Phytochemistry, Traditional Uses and Pharmacological properties of Enhydra fluctuans Lour: A Comprehensive Review.

Background: Enhydra fluctuans Lour, a tropical herb, commonly known as helencha or harkuch, belonging to family Asteraceae, and is an edible semi-aquatic herbaceous vegetable plant with serrate leaves, grows commonly in different parts of the world. Enhydra fluctuans possesses potential pharmacological role against inflammation, cancer, diarrhea, microbial infection, diabetes, and so on. Aim of the review: This review aims to provide the most current information on the botanical characterization, distribution, traditional uses, chemical constituents, as well as the pharmacological activities of Enhydra fluctuans Lour. Materials and methods: The recently updated information on Enhydra fluctuans was gathered from scientific journals, books, and worldwide accepted scientific databases via a library and electronic search (PubMed, Elsevier, Google Scholar, Springer, Scopus, Web of Science, Wiley online library. All of the full-text articles and abstracts related to Enhydra were screened. The most important and relevant articles were carefully chosen for study in this review. Results: Crude extracts and isolated compounds of Enhydra fluctuans Lour has been reported pharmacologically active against cytoprotective, analgesic and anti-inflammatory, antimicrobial, anticancer, anti-diarrhoeal, antihelmintic, CNS depressant, hepatoprotective, thrombolytic, antidiabetic, anti-oxidant, phagocytic and cytotoxic, and neuroprotective potential activities. Discussion: Phytochemical analysis from different studies has reported Germacranolide, Sesquiterpene lactone, Flavonoid, Essential oil, Steroid, Diterpenoid, Melampolide, Sesquiterpene lactone, Isoflavone glycoside as major compounds of Enhydra fluctuans Lour. Conclusions: However, more research is important to explore the mode of action of bioactive components of the plant and its therapeutic capabilities.

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Capsella bursa-pastoris (L.) Medic: An Insight into its pharmacology, Expository traditional uses and Extensive Phytochemistry

Current Traditional Medicine ◽

10.2174/2215083806666200203142107 ◽

2020 ◽

Vol 06 ◽

Author(s):

Mohd Akbar Dar ◽

Reyaz Hassan Mir ◽

Roohi Mohi-ud-din ◽

Prince Ahad Mir ◽

Mubashir Hussain Masood ◽

...

Keyword(s):

Bioactive Compounds ◽

Therapeutic Potential ◽

Chemical Constituents ◽

Scientific Evidence ◽

Acetylcholinesterase Inhibitor ◽

Smooth Muscles ◽

Scientific Databases ◽

Wide Range ◽

Pharmacological Potential ◽

Online Library

Introduction: Capsella bursa-pastoris(L.) Medic is a traditional herb of the genus Capsella with long-standing Pakistan, India, Iraq, Cyprus, Turkey, Iran, Azarbayjan, Europe, Saudi Arabia, China and many other regions of Asian countries ethnomedical records. Preliminary studies from the animal model have provided valuable scientiﬁc evidence for its use, also the novel bioactive compounds. Aim: This review aims to summarize the ethnopharmacology, selected scientiﬁc evidence on the pharmacological properties and phytochemistry of C. bursa-pastoris(L.) Medic over the past 38 years while identifying potential areas of further development of this herb as an economical adjunct. Methods: The review covers literature pertaining to the evidence based on ethnopharmacology, therapeutic potential, and phytochemistry of C. bursa-pastoris(L.) Medic spanning from 1980 to 2018 available on Non-English journals and English/Non-English- MS worldwide accepted scientiﬁc databases via electronic search (Elsevier, Google Scholar, PubMed, Scopus, Springer, Web of Science, Wiley online library) and Ph.D. thesis databases (e.g., CKNI-China, JAIRO-Japan, Shodhganga-India, Myto-Malaysia, etc.) Result: Evidence suggests that the extracts and some compounds from. bursa-pastoris(L.) Medic possesses antimicrobial, anticancer, anti-inflammatory, smooth muscles contraction, infertility, antioxidant, cardiovascular, sedative, hepatoprotective, acetylcholinesterase inhibitor properties. C. bursa-pastoris besides having pharmacological profile have a acceptable nutritional value also due to its novel bioactive compounds such as phytosterols, phenolics, flavonoids, fatty acids, organic acids, peptides, amino acids. Conclusion: Scientiﬁc evidence suggests that there is strong pharmacological potential in developing C. bursa-pastoris (L.) Medic as a drug to be used in the treatment of various disorders from antimicrobial to anticancer therapy. C. bursa-pastoris can be a rich source for the advancement of novel drugs to treat many human diseases due to wide range of chemical constituents present in the plant. Various ethno medical uses and phytochemicals responsible for these uses have not been evaluated yet to their fullest.

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BIOACTIVITY-GUIDED PHYTOCHEMICAL INVESTIGATIONS OF ARTEMISIA MARITIMA: ISOLATION AND CHARACTERIZATION OF CHEMICAL CONSTITUENTS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v12i1.28600 ◽

2019 ◽

Vol 12 (1) ◽

pp. 269

Author(s):

Mahpara Qadir ◽

Nissar A Dangroo ◽

Syed Wajaht Amin Shah

Keyword(s):

Antioxidant Activity ◽

Petroleum Ether ◽

Anticancer Activity ◽

Sesquiterpene Lactone ◽

Cancer Cell ◽

Chemical Constituents ◽

Reducing Power ◽

Phytochemical Analysis ◽

Isolation And Characterization ◽

Artemisia Maritima

Objective: In the present study, the extracts (petroleum ether and methanolic extract) of plant Artemisia maritima were subjected to bioactivity evaluation and compound isolation and characterization.Methods: Antioxidant activity was carried out using ferric reducing power and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The anticancer activity was evaluated by MTT assay using three different human cancer cell lines: Embryonic kidney cancer cell (HEK), lung adenocarcinoma epithelial cell (A-549), and human colon cancer cell (HCT), and isolated compounds were characterized using nuclear magnetic resonance (1HNMR), 13CNMR, DEPT, infrared, and mass spectroscopic techniques.Results: The petroleum ether extract of the plant displayed significant antioxidant and cytotoxic effects, which on phytochemical analysis led to the isolation of two bioactive sesquiterpene lactone compounds. These phytochemicals were identified using different spectral techniques in the light of literature. All the compounds displayed significant cytotoxic activity; however, compound-1 exhibited potent anticancer activity with inhibitory concentration value of 17.3 μg/mL. The isolated compounds also displayed significant antioxidant potential.Conclusion: Artemisia maritima, a rich source of sesquiterpene lactone which may be responsible for significant anticancer potential and it also possess remarkable antioxidant activity and hence may be of immense importance to food Chemistry.

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Calea ternifolia Kunth, the Mexican dream herb, a concise review

Botany ◽

10.1139/cjb-2021-0063 ◽

2021 ◽

Author(s):

Rachel Mata ◽

Aldo Contreras-Rosales ◽

José-Alberto Gutierrez-Gónzalez ◽

José L. Villaseñor ◽

Araceli Pérez-Vásquez

Keyword(s):

Information Science ◽

Skin Diseases ◽

Chemical Constituents ◽

Indigenous Communities ◽

Web Pages ◽

Scientific Databases ◽

Traditional Uses ◽

Toxicological Studies ◽

Upset Stomach ◽

History Of

Calea ternifolia Kunth (Asteraceae), the Dream Herb, is an important medicinal plant distributed from Mexico to Costa Rica. The plant is highly valued for rituals and treating several illnesses, including anorexia, upset stomach, diabetes, periodic fevers, diarrhea, bile problems, and skin diseases. This comprehensive literature survey on Calea ternifolia was performed up to January 2021. Our review focuses on traditional uses, botanical aspects, chemical constituents, quality control tests as well pharmacological and toxicological studies. Data were recorded using online scientific databases, including Scopus, Pubmed, Google Scholar, Taylor and Francis Imprints, National Center for Biotechnology Information, Science Direct, JSTOR, and SciFinder. The information was assembled from research articles, relevant books on herbal and history of medicinal plants from Mexico, theses, reports, and web pages. The more significant botanical and ethnomedical aspects were recorded, including discovering the oneirogenic use (enhancer of dreams) of C. ternifolia by the Chontal indigenous communities in Oaxaca, Mexico. The plant contains sesquiterpenes and flavonoids as the major constituents. Some properties associated with the plant's traditional uses have been demonstrated, including spasmolytic, antidiabetic, antidepressant, anti-inflammatory, and antinociceptive effects. Plant's toxicity will be discussed. Solid pharmacological research provided evidence supporting the use of the dream plant for oneiromancy.

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Botanical, Traditional Use, Phytochemical, and Toxicological of Arisaematis rhizoma

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/9055574 ◽

2021 ◽

Vol 2021 ◽

pp. 1-25

Author(s):

Chun-yan Qi ◽

Jing Wang ◽

Xu Wu ◽

Su-rong He ◽

Qiao Zhang ◽

...

Keyword(s):

Hot Spot ◽

Chemical Constituents ◽

Pharmacological Action ◽

Human Beings ◽

Traditional Use ◽

Traditional Uses ◽

Wide Range ◽

Online Library

Aim of the Study. This paper summarizes the traditional uses, botany, chemical composition, pharmacology, pharmacodynamics, and toxicology of Arisaematis rhizoma (hereafter referred to as AR). In addition, the future development and research prospect of AR were discussed in detail. Although many traditional uses of AR have been confirmed, it is essential to study the relationship between its structure and function, clarify the mechanism of pharmacological action, and explore new clinical applications. Materials and Methods. This review is a collection of all possible studies on AR, published in scientific journals, papers, and books. Using the papers related to Arisaematis, such as ScienceDirect, Wiley Online Library, Springer Link, Web of Science, CNKI, and WanFang Database. In this paper, the traditional uses, botany, phytochemistry, pharmacology, and toxicology of AR were reviewed. Finally, the existing problems and research directions of the research on AR are discussed. Results. Ninety-eight chemical constituents were isolated from AR. AR has a wide range of pharmacological effects, such as the effects on the central nervous system and cardiovascular system. It also has anti-tumor, sedative, analgesic, anticonvulsant, anti-inflammatory, expectorant, antiarrhythmic, anticoagulant, and other effects. It is also considered an effective drug for in vitro and in vivo validation. Conclusions. AR is an excellent traditional medicinal plant in China. Pharmacological studies support the traditional use of AR and may verify the folk use of AR in the treatment of different diseases. The anti-tumor effect of AR has been widely concerned by scholars at home and abroad. It has become a hot spot in recent years and has made great contributions to the survival and development of human beings. Although it has a high value of comprehensive utilization, its development and utilization are far from enough. Therefore, the comprehensive development of AR is worthy of further analysis.

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Holoptelea integrifolia(Roxb.) Planch: A Review of Its Ethnobotany, Pharmacology, and Phytochemistry

BioMed Research International ◽

10.1155/2014/401213 ◽

2014 ◽

Vol 2014 ◽

pp. 1-12 ◽

Cited By ~ 6

Author(s):

Showkat Ahmad Ganie ◽

Surender Singh Yadav

Keyword(s):

Chronic Wounds ◽

Biological Activities ◽

Chemical Constituents ◽

Phytochemical Analysis ◽

Treatment And Prevention ◽

Cns Depressant ◽

Crude Extracts ◽

Prevention And Treatment

Holoptelea integrifolia(Ulmaceae) is a versatile medicinal plant used in various indigenous systems of medicine for curing routine healthcare maladies. It is traditionally used in the treatment and prevention of several ailments like leprosy, inflammation, rickets, leucoderma, scabies, rheumatism, ringworm, eczema, malaria, intestinal cancer, and chronic wounds.In vitroandin vivopharmacological investigations on crude extracts and isolated compounds showed antibacterial, antifungal, analgesic, antioxidant, anti-inflammatory, anthelmintic, antidiabetic, antidiarrhoeal, adaptogenic, anticancer, wound healing, hepatoprotective, larvicidal, antiemetic, CNS depressant, and hypolipidemic activities. Phytochemical analysis showed the presence of terpenoids, sterols, saponins, tannins, proteins, carbohydrates, alkaloids, phenols, flavonoids, glycosides, and quinines. Numerous compounds including Holoptelin-A, Holoptelin-B, friedlin, epifriedlin,β-amyrin, stigmasterol,β-sitosterol, 1, 4-napthalenedione, betulin, betulinic acid, hexacosanol, and octacosanol have been identified and isolated from the plant species. The results of several studies indicated thatH. integrifoliamay be used as an effective therapeutic remedy in the prevention and treatment of various ailments. However, further studies on chemical constituents and their mechanisms in exhibiting certain biological activities are needed. In addition, study on the toxicity of the crude extracts and the compounds isolated from this plant should be assessed to ensure their eligibility to be used as source of modern medicines.

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Adhatoda vasica (Nees.): A review on its botany, traditional uses, phytochemistry, pharmacological activities and toxicity

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557521666210226152238 ◽

2021 ◽

Vol 21 ◽

Author(s):

Tahmida Shamsuddin ◽

Muhammad Shaiful Alam ◽

Md. Junaid ◽

Rasheda Akter ◽

S. M. Zahid Hosen ◽

...

Keyword(s):

Whooping Cough ◽

Chemical Constituents ◽

Research Papers ◽

Pharmacological Activities ◽

Tropical Zone ◽

Adhatoda Vasica ◽

Scientific Databases ◽

Traditional Uses ◽

Different Types ◽

Promising Source

Background:: Adhatoda vasica (Nees.) of family Acanthaceae has been used in the Southeast tropical zone as it is efficacious against headache, colds, cough, whooping cough, fever, asthma, dyspnea, phthisis, jaundice, chronic bronchitis and diarrhea and exhibits commendable pharmacological activities. Objective: The aim of the review is to provide a systematic overview of pharmacological activities with toxicity and clinical assessment, phytochemistry of A. vasica along with its characterization, geographical observation, phenology, traditional uses as well as an organized representation of the findings. Method: The overall information of A. vasica were collected from various resources including books, review papers, research papers and reports which were obtained by an online search of worldwide-accepted scientific databases. ChemDraw software was used to draw the compounds’s structure. Results: Phytochemical review on A. vasica has led to the collection of 233 compounds of different types such as alkaloids, flavonoids, essential oils, terpenoids, fatty acids, phenols etc. It is a promising source of phytopharmaceutical potential agent that exhibits diverse pharmacological activities including antibacterial, antifungal, hepatoprotective, anti-ulcer, abortifacient, antiviral, anti-inflammatory, thrombolytic, hypoglycemic, anti-tubercular, antioxidant and antitussive activities. Conclusions: The sufficient number of studies on ethno-pharmacology, traditional uses and pharmacological activities of A. vasica are conducted. Furthermore, it is necessary to study the activity of chemical constituents for new drug design and discovery from natural products.

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BIOACTIVITY-GUIDED PHYTOCHEMICAL INVESTIGATIONS OF ARTEMISIA MARITIMA: ISOLATION AND CHARACTERIZATION OF CHEMICAL CONSTITUENTS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i1.28600 ◽

2019 ◽

Vol 12 (1) ◽

pp. 269

Author(s):

Mahpara Qadir ◽

Nissar A Dangroo ◽

Syed Wajaht Amin Shah

Keyword(s):

Antioxidant Activity ◽

Petroleum Ether ◽

Anticancer Activity ◽

Sesquiterpene Lactone ◽

Cancer Cell ◽

Chemical Constituents ◽

Reducing Power ◽

Phytochemical Analysis ◽

Isolation And Characterization ◽

Artemisia Maritima

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Pharmacognostical and pharmacological activity of Justicia gendarussa burm.f.: a comprehensive review

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i3.2475 ◽

2020 ◽

Vol 11 (3) ◽

pp. 3384-3390

Author(s):

Ashish ◽

Anjali ◽

Dixit Praveen K ◽

Nagarajan K ◽

Sahoo Jagannath

Keyword(s):

Pharmacological Activity ◽

Chemical Constituents ◽

Biological Action ◽

Andaman Islands ◽

Comprehensive Review ◽

Medicinal Value ◽

Anti Oxidant ◽

Phytochemical Constituents ◽

Pharmacologically Active ◽

Different Parts

Justicia gendarussa Burm .f. (family Acanthaceae) which is also known as willow-leaves and commonly known as Nili-Nirgundi, it is very commonly found nearby to China and its availability is very common in larger parts of India and Andaman islands. Traditionally it is used to treat various sorts of disorders such as wound healing, anti-inflammatory, anti-oxidant, antiproliferative, anti-arthritic etc. Justicia gendarussa is one of the crucial herbs which has been used in the Ayurveda. Majorly leaves parts of the plant shows the pharmacological activity but the root of the plant Justicia gendarussa is also have the important medicinal values. A large variety of pharmacologically active constituents i.e., alkaloids, flavonoids, saponin, carbohydrates, steroids, triterpenoids, carotenoids, aminoacids, tannins, phenolics, coumarines and anthaquinones are also present in this plant and they makes the plant pharmacologically important. The activity of the plant is also dependent on the solvent which is used for the extraction the various vital chemical constituents. The different- different parts of the plants having the different medicinal values also differ in the chemical values. This review is not only focused on the essential phytochemical constituents which is available in the plant but it also explains their necessary medicinal value to shows the essential biological action and phytopharmacological actions of various parts of the plant.

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Phytochemical and Pharmacological Review on Two Herbs of Baijiangcao: Patrinia scabiosaefolia Fisch. ex Trev. and Patrinia villosa (Thunb.) Juss

Mini-Reviews in Organic Chemistry ◽

10.2174/1570193x16666190617161124 ◽

2020 ◽

Vol 17 (5) ◽

pp. 496-517

Author(s):

Yangcheng Liu ◽

Wei Liu ◽

Jiaqi Wang ◽

Yang Liu ◽

Changlan Chen ◽

...

Keyword(s):

Chemical Constituents ◽

Volatile Components ◽

Research Papers ◽

Pharmacological Activities ◽

Comprehensive Review ◽

Scientific Databases ◽

The Past ◽

Current State ◽

Patrinia Scabiosaefolia ◽

Antiviral Activities

Patrinia scabiosaefolia Fisch. Trev. and Patrinia villosa (Thunb.) Juss, are two species of Patrinia recorded in the Chinese Pharmacopoeia with the same Chinese name “Baijiangcao” and similar therapeutic effect in traditional Chinese medicine. The present article is the first comprehensive review on the chemical composition and pharmacological activities of these herbs. In this review, data on chemical constituents and pharmacological profile of the two herbs are provided. This review discusses all the classes of the 223 compounds (phenylpropanoids, flavonoids, terpenes, saponins and volatile components, etc.) detected in the two herbs providing information on the current state of knowledge of the phytochemicals present in them. In the past three years, our research group has isolated and identified about more than 100 ingredients from the two herbs. Therefore, we published a systematic review of our research papers and studies on the two herbs were carried out using resources such as classic books about Chinese herbal medicine and scientific databases including Pubmed, Web of Science, SciFinder, CNKI. etc. The present review discusses the most thoroughly studied pharmacological activities (antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, antitumor and antiviral activities) of the two herbs. This comprehensive review will be informative for scientists searching for new properties of these herbs and will be important and significant for the discovery of bioactive compounds from the two herbs and in complete utilization of Patrinia scabiosaefolia Fisch. ex Trev. and Patrinia villosa (Thunb.) Juss.

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