scholarly journals Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 153
Author(s):  
Janarthanan Pushpamalar ◽  
Puviarasi Meganathan ◽  
Hui Li Tan ◽  
Nuraina Anisa Dahlan ◽  
Li-Ting Ooi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Chemical Properties ◽  
Target Site ◽  
Sustained Drug Release ◽  
3D Network ◽  
Therapeutic Molecules ◽  
Physical And Chemical

Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use.

scholarly journals Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 619
Author(s):  
Krisztián Pamlényi ◽  
Katalin Kristó ◽  
Orsolya Jójárt-Laczkovich ◽  
Géza Regdon
Keyword(s):  
Drug Delivery ◽  
Tensile Strength ◽  
Sodium Alginate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymer Films ◽  
Hydroxypropyl Methylcellulose ◽  
Chemical Properties ◽  
Active Pharmaceutical Ingredient ◽  
Swallowing Problems

Currently, pharmaceutical companies are working on innovative methods, processes and products. Oral mucoadhesive systems, such as tablets, gels, and polymer films, are among these possible products. Oral mucoadhesive systems possess many advantages, including the possibility to be applied in swallowing problems. The present study focused on formulating buccal mucoadhesive polymer films and investigating the physical and physical–chemical properties of films. Sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) were used as film-forming agents, glycerol (GLY) was added as a plasticizer, and cetirizine dihydrochloride (CTZ) was used as an active pharmaceutical ingredient (API). The polymer films were prepared at room temperature with the solvent casting method by mixed two-level and three-level factorial designs. The thickness, tensile strength (hardness), mucoadhesivity, surface free energy (SFE), FTIR, and Raman spectra, as well as the dissolution of the prepared films, were investigated. The investigations showed that GLY can reduce the mucoadhesivity of films, and CTZ can increase the tensile strength of films. The distribution of CTZ proved to be homogeneous in the films. The API could dissolve completely from all the films. We can conclude that polymer films with 1% and 3% GLY concentrations are appropriate to be formulated for application on the buccal mucosa as a drug delivery system.

Chylomicrons-Simulating Sustained Drug Release in Mesenteric Lymphatics for the Treatment of Crohn’s-Like Colitis

2020 ◽  
Author(s):  
Yi Yin ◽  
Jingjing Yang ◽  
Yongchun Pan ◽  
Zhen Guo ◽  
Yanfeng Gao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lymphatic System ◽  
Intestinal Inflammation ◽  
Lymphatic Vessels ◽  
Experimental Colitis ◽  
Therapeutic Effects ◽  
Sustained Drug Release

Abstract Background and Aims Alteration to both the structures and functions of mesenteric lymphatic vessels is a typical hallmark of Crohn’s disease [CD]. Dysfunctional lymphatics was observed in patients with both CD and experimental colitis, suggesting mesenteric lymphatics could be potential therapeutic targets. This study aimed to develop a nano-delivery system which can enhance drug delivery in mesenteric lymphatic tissue [MLT] and evaluate the therapeutic effects in Crohn’s colitis. Methods We designed a mesoporous silica nanoparticle [MSN] conjugated with long-chain fatty acid [LMSN] and covered with enteric coating [ELMSN] which can be specifically transported via the mesenteric lymphatic system. The therapeutic efficacy of laquinimod-loaded nanoparticles [LAQ@ELMSN] was evaluated in the well-established interleukin [IL]-10−/− spontaneous experimental colitis. Results ELMSNs induced sustainable drug release that markedly increased drug concentration in MLT. In experimental colitis, the lymphatics-targeting drug delivery system suppressed lymphangitis and promoted lymphatic drainage. The downregulation of pro-inflammatory cytokines and the downstream NF-κB-related proteins efficiently inhibited lymphangiogenesis and restored tight junctions of mesenteric lymphatic vessels [MLVs]. LAQ@ELMSN showed a superior therapeutic effect in ameliorating intestinal inflammation compared with free drug administration. Alteration of gut microbiota and metabolites in experimental colitis was also reversed by LAQ@ELMSN. Conclusion Our study demonstrates a convenient, orally administered drug delivery system which enhances drug release in MLT. The results confirm the contribution of the mesenteric lymphatic system to the pathogenesis of gut inflammation and shed light on the application of lymphatics-targeting drug delivery therapy as a potential therapeutic strategy for CD treatment.

scholarly journals Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers

2017 ◽  
Vol 8 (5) ◽  
pp. 3427-3433 ◽  
Author(s):  
Brigitte Renoux ◽  
Florian Raes ◽  
Thibaut Legigan ◽  
Elodie Péraudeau ◽  
Balkis Eddhif ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Triple Negative ◽  
Tumour Microenvironment ◽  
Pancreatic Cancers

A drug delivery system targeting the tumour microenvironment produces outstanding therapeutic efficacy on triple-negative mammary and pancreatic models.

scholarly journals Frog nest foam as a drug delivery system

2021 ◽  
Author(s):  
Sarah Brozio ◽  
Erin M O Shaughnessy ◽  
Stuart Woods ◽  
Ivan Hall-Barrientos ◽  
Patrica E Martin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Active Pharmaceutical Ingredient ◽  
Natural World ◽  
Ex Situ ◽  
Foaming Properties ◽  
Amphibian Skin ◽  
Tropical Environments ◽  
Therapeutic Molecules

Foams have frequently been used as systems for the delivery of cosmetic and therapeutic molecules; however, there is high variability in the foamability and long-term stability of synthetic foams. The development of pharmaceutical foams that exhibit desirable foaming properties, delivering appropriate amounts of the active pharmaceutical ingredient (API) and that have excellent biocompatibility is of great interest. The production of stable foams is rare in the natural world; however, certain species of frogs have adopted foam production as a means of providing a protective environment for their eggs and larvae from a predators and parasites, to prevent desiccation, to control gaseous exchange, temperature extremes, and to reduce UV damage. These foams show great stability (up to 10 days in tropical environments) and are highly biocompatible due to the sensitive nature of amphibian skin. This work demonstrates for the first time, that nests of the Tungara frog (Engystomops pustulosus) is stable ex situ with useful physiochemical and biocompatible properties and is capable of encapsulating a range of compounds, including antibiotics. These protein foam mixtures may find utility as a topical drug delivery system (DDS).

scholarly journals Niosomes: A Promising Drug Delivery System in Transdermal Drug Delivery (TDDS)

2021 ◽  
pp. 6-17
Author(s):  
Vibhavari M. Chatur ◽  
Shashikant N. Dhole
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Systemic Absorption ◽  
Ionic Surfactant ◽  
Transformative Change ◽  
Transdermal Drug Delivery System ◽  
Sustained Drug Release ◽  
High Level

Infectious disease treatment and immunisation have undergone a transformative change in recent years. With the advancement of biotechnology and genetic engineering, a large number of disease-specific biological have been created, as well as a focus on delivering these biological effectively. Niosomes are vesicular Nano carriers that are gaining popularity as a potential transdermal drug delivery system due to properties like enhanced drug penetration, a local depot for sustained drug release, and a rate-limiting membrane for modulating systemic absorption of drugs through the skin. Niosomes are non-ionic surfactant-based vesicles that are biodegradable, relatively nontoxic, more stable, and less expensive than liposomes. This analysis gives a high-level overview of niosomes, including their chemical composition, structure, benefits, and applications, as well as some general observations on niosomes as percutaneous permeation enhancers.

Application of Poloxamers for the Development of Drug Delivery System to Treat Leishmaniasis: A Review

2020 ◽  
Vol 21 ◽  
Author(s):  
Audrey Silva ◽  
Amanda Costa ◽  
Sona Jain ◽  
Eduardo Coelho ◽  
Ricardo Fujiwara ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Drug Delivery System ◽  
Disease Severity ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Triblock Copolymers ◽  
Tropical Disease ◽  
Neglected Tropical Disease ◽  
Annual Mortality

: Leishmaniasis is a neglected tropical disease affecting more than 1.5 million people annually, with an annual mortality of over 20.000. The drugs used to for its treatment are toxic, expensive, require extended treatment times and present variable efficacy. The disease severity and therapy limitations suggest the need for new antileishmanial agents. In this context, in order to identify new options for treatment, a number of studies based on nanotechnological strategies have been carried out. Poloxamers are triblock copolymers very often utilized for nanotherapeutic solutions, resulting in products with better solubility, higher stability, superior therapeutic efficacy and less toxicity. This review will discuss the physicochemical properties of the copolymers, as well as describe the use of poloxamers for the development of therapeutic formulations to treat leishmaniasis.

scholarly journals Перспективи використання ліпосом для створення нових форм лікувально-профілактичних препаратів

2010 ◽  
Vol 1 (2) ◽  
pp. 38-42
Author(s):  
M. A. Kisjakova ◽  
A. F. Gavrylyuk ◽  
T. N. Polishko ◽  
V. M. Moiseenko ◽  
A. I. Vinnikov
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Phospholipid Vesicles ◽  
Chemical Characteristics ◽  
Structure Control ◽  
Physical And Chemical Characteristics ◽  
Functional Features ◽  
Physical And Chemical ◽  
Liposomal Drugs

Information on the structure, physical and chemical characteristics of the phospholipid vesicles (liposomes) – the effective natural drug delivery system is presented. Types of liposomes, procedures of its productions, penetration mechanisms into cells and functional features of liposomal drugs are described. Data on production of liposomes with lactobacilli acellular homogenates and the methods of the liposomes structure control asre demonstrated.

scholarly journals MICROSPHERE A DRUG DELIVERY SYSTEM–A REVIEW

2019 ◽  
pp. 34-41
Author(s):  
MANOJ KUMAR DAS ◽  
ABDUL BAQUEE AHMED ◽  
DIPANKAR SAHA
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Relative Concentration ◽  
Central Place ◽  
The Body ◽  
Polymeric Membrane ◽  
Conventional Drug

The targeted drug delivery is designed for endeavoring to concentrate the drug in the tissues of curiosity while reducing relative concentration of medication in the remaining tissues. There for drug is localized on the targeted site. Hence, surrounding tissues are not affected by the drug. Controlled drug delivery system can overcome the problems of conventional drug therapy and gives better therapeutic efficacy of a drug. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 µm. The range of Techniques for the preparation of microspheres offers a Variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. Microspheres has a drug located centrally within the particle, where it is encased within a unique polymeric membrane. In future various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.

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