The Impact of Omega-3 Fatty Acids on Osteoporosis

2009 ◽  
Vol 15 (36) ◽  
pp. 4157-4164 ◽  
Author(s):  
M. Maggio ◽  
A. Artoni ◽  
F. Lauretani ◽  
L. Borghi ◽  
A. Nouvenne ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
The Impact

scholarly journals The Role of Micronutrients in Support of the Immune Response against Viral Infections

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3198 ◽  
Author(s):  
Francesco Pecora ◽  
Federica Persico ◽  
Alberto Argentiero ◽  
Cosimo Neglia ◽  
Susanna Esposito
Keyword(s):  
Fatty Acids ◽  
Immune Response ◽  
Immune System ◽  
Viral Infections ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Optimal Function ◽  
The Impact

Viral infections are a leading cause of morbidity and mortality worldwide, and the importance of public health practices including handwashing and vaccinations in reducing their spread is well established. Furthermore, it is well known that proper nutrition can help support optimal immune function, reducing the impact of infections. Several vitamins and trace elements play an important role in supporting the cells of the immune system, thus increasing the resistance to infections. Other nutrients, such as omega-3 fatty acids, help sustain optimal function of the immune system. The main aim of this manuscript is to discuss of the potential role of micronutrients supplementation in supporting immunity, particularly against respiratory virus infections. Literature analysis showed that in vitro and observational studies, and clinical trials, highlight the important role of vitamins A, C, and D, omega-3 fatty acids, and zinc in modulating the immune response. Supplementation with vitamins, omega 3 fatty acids and zinc appears to be a safe and low-cost way to support optimal function of the immune system, with the potential to reduce the risk and consequences of infection, including viral respiratory infections. Supplementation should be in addition to a healthy diet and fall within recommended upper safety limits set by scientific expert bodies. Therefore, implementing an optimal nutrition, with micronutrients and omega-3 fatty acids supplementation, might be a cost-effective, underestimated strategy to help reduce the burden of infectious diseases worldwide, including coronavirus disease 2019 (COVID-19).

Modulatory effect of cod-liver oil on Na+-K+ ATPase in rats’ brain

2010 ◽  
Vol 30 (4) ◽  
pp. 267-274 ◽  
Author(s):  
Taha A Kumosani ◽  
Said S Moselhy
Keyword(s):  
Fatty Acids ◽  
Atpase Activity ◽  
Cod Liver Oil ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Partial Restoration ◽  
Significant Depression ◽  
Cholinesterase Activities ◽  
The Impact ◽  
The Brain

Omega-3 fatty acids were used in the treatment of psychiatric diseases such as bipolar disorder. Na +, K+-ATPase is also a well-known target for these fatty acids. In this study, we investigated the impact of cod-liver oil (CLO), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on Na+, K+-ATPase, cholinesterase activities, the levels of norepinephrine (NE) and acetylcholine in different regions of rat brain. Our results showed that DHA caused a significant depression in cerebellum Na+, K +-ATPase, whereas CLO activated it. In addition, CLO, EPA and DHA produced a significant activation in Na+, K+-ATPase activity in medulla, midbrain and hypothalamus. There were non-significant changes in the activity of cholinesterase enzyme in cerebellum and medulla, while in midbrain and hypothalamus the CLO, DHA and EPA enhanced the activity by 75%, 100% and 78%, respectively. The content of NE in hypothalamus showed slight increase in different regions of the brain of animals fed CLO, DHA or EPA. In conclusion, CLO, DHA or EPA supplementation had a beneficial effect that associated with a normalization of fatty acids incorporation into phospholipid membranes and a partial restoration of Na+, K+-ATPase activity, suggesting that CLO supplementation may improve fatty acid composition and moderately enhance Na+, K+-ATPase activity.

scholarly journals Are the Adaptogenic Effects of Omega 3 Fatty Acids Mediated via Inhibition of Proinflammatory Cytokines?

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Joanne Bradbury ◽  
Lyndon Brooks ◽  
Stephen P. Myers
Keyword(s):  
Fatty Acids ◽  
Proinflammatory Cytokines ◽  
Structural Equation ◽  
Ex Vivo ◽  
Equation Modeling ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
The Impact ◽  
Necrosis Factor ◽  
Analyze Data

The study was undertaken to estimate the size of the impact of n-3 fatty acids in psychological stress and the extent to which it is mediated via proinflammatory cytokines. Structural equation modeling (SEM) was used to analyze data from 194 healthy Australians. Biomarkers used were erythrocyte polyunsaturated fatty acids (docosahexaenoic acid (DHA) and arachidonic acid (AA)),ex-vivostimulated secretion of proinflammatory cytokines (interleukins (IL-1 and IL-6), and tumor necrosis factor (TNF)). Stress was measured with the perceived stress scale (PSS-10), found to comprise three factors: Coping (items 4, 7, 5), Overwhelm (2, 10, 6 and 8), and Emotional (1, 9 and 3). This modeling demonstrated that the effects of DHA on coping are largely direct effects (0.26,t=2.05) and were not significantly mediated via the suppression of proinflammatory cytokines. Future modeling should explore whether adding EPA to the model would increase the significance of the mediation pathways.

scholarly journals Omega-3 fatty acids and cardiovascular disease risk: do we understand the relationship?

2009 ◽  
pp. S19-S26 ◽  
Author(s):  
M Vrablík ◽  
M Prusíková ◽  
M Šnejdrlová ◽  
L Zlatohlávek
Keyword(s):  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Disease Risk ◽  
Large Body ◽  
Current Evidence ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Cvd Risk ◽  
Positive Effects ◽  
The Impact

There is a large body of evidence documenting the effects of long-chain polyunsaturated fatty acids with the first double bond at the third position from methyl-terminal (so called omega-3 fatty acids (FAs)) on different components of cardiovascular disease (CVD) risk. However, it may seem the more answers on the topic we learn, the more questions remain to be elucidated. There are three levels of evidence documenting the impact of fish omega-3 FAs on CVD risk. Epidemiological data have shown unequivocally the increased intake of fish is associated with lower CVD morbidity and mortality. Numerous experimental studies have shown (almost always) positive effects of omega-3 FAs on lipoprotein metabolism, coagulation and platelet function, endothelial function, arterial stiffness etc. Most importantly, there are a few prospective clinical endpoint trials (DART, JELIS, GISSI Prevenzione and GISSI-HF) that have examined the impact of omega-3 FAs supplementation on cardiovascular outcomes in different patient populations. Recent meta-analyses of these and other clinical studies have yielded somewhat conflicting results. In this review we will summarize current evidence of omega-3 FAs effects on cardiovascular risk focusing on new data from recent clinical trials as well as possible practical implications for clinical practice.

The Impact of Low Omega-3 Fatty Acids Diet on the Development of the Visual System

2019 ◽  
pp. 369-395
Author(s):  
Poliana Capucho Sandre ◽  
Patricia Coelho de Velasco ◽  
Claudio Alberto Serfaty
Keyword(s):  
Fatty Acids ◽  
Visual System ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
The Impact

The Impact of Omega-3 Fatty Acids on Quality of Life

2019 ◽  
pp. 33-41
Author(s):  
Ondine van de Rest ◽  
M. Yulianto Kurniawan ◽  
Lisette CPGM de Groot
Keyword(s):  
Quality Of Life ◽  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
The Impact

scholarly journals Omega 3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials

2019 ◽  
Author(s):  
Rossella Avallone ◽  
Giovanni Vitale ◽  
Marco Bertolotti
Keyword(s):  
Fatty Acids ◽  
Clinical Trials ◽  
Neurodegenerative Diseases ◽  
Epidemiological Studies ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Beneficial Effects ◽  
Cell Membrane Fluidity ◽  
The Impact ◽  
New Evidence

A nutritional approach could be a promising strategy to prevent or slow the progression of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, since there is no effective therapy for these diseases so far. The beneficial effects of omega-3 fatty acids are now well established by a plethora of studies through their involvement in multiple biochemical functions, including synthesis of antinflammatory mediators, cell membrane fluidity, intracellular signalling and gene expression. This systematic review will consider epidemiological studies and clinical trials that assessed the impact of supplementation or dietary intake of omega-3 polyunsaturated fatty acids on neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases. Indeed, treatment with omega-3 fatty acids, being safe and well tolerated, represent a valuable and biologically plausible tool in the management of neurodegenerative diseases in their early stages.

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