++CD16- is 57.77 [of 46.35; 79.76]%, CD14++CD16+ – 25.06 [4.96; 42.31]%, CD14+CD16+ 5.05 [4.08; 6.58]% and CD14+CD16- – 6.03 [3.58; 10.89]%; in the bone marrow – 43.44 [40.54; 44.68]%, 0.16 [0; 1.07]%, 0,54 [0.35; 1.07]% and 54,32 [52.83; 56.08]%, respectively, which is different from the content of the data cells subpopulations in the blood (p < 0.05). At the same time, the content of non-classical monocytes in the patients’ blood is 2 times lower than in healthy donors, and the number of other cells varies within the norm.Conclusion. The differentiation of monocytes into 4 subpopulations in patients with CHF occurs directly in the bloodstream, since mainly the classical and transitional monocyte fractions with the prevalence of the latter are present in the bone marrow. Deficiency of non-classical monocytes of blood in CHF is probably associated with a disruption of their extramedullary differentiation.

Concentration of renin in renal venous blood in patients with chronic heart failure

1946 ◽  
Vol 1 (5) ◽  
pp. 468-472 ◽  
Author(s):  
Arthur J. Merrill ◽  
Jas.L. Morrison ◽  
Emmett S. Brannon
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Venous Blood

scholarly journals Early changes of energy metabolism, isoformic content and level of titin phosphorylation at diastolic dysfunction

Kardiologiia ◽  
2020 ◽  
Vol 60 (2) ◽  
pp. 4-9
Author(s):  
V. L. Lakomkin ◽  
A. A. Abramov ◽  
I. M. Studneva ◽  
A. D. Ulanova ◽  
I. M. Vikhlyantsev ◽  
...  
Keyword(s):  
Heart Failure ◽  
Energy Metabolism ◽  
Chronic Heart Failure ◽  
Left Ventricle ◽  
Diastolic Dysfunction ◽  
Anaerobic Metabolism ◽  
Normal Values ◽  
Adenine Nucleotides ◽  
Lactate Levels ◽  
Myofibril Protein

Relevance. Diastolic dysfunction occurring at hypertension, obesity, diabetes, or treatment with doxorubicin tends to prevail in all patterns of chronic heart failure. Lack of effective therapy forces to look more into the metabolic processes in cardiomyocytes.Objective. Assess energy metabolism in cardiomyocytes and changes in titin, a giant myofibril protein that responsible for their elasticity.Material and Methods. The study model was cardiomyopathy occurring after the 4-week administration of doxorubicin (2 mg/kg weekly). Diastolic dysfunction was identified by echocardiography and catheterization with the simultaneous measurement of pressure and volume of the left ventricle (LV).Results. The levels of adenine nucleotides and phosphocreatine in the heart of animals treated with doxorubicin differed little from the normal values, but lactate levels were increased manifold. A 50% increase in the level of titin phosphorylation was detected, which correlated (r = 0,94) with a nearly twofold increase in the share of a more elastic N2BA-isoform of this protein.Conclusion. This form of diastolic dysfunction involves the activation of anaerobic metabolism and increased stretching of myofibrils facilitating LV filling.

scholarly journals Circulating Biomarkers of Cell Adhesion Predict Clinical Outcome in Patients with Chronic Heart Failure

2020 ◽  
Vol 9 (1) ◽  
pp. 195 ◽  
Author(s):  
Elke Bouwens ◽  
Victor J. van den Berg ◽  
K. Martijn Akkerhuis ◽  
Sara J. Baart ◽  
Kadir Caliskan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cell Adhesion ◽  
Chronic Heart Failure ◽  
Clinical Outcome ◽  
Adhesion Molecule ◽  
Temporal Patterns ◽  
Cellular Adhesion ◽  
Left Ventricular ◽  
Blood Samples ◽  
Two Samples

Cardiovascular inflammation and vascular endothelial dysfunction are involved in chronic heart failure (CHF), and cellular adhesion molecules are considered to play a key role in these mechanisms. We evaluated temporal patterns of 12 blood biomarkers of cell adhesion in patients with CHF. In 263 ambulant patients, serial, tri-monthly blood samples were collected during a median follow-up of 2.2 (1.4–2.5) years. The primary endpoint (PE) was a composite of cardiovascular mortality, HF hospitalization, heart transplantation and implantation of a left ventricular assist device and was reached in 70 patients. We selected the baseline blood samples in all patients, the two samples closest to a PE, or, for event-free patients, the last sample available. In these 567 samples, associations between biomarkers and PE were investigated by joint modelling. The median age was 68 (59–76) years, with 72% men and 74% New York Heart Association class I–II. Repeatedly measured levels of Complement component C1q receptor (C1qR), Cadherin 5 (CDH5), Chitinase-3-like protein 1 (CHI3L1), Ephrin type-B receptor 4 (EPHB4), Intercellular adhesion molecule-2 (ICAM-2) and Junctional adhesion molecule A (JAM-A) were independently associated with the PE. Their rates of change also predicted clinical outcome. Level of CHI3L1 was numerically the strongest predictor with a hazard ratio (HR) (95% confidence interval) of 2.27 (1.66–3.16) per SD difference in level, followed by JAM-A (2.10, 1.42–3.23) and C1qR (1.90, 1.36–2.72), adjusted for clinical characteristics. In conclusion, temporal patterns of C1qR, CDH5, CHI3L1, EPHB4, ICAM2 and JAM-A are strongly and independently associated with clinical outcome in CHF patients.

scholarly journals The evaluation of 25(OH)D concentration in blood serum of chronic heart failure patients

2016 ◽  
Vol 29 (3) ◽  
pp. 107-110
Author(s):  
Tomasz Lewandowski ◽  
Andrzej Baginski ◽  
Arleta Malecha-Jedraszek ◽  
Jerzy Mosiewicz ◽  
Helena Donica
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Chronic Heart Failure ◽  
Statistical Significance ◽  
Venous Blood ◽  
Control Group ◽  
Total Calcium ◽  
Phosphate Homeostasis ◽  
Creatinine Concentration ◽  
Inorganic Phosphates

Abstract This current study examined patients with severe chronic heart failure (CHF) in order to ascertain the held vitamin D, based on an assessment of calcidiol [25(OH)D] concentration. It also identified and evaluated possible correlations between 25(OH)D level and the concentration of total calcium, inorganic phosphates and creatinine concentration in their serum. Herein, venous blood samples were taken from 36 patients with CHF. Diagnosis was confirmed by echocardiographic, as well as by electrocardiographic examinations. In this work, the control group consisted of 41 randomly selected healthy individuals. The results of our study showed that CHF patients had significantly lower concentration of 25(OH)D, as well as total calcium and inorganic phosphates. Moreover, mean creatinine concentration was higher, in comparison to the control group, but did not exhibit statistical significance. As calcium-phosphate homeostasis is regulated by numerous factors, including PTH, neurohormonal factors and calcitriol (1,25(OH)2D), it is possible that vitamin D deficiency may play a significant role in the pathomechanism of CHF, and a lowered 25(OH)D level may be related to progression of the disease.

N-acetyl-ß-D-glucosaminidase is predictive of mortality in chronic heart failure: a 10-year follow-up

2021 ◽  
Author(s):  
Christina Strack ◽  
Susanne Bauer ◽  
Ute Hubauer ◽  
Ekrem Ücer ◽  
Christoph Birner ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Cox Regression ◽  
Kidney Injury ◽  
Blood Samples ◽  
Cox Regression Analysis ◽  
All Cause Mortality ◽  
Long Term Follow Up

Aim: The study focused on biomarkers of kidney injury as predictors of mortality in patients with chronic heart failure (CHF) in a long-term follow-up (median 104 months). Methods/results: KIM-1, NAG and NGAL were assessed from urine, NT-proBNP from blood samples. 149 patients (age 62 ± 12 years) with CHF (mean EF 30% [IQR 24–40%]) were enrolled. 79 (53%) patients died. Cox regression analysis revealed Log2NAG (HR: 1.46, CI: 1.12–1.89), Log2KIM-1 (HR: 1.23, CI: 1.02–1.49) and Log2NT-proBNP (HR: 1.50, CI: 1.32–1.72) as significant predictors of all-cause mortality as opposed to Log2NGAL (HR: 1.04, CI: 0.90–1.20). Log2NAG remained a significant predictor of all-cause mortality in a multivariate Cox regression model but lost its predictive value in combination with Log2NT-proBNP. Conclusion: The 10-year follow-up suggests NAG as a predictive tubular marker in CHF patients.

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