Recent Progress in the Development of Synthetic Hybrids of Natural or Unnatural Bioactive Compounds for Medicinal Chemistry

Diaryl ketones are an important scaffold in drug discovery due to their prevalence in naturally occurring bioactive compounds. This review discusses molecules containing the benzophenone moiety that have potent biological activity.

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Recent Progress in the Synthesis of Benzo[b]thiophene

Current Organic Chemistry ◽

10.2174/1385272824999200820151545 ◽

2020 ◽

Vol 24 (19) ◽

pp. 2256-2271

Author(s):

Dau Xuan Duc

Keyword(s):

Organic Semiconductors ◽

Heterocyclic Compounds ◽

Recent Progress ◽

Medicinal Chemistry ◽

Building Blocks ◽

Intensive Research ◽

Wide Range ◽

Thiophene Derivatives ◽

Anti Hiv ◽

Aromatic Heterocyclic

: Benzo[b]thiophenes are aromatic heterocyclic compounds containing benzene and thiophene rings. This class of heterocycles is present in a large number of natural and non-natural compounds. Benzo[b]thiophene derivatives have a broad range of applications in medicinal chemistry such as antimicrobial, anticancer, antioxidant, anti-HIV and antiinflammatory activities. The use of benzo[b]thiophene derivatives in other fields has also been reported. Various benzo[b]thiophenes compounds have been employed as organic photoelectric materials, while several benzo[b]thiophenes have been used as organic semiconductors. Benzo[b]thiophenes have also been used as building blocks or intermediates for the synthesis of pharmaceutically important molecules. : Due to such a wide range of applicability, the synthesis of benzo[b]thiophene derivatives has attracted intensive research. Numerous mild and efficient approaches for the synthesis of benzo[b]thiophenes have been developed over the years. Different catalysts and substrates have been applied for benzo[b]thiophene synthesis. This review will focus on the studies in the construction of benzo[b]thiophene skeleton, which date back from 2012.

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Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development, and Promising Results Obtained from Multi-target Approaches

Current Drug Targets ◽

10.2174/1389450121999200819144544 ◽

2020 ◽

Vol 21 ◽

Author(s):

Natália F. F. Pirolla ◽

Victor S. Batista ◽

Flávia Pereira Dias Viegas ◽

Vanessa Silva Gontijo ◽

Caitlin R. McCarthy ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Bioactive Compounds ◽

Medicinal Chemistry ◽

Therapeutic Targets ◽

Effective Drug ◽

Research Projects ◽

Drug Candidates ◽

Structure Activity ◽

Synthetic Routes

We describe herein the therapeutic targets involved in Alzheimer's disease as well as the available drugs and their synthetic routes. Bioactive compounds under development are also exploited to illustrate some recent research ad-vances on the medicinal chemistry of Alzheimer's disease, including structure-activity relationships for some targets. The importance of multi-target approaches, including some examples from our research projects, guides new perspectives in the search of more effective drug candidates. This review comprises the period between 2001 and early 2020.

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Multicomponent Reactions for the Synthesis of Bioactive Compounds: A Review

Current Organic Synthesis ◽

10.2174/1570179416666190718153703 ◽

2019 ◽

Vol 16 (6) ◽

pp. 855-899 ◽

Cited By ~ 11

Author(s):

Cedric S. Graebin ◽

Felipe V. Ribeiro ◽

Kamilla R. Rogério ◽

Arthur E. Kümmerle

Keyword(s):

Bioactive Compounds ◽

Multicomponent Reactions ◽

Medicinal Chemistry ◽

Structural Complexity ◽

Original Report ◽

Approved Drugs

Multicomponent reactions (MCRs) are composed of three or more reagents in which the final product has all or most of the carbon atoms from its starting materials. These reactions represent, in the medicinal chemistry context, great potential in the research for new bioactive compounds, since their products can present great structural complexity. The aim of this review is to present the main multicomponent reactions since the original report by Strecker in 1850 from nowadays, covering their evolution, highlighting their significance in the discovery of new bioactive compounds. The use of MCRs is, indeed, a growing field of interest in the synthesis of bioactive compounds and approved drugs, with several examples of commerciallyavailable drugs that are (or can be) obtained through these protocols.

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