Nano Phytomedicine Based Delivery System for CNS Disease

2020 ◽  
Vol 21 (9) ◽  
pp. 661-673 ◽  
Author(s):  
Mohammed Asadullah Jahangir ◽  
Chettupalli Anand ◽  
Abdul Muheem ◽  
Sadaf Jamal Gilani ◽  
Mohamad Taleuzzaman ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Low Cost ◽  
Herbal Medicines ◽  
Herbal Drugs ◽  
Widespread Acceptance ◽  
The Central Nervous System ◽  
Low Toxicity ◽  
Ancient Times ◽  
Plant Sources ◽  
Herbal Formulations

Herbal medicines are being used since ancient times and are an important part of the alternative and traditional medicinal system. In recent decades, scientists are embracing herbal medicines based on the fact that a number of drugs that are currently in use are derived directly or indirectly from plant sources. Moreover, herbal drugs have lesser side effects, albeit are potentially strong therapeutic agents. The herbal medicine market is estimated to be around US $62 billion globally. Herbal medicine has gained widespread acceptance due to its low toxicity, low cost, ease of accessibility and efficacy in treating difficult diseases. Safety and efficacy are another important factors in the commercialization process of herbal medicines. Nanotechnology has been shown to be potentially effective in improving the bioactivity and bioavailability of herbal medicines. Development of nano-phytomedicines (or by reducing the size of phytomedicine), attaching polymers with phytomedicines and modifying the surface properties of herbal drugs, have increased the solubility, permeability and eventually the bioavailability of herbal formulations. Novel formulations such as niosomes, liposomes, nanospheres, phytosomes etc., can be exploited in this area. This article reviews herbal medicines, which have prominent activity in the Central Nervous System (CNS) disorders and reported nano-phytomedicines based delivery systems.

Herbal Medicine: Clinical Perspective & Regulatory Status

2020 ◽  
Vol 23 ◽  
Author(s):  
Md Abul Barkat ◽  
Anjali Goyal ◽  
Harshita Abul Barkat ◽  
Mohammad Salauddin ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Herbal Medicines ◽  
New Drugs ◽  
Herbal Drugs ◽  
Clinical Perspective ◽  
Regulatory Status ◽  
Novel Drugs ◽  
History Of ◽  
Pros And Cons ◽  
Health Complications

Abstract:: Herbal medicines pays an important in treating the vaious diseases mainly due to the their potentially high therapeutic values and also due to the better acceptance of vaioruspatient under different health complications. The herbal medicine practice involves use of part of plant, entire plant or the selectctive isolated phytomedicineand the use and practices based on these has its pros and cons and has been greatly affected during the dawn. The search of new drugs during scientific era revives the interest in discovery of herbal drugs from different natural resources during 20th century. The present modern healthcare system invovlves utilization drugs and 50% of them are of ofnaural origin. Herbal drug disocovery found to be highly costly affair with low success rate and it hinders the further progress in utilizting the phytomedicine in treating the various deseases. But in recent years there is an increase in the search interest of herbal drugs mainly by the pharmaceutical industry and those invoves in the search of novel drugs from the herbs. Discovery of such new novel phytomedicines has to overcomes various challenges in indentification of active extracts and their toxicity, advereffects, herb drug interaction and importantly their regulatory requirments. The present review mainly focused on the history of herbal medicine, current clinical perspective, pharmaceutical, and regulatory challenges as well as its clinical presentation. Moreover, problems encountered in drug discovery from herbal resources and its possible solutions are delineated.

scholarly journals Traditional Herbal Medicine: A Review of Potential of Inhibitory Hepatocellular Carcinoma in Basic Research and Clinical Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Zhidong Wang ◽  
Jun Li ◽  
Yuanyuan Ji ◽  
Peng An ◽  
Shu Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Herbal Medicine ◽  
Herbal Remedy ◽  
Low Cost ◽  
Basic Research ◽  
Traditional Herbal Medicine ◽  
Aggressive Cancer ◽  
Low Toxicity ◽  
Arterial Chemoembolization

Although significantly develops in hepatocellular carcinoma (HCC), features of HCC remain an aggressive cancer with a dismal outcome. Traditional Chinese medicine (TCM), specifically Chinese herbal medicine (CHM), is one of the most popular complementary and alternative medicine modalities worldwide. The use of heat-clearing and detoxicating (Chinese namedqingre jiedu) CHM has attracted great attention as an alternative antitumor including HCC considering its low toxicity and high activity. Together these reports indicate that CHM is a promising anti-HCC herbal remedy in basic research. For patients with advanced HCC, CHM including formula and single combined with transcatheter arterial chemoembolization or chemotherapy is able to decrease tumor growth and the side effect of toxicity and improve overall survival, quality of life, and immune function. Due to its abundance, low cost, and safety in consumption, CHM remains a species with tremendous potential for further investigation in HCC.

scholarly journals AN EXHAUSTIVE REVIEW ON HERBS USED IN THE MANAGEMENT OF DIABETES MELLITUS TYPE 2

2019 ◽  
pp. 5-11
Author(s):  
Salman Mau ◽  
Shakir Saleem ◽  
Vishwadeepak Kimothi ◽  
Vineet Joshi ◽  
Sanjay Singh
Keyword(s):  
Diabetes Mellitus ◽  
Raw Materials ◽  
Nigella Sativa ◽  
Low Cost ◽  
Herbal Medicines ◽  
Analytical Techniques ◽  
Herbal Drugs ◽  
Herbal Products ◽  
High Blood Glucose ◽  
Glucose Levels

Diabetes mellitus is one of the most common metabolic disorders associated with disturbed hormonal secretion. Diabetes is characterized by high blood glucose levels over a prolonged period of time. High sugar levels are due to abnormal metabolism of carbohydrates and lipids which is caused by absolute or relative insulin deficiency. Herbal medicines have been the highly esteemed source of medicine throughout the human history. Herbs are becoming more popular today because of their least side effects, holistic beliefs, easy availability and low cost. Individual herbal products and formulations are gaining popularity because of their quality manufacturing using modern analytical techniques and standardized raw materials. Herbal drugs are widely used for the treatment of diabetes worldwide in various dosage forms. India has a long list of native herbal drugs with scientifically proven blood sugar lowering properties. The seeds of Nigella sativa, Olea europaea, fruits of Aegle marmelos, Momordica charantia, Coccinia indica, Nigella sativa,Gymnema sylvestre leaves,whole plant of Pterocarpus marsupium, Syzygium cumini fruits, Swertia punicea, Urtica dioica, gum of Ferula assa-foetida and seeds of Trigonella foenum graecum were discussed along with their reported mechanisms of action. In this review paper an attempt has been made to give an overview of certain Indian plants which have shown their anti-diabetic activity in various pre-clinical studies.

scholarly journals Metal Nanodelivery Systems for Improved Efficacy of Herbal Drugs

2019 ◽  
Vol 16 (2) ◽  
pp. 251-261 ◽  
Author(s):  
Sonu Ambwani ◽  
Roopali Tandon ◽  
Tanuj Kumar Ambwani
Keyword(s):  
Release Site ◽  
The Body ◽  
Herbal Drugs ◽  
Sustained Drug Release ◽  
Dose Administration ◽  
Site Of Action ◽  
Ancient Times ◽  
Solvent Systems ◽  
Specific Tissue ◽  
Herbal Formulations

Herbal drugs have been used since ancient times in various parts of the world. These have wide acceptability due to their time-tested therapeutic values and minimal side effects in contrast to modern allopathic medicines. Mostly, the herbal drugs are either in dried powder form or in crude extract form prepared in different solvent systems. These preparations generally need large dose administration and also could be less effective in the form of conventional formulations. Moreover, these herbal formulations cannot be targeted to specific tissue in case of different chronic diseases. Oral consumed herbal formulations display reduced bioavailability as these are subjected to adverse pH, enzymatic degradation and ultimately poor gut absorption. Constraints associated with conventional phytopharmaceuticals have been improved by designing and using “Nano Delivery Systems” (NDS). The foremost aim of NDS is to provide sustained drug release, site-specific action, and improved patient’s compliance. Nanometal based herbal drugs can be used for targeted drug delivery in the body which improves their safety, effectiveness and reduces need of frequent large doses. Metal Nanocarriers loaded with herbal drugs can carry the optimal amount of the drug to their site of action avoiding different obstructions such as low pH in the stomach, metabolism by liver so that the drug can circulate into the blood for a longer period of time. Herbal drugs with NDS thus would be helpful in enhancing their efficacy.

scholarly journals Impact of herbal drugs and its clinical application

2019 ◽  
Vol 10 (2) ◽  
pp. 1340-1345
Author(s):  
Vetriselvan Subramaniyan ◽  
Saminathan Kayarohanam ◽  
Ashok Kumar J ◽  
Vinoth Kumarasamy
Keyword(s):  
Health Care Professionals ◽  
Herbal Medicines ◽  
Drug Formulation ◽  
Therapeutic Effects ◽  
Clinical Use ◽  
Herbal Drugs ◽  
Herbal Drug ◽  
Alternative Medicines ◽  
Ancient Times ◽  
The Impact

Since ancient times until now exploring the importance of herbal medicines to treat the variety of diseases. Currently the herbal medicines searching for health, wellness and aim to achieve effective treatment without much side effect. Recent days the impact of herbal medicines well established even herbal treatment is one of the alternative medicines for most of the diseases such as hyperlipidemia, diabetes mellitus etc. Medicinal plants always have been rich sources of bioactive compounds, and that will be very helpful to human health. The reasons for herbal medicines attracted by the health care professionals and common individuals, including concern about confidence and safety of drugs. Allopathic medicines have many side effects and sometimes failing to treat and most of the herbal drugs proven better therapeutic effects without any major adverse effects. With the demand for phytomedicine user, this review highlights modern herbal drug formulation and its clinical use.

scholarly journals Standardization of Herbal Drugs – A Overview

2021 ◽  
Vol 68 (1) ◽  
Author(s):  
D. Umamaheswari ◽  
R. Muthuraja ◽  
M. Kumar ◽  
B.S. Venkateswarlu
Keyword(s):  
Medicinal Plants ◽  
Raw Materials ◽  
Herbal Medicines ◽  
Therapeutic Agents ◽  
Pharmaceutical Manufacturing ◽  
Quality Assurance Program ◽  
Herbal Drugs ◽  
Quantitative Analyses ◽  
Herbal Formulations ◽  
Dosage Formulation

The medicinal plants are important source for pharmaceutical manufacturing. Medicinal plants & herbal medicines account for a significant percentage of the pharmaceutical market. As the side effects of Synthetic medicine have started getting more apparent, majority of formulation are prepared from herbs. The herbal medicines however, suffer from lack of standardization parameters. The main limitation is the lack of standardization of raw materials, of processing methods and of the final products, dosage formulation, and the non existence of criteria for quality control. Herbal formulations have reached extensive acceptability as therapeutic agents for several diseases. The development of authentic analytical methods which can reliably profile the phytochemical composition, including quantitative analyses of marker/bioactive compounds and other major constituents, is a major challenge to scientists. Standardization is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production and manufacturing of herbal drugs.

Herbal Medicine in the Treatment of Epilepsy

2020 ◽  
Vol 21 ◽  
Author(s):  
Simin Namvar Aghdash
Keyword(s):  
Herbal Medicine ◽  
Herbal Medicines ◽  
Epileptic Seizures ◽  
Middle Income ◽  
Treatment Of Epilepsy ◽  
Traditional Remedies ◽  
Epileptic Patients ◽  
The Central Nervous System ◽  
Phytochemical Components ◽  
And Control

: Epilepsy is one of the most common disorders of the central nervous system. Although epilepsy is common worldwide, however, approximately 80% of epileptic patients live in the developing countries or those with low-middle income. Up until the second decade of the 20th century, epilepsy was treated mostly by traditional remedies. Today, an-tiepileptic drugs are used as a general treatment instead to prevent and control epileptic seizures, however, patient access to these drugs is hindered due to the healthcare systems of their countries and a number of other reasons, such as cultural, socio-demographic, and financial poverty. In addition, approximately 30-40%of epileptic patients suffer from refractory epilepsy, additionally, AEDs have adverse side-effects that can lead to treatment failure or reduce the patient’s quality of life. Despite recent advances in the treatment of epilepsy, there is still a need for improving medical treatment with a par-ticular focus on efficacy, safety, and accessibility. Since herbal medicines have been used for many centuries around the world for treating epilepsy, it is, therefore, plausible that a rigorous study on herbal medicine and phytochemical compo-nents within plants of various species and origin, may lead to the discovery of novel AEDs. Nowadays, many medicinal plants used in different cultures and regions of world have been identified. Most phytochemical components of these plants have been identified and, in some cases, their targets located. Therefore, it is possible that new, effective, and ac-cessible anticonvulsants drugs can be obtained from medicinal plant.

Stratagems of Nanotechnology Augmenting the Bioavailability and Therapeutic Efficacy of Traditional Medicine to Formulate Smart Herbal Drugs Combating

2017 ◽  
pp. 250-282
Author(s):  
Anita Margret
Keyword(s):  
Mental Health ◽  
Traditional Medicine ◽  
Herbal Medicines ◽  
Global Burden ◽  
Emotional States ◽  
Herbal Drugs ◽  
Active Components ◽  
Scientific Analysis ◽  
Mental Abilities ◽  
Herbal Formulations

Mental illness is one of the most fundamental emotional states of conscious being which becomes unbalanced and leads to neurological disorders. It is a significant contributor to the global burden of disease and there is a strong desire to devise a remedy. Ayurveda represents a traditional medicine system of India that endorses antiquity than western medicine and relies on formulations rather than their active components. It has categorised a group of herbal medicines to improve mental abilities. Conversely, the mechanistic details of the therapy are not available in ayurvedic literature and there is a need to fortify this system with modern scientific analysis. The design of nanosystems encompasses promising characteristics in the field of drug delivery with a limited dosage thereby decreasing adverse effects. This chapter confers stratagems of devising polymeric nano herbal formulations as smart nano brain drugs to espouse mental health.

Stratagems of Nanotechnology Augmenting the Bioavailability and Therapeutic Efficacy of Traditional Medicine to Formulate Smart Herbal Drugs Combating

2017 ◽  
pp. 1780-1804
Author(s):  
Anita Margret
Keyword(s):  
Mental Health ◽  
Traditional Medicine ◽  
Herbal Medicines ◽  
Global Burden ◽  
Emotional States ◽  
Herbal Drugs ◽  
Active Components ◽  
Scientific Analysis ◽  
Mental Abilities ◽  
Herbal Formulations

Mental illness is one of the most fundamental emotional states of conscious being which becomes unbalanced and leads to neurological disorders. It is a significant contributor to the global burden of disease and there is a strong desire to devise a remedy. Ayurveda represents a traditional medicine system of India that endorses antiquity than western medicine and relies on formulations rather than their active components. It has categorised a group of herbal medicines to improve mental abilities. Conversely, the mechanistic details of the therapy are not available in ayurvedic literature and there is a need to fortify this system with modern scientific analysis. The design of nanosystems encompasses promising characteristics in the field of drug delivery with a limited dosage thereby decreasing adverse effects. This chapter confers stratagems of devising polymeric nano herbal formulations as smart nano brain drugs to espouse mental health.

scholarly journals Cytotoxic and Gene Expression Research on Kras Gene in Lung Cancer Cell Line of A549 Treated with Tinospora Coridifolia Extract

2019 ◽  
Vol 8 (9S2) ◽  
pp. 295-297
Keyword(s):  
Low Cost ◽  
Herbal Medicines ◽  
Cancer Cell Line ◽  
Modern Medicine ◽  
Lung Cancer Cell Line ◽  
Herbal Drugs ◽  
Human Beings ◽  
Kras Gene ◽  
Modern Times ◽  
Synthetic Drugs

There has been global resurgence of interest in herbal drugs in the recent past. Though herbal medicines are effective in the treatment of various ailments very often these drugs are unscientifically exploited or improperly used. Therefore, these herbal drugs deserve detailed studies in the light of modern medicine. In spite of synthetic drugs, herbal drugs have their place in therapy. Their effectiveness, low-cost and comparative freedom from serious toxic effects makes these medicines not only popular but also an acceptable mode of treating diseases even in modern times. Medicinal plants are those plants that are used in treating and preventing specific and human has been using herbs for generations around the world, due to charm needed to cure the disease, many people have come to the conclusion that even chemical drugs their answers may already be sick of these medications may be harmful for health them in the future. Still, the use of plants as a source of medicine is very much important for human beings. Identify medicinal and how to use them is so important.

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