Towards A Multimodal Treatment of Depression: A Minireview on the Potential Role of Antibiotics

2011 ◽  
Vol 11 (11) ◽  
pp. 984-987
Author(s):  
B. Yulug ◽  
W.-R. Schabitz
Keyword(s):  
Multimodal Treatment ◽  
Potential Role ◽  
Treatment Of Depression

scholarly journals Exosomes: A Novel Therapeutic Paradigm for Treatment of Depression

2020 ◽  
Vol 21 ◽  
Author(s):  
Shvetank Bhatt ◽  
Jovita Kanoujia ◽  
Arghya Kusum Dhar ◽  
Surendar Arumugam ◽  
Amanda K. A. Silva ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Small Rna ◽  
Potential Role ◽  
Vital Role ◽  
Physiological Processes ◽  
Treatment Of Depression ◽  
As Stress ◽  
Novel Therapeutic

Abstract: Extracellular vesicles (EVs) of endocytic origin are known as exosomes. These vesicles are released by cells and are accessible in biofluids, such as saliva, urine, and plasma. These vesicles are made up of small RNA, DNA, proteins and play a vital role in many physiological processes. In central nervous system (CNS), they participate in various physiological processes such as stress of nerve cells, communication between the cells, synaptic plasticity and neurogenesis. The role of exosomes in depression needs to be explored further. It is known that exosomes can cross blood brain barrier (BBB), which is made up of glial cells astrocytes. One of the advantages of these vescicles is that they are able to transfer macromolecules like DNA, protein, mRNAs and miRNAs to recipient cells. This review focuses on the potential role of exosomes in de-pression and their utilization as atreatmentoption or diagnostic tool of depression.

scholarly journals The role of nutrients and probiotics in treatment of depression

2022 ◽  
Vol 20 (4) ◽  
pp. 171-179
Author(s):  
N. G. Neznanov ◽  
G. V. Rukavishnikov ◽  
E. D. Kasyanov ◽  
M. A. Ganzenko ◽  
L. V. Leonova ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Environmental Factors ◽  
Potential Role ◽  
Early Prevention ◽  
Major Depressive ◽  
Factors Associated ◽  
Treatment And Prevention ◽  
Treatment Of Depression ◽  
The Impact

Currently, a growing amount of data is emerging on the role of various environmental factors (nutrients, gut microbiota, etc.) on formation of depression. The impact on these factors can be effective not only in treatment of major depressive disorder, but also in its early prevention. Therefore, a more detailed study of environmental factors in depression can lead both to a better understanding of the etiology and pathogenesis of the disorder and to optimization of approaches to its treatment. The aim of the review was to assess the potential role of a number of environmental factors associated with nutritional aspects and characteristics of individual microflora, as well as to review the prospects of a strategy for affecting these factors in treatment and prevention of depression. 

scholarly journals The Potential Role of Serotonergic Hallucinogens in Depression Treatment

Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 765
Author(s):  
Dominika Psiuk ◽  
Emilia Nowak ◽  
Krystian Cholewa ◽  
Urszula Łopuszańska ◽  
Marzena Samardakiewicz
Keyword(s):  
Potential Role ◽  
Comparable Efficacy ◽  
Depression Symptoms ◽  
Serious Adverse Events ◽  
Symptoms Of Depression ◽  
Treatment Of Depression ◽  
Novel Method ◽  
Psychological Scales ◽  
Novel Therapeutic Strategies

Due to an increasing number of depression diagnoses and limited effective treatments, researchers continue to explore novel therapeutic strategies for this disorder. Recently, interest has revolved around the use of serotonergic psychedelics to reduce the symptoms of depression. In this systematic review, we summarize the currently available knowledge on the safety and efficacy of psychedelic substances for the treatment of depression. A literature search of the PubMed/MEDLINE database identified 14 clinical trials from the last 10 years that examined the use of psilocybin, MDMA, DMT, or LSD for the treatment of depression symptoms. Some psychedelics, especially psilocybin, demonstrated an ability to reduce depressive symptoms as measured by several psychological scales, which was often sustained for months after the last psychedelic session. Moreover, one study revealed that psilocybin has comparable efficacy to escitalopram in the treatment of depression. None of the studies reported any serious adverse events associated with psychedelic administration. The reviewed studies suggest that psychedelics have great potential in depression therapy and, after addressing and overcoming the current study limitations, may be used as a novel method of treating depression in the future.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

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