Efficacy of Aloe vera/ Plantago Major Gel in Diabetic Foot Ulcer: A Randomized Double-Blind Clinical Trial

2019 ◽  
Vol 16 (2) ◽  
pp. 223-231 ◽  
Author(s):  
Younes Najafian ◽  
Zahra M. Khorasani ◽  
Mona N. Najafi ◽  
Shokouh S. Hamedi ◽  
Marjan Mahjour ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Diabetic Foot ◽  
Intervention Group ◽  
Aloe Vera ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Control Group ◽  
Plantago Major ◽  
Double Blind ◽  
Significant Difference

Background:Diabetic foot ulcer (DFU) is one of the most common complications of diabetic patients. Mostly, non-healing DFU leads to infection, gangrene, amputation and even death. High costs and poor healing of the wounds need a new treatment such as alternative medicine. So, the aim of this study was to evaluate the efficacy of Aloe vera/ Plantago major gel (Plantavera gel) in healing of DFUMethods:Forty patients with DFU enrolled in a double-blind randomized clinical trial. The patients who were randomly assigned into the intervention group (n = 20), received topical Plantavera gel in addition to the routine cares, whereas the patients in the control group (n = 20), received topical Placebo gel in addition to the routine cares. Intervention was done twice a day for 4 weeks in the both groups. Photography and an evaluation of DFU healing were conducted by a checklist and then were scored at baseline and at the end of each week. The collected data was analyzed by SPSS software.Results:At the end of the study, there was a significant difference between the two groups in terms of total ulcer score (P<0.001) and Plantavera gel significantly reduced the ulcer surface comparing with the control group (P=0.039). However, there was not a significant difference between the two groups (P=0.263) in terms of the ulcer depth. During this study, no side effect was observed for Plantavera gel in the intervention group.Conclusion:Topical Plantavera gel seems to be an effective, cheap and safe treatment. Of course, further studies are required to confirm the properties of the wound healing of this gel.

scholarly journals Pengaruh Range of Motion (ROM) Aktif Kaki terhadap Risiko terjadinya Ulkus Kaki Diabetik pada Pasien Diabetes Mellitus Tipe 2 di Desa Kaliwining Kabupaten Jember

2018 ◽  
Vol 6 (2) ◽  
pp. 305
Author(s):  
Yulfa Intan Lukita ◽  
Nur Widyati ◽  
Wantiyah Wantiyah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Range Of Motion ◽  
Diabetic Foot ◽  
Intervention Group ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Control Group ◽  
Significant Difference

Diabetic foot ulcer is one of serious complications in diabetic patients which can lead to amputation.Active Leg range of motion (ROM) exercise is one of physical activities which can improve bloodcirculation in lower extremities. The objective of this research was to analyze the effect of active legROM on the risk of diabetic foot ulcer. This research employed non randomized control group pretestpostest design. The sampling technique was purposive sampling involving 30 repondents whichwere divided into 15 respondents as intervention group and 15 respondents as control group. Thedata were analyzed using dependent t test and independent t test with significant level of 0.05. Theresult revealed a significant difference between pretest and posttest in the intervention group (p =0.000) but no significant difference in the control group (p = 0.582). Furthemore, independent t testshowed a significant difference between intervention group and control group (p = 0.000). This resultindicates that there is a significant effect of active leg ROM on the risk of diabetic foot ulcer in clientwith type 2 diabetes mellitus. Nurse is expected to apply range of motion as one of intervention toprevent diabetic foot ulcer in diabetes mellitus patients.Keywords: type 2 diabetes mellitus, active leg range of motion, risk of diabetic foot ulcer

scholarly journals The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Alireza Yargholi ◽  
Leila Shirbeigi ◽  
Roja Rahimi ◽  
Parvin Mansouri ◽  
Mohammad Hossein Ayati
Keyword(s):  
Clinical Trial ◽  
Intervention Group ◽  
Herbal Medicines ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Skin Area ◽  
Melissa Officinalis ◽  
Double Blind ◽  
Significant Difference ◽  
Pre Treatment

Abstract Objective Psoriasis is an immune-mediated inflammatory skin disease. It can involve any body skin area, particularly the scalp, lower back, elbows, and knees. There are several topical and systemic therapies for the treatment. Nowadays, herbal medicines are popular treatments for dermatologic conditions. This two-arm parallel, randomized placebo-controlled clinical trial was conducted to examine the hypothesis of the efficacy of Melissa officinalis syrup on patients with mild-to-moderate Plaque psoriasis. Result Among 100 patients, 95 participants completed the trial and five of them withdrew. The mean pruritus intensity and PASI scores decreased significantly in the intervention group compared to the placebo group (P < 0.001). The DLQI score in the intervention group increased post-treatment compared to pre-treatment (P = 0.029); however, there was no significant difference between the intervention and control group at the end of the study (0.065). Trial registration: The trial was registered in the Iranian registry of clinical trials on November 9th, 2019 (https://www.irct.ir/trial/43434; registration number: IRCT20191104045326N1).

scholarly journals Effectiveness of combined laser-puncture and conventional wound care to accelerate diabetic foot ulcer healing

2017 ◽  
Vol 26 (1) ◽  
pp. 26-34
Author(s):  
Adiningsih Srilestari ◽  
Irma Nareswari ◽  
Christina Simadibrata ◽  
Tri J.E. Tarigan
Keyword(s):  
Diabetic Foot ◽  
Wound Care ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Control Group ◽  
Acupuncture Points ◽  
Double Blind ◽  
Impaired Wound Healing ◽  
Ulcer Size ◽  
The Mean

Background: Impaired wound healing is a common complication of diabetes. It has complex pathophysiologic mechanisms and often necessitates amputation. Our study aimed to evaluate the effectiveness of combined laser-puncture and conventional wound care in the treatment of diabetic foot ulcers.Methods: This was a double-blind controlled randomized clinical trial on 36 patients, conducted at the Metabolic Endocrine Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, between May and August 2015. Stimulation by laser-puncture (the treatment group) or sham stimulation (the control group) were performed on top of the standard wound care. Laser-puncture or sham were done on several acupuncture points i.e. LI4 Hegu, ST36 Zusanli, SP6 Sanyinjiao and KI3 Taixi bilaterally, combined with irradiation on the ulcers itself twice a week for four weeks. The mean reduction in ulcer sizes (week 2–1, week 3–1, week 4–1) were measured every week and compared between the two groups and analyzed by Mann-Whitney test.Results: The initial median ulcer size were 4.75 (0.10–9.94) cm2 and 2.33 (0.90–9.88) cm2 in laser-puncture and sham groups, respectively (p=0.027). The median reduction of ulcer size at week 2–1 was -1.079 (-3.25 to -0.09) vs -0.36 (-0.81 to -1.47) cm2, (p=0.000); at week 3–1 was -1.70 (-3.15 to -0.01) vs -0.36 (-0.80 to -0.28) cm2, (p=0.000); and at week 4–1 was -1.22 (-2.72 to 0.00) vs -0.38 (-0.74 to -0.57) cm2, (p=0.012).Conclusion: Combined laser-puncture and conventional wound care treatment are effective in accelerating the healing of diabetic foot ulcer.

scholarly journals The Effect of Capsella bursa-pastoris Extract on Heavy Menstrual Bleeding and Quality of Life in Patients with Uterine Leiomyoma: A Double-blind Randomized Clinical Trial

2019 ◽  
pp. 1-10
Author(s):  
Atieh Sadat Danesh ◽  
Faraz Mojab ◽  
Abolfazl Mohammadbeigi ◽  
Soodabeh Bioos ◽  
Zahra Siaghati ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Uterine Leiomyoma ◽  
Intervention Group ◽  
Menstrual Bleeding ◽  
Control Group ◽  
Double Blind ◽  
Significant Difference ◽  
The Mean

Objectives: Heavy Menstrual Bleeding (HMB) is the most important problems of Uterine Leiomyoma (UL). This study aimed to assess the effect of the extract of the Capsella bursa-pastoris (CBP) on the control of HMB and quality of life in patients with uterine leiomyoma. Design: In a double-blind randomized, clinical trial 54 women with uterine leiomyoma were randomly assigned to the intervention/control groups by block randomization. Setting: Gynecology outpatient clinics. Intervention: The intervention group received 350 mg of alcoholic extract of Capsella bursa-pastoris and the control group received placebo twice daily for three months. Main Outcome Measures: Amount of bleeding by Pictorial blood loss assessment chart (PBAC), quality of life by menstrual quality of life questionnaires (MQ) and bleeding duration by calendar were evaluated. Results: The mean of PBAC decreased from 464.00± 283.61 at baseline to 323.82±207.66 in the intervention group and decreased from 445.92±362.64 to 214.36±137.68 in control group in the third month. The improvement trend was significant in the two groups, but there was no significant difference between groups. The mean of bleeding duration and menstrual quality of life showed improvement in patients of two groups without significant difference between the two groups. Conclusion: Despite the effectiveness of CBP in the intervention group in decreasing of PBAC score and menstrual bleeding duration and improvement of menstrual quality of life in patients who suffered from UL, it did not show a significant effect compared to the control group. Future studies with a larger sample size in one specific type of UL suggested.

scholarly journals Different Pain Level Of Diabetes Mellitus Patients With Peripheral Neuropathy Who Have Been Given Tens And Deep Breathing Interventions In Diabetic Foot Ulcer Treatment In Yogyakarta General Hospital

2017 ◽  
Vol 3 (2) ◽  
pp. 11
Author(s):  
SATRIYA PRANATA
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Foot ◽  
Wound Care ◽  
Intervention Group ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
The Body ◽  
Control Group ◽  
Diabetic Patients ◽  
Ulcer Treatment

Introduction : Regular intervention of diabetic� foot ulcers is wound care. Patients often complain of pain when nurse performs wound care. If the pain is not resolved it will result in anxiety feeling. A routine intervention conducted so far is intra-breath in intervention to reduce pain, as it is expected by reducing the pain it will be followed by a decrease of patients� anxiety. Intra-breath intervention has not been able to reduce pain quickly on a moderate scale, especially high-scale so it is necessary to find out other alternative interventions. The available comparative intervention is TENS. The purpose of this study is to know the difference between intra-breath and TENS intervention in the level of anxiety in diabetic patients with peripheral neuropathy in diabetic foot ulcer treatment. Method : This study used RCT method on 28 respondents divided into 14 intervention groups and 14 control groups. The anxiety of respondents was assessed using Hamilton Scale of Anxiety tools before and after conductin TENS intervention and intra-breath. TENS intervention was given for 15 minutes at a frequency of 100 Hz and intra-breath was given until the wound care intervention was completed. Result : The results showed that there was significant average difference of anxiety level between the use of TENS intervention and the use of intra-breath intervention in intervention group and the control group with value of P <0.05. TENS can reduce the level of anxiety with the value of P 0.000, while intra -breath is able to lower the level of anxiety with the value of P 0.006. Discussion : The respondents admitted the difficulty of experience maximum relaxation when wound care is done, this condition is related to the comfortable position of respondents. When wound care is done, the respondents can not relax maximaly because many of the foot that has ulcers should be padded with a pillow to maximize the treatment. Provision of TENS with a frecuency of 100 Hz is corresponding to the body�s bioelectricity, the patients that receive TENS intervention may become more rrelaxed with endorphine hormone release and decreasing of pain because the electricity blocks pain implans in the neural tube.

scholarly journals The Effect of Melissa Officinalis Syrup on Patients With Mild to Moderate Psoriasis: a Randomized, Double-blind Placebo-controlled Clinical Trial

2021 ◽  
Author(s):  
Alireza Yargholi ◽  
Leila Shirbeigi ◽  
Roja Rahimi ◽  
Parvin Mansouri ◽  
Mohammad Hossein Ayati
Keyword(s):  
Clinical Trial ◽  
Intervention Group ◽  
Herbal Medicines ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Skin Area ◽  
Melissa Officinalis ◽  
Double Blind ◽  
Significant Difference ◽  
Pre Treatment

Abstract Objective: Psoriasis is an immune-mediated inflammatory skin disease. It can involve any body skin area, particularly the scalp, lower back, elbows, and knees. There are several topical and systemic therapies for the treatment. Nowadays, herbal medicines are popular treatments for dermatologic conditions. This two-arm parallel, randomized placebo-controlled clinical trial was conducted to examine the hypothesis of the efficacy of Melissa officinalis syrup on patients with mild-to-moderate Plaque psoriasis.Result: Among 100 patients, ninety-five participants completed the trial and five of them withdrew. The mean pruritus intensity and PASI scores decreased significantly in the intervention group compared to the placebo group (P<0.001). The DLQI score in the intervention group increased post-treatment compared to pre-treatment (P= 0.029); however, there was no significant difference between the intervention and control group at the end of the study (0.065). Trial registration The trial was registered in the Iranian registry of clinical trials on November 9th, 2019 (https://www.irct.ir/trial/43434 ; registration number: IRCT20191104045326N1).

scholarly journals Comparing the Effects of Aloe Vera Ointment with Routine Treatment on the Severity of Diaper Dermatitis: A Randomized Controlled Double-Blinded Clinical Trial

2020 ◽  
Vol 9 (4) ◽  
pp. 158-162
Author(s):  
Shiva Heidari ◽  
Naser Parizad ◽  
Fatemeh Shirazi ◽  
Vahid Alinejad ◽  
Sima Ghanipour Badelbuu
Keyword(s):  
Clinical Trial ◽  
Therapeutic Option ◽  
Intervention Group ◽  
Aloe Vera ◽  
Control Group ◽  
Diaper Dermatitis ◽  
Herbal Products ◽  
Routine Treatment ◽  
Significant Difference ◽  
Double Blinded

Background: Diaper dermatitis (DD) is a prevalent skin disease in children, which causes child discomfort and parental concern. This study aimed to compare the effects of aloe vera ointment with routine treatment on the severity of DD in hospitalized children. Materials and Methods: This double-blinded randomized clinical trial was carried out on 60 children aged less than two years admitted to Tabriz pediatric hospital in Iran from February to June 2017. Using convenience sampling method, the patients were assigned into two equal groups (n=30 in each) of intervention and control. The intervention group received routine combination treatment, whereas the control group received aloe vera ointment. The patients were examined on the first, third, and sixth days of the study. Data analysis was performed using SPSS software (version 22) and descriptive and analytical statistics. Results: The severity of DD in both groups improved on the sixth day compared to the first day. In comparison, no significant difference was observed between the two groups regarding the severity of dermatitis (P>0.05). Conclusion: Herbal products cause fewer side effects than chemical products and seem to have significant pharmacological effects on the skin. Thus, aloe vera ointment appears to help treat DD and, with further studies, may emerge as a possible therapeutic option.

scholarly journals Effect of antimicrobial activity of Teucrium polium on oral Streptococcus mutans: a randomized cross-over clinical trial study

2020 ◽  
Author(s):  
Somayeh Khoramian Tusi ◽  
Ahmad Jafari ◽  
Seyed Mahmoud Amin Marashi ◽  
Salomeh Faramarzi Niknam ◽  
Malihe Farid ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Streptococcus Mutans ◽  
Biological Effects ◽  
Intervention Group ◽  
Dental Students ◽  
Control Group ◽  
Double Blind ◽  
Significant Difference ◽  
Teucrium Polium ◽  
Two Phases

Abstract Background : The purpose of this study was to determine the effect of a mouthwash containing Teucrium polium herb on Streptococcus mutans in mouth. Methods : This study was a randomized, crossover, double-blind clinical trial, where twenty-two volunteer dental students were randomly divided into two groups. The study had two phases. In each phase, one group was chosen as the intervention group, while the other one was the control group. Both the intervention and control groups were given the mouthwash with and without Teucrium polium , respectively. S. mutans of saliva were measured before and after each phase to compare the effects of the mouthwashes. A three-week washout period was considered between the two phases. An independent two-sample t-test was used to compare the mean number of S. mutans colonies. Additionally, a standard AB/BA crossover model was used to find the results of the treatment and the carryover effect on the residual biological effects. The significance level was considered 0.05 in this experiment. Results : There was no significant difference between the two groups in the number of S. mutans before using the mouthwashes. Using the mouthwash containing Teucrium polium extract significantly decreased the number of S. mutans colonies in both phases (P = 0.002). Conclusion : The results of this study showed that the mouthwash containing aqueous extract of Teucrium polium can significantly reduce the colonization of S. mutans in human saliva.

scholarly journals The Effects of Silver-Releasing Foam Dressings on Diabetic Foot Ulcer Healing

2021 ◽  
Vol 10 (7) ◽  
pp. 1495
Author(s):  
Yu-Chi Wang ◽  
Hsiao-Chen Lee ◽  
Chien-Lin Chen ◽  
Ming-Chun Kuo ◽  
Savitha Ramachandran ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Rate ◽  
Early Period ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Wound Management ◽  
Control Group ◽  
Diabetic Patients ◽  
High Morbidity

Diabetic foot ulcers (DFUs) are a serious complication in diabetic patients and lead to high morbidity and mortality. Numerous dressings have been developed to facilitate wound healing of DFUs. This study investigated the wound healing efficacy of silver-releasing foam dressings versus silver-containing cream in managing outpatients with DFUs. Sixty patients with Wagner Grade 1 to 2 DFUs were recruited. The treatment group received silver-releasing foam dressing (Biatain® Ag Non-Adhesive Foam dressing; Coloplast, Humlebaek, Denmark). The control group received 1% silver sulfadiazine (SSD) cream. The ulcer area in the silver foam group was significantly reduced compared with that in the SSD group after four weeks of treatment (silver foam group: 76.43 ± 7.41%, SSD group: 27.00 ± 4.95%, p < 0.001). The weekly wound healing rate in the silver foam group was superior to the SSD group during the first three weeks of treatment (p < 0.05). The silver-releasing foam dressing is more effective than SSD in promoting wound healing of DFUs. The effect is more pronounced in the initial three weeks of the treatment. Thus, silver-releasing foam could be an effective wound dressing for DFUs, mainly in the early period of wound management.

scholarly journals 1548. Association of bacterial colonization in ulcerative lesions of the diabetic foot together with the cicatrization process

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S773-S775
Author(s):  
Alexander A Ozoria Loveras ◽  
Jacques Paré Espinal ◽  
David de luna ◽  
Noemi Acevedo
Keyword(s):  
Diabetic Foot ◽  
Bacterial Colonization ◽  
Healing Process ◽  
Foot Ulcer ◽  
Primary Source ◽  
Diabetic Foot Ulcer ◽  
Care Program ◽  
Antimicrobial Treatment ◽  
Control Group ◽  
Experimental Group

Abstract Background In 2018, a review of the scientific literature identifed biofilm studies in the past 3 years. Wherein, the role of the biofilm in the progression of the diabetic foot ulcer with the presence of biofilm is reviewed. As a result, tissue sampling is more effective than transcure, Levin, and aspiration. A study in Cuba evaluate the effectiveness of a new proposal for antimicrobial treatment in patients with diabetic foot infection in 2017. The method used was a experimental type of two groups. The control group, was treated with the treatment scheme proposed in the Comprehensive Care Program for the patient with diabetic foot ulcer (PAIPUPD). Instead, the other experimental group was treated according to the scheme based on the local microbial map. They used a random distribution. Using the Wagner classification, there were patients classificate with a grade of W2 (13% of patients), W3 (66%) and W4 (12%). The most frequent germs found were Staphylococcus aureus, Escherichia coli and Enterobacter sp. The experimental group required less days with hospitalization. Methods This is an observational study of primary source with a non-probability sample with 58 patients. Adult patients diagnosed with type 2 diabetes mellitus, with diabetic foot, Wagner classification 1, 2 and 3, who attended the healing area of the Institute of Diabetes of Santiago were included. After identifying the colonized pathogen, its cicatrization process was evaluate for four weeks. Results Of the total sample, 12.07% belonged to Wagner 1, 43.1% to Wagner 2 and 44.83% to the Wagner 3 classification. In the case of the Wagner 3 group, S. aureus and Pseudomona aeruginosa were present in 6 cases. Despite the infectious processes detected by the culture, the patients showed a successful cicatrization process after four weeks of evaluation. Graph 1: Isolated Microorganism Vs Wagner’s Degree (n=60) Graph 2: Gram positive microorganism vs. healing process per week in patients with diabetic foot (n=22) Graph 3: Gram-negative microorganism vs. healing process (n=33) Conclusion During the four weeks of clinical evaluation, more than 88% of patients progressed positively to clinical recovery, regardless of the type of bacteria colonized and/or their resistance to antibiotics. Disclosures All Authors: No reported disclosures

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