Clinical Features of Systemic Lupus Erythematosus in Tunisian Males

Purpose: Systemic Lupus Erythematosus (SLE) in males is rare. Clinical and biological features, as well as, the outcome may differ comparatively to female patients. The purpose of our study is to define these clinical and biological features in Tunisian male patients presenting SLE. Methods: A mono-centric, retrospective and descriptive study of 96 patients followed for SLE out of which 21 are males. A comparative study was then performed between male and female patients groups. Results: Sex-ratio female/male was 3.6/1, the average age at diagnosis of SLE was 37.8±14 years. The most frequently noted clinical manifestations were: skin involvement (81%), renal involvement (71.4%) and joint damage (66.7). We observed a significant difference in clinical features between male and female patients (21 males and 76 females): renal failure (52% vs. 71.4%), serositis (23.8% vs. 2.7%), peripheral neuropathy (19% vs. 4%) and lung interstitial disease (14.3% vs. 1.3%). No significant difference was found in the positivity of serum antibodies between the two groups. Fifteen male patients (71.4%) had a SLEDAI score greater than or equal to 11, referring to high/very high disease activity. Out of the 32 patients who developed infectious complications during the course of the disease, 11 were male (52.4% of males). Concerning the male group, complete remission was observed in 10 patients (47.6%), while 10 others presented persistent sequella. We observed one death in the male group secondary to infective acute respiratory failure. Conclusion: SLE in male patients is rare and associated with poor prognosis. Disparity was observed in clinical and biological features as well as outcome in the different studies. In our study, we concluded that male lupus is more severe.

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Chinese Systemic Lupus Erythematosus Treatment and Research Group (CSTAR) Registry XI: gender impact on long-term outcomes

Lupus ◽

10.1177/0961203319839845 ◽

2019 ◽

Vol 28 (5) ◽

pp. 635-641

Author(s):

S Zhang ◽

Z Ye ◽

C Li ◽

Z Li ◽

X Li ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Causes Of Death ◽

Survival Rates ◽

Systemic Lupus ◽

Male And Female ◽

Female Patients ◽

American College Of Rheumatology ◽

Male Patients

Objective The objective of this paper is to assess the role of gender on survival rate and causes of death and organ damage in systemic lupus erythematosus (SLE) patients in China from 2009 to 2015. Methods We conducted a multicenter cohort study to analyze the differences in outcome data between male and female SLE patients. A group of 1494 SLE patients who fulfilled the 1997 American College of Rheumatology SLE classification criteria were enrolled in the Chinese Systemic Lupus Erythematosus Treatment and Research Group (CSTAR) registry from April 2009 to February 2010. All enrolled patients were followed up at least once per year from 2009 to 2015. For patients who could not attend the outpatient clinic, follow-up was conducted by telephone interview. We collected demographic data, clinical manifestations and damage scores (System Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)). Survival rates were evaluated using the Kaplan-Meier method. Results This study included 1352 women and 142 men. The five-year survival rates were 92.0% for men and 97.6% for women. The survival rates of males were significant lower than for females ( p = 0.019). Male patients received methylprednisolone pulse therapy and cyclophosphamide significantly more than female patients ( p = 0.010). During follow-up, 12 male patients and 66 female patients died. The most common cause of death was infection (41.7%) for men and active SLE disease (27.3%) for women. At the end of the study, the major accumulated organ damages included renal (8.5%) and musculoskeletal (7.7%), and nervous system (5.6%) for men and renal (8.8%) and musculoskeletal (6.7%) for women. There were no significant differences in SDI scores between the two groups at baseline and at the end of the study. Conclusions Male SLE patients had lower survival rates than female patients. Male patients received more methylprednisolone pulse and cyclophosphamide therapy. The most common causes of death were infection for male patients and active SLE disease for female patients. The major accumulated organ damages were renal, musculoskeletal, and nervous system both for male and female SLE patients in China.

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Association study between X-linked susceptibility genes and clinical features in Chinese female patients with systemic lupus erythematosus

Autoimmunity ◽

10.1080/08916934.2019.1688792 ◽

2019 ◽

Vol 52 (7-8) ◽

pp. 289-293

Author(s):

Shen Li ◽

Dongsheng Di ◽

Xiaoxiao Wu ◽

Linlin Zhang ◽

Ruishan Liu ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Association Study ◽

Clinical Features ◽

Lupus Erythematosus ◽

Susceptibility Genes ◽

Systemic Lupus ◽

Female Patients

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FRI0235 DIFFERENCES BETWEEN MALE AND FEMALE PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A SINGLE CENTER EXPERIENCE OVER 20 YEARS OF FOLLOW-UP

10.1136/annrheumdis-2019-eular.2357 ◽

2019 ◽

Author(s):

Micaela Fredi ◽

Federica Tomasoni ◽

Laura Andreoli ◽

Ilaria Cavazzana ◽

Angela Tincani ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Single Center ◽

Systemic Lupus ◽

Male And Female ◽

Female Patients ◽

Single Center Experience

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Clinical and autoantibody profile in male and female patients with systemic lupus erythematosus: A retrospective study in 603 Brazilian patients

European Journal of Rheumatology ◽

10.5152/eurjrheum.2020.20023 ◽

2020 ◽

Vol 7 (4) ◽

pp. 164-168

Author(s):

Natália Teixeira De Oliveira ◽

◽

Nícolas Gomes Silva ◽

Thiago A.F. Gomes Dos Santos ◽

Renato Nisihara ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Retrospective Study ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Male And Female ◽

Female Patients ◽

Autoantibody Profile

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Differences between Male and Female Systemic Lupus Erythematosus in a Multiethnic Population

The Journal of Rheumatology ◽

10.3899/jrheum.111061 ◽

2012 ◽

Vol 39 (4) ◽

pp. 759-769 ◽

Cited By ~ 89

Author(s):

TZE CHIN TAN ◽

HONG FANG ◽

LAURENCE S. MAGDER ◽

MICHELLE A. PETRI

Keyword(s):

Systemic Lupus Erythematosus ◽

African American ◽

Lupus Erythematosus ◽

Organ Damage ◽

Systemic Lupus ◽

Male And Female ◽

Female Patients ◽

Oral Ulcers ◽

Lower Education Level ◽

And Gender

Objective.Male patients with systemic lupus erythematosus (SLE) are thought to be similar to female patients with SLE, but key clinical characteristics may differ. Comparisons were made between male and female patients with SLE in the Hopkins Lupus Cohort.Methods.A total of 1979 patients in the Hopkins Lupus Cohort were included in the analysis.Results.The cohort consisted of 157 men (66.2% white, 33.8% African American) and 1822 women (59.8% white, 40.2% African American). The mean followup was 6.02 years (range 0–23.73). Men were more likely than women to have disability, hypertension, thrombosis, and renal, hematological, and serological manifestations. Men were more likely to be diagnosed at an older age and to have a lower education level. Women were more likely to have malar rash, photosensitivity, oral ulcers, alopecia, Raynaud’s phenomenon, or arthralgia. Men were more likely than women to have experienced end organ damage including neuropsychiatric, renal, cardiovascular, peripheral vascular disease, and myocardial infarction, and to have died. In general, differences between males and females were more numerous and striking in whites, especially with respect to lupus nephritis, abnormal serologies, and thrombosis.Conclusion.Our study suggests that there are major clinical differences between male and female patients with SLE. Differences between male and female patients also depend on ethnicity. Future SLE studies will need to consider both ethnicity and gender to understand these differences.

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Sex Hormones and Prolactin Levels and Their Association with Anti Cardiolipin Antibody in Patients with Systemic Lupus Erythematosus

Iranian Journal of Allergy Asthma and Immunology ◽

10.18502/ijaai.v17i4.93 ◽

2018 ◽

Author(s):

Dariyush Raeisi ◽

Mohammad Erfan Zare ◽

Atefeh Nasir Kansestani ◽

Hamid Reza Sherkatolabbasieh ◽

Shiva Shafiezadeh

Keyword(s):

Systemic Lupus Erythematosus ◽

Sex Hormones ◽

Lupus Erythematosus ◽

Renal Involvement ◽

Serum Levels ◽

Antiphospholipid Antibody ◽

Antiphospholipid Antibody Syndrome ◽

Systemic Lupus ◽

Female Patients ◽

Significant Difference

Pathogenesis of systemic lupus erythematosus (SLE) is complex and multi-factorial. Among various suggested mechanisms for the disease, the hormonal theory has been considered as one of the most important mechanisms. Recently, the association of sex hormones with manifestations of antiphospholipid antibody syndrome (APLS) has been hypothesized. The aim of present study was to assess the serum levels of anticardiolipin antibody (ACA), sex hormones and prolactin in SLE female patients and their association with the disease. This study comprised 40 SLE female patients and 41 healthy age-matched female subjects. For all patients and controls, the serum levels of ACA (IgG and IgM), estradiol, testosterone, progesterone, dehydroepiandrosterone sulfate (DHEA-S) and prolactin were measured by ELISA method. Our study revealed that serum levels of testosterone, DHEA-S and progesterone were significantly lower in SLE patients than control (p<0.001). However, serum levels of estradiol and prolactin were significantly higher in SLE patients compared to controls (p<0.001). There was a significant difference between mild and moderate severity patients group for ACA positivity (95% CI 13.67-41.3; p=0.03). Also, SLE patients with positive ACA showed significantly lower (p<0.001) serum levels of testosterone, DHEA-S and progesterone and significantly higher (p<0.001) estradiol and prolactin serum levels compared to negative ACA patients. The results of our study indicated that expression and metabolism of sex hormones and prolactin are different in female SLE patients compared to healthy subjects. It seems, change in serum levels of these hormones is related to higher SLE disease activity, increased thrombotic risks and increased renal involvement.

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Clinical profile of young females with systemic lupus erythematosus: an observational study

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20213638 ◽

2021 ◽

Author(s):

Rishman Tandi ◽

Tanvi Kumar ◽

Atamjeet Singh ◽

Harmanpal Kathura

Keyword(s):

Systemic Lupus Erythematosus ◽

Clinical Features ◽

Lupus Erythematosus ◽

Young Female ◽

Clinical Profile ◽

Complement C3 ◽

Age Group ◽

Systemic Lupus ◽

Female Patients ◽

Child Bearing

Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder predominantly affecting women of child bearing age group and is known to require significant lifestyle modifications. The manifestations of SLE are myriad and it may virtually affect every system of affected individual. We Undertook this study to know the clinical profile of young female patients having SLE. The aim of the study was to study clinical features and medical therapy of young female patients having SLE.Methods: This was a prospective study in which 60 female patients diagnosed to be having lupus were included on the basis of a predefined inclusion and exclusion criteria. Investigations relevant to the diagnosis such as Antinuclear antibodies, Antiphospholipid Antibodies, Anti B2GP1 IgG, Anti-dsDNA antibody, Anti Smith Antibody and complement (C3 and C4) levels were done in all the cases. Other investigations such as imaging studies were done in selected cases. Clinical features and medical management being taken by these patients were analyzed. SSPS 21.0 software was used for statistical purpose.Results: The mean duration of the disease in studied cases was found to be 6.96±4.51 years. Malar rash was the commonest type of rash seen in these patients and was present in 53 (88.33%). Arthralgia with or without arthritis was seen in 54 (90%) of the cases. Anemia was the most common hematological abnormality and was seen in 17 (28.33%) patients. Renal involvement in the form of proteinuria was seen in 25 (41.67%) cases. The most common form of pulmonary involvement was pleural effusion which was seen in 4 (6.67%) patients. Cardiovascular manifestations were seen in 11 patients (18.33%).Conclusions: SLE usually affect women of child bearing age group and have a myriad clinical presentation. A thorough knowledge of various clinical presentations and a high index of suspicion is necessary to diagnose SLE particularly in its early stages.

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Clinical features of 17 male patients with systemic lupus erythematosus.

Japanese Journal of Clinical Immunology ◽

10.2177/jsci.16.52 ◽

1993 ◽

Vol 16 (1) ◽

pp. 52-57

Author(s):

Shigeru Hosaka ◽

Kumi Manaka ◽

Jun Okada ◽

Hirobumi Kondo ◽

Sadao Kashiwazaki

Keyword(s):

Systemic Lupus Erythematosus ◽

Clinical Features ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Male Patients

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Awareness of Systemic Lupus Erythematosus among Primary Health Care Patients in Riyadh, Saudi Arabia

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2018.370 ◽

2018 ◽

Vol 6 (12) ◽

pp. 2386-2392 ◽

Cited By ~ 1

Author(s):

Kholoud A. Bin Haikel ◽

Bader Al Tulaihi

Keyword(s):

Systemic Lupus Erythematosus ◽

Health Care ◽

Primary Health Care ◽

Lupus Erythematosus ◽

Categorical Variables ◽

P Value ◽

Systemic Lupus ◽

Male And Female ◽

Primary Health ◽

Significant Difference

AIM: To measure the level of Systemic Lupus Erythematosus awareness among visitors in PHC at KAMC and to explores the factors which influence the Systemic Lupus Erythematosus awareness. METHODS: The study was a cross-sectional study conducted between February and September 2018 in four primary health care centers belong to King Abdulaziz Medical City. The study participants were male and female adult visitors to the centers` age from 18 to 60 years of age. The sample size was 400 participants. The participants were enrolled via a random convenience sampling method. Study data was collected using a self-administered questionnaire. Analytic statistics were done using the Chi-square (c2) test for associations and/or the difference between two categorical variables. A P-value ≤ 0.05 was considered statistically significant. RESULTS: The awareness about Systemic Lupus Erythematosus among male and female was not statistically significant as (P = 0.304), but there was a statistically significant difference according to education level. Visitors with high school education are aware of Systemic Lupus Erythematosus than those with a lower level of education (Primary & Middle school) who are not aware of the Systemic Lupus Erythematosus by (P = 0.023). CONCLUSION: The study shows that this survey is valuable and beneficial to the community as it helps people to assess their knowledge about Systemic Lupus Erythematosus and become aware of this disease, as well as awareness of Systemic Lupus Erythematosus should be promoted among the community.

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