scholarly journals Lipid Oxidation Products in the Pathogenesis of Inflammation-related Gut Diseases

2018 ◽  
Vol 25 (11) ◽  
pp. 1311-1326 ◽  
Author(s):  
Barbara Sottero ◽  
Daniela Rossin ◽  
Giuseppe Poli ◽  
Fiorella Biasi
Keyword(s):  
Lipid Oxidation ◽  
Intestinal Inflammation ◽  
Biological Effects ◽  
Oxidation Products ◽  
Cholesterol Oxidation ◽  
Intestinal Damage ◽  
Therapeutic Benefits ◽  
Lipid Oxidation Products ◽  
Wide Range ◽  
Mucosal Barrier Function

Background: A defective mucosal barrier function is the principal cause of the uncontrolled onset and progression of a number of human inflammatory gut diseases, most of which are characterized by chronic intermittent immune and inflammatory responses leading to structural intestinal damage, which can represent a potential risk for colorectal cancer development. During the active disease phase the production of pro-inflammatory cytokines and chemokines, and the induction of oxidative reactions by activated leukocytes and epithelial cells represent the main event in the intestinal inflammation. Objective: Oxidative stress plays a key role in the development of intestinal damage. Indeed reactive oxygen species and their oxidized by-products regulate redox-sensitive signaling pathways and transcription factors, which sustain inflammation within the intestinal layer. Methods: Polyunsaturated fatty acids and cholesterol are the principal targets of oxidative modifications. These lipids, which are cell membrane constituents or are present in food, readily undergo non-enzymatic oxidation to form chemically-reactive species that can induce a wide range of biological effects including inflammation, programmed cell death, and proliferation. Results and Conclusions: In this review we summarize the current knowledge on the role of lipid oxidation products in regulating redox pathways involved in the pathogenesis of inflammation- related gut diseases. In particular, lipid peroxidation end products, such as isoprostanes and aldehydes, and cholesterol oxidation-derived oxysterols are taken into consideration. Results and Conclusions: The control of oxidative damage and consequently tissue local over-production of lipid oxidation products by using specific antioxidant and anti-inflammatory molecules in the diet may have clinical and therapeutic benefits.

Atherogenic and anti-atherogenic factors in the human diet

1995 ◽  
Vol 61 ◽  
pp. 259-271 ◽  
Author(s):  
P.B. Addis ◽  
T.P. Carr ◽  
C.A. Hassel ◽  
Z.Z. Huang ◽  
G.J. Warner
Keyword(s):  
Fatty Acids ◽  
Lipid Oxidation ◽  
Saturated Fatty Acids ◽  
Oxidation Products ◽  
Cholesterol Oxidation ◽  
Lipid Oxidation Products ◽  
Causative Factors ◽  
Copper Manganese ◽  
Potential Promoter ◽  
Arterial Damage

New atherosclerosis causative factors and preventive modalities have been identified. Atherogenic factors include lipid oxidation products, such as cholesterol oxidation products, malonaldehyde and other aldehydes; trans-fatty acids; some saturated fatty acids (lauric, myristic and possibly palmitic acids); and myristic acid plus cholesterol. Lipid oxidation products are well suited to induce arterial damage, based on their known cytotoxic effects; evidence also indicates the possibility of plaque promotion and stimulation of thrombogenesis. Anti-atherogenic factors include antioxidants, fish oils and other polyunsaturates (if protected from oxidation), fibre and trace minerals such as copper, manganese, selenium and zinc. Iron is unique, being considered as both a potential promoter of atherosclerosis (component of ferritin, conceivably inducing lipid oxidation) and a possible anti-atherogenic component (of antioxidant enzyme catalase). It is apparent that an entire new series of research challenges has been uncovered.

scholarly journals Oxidized Phospholipids in Healthy and Diseased Lung Endothelium

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 981 ◽  
Author(s):  
Pratap Karki ◽  
Konstantin G. Birukov
Keyword(s):  
Lung Injury ◽  
Therapeutic Potential ◽  
Biological Effects ◽  
Full Length ◽  
Oxidation Products ◽  
Lipid Mediator ◽  
Oxidized Phospholipids ◽  
Lipid Oxidation Products ◽  
Wide Range ◽  
Anti Inflammatory

Circulating and cell membrane phospholipids undergo oxidation caused by enzymatic and non-enzymatic mechanisms. As a result, a diverse group of bioactive oxidized phospholipids generated in these conditions have both beneficial and harmful effects on the human body. Increased production of oxidized phospholipid products with deleterious effects is linked to the pathogenesis of various cardiopulmonary disorders such as atherosclerosis, thrombosis, acute lung injury (ALI), and inflammation. It has been determined that the contrasting biological effects of lipid oxidation products are governed by their structural variations. For example, full-length products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine oxidation (OxPAPC) have prominent endothelial barrier protective and anti-inflammatory activities while most of the truncated oxidized phospholipids induce vascular leak and exacerbate inflammation. The extensive studies from our group and other groups have demonstrated a strong potential of OxPAPC in mitigating a wide range of agonist-induced lung injuries and inflammation in pulmonary endothelial cell culture and rodent models of ALI. Concurrently, elevated levels of truncated oxidized phospholipids are present in aged mice lungs that potentiate the inflammatory agents-induced lung injury. On the other hand, increased levels of full length OxPAPC products accelerate ALI recovery by facilitating production of anti-inflammatory lipid mediator, lipoxin A4, and other molecules with anti-inflammatory properties. These findings suggest that OxPAPC-assisted lipid program switch may be a promising therapeutic strategy for treatment of acute inflammatory syndromes. In this review, we will summarize the vascular-protective and deleterious aspects of oxidized phospholipids and discuss their therapeutic potential including engineering of stable analogs of oxidized phospholipids with improved anti-inflammatory and barrier-protective properties.

scholarly journals Effects of Dietary Cholesterol and Its Oxidation Products on Pathological Lesions and Cholesterol and Lipid Oxidation in the Rabbit Liver

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Sun Jin Hur ◽  
Ki Chang Nam ◽  
Byungrok Min ◽  
Min Du ◽  
Kwon Il Seo ◽  
...  
Keyword(s):  
Lipid Oxidation ◽  
Dietary Cholesterol ◽  
Thiobarbituric Acid ◽  
Oxidation Products ◽  
Rabbit Liver ◽  
Cholesterol Oxidation ◽  
Liver Lesions ◽  
Thiobarbituric Acid Reactive Substances ◽  
Pathological Lesions ◽  
Very High

This study was conducted to determine the effects of dietary cholesterol (CHO) and cholesterol oxidation products (COPs) on the induction of pathological lesions in rabbit liver tissues. Liver lesions were induced only when the levels of CHO and COPs in the diet were very high. The amount of CHO measured in the liver increased when dietary CHO was increased; by comparison, dietary COPs affected liver CHO amounts to a lesser extent. The TBARS (thiobarbituric acid reactive substances) value measured for the liver samples also increased when dietary CHO and COP levels were elevated, and the TBARS value was more strongly affected by the amount of COPs in the diet than by the amount of CHO. At 6 and 12 weeks, COP levels were the highest in the group that received 1.2 g CHO + 0.8 g COPs, followed by the 0.5 g CHO + 0.5 g COPs and 1.6 g CHO + 0.4 g COPs groups; the control (0 g) group showed the lowest COP levels among all groups. In this study, we found that not only dietary CHO but also COPs were involved in hypercholesterolemia induced liver lesions when the amount of CHO and COPs was high.

scholarly journals Accumulation of Aluminium and Physiological Status of Tree Foliage in the Vicinity of a Large Aluminium Smelter

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
E. D. Wannaz ◽  
J. H. Rodriguez ◽  
T. Wolfsberger ◽  
H. A. Carreras ◽  
M. L. Pignata ◽  
...  
Keyword(s):  
Lipid Oxidation ◽  
Membrane Lipid ◽  
Physiological Parameters ◽  
Oxidation Products ◽  
Physiological Status ◽  
Pollution Gradient ◽  
Sulphur Deposition ◽  
Aluminium Production ◽  
Lipid Oxidation Products ◽  
Tree Foliage

A pollution gradient was observed in tree foliage sampled in the vicinity of a large aluminium production facility in Patagonia (Argentina). Leaves ofEucalyptus rostrata, and Populus hybridusand different needle ages ofPinusspec. were collected and concentrations of aluminium (Al) and sulphur (S) as well as physiological parameters (chlorophyll and lipid oxidation products) were analyzed. Al and S concentrations indicate a steep pollution gradient in the study showing a relationship with the physiological parameters in particular membrane lipid oxidation products. The present study confirms that aluminium smelting results in high Al and sulphur deposition in the study area, and therefore further studies should be carried out taking into account potentially adverse effects of these compounds on human and ecosystem health.

Volatile Lipid Oxidation Products of Wagyu and Domestic Breeds of Beef

1996 ◽  
Vol 44 (4) ◽  
pp. 1091-1095 ◽  
Author(s):  
Terri D. Boylston ◽  
Sarah A. Morgan ◽  
Kristen A. Johnson ◽  
Ray W. Wright, ◽  
Jan R. Busboom ◽  
...  
Keyword(s):  
Lipid Oxidation ◽  
Oxidation Products ◽  
Lipid Oxidation Products
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