Therapeutic Effects of Renal Denervation on Renal Failure

2013 ◽  
Vol 10 (2) ◽  
pp. 172-184 ◽  
Author(s):  
Yutang Wang ◽  
Sai-Wang Seto ◽  
Jonathan Golledge
Keyword(s):  
Renal Failure ◽  
Renal Denervation ◽  
Therapeutic Effects

Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice

2002 ◽  
Vol 283 (3) ◽  
pp. F583-F587 ◽  
Author(s):  
Wei Wang ◽  
Sandor A. Falk ◽  
Suparoek Jittikanont ◽  
Patricia E. Gengaro ◽  
Charles L. Edelstein ◽  
...  
Keyword(s):  
Renal Failure ◽  
Blood Flow ◽  
Acute Renal Failure ◽  
Glomerular Filtration Rate ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Plasma Renin Activity ◽  
Filtration Rate ◽  
Renal Denervation ◽  
Plasma Renin

Acute renal failure (ARF) contributes substantially to the high morbidity and mortality observed during endotoxemia. We hypothesized that selective blockade of the renal nerves would be protective against ARF during the early (16 h) stage of endotoxemia [5 mg lipopolysaccharide (LPS)/kg ip in mice]. At 16 h after LPS, there was no change in mean arterial pressure, but plasma epinephrine (4,604 ± 719 vs. 490 ± 152 pg/ml, P < 0.001), norepinephrine (2,176 ± 306 vs. 1,224 ± 218 pg/ml, P < 0.05), and plasma renin activity (40 ± 5 vs. 27 ± 2 ng · ml−1 · h−1, P < 0.05) were higher in the LPS-treated vs. control mice. The high plasma renin activity level decreased to the control level with renal denervation in endotoxemic mice. After intravenous injection of phentolamine (200 μg/kg), the decrement in mean arterial pressure was significantly greater in LPS-treated vs. control mice (19.4 ± 3.5 vs. 8.1 ± 1.5 mmHg, P < 0.01). Sixteen hours after LPS administration, there were significant decreases in glomerular filtration rate (52 ± 18 vs. 212 ± 23 μl/min, P < 0.01) and renal blood flow (0.58 ± 0.08 vs. 0.85 ± 0.06 ml/min, P < 0.01) in sham-operated mice. The decrement in glomerular filtration rate during endotoxemia was significantly attenuated in mice with denervated kidneys (32 vs. 79%). Moreover, there was no change in renal blood flow during endotoxemia in mice with renal denervation. The present results therefore demonstrate a protective role of renal denervation during normotensive endotoxemia-related ARF in mice, an effect that may be, at least in part, due to a diminished activation of the renin-angiotensin system.

scholarly journals Protective effects of Pai-Du-Yang-Shen formula on chronic renal failure in rats

2019 ◽  
Vol 17 ◽  
pp. 205873921987141
Author(s):  
Ronghua Pan ◽  
Guohua Rui ◽  
Xiaohui Bai ◽  
Zhiyin Teng ◽  
Gang Chen ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Transforming Growth Factor ◽  
Smooth Muscle Actin ◽  
Transforming Growth Factor Β ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Protein Levels ◽  
Yang Shen ◽  
Necrosis Factor

This study aimed to elucidate the therapeutic effects of a traditional Chinese medicine, Pai-Du-Yang-Shen (PDYS) Formula, in 5/6 nephrectomy-induced chronic renal failure (CRF). The CRF model was established via 5/6 nephrectomy (Nx) in rats. Then, PDYS (0.9 and 1.8 g/kg/day), or an equal amount of normal saline, was administrated to the rats in respective groups. Our results showed that PDYS treatment improved degeneration, fibrosis, and histopathological abnormalities of renal tissues in 5/6 Nx rats. Furthermore, the increase in serum creatinine (Scr), blood urea nitrogen (BUN), and total urinary protein (TUP) in 5/6 Nx rats was reduced by PDYS treatment. In addition, the levels of tumor necrosis factor (TNF), fibronectin (FN), and laminin (LN) that were induced in 5/6 Nx rats were also decreased by PDYS treatment. Finally, relative mRNA expression of α-smooth muscle actin (α-SMA), FN, transforming growth factor-β (TGF-β), and TNF as well as protein levels of TGF-β, NF-κB p65, and phosphorylated NF-κB p65 (p-p65) in renal tissues correlated with the concentration of TNF. In conclusion, PDYS shows therapeutic effects against CRF as determined by a reduction in markers for inflammation and fibrosis.

scholarly journals Therapeutic effects of adipose-derived mesenchymal stem cells on gentamicin-induced renal failure

2020 ◽  
pp. 133-141
Author(s):  
Leila Hafazeh ◽  
Saeed Changizi-Ashtiyani ◽  
Houshang Najafi ◽  
Faezeh Ghasemi ◽  
Tina Rahjoo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Failure ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Effects

scholarly journals Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury through Dual Suppression of Apoptosis and Necroptosis

Biology ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 64 ◽  
Author(s):  
Jong Woo Kim ◽  
Jungmin Jo ◽  
Jung-Yeon Kim ◽  
Misun Choe ◽  
Jaechan Leem ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Side Effects ◽  
Apoptotic Cell ◽  
Kidney Injury ◽  
Therapeutic Effects ◽  
Melatonin Treatment ◽  
Cisplatin Therapy

Melatonin is well known to modulate the sleep–wake cycle. Accumulating evidence suggests that melatonin also has favorable effects such as anti-oxidant and anti-inflammatory properties in numerous disease models. It has been reported that melatonin has therapeutic effects against cisplatin-induced acute kidney injury (AKI). However, mechanisms underlying the therapeutic action of melatonin on the renal side-effects of cisplatin therapy remain poorly understood. In this study, we showed that melatonin treatment significantly ameliorates cisplatin-induced acute renal failure and histopathological alterations. Increased expression of tubular injury markers was largely reduced by melatonin. Melatonin treatment inhibited caspase-3 activation and apoptotic cell death. Moreover, protein levels of key components of the molecular machinery for necroptosis were decreased by melatonin. Melatonin also attenuated nuclear factor-κB activation and suppressed expression of pro-inflammatory cytokines. Consistent with in vivo findings, melatonin dose-dependently decreased apoptosis and necroptosis in cisplatin-treated mouse renal tubular epithelial cells. Collectively, our findings suggest that melatonin ameliorates cisplatin-induced acute renal failure and structural damages through dual suppression of apoptosis and necroptosis. These results reveal a novel mechanism underlying the therapeutic effect of melatonin against cisplatin-induced AKI and strengthen the idea that melatonin might be a promising therapeutic agent for the renal side-effects of cisplatin therapy.

scholarly journals Protection effect of intracellular melanin from Lachnum YM156 and Haikunshenxi capsule combination on adenine-induced chronic renal failure in mice

MedChemComm ◽  
2017 ◽  
Vol 8 (5) ◽  
pp. 917-923 ◽  
Author(s):  
Shenglan Li ◽  
Jinglei Li ◽  
Fang Shi ◽  
Liuqing Yang ◽  
Ming Ye
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Oral Administration ◽  
Therapeutic Effects ◽  
Protection Effect

This study aimed to elucidate the therapeutic effects of oral administration of intracellular melanin fromLachnumYM156 (LIM) on chronic renal failure (CRF) in mice.

scholarly journals Protective effects of olive in renal failure; a review on current knowledge

2018 ◽  
Vol 8 (1) ◽  
pp. 2-2
Author(s):  
Esmaeel Babaeenezhad ◽  
Hassan Ahmadvand ◽  
Reza Mohammadrezaei Kkorramabadi ◽  
Shahrokh Bagheri ◽  
Peyman Khosravi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Olive Oil ◽  
Renal Damage ◽  
Current Knowledge ◽  
The Body ◽  
Antioxidant Compounds ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Antioxidant Power ◽  
Open Access Journals

Context: The pathogenesis of renal damage as a risk factor of renal failure can be due to oxidative stress resulting from an imbalance between the production of free radicals and antioxidants. Therefore, antioxidant therapy can be a good strategy to decrease the effects of such diseases. Hence, the aim of this review was to evaluate the protective effect of olive oil as an herb rich in antioxidant compounds on kidney damage in previous studies. Evidence Acquisitions: Present review is based on scrutinizing the contents of relevant papers searched in PubMed, Google Scholar, EBSCO, Embase, directory of open access journals (DOAJ), Web of Science and Scopus. Results: Numerous studies have introduced herbal treatments, being rich sources of antioxidants, as appropriate alternatives for several diseases, including renal damage, when considering the pathogenesis of the diseases. The olive has also been recommended as a plant that has different therapeutic effects, and its therapeutic effects on the kidneys are mentioned in several studies, including the reduction of renal damage parameters and an increase in the antioxidant power of enzymes in the body. Conclusions: Considering the numerous studies on animal models, particularly rats and renal cell lines, olive oil can be used as a reliable method for the treatment of various kidney damages. However, further studies are also recommended in humans.

Acute Renal Failure after Renal Denervation

2015 ◽  
Vol 26 (3) ◽  
pp. 450-451 ◽  
Author(s):  
Alexander G. Logan ◽  
Vlad Diaconita ◽  
Douglas J. Ing ◽  
George D. Oreopoulos ◽  
John S. Floras ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Renal Denervation
Sign in / Sign up

Export Citation Format

Share Document