Application of Poloxamers for the Development of Drug Delivery System to Treat Leishmaniasis: A Review

2020 ◽  
Vol 21 ◽  
Author(s):  
Audrey Silva ◽  
Amanda Costa ◽  
Sona Jain ◽  
Eduardo Coelho ◽  
Ricardo Fujiwara ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Drug Delivery System ◽  
Disease Severity ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Triblock Copolymers ◽  
Tropical Disease ◽  
Neglected Tropical Disease ◽  
Annual Mortality

: Leishmaniasis is a neglected tropical disease affecting more than 1.5 million people annually, with an annual mortality of over 20.000. The drugs used to for its treatment are toxic, expensive, require extended treatment times and present variable efficacy. The disease severity and therapy limitations suggest the need for new antileishmanial agents. In this context, in order to identify new options for treatment, a number of studies based on nanotechnological strategies have been carried out. Poloxamers are triblock copolymers very often utilized for nanotherapeutic solutions, resulting in products with better solubility, higher stability, superior therapeutic efficacy and less toxicity. This review will discuss the physicochemical properties of the copolymers, as well as describe the use of poloxamers for the development of therapeutic formulations to treat leishmaniasis.

scholarly journals Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers

2017 ◽  
Vol 8 (5) ◽  
pp. 3427-3433 ◽  
Author(s):  
Brigitte Renoux ◽  
Florian Raes ◽  
Thibaut Legigan ◽  
Elodie Péraudeau ◽  
Balkis Eddhif ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Triple Negative ◽  
Tumour Microenvironment ◽  
Pancreatic Cancers

A drug delivery system targeting the tumour microenvironment produces outstanding therapeutic efficacy on triple-negative mammary and pancreatic models.

A tumor-targeted nano-drug delivery system based on amphiphilic polyrotaxane-based triblock copolymers

2013 ◽  
Vol 172 (1) ◽  
pp. e47
Author(s):  
Lan Jiang ◽  
Ze-Ming Gao ◽  
Lin Ye ◽  
Ai-Ying Zhang ◽  
Zeng-Guo Feng
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Triblock Copolymers ◽  
Nano Drug Delivery

scholarly journals Study of the physicochemical properties of drugs suitable for administration using a lymphatic drug delivery system

2021 ◽  
Author(s):  
Ryoichi Fukumura ◽  
Ariunbuyan Sukhbaatar ◽  
Radhika Mishra ◽  
Maya Sakamoto ◽  
Shiro Mori ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Drug Delivery System ◽  
Delivery System

scholarly journals Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 153
Author(s):  
Janarthanan Pushpamalar ◽  
Puviarasi Meganathan ◽  
Hui Li Tan ◽  
Nuraina Anisa Dahlan ◽  
Li-Ting Ooi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Chemical Properties ◽  
Target Site ◽  
Sustained Drug Release ◽  
3D Network ◽  
Therapeutic Molecules ◽  
Physical And Chemical

Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use.

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