Capsella bursa-pastoris (L.) Medic: An Insight into its pharmacology, Expository traditional uses and Extensive Phytochemistry

2020 ◽  
Vol 06 ◽  
Author(s):  
Mohd Akbar Dar ◽  
Reyaz Hassan Mir ◽  
Roohi Mohi-ud-din ◽  
Prince Ahad Mir ◽  
Mubashir Hussain Masood ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Scientific Evidence ◽  
Acetylcholinesterase Inhibitor ◽  
Smooth Muscles ◽  
Scientific Databases ◽  
Wide Range ◽  
Pharmacological Potential ◽  
Online Library

Introduction: Capsella bursa-pastoris(L.) Medic is a traditional herb of the genus Capsella with long-standing Pakistan, India, Iraq, Cyprus, Turkey, Iran, Azarbayjan, Europe, Saudi Arabia, China and many other regions of Asian countries ethnomedical records. Preliminary studies from the animal model have provided valuable scientific evidence for its use, also the novel bioactive compounds. Aim: This review aims to summarize the ethnopharmacology, selected scientific evidence on the pharmacological properties and phytochemistry of C. bursa-pastoris(L.) Medic over the past 38 years while identifying potential areas of further development of this herb as an economical adjunct. Methods: The review covers literature pertaining to the evidence based on ethnopharmacology, therapeutic potential, and phytochemistry of C. bursa-pastoris(L.) Medic spanning from 1980 to 2018 available on Non-English journals and English/Non-English- MS worldwide accepted scientific databases via electronic search (Elsevier, Google Scholar, PubMed, Scopus, Springer, Web of Science, Wiley online library) and Ph.D. thesis databases (e.g., CKNI-China, JAIRO-Japan, Shodhganga-India, Myto-Malaysia, etc.) Result: Evidence suggests that the extracts and some compounds from. bursa-pastoris(L.) Medic possesses antimicrobial, anticancer, anti-inflammatory, smooth muscles contraction, infertility, antioxidant, cardiovascular, sedative, hepatoprotective, acetylcholinesterase inhibitor properties. C. bursa-pastoris besides having pharmacological profile have a acceptable nutritional value also due to its novel bioactive compounds such as phytosterols, phenolics, flavonoids, fatty acids, organic acids, peptides, amino acids. Conclusion: Scientific evidence suggests that there is strong pharmacological potential in developing C. bursa-pastoris (L.) Medic as a drug to be used in the treatment of various disorders from antimicrobial to anticancer therapy. C. bursa-pastoris can be a rich source for the advancement of novel drugs to treat many human diseases due to wide range of chemical constituents present in the plant. Various ethno medical uses and phytochemicals responsible for these uses have not been evaluated yet to their fullest.

Phytochemistry, Traditional Uses and Pharmacological properties of Enhydra fluctuans Lour: A Comprehensive Review.

2020 ◽  
Vol 21 ◽  
Author(s):  
Antica Barua ◽  
Muhammad Shaiful Alam ◽  
Md. Junaid ◽  
Yeasmin Akter ◽  
Syeda Samira Afrose ◽  
...  
Keyword(s):  
Sesquiterpene Lactone ◽  
Chemical Constituents ◽  
Phytochemical Analysis ◽  
Microbial Infection ◽  
Scientific Databases ◽  
Traditional Uses ◽  
Cns Depressant ◽  
Isoflavone Glycoside ◽  
Online Library ◽  
Pharmacologically Active

Background: Enhydra fluctuans Lour, a tropical herb, commonly known as helencha or harkuch, belonging to family Asteraceae, and is an edible semi-aquatic herbaceous vegetable plant with serrate leaves, grows commonly in different parts of the world. Enhydra fluctuans possesses potential pharmacological role against inflammation, cancer, diarrhea, microbial infection, diabetes, and so on. Aim of the review: This review aims to provide the most current information on the botanical characterization, distribution, traditional uses, chemical constituents, as well as the pharmacological activities of Enhydra fluctuans Lour. Materials and methods: The recently updated information on Enhydra fluctuans was gathered from scientific journals, books, and worldwide accepted scientific databases via a library and electronic search (PubMed, Elsevier, Google Scholar, Springer, Scopus, Web of Science, Wiley online library. All of the full-text articles and abstracts related to Enhydra were screened. The most important and relevant articles were carefully chosen for study in this review. Results: Crude extracts and isolated compounds of Enhydra fluctuans Lour has been reported pharmacologically active against cytoprotective, analgesic and anti-inflammatory, antimicrobial, anticancer, anti-diarrhoeal, antihelmintic, CNS depressant, hepatoprotective, thrombolytic, antidiabetic, anti-oxidant, phagocytic and cytotoxic, and neuroprotective potential activities. Discussion: Phytochemical analysis from different studies has reported Germacranolide, Sesquiterpene lactone, Flavonoid, Essential oil, Steroid, Diterpenoid, Melampolide, Sesquiterpene lactone, Isoflavone glycoside as major compounds of Enhydra fluctuans Lour. Conclusions: However, more research is important to explore the mode of action of bioactive components of the plant and its therapeutic capabilities.

scholarly journals Effects of Curcumin on Vessel Formation Insight into the Pro- and Antiangiogenesis of Curcumin

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Ting-ye Wang ◽  
Jia-xu Chen
Keyword(s):  
Curcuma Longa ◽  
Scientific Evidence ◽  
Short Review ◽  
Dual Effect ◽  
Scientific Databases ◽  
Wide Range ◽  
Available Information ◽  
Insight Into

Curcumin is a compound extracted from the Curcuma longa L, which possesses a wide range of pharmacological effects. However, few studies have collected scientific evidence on its dual effect on angiogenesis. The present review gathered the fragmented information available in the literature to discuss the dual effect and possible mechanisms of curcumin on angiogenesis. Available information concerning the effect of curcumin on angiogenesis is compiled from scientific databases, including PubMed and Web of Science using the key term (curcumin and angiogenesis). The results were reviewed to identify relevant articles. Related literature demonstrated that curcumin has antiangiogenesis effect via regulating multiple factors, including proangiogenesis factor VEGF, MMPs, and FGF, both in vivo and in vitro, and could promote angiogenesis under certain circumstances via these factors. This paper provided a short review on bidirectional action of curcumin, which should be useful for further study and application of this compound that require further studies.

scholarly journals A Comprehensive Mini-Review of Curcumae Radix: Ethnopharmacology, Phytochemistry, and Pharmacology

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110206
Author(s):  
Dongyi Hu ◽  
Jiayu Gao ◽  
Xiao Yang ◽  
Ying Liang
Keyword(s):  
Therapeutic Potential ◽  
Curcuma Longa ◽  
Web Based ◽  
Medicinal Uses ◽  
Scientific Databases ◽  
Wide Range ◽  
Fundamental Understanding ◽  
Medicinal Properties ◽  
Curcuma Kwangsiensis ◽  
Anti Inflammation

Curcumae Radix is an efficacious ingredient with various medicinal properties empirically used in traditional Chinese medicine (TCM) formula for the treatment of cancer, depression, chest pain, dysmenorrhea, epilepsy, and jaundice. However, either phytochemical or pharmacological information of Curcumae Radix underlying its traditionally medicinal uses is rarely summarized and systematically analyzed. To provide evidence for clinical trials, a comprehensive literature review has been prepared of the phytochemicals, and ethnopharmacological and pharmacological mechanisms of this herb. The review approach consisted of searching several web-based scientific databases, including PubMed, Web of Science, and Elsevier. The keywords included “Curcumae Radix,” “ Curcuma wenyujin,” “ Curcuma longa,” “ Curcuma kwangsiensis,” and “ Curcuma phaeocaulis.” Based on the proposed criteria, 57 articles were evaluated in detail. The accumulated data indicate that Curcumae Radix contains a number of bioactive phytochemicals, mainly sesquiterpenes, diarylheptanoids, and diarylpentanoids, which account for a variety of medicinal values, such as anticancer, anti-inflammation, anti-hepatic fibrosis, and antioxidant. A wide range of apoptotic proteins, cell adhesion molecules, inflammatory cytokines, and enzymic and nonenzymic antioxidants could be modulated by either Curcumae Radix or its bioactive compounds, thus underpinning a fundamental understanding for the pharmacological effects of this herb. This review highlights the therapeutic potential of Curcumae Radix to progress the development of versatile adjuvants or therapeutic agents in the future.

scholarly journals Imperata cylindrica: A Review of Phytochemistry, Pharmacology, and Industrial Applications

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1454
Author(s):  
Young-Kyung Jung ◽  
Dongyun Shin
Keyword(s):  
Medicinal Plant ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Industrial Applications ◽  
Imperata Cylindrica ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Pharmacological Studies

Imperata cylindrica is a medicinal plant native to southwestern Asia and the tropical and subtropical zones. To date, 72 chemical constituents have been isolated and identified from I. cylindrica Among these compounds, saponins, flavonoids, phenols, and glycosides are the major constituents. Investigations of pharmacological activities of I. cylindrica revealed that this edible medicinal herb exhibits a wide range of therapeutic potential including immunomodulatory, antibacterial, antitumor, anti-inflammatory, and liver protection activities both in vivo and in vitro. The purpose of this review is to provide an overview of I. cylindrica studies until 2019. This article also intends to review advances in the botanical, phytochemical, and pharmacological studies and industrial applications of I. cylindrica, which will provide a useful bibliography for further investigations and applications of I. cylindrica in medicines and foods.

scholarly journals Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiang Li ◽  
Chuan-Tao Zhang ◽  
Wei Ma ◽  
Xin Xie ◽  
Qun Huang
Keyword(s):  
Therapeutic Potential ◽  
Future Research ◽  
Research Directions ◽  
Traditional Chinese Herbal Medicine ◽  
Comprehensive Information ◽  
Wide Range ◽  
Future Research Directions ◽  
Online Library ◽  
New Evidence ◽  
Intense Debate

Oridonin, as a natural terpenoids found in traditional Chinese herbal medicine Isodon rubescens (Hemsl.) H.Hara, is widely present in numerous Chinese medicine preparations. The purpose of this review focuses on providing the latest and comprehensive information on the pharmacology, pharmacokinetics and toxicity of oridonin, to excavate the therapeutic potential and explore promising ways to balance toxicity and efficacy of this natural compound. Information concerning oridonin was systematically collected from the authoritative internet database of PubMed, Elsevier, Web of Science, Wiley Online Library and Europe PMC applying a combination of keywords involving “pharmacology,” “pharmacokinetics,” and “toxicology”. New evidence shows that oridonin possesses a wide range of pharmacological properties, including anticancer, anti-inflammatory, hepatorenal activities as well as cardioprotective protective activities and so on. Although significant advancement has been witnessed in this field, some basic and intricate issues still exist such as the specific mechanism of oridonin against related diseases not being clear. Moreover, several lines of evidence indicated that oridonin may exhibit adverse effects, even toxicity under specific circumstances, which sparked intense debate and concern about security of oridonin. Based on the current progress, future research directions should emphasize on 1) investigating the interrelationship between concentration and pharmacological effects as well as toxicity, 2) reducing pharmacological toxicity, and 3) modifying the structure of oridonin—one of the pivotal approaches to strengthen pharmacological activity and bioavailability. We hope that this review can provide some inspiration for the research of oridonin in the future.

scholarly journals New Approaches on Japanese Knotweed (Fallopia japonica) Bioactive Compounds and Their Potential of Pharmacological and Beekeeping Activities: Challenges and Future Directions

Plants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2621
Author(s):  
Alexandra-Antonia Cucu ◽  
Gabriela-Maria Baci ◽  
Ştefan Dezsi ◽  
Mircea-Emil Nap ◽  
Florin Ioan Beteg ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Negative Impact ◽  
Ecological Impact ◽  
Japanese Knotweed ◽  
Future Directions ◽  
Fallopia Japonica ◽  
Beneficial Effects ◽  
Health Promoting ◽  
Pharmacological Potential

Known especially for its negative ecological impact, Fallopia japonica (Japanese knotweed) is now considered one of the most invasive species. Nevertheless, its chemical composition has shown, beyond doubt, some high biological active compounds that can be a source of valuable pharmacological potential for the enhancement of human health. In this direction, resveratrol, emodin or polydatin, to name a few, have been extensively studied to demonstrate the beneficial effects on animals and humans. Thus, by taking into consideration the recent advances in the study of Japanese knotweed and its phytochemical constituents, the aim of this article is to provide an overview on the high therapeutic potential, underlining its antioxidant, antimicrobial, anti-inflammatory and anticancer effects, among the most important ones. Moreover, we describe some future directions for reducing the negative impact of Fallopia japonica by using the plant for its beekeeping properties in providing a distinct honey type that incorporates most of its bioactive compounds, with the same health-promoting properties.

scholarly journals The Role of Momordica charantia in Resisting Obesity

2019 ◽  
Vol 16 (18) ◽  
pp. 3251 ◽  
Author(s):  
Fan ◽  
Kim ◽  
Choi ◽  
Tang ◽  
Moon
Keyword(s):  
Therapeutic Potential ◽  
Momordica Charantia ◽  
Lipid Lowering ◽  
Bioactive Components ◽  
Scientific Databases ◽  
Advanced Search ◽  
Online Databases ◽  
Health Products ◽  
Excessive Consumption ◽  
Online Library

Momordica charantia (M. charantia), commonly known as bitter gourd, bitter melon, kugua, balsam pear, or karela, is a tropical and sub-tropical vine belonging to the Cucurbitaceae family. It has been used to treat a variety of diseases in the traditional medicine of China, India, and Sri Lanka. Here, we review the anti-obesity effects of various bioactive components of M. charantia established at the cellular and organismal level. We aim to provide links between various bioactive components of M. charantia and their anti-obesity mechanism. An advanced search was conducted on the worldwide accepted scientific databases via electronic search (Google Scholar, Web of Science, ScienceDirect, ACS Publications, PubMed, Wiley Online Library, SciFinder, CNKI) database with the query TS = “Momordica charantia” and “obesity”. Information was also obtained from International Plant Names Index, Chinese Pharmacopoeia, Chinese herbal classic books, online databases, PhD and MSc dissertations, etc. First, studies showing the anti-obesity effects of M. charantia on the cells and on animals were classified. The major bioactive components that showed anti-obesity activities included proteins, triterpenoids, saponins, phenolics, and conjugated linolenic acids. Their mechanisms included inhibition of fat synthesis, promotion of glucose utilization, and stimulation of auxiliary lipid-lowering activity. Finally, we summarized the risks of excessive consumption of M. charantia and the application. Although further research is necessary to explore various issues, this review establishes the therapeutic potential of M. charantia and it is highly promising candidate for the development of anti-obesity health products and medicines.

scholarly journals Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2297
Author(s):  
Faisal Omar ◽  
Abu Montakim Tareq ◽  
Ali M. Alqahtani ◽  
Kuldeep Dhama ◽  
Mohammed Abu Sayeed ◽  
...  
Keyword(s):  
Indole Alkaloids ◽  
Lipid Lowering ◽  
Moderate Activity ◽  
Pharmacological Activities ◽  
Comprehensive Overview ◽  
Scientific Databases ◽  
Lead Compounds ◽  
Indole Compounds ◽  
Pharmacological Potential ◽  
Online Library

Plant-based indole alkaloids are very rich in pharmacological activities, and the indole nucleus is considered to contribute greatly to these activities. This review’s fundamental objective is to summarize the pharmacological potential of indole alkaloids that have been derived from plants and provide a detailed evaluation of their established pharmacological activities, which may contribute to identifying new lead compounds. The study was performed by searching various scientific databases, including Springer, Elsevier, ACS Publications, Taylor and Francis, Thieme, Wiley Online Library, ProQuest, MDPI, and online scientific books. A total of 100 indole compounds were identified and reviewed. The most active compounds possessed a variety of pharmacological activities, including anticancer, antibacterial, antiviral, antimalarial, antifungal, anti-inflammatory, antidepressant, analgesic, hypotensive, anticholinesterase, antiplatelet, antidiarrheal, spasmolytic, antileishmanial, lipid-lowering, antimycobacterial, and antidiabetic activities. Although some compounds have potent activity, some only have mild-to-moderate activity. The pharmacokinetic profiles of some of the identified compounds, such as brucine, mitragynine, 7-hydroxymitragynine, vindoline, and harmane, were also reviewed. Most of these compounds showed promising pharmacological activity. An in-depth pharmacological evaluation of these compounds should be performed to determine whether any of these indoles may serve as new leads.

scholarly journals Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review

2021 ◽  
Vol 7 (2) ◽  
pp. 147
Author(s):  
Bartholomew Adeleke ◽  
Olubukola Babalola
Keyword(s):  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Fungal Endophytes ◽  
New Drugs ◽  
Bioactive Metabolites ◽  
World Population ◽  
Fungal Metabolites ◽  
Human Needs ◽  
Pharmacological Potential

Endophytic microbes are microorganisms that colonize the intracellular spaces within the plant tissues without exerting any adverse or pathological effects. Currently, the world population is facing devastating chronic diseases that affect humans. The resistance of pathogens to commercial antibiotics is increasing, thus limiting the therapeutic potential and effectiveness of antibiotics. Consequently, the need to search for novel, affordable and nontoxic natural bioactive compounds from endophytic fungi in developing new drugs with multifunction mechanisms to meet human needs is essential. Fungal endophytes produce invaluable bioactive metabolic compounds beneficial to humans with antimicrobial, anticancer, antidiabetic, anti-inflammatory, antitumor properties, etc. Some of these bioactive compounds include pestacin, taxol, camptothecin, ergoflavin, podophyllotoxin, benzopyran, isopestacin, phloroglucinol, tetrahydroxy-1-methylxanthone, salidroside, borneol, dibenzofurane, methyl peniphenone, lipopeptide, peniphenone etc. Despite the aforementioned importance of endophytic fungal metabolites, less information is available on their exploration and pharmacological importance. Therefore, in this review, we shall elucidate the fungal bioactive metabolites from medicinal plants and their pharmacological potential.

scholarly journals Botanical, Traditional Use, Phytochemical, and Toxicological of Arisaematis rhizoma

2021 ◽  
Vol 2021 ◽  
pp. 1-25
Author(s):  
Chun-yan Qi ◽  
Jing Wang ◽  
Xu Wu ◽  
Su-rong He ◽  
Qiao Zhang ◽  
...  
Keyword(s):  
Hot Spot ◽  
Chemical Constituents ◽  
Pharmacological Action ◽  
Human Beings ◽  
Traditional Use ◽  
Traditional Uses ◽  
Wide Range ◽  
Online Library

Aim of the Study. This paper summarizes the traditional uses, botany, chemical composition, pharmacology, pharmacodynamics, and toxicology of Arisaematis rhizoma (hereafter referred to as AR). In addition, the future development and research prospect of AR were discussed in detail. Although many traditional uses of AR have been confirmed, it is essential to study the relationship between its structure and function, clarify the mechanism of pharmacological action, and explore new clinical applications. Materials and Methods. This review is a collection of all possible studies on AR, published in scientific journals, papers, and books. Using the papers related to Arisaematis, such as ScienceDirect, Wiley Online Library, Springer Link, Web of Science, CNKI, and WanFang Database. In this paper, the traditional uses, botany, phytochemistry, pharmacology, and toxicology of AR were reviewed. Finally, the existing problems and research directions of the research on AR are discussed. Results. Ninety-eight chemical constituents were isolated from AR. AR has a wide range of pharmacological effects, such as the effects on the central nervous system and cardiovascular system. It also has anti-tumor, sedative, analgesic, anticonvulsant, anti-inflammatory, expectorant, antiarrhythmic, anticoagulant, and other effects. It is also considered an effective drug for in vitro and in vivo validation. Conclusions. AR is an excellent traditional medicinal plant in China. Pharmacological studies support the traditional use of AR and may verify the folk use of AR in the treatment of different diseases. The anti-tumor effect of AR has been widely concerned by scholars at home and abroad. It has become a hot spot in recent years and has made great contributions to the survival and development of human beings. Although it has a high value of comprehensive utilization, its development and utilization are far from enough. Therefore, the comprehensive development of AR is worthy of further analysis.

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