Gene Delivery for Periodontal Tissue Engineering: Current Knowledge – Future Possibilities

2009 ◽  
Vol 9 (4) ◽  
pp. 248-266 ◽  
Author(s):  
Fa-Ming Chen ◽  
Zhi-Wei Ma ◽  
Qin-Tao Wang ◽  
Zhi-Fen Wu
Keyword(s):  
Tissue Engineering ◽  
Gene Delivery ◽  
Current Knowledge ◽  
Periodontal Tissue

scholarly journals Platelet-Derived Growth Factor (PDGF) Gene Delivery for Application in Periodontal Tissue Engineering

2001 ◽  
Vol 72 (6) ◽  
pp. 815-823 ◽  
Author(s):  
William V. Giannobile ◽  
Caroline S. Lee ◽  
Matthew P. Tomala ◽  
Kristina M. Tejeda ◽  
Zhimin Zhu
Keyword(s):  
Tissue Engineering ◽  
Growth Factor ◽  
Gene Delivery ◽  
Platelet Derived Growth Factor ◽  
Periodontal Tissue

scholarly journals Gene Therapy in Periodontal Tissue Engineering

2016 ◽  
Vol 8 (1) ◽  
pp. 46-48
Keyword(s):  
Tissue Engineering ◽  
Gene Therapy ◽  
Gene Delivery ◽  
Periodontal Regeneration ◽  
Periodontal Tissue ◽  
Delivery Method ◽  
Molecular Events ◽  
Artificial Extracellular Matrix ◽  
Periodontal Healing ◽  
Primary Strategy

ABSTRACT An elaborate system of signaling molecules regulates the cellular and molecular events of periodontal healing, the primary strategy for which is functional periodontal compartment regeneration and replication of components of the natural cellular microenvironment by providing an artificial extracellular matrix and by delivering growth factors. A new, so-called gene delivery method works by converting cells into protein- producing factories, thereby bypassing the dilemma. Gene therapy can channel the cellular signals in a controlled and very systematic manner, to provide encoded proteins at every stage of tissue regeneration. The aim of this review is to highlight the applications of gene delivery and tissue engineering in periodontal regeneration. How to cite this article Lakhani N, Vandana KL. Gene Therapy in Periodontal Tissue Engineering. CODS J Dent 2016;8(1):46-48.

Graphene and Graphene-Based Materials in Biomedical Applications

2019 ◽  
Vol 26 (38) ◽  
pp. 6834-6850 ◽  
Author(s):  
Mohammad Omaish Ansari ◽  
Kalamegam Gauthaman ◽  
Abdurahman Essa ◽  
Sidi A. Bencherif ◽  
Adnan Memic
Keyword(s):  
Tissue Engineering ◽  
Thermal Properties ◽  
Gene Delivery ◽  
Regenerative Medicine ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Two Dimensional ◽  
Drug And Gene Delivery ◽  
Biomedical Fields

: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

scholarly journals 3D-Bioprinting Strategies Based on In Situ Bone-Healing Mechanism for Vascularized Bone Tissue Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 287
Author(s):  
Ye Lin Park ◽  
Kiwon Park ◽  
Jae Min Cha
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Healing ◽  
Critical Size ◽  
Current Knowledge ◽  
3D Bioprinting ◽  
The Past ◽  
Regeneration Processes

Over the past decades, a number of bone tissue engineering (BTE) approaches have been developed to address substantial challenges in the management of critical size bone defects. Although the majority of BTE strategies developed in the laboratory have been limited due to lack of clinical relevance in translation, primary prerequisites for the construction of vascularized functional bone grafts have gained confidence owing to the accumulated knowledge of the osteogenic, osteoinductive, and osteoconductive properties of mesenchymal stem cells and bone-relevant biomaterials that reflect bone-healing mechanisms. In this review, we summarize the current knowledge of bone-healing mechanisms focusing on the details that should be embodied in the development of vascularized BTE, and discuss promising strategies based on 3D-bioprinting technologies that efficiently coalesce the abovementioned main features in bone-healing systems, which comprehensively interact during the bone regeneration processes.

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

2021 ◽  
Vol 32 (5) ◽  
pp. 1924-1950
Author(s):  
Amir Ghaderpour ◽  
Zohreh Hoseinkhani ◽  
Reza Yarani ◽  
Sina Mohammadiani ◽  
Farshid Amiri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Gene Delivery ◽  
Delivery Systems

scholarly journals Fibre guiding scaffolds for periodontal tissue engineering

2020 ◽  
Vol 55 (3) ◽  
pp. 331-341 ◽  
Author(s):  
Reuben J. Staples ◽  
Saso Ivanovski ◽  
Cedryck Vaquette
Keyword(s):  
Tissue Engineering ◽  
Periodontal Tissue

scholarly journals Today Prospects for Tissue Engineering Therapeutic Approach in Dentistry

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Maurizio Bossù ◽  
Andrea Pacifici ◽  
Daniele Carbone ◽  
Gianluca Tenore ◽  
Gaetano Ierardo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Current Knowledge ◽  
Dental Stem Cells ◽  
Therapeutic Tool ◽  
Exponential Increase ◽  
Major Interest ◽  
Adult Mesenchymal Stem Cells ◽  
Therapeutic Protocols ◽  
Near Future

In dental practice there is an increasing need for predictable therapeutic protocols able to regenerate tissues that, due to inflammatory or traumatic events, may suffer from loss of their function. One of the topics arising major interest in the research applied to regenerative medicine is represented by tissue engineering and, in particular, by stem cells. The study of stem cells in dentistry over the years has shown an exponential increase in literature. Adult mesenchymal stem cells have recently been isolated and characterized from tooth-related tissues and they might represent, in the near future, a new gold standard in the regeneration of all oral tissues. The aim of our review is to provide an overview on the topic reporting the current knowledge for each class of dental stem cells and to identify their potential clinical applications as therapeutic tool in various branches of dentistry.

scholarly journals In silico study of PEI-PEG-squalene-dsDNA polyplex formation: The delicate role of PEG length to the binding of PEI to DNA

2021 ◽  
Author(s):  
Tudor Vasiliu ◽  
Bogdan Florin Florin Craciun ◽  
Andrei Neamtu ◽  
Lilia Clima ◽  
Dragos Lucian Isac ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Polyethylene Glycol ◽  
Gene Delivery ◽  
In Silico ◽  
Biomedical Applications ◽  
Experimental Studies ◽  
Biomedical Devices ◽  
In Silico Study ◽  
Or Gene

The biocompatible hydrophilic polyethylene glycol (PEG) is widely used in biomedical applications, such as drug or gene delivery, tissue engineering or as antifouling in biomedical devices. Experimental studies have shown...

Nanobiomaterials in periodontal tissue engineering

2016 ◽  
pp. 323-351 ◽  
Author(s):  
Mehdi Razavi ◽  
Erfan Salahinejad ◽  
Mina Fahmy ◽  
Aatif Nowman ◽  
Hossein Jazayeri ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Periodontal Tissue
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