Computational Prediction of Protein Hot Spot Residues

2012 ◽  
Vol 18 (9) ◽  
pp. 1255-1265 ◽  
Author(s):  
John Kenneth Morrow ◽  
Shuxing Zhang
2012 ◽  
Vol 18 (9) ◽  
pp. 1255-1265 ◽  
Author(s):  
John Kenneth Morrow ◽  
Shuxing Zhang

1996 ◽  
Vol 75 (04) ◽  
pp. 546-550 ◽  
Author(s):  
Marianne Schwartz ◽  
Albert Békássy ◽  
Mikael Donnér ◽  
Thomas Hertel ◽  
Stefan Hreidarson ◽  
...  

SummaryTwelve different mutations in the WASP gene were found in twelve unrelated families with Wiskott-Aldrich syndrome (WAS) or X-linked thrombocytopenia (XLT). Four frameshift, one splice, one nonsense mutation, and one 18-base-pair deletion were detected in seven patients with WAS. Only missense mutations were found in five patients diagnosed as having XLT. One of the nucleotide substitutions in exon 2 (codon 86) results in an Arg to Cys replacement. Two other nucleotide substitutions in this codon, R86L and R86H, have been reported previously, both giving rise to typical WAS symptoms, indicating a mutational hot spot in this codon. The finding of mutations in the WASP gene in both WAS and XLT gives further evidence of these syndromes being allelic. The relatively small size of the WASP gene facilitates the detection of mutations and a reliable diagnosis of both carriers and affected fetuses in families with WAS or XLT.


2013 ◽  
Vol 10 (3) ◽  
pp. 342-358 ◽  
Author(s):  
Apostolos G. Papadopoulos ◽  
Christos Chalkias ◽  
Loukia-Maria Fratsea

The paper explores the challenges faced today, in a context of severe economic crisis, by immigrant associations (ΙΜΑs) and Non-Governmental Organizations (NGOs) in Greece. The data analysed here was collected between October 2009 and February 2010 and incorporates references to all recorded migration-related social actors operating in Greece. The paper takes into account such indicators as legal form, objectives, financial capacity and geographical range of activity, concluding with a typology of civil society actors dealing with migration issues. This study aims at informing the migration policymaking and migrant integration processes. By a spatial hot-spot clustering of IMAs and NGOs, we also illustrate the concentration patterns of civil society actors in Greece.


2020 ◽  
pp. 116-122
Author(s):  
Emre Öztürk ◽  
Mehmet Aktaş ◽  
Tunç Şenyüz

The purpose of this research is to reach good correlation between sun load simulation and solar focusing test for exterior automotive lighting products. Light coming from sun is highly collimated (parallel rays) and focusable from lenses with concave structure. Focusing incidence leads to a hot spot on lens surrounding plastic parts which may cause melting failures at high temperature zones. Sun load simulation is performing to eliminate risk of discoloration, deformation, out gassing, coating failures and fire with prolonged exposure from field. Irradiance values in W/m2 defined in simulation as heat source depending of an angle of incidence of the sun radiation. At first step, simulation is performing with 5 degree intervals to define the critical zones then intervals decreased to 2 degree to detect the critical azimuth and inclination angles. Critical azimuth and inclination angles is checking with ray trace analysis to check the bouncing of sun rays and possible solution to eliminate focuses with design solutions. After numerical analysis to release and validate the automotive lighting products regarding the sun load test, measurement with first parts is necessary. Measurement is performing for all critical angles which have been detected at simulation with thermal camera under ultra high-collimation solar simulator. Measured temperatures are settled according to environment conditions and correlation is checking with simulations.


Author(s):  
Yonghee PARK ◽  
Junghoe CHOI ◽  
Jisuk HONG ◽  
Sanghoon LEE ◽  
Moonhyun YOO ◽  
...  
Keyword(s):  
Hot Spot ◽  

Author(s):  
Georgiana Grigoraș ◽  
Bogdan Urițescu

Abstract The aim of the study is to find the relationship between the land surface temperature and air temperature and to determine the hot spots in the urban area of Bucharest, the capital of Romania. The analysis was based on images from both moderate-resolution imaging spectroradiometer (MODIS), located on both Terra and Aqua platforms, as well as on data recorded by the four automatic weather stations existing in the endowment of The National Air Quality Monitoring Network, from the summer of 2017. Correlation coefficients between land surface temperature and air temperature were higher at night (0.8-0.87) and slightly lower during the day (0.71-0.77). After the validation of satellite data with in-situ temperature measurements, the hot spots in the metropolitan area of Bucharest were identified using Getis-Ord spatial statistics analysis. It has been achieved that the “very hot” areas are grouped in the center of the city and along the main traffic streets and dense residential areas. During the day the "very hot spots” represent 33.2% of the city's surface, and during the night 31.6%. The area where the mentioned spots persist, falls into the "very hot spot" category both day and night, it represents 27.1% of the city’s surface and it is mainly represented by the city center.


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