Effects of Probiotics on Diabetic Nephropathy: A Systematic Review

Background: Diabetic Nephropathy is a frequent complication of diabetes mellitus due to functional and structural modifications in multiple kidney compartments. Probiotics have risen lately as a forthcoming therapeutic intervention but they have not been systematically evaluated in diabetic nephropathy so far. The aim of this systematic review was to evaluate randomized controlled trials and experimental studies assessing the effect of probiotic supplements on diabetic nephropathy. Methods: An extensive literature search was conducted through electronic databases (PubMed, Scopus, Cinahl and Medline) with the Medical Subject Headings and entry terms of “diabetic nephropathy”, “diabetic renal disease” and “probiotics”. The search yielded 116 results, 9 of which met the inclusion criteria for this systematic review. Results: Most of the microorganisms used in the studies belonged to the Lactobacillus and Bifidobacterium genus. The dosage ranged from 2×107 to 6×1010 CFU/ g. The form of the probiotics varied across the studies (capsules, sachets, soy milk, kefir and honey). The majority of the studies demonstrated the benefits of probiotic supplementation on the reduction of inflammation, oxidative stress and on the amelioration of renal function biomarkers in subjects with diabetic nephropathy. No major gastrointestinal adverse events were observed during the intervention time with probiotics. Conclusion: : Findings of this systematic review demonstrate the positive impact of probiotics on Diabetic Nephropathy without any major adverse events. Moreover, future larger randomized controlled trials with bigger samples and longer follow-up time are deemed necessary for further valid results on the effectiveness of probiotic supplementation on Diabetic Nephropathy.

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Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials

The American Journal of Medicine ◽

10.1016/j.amjmed.2005.10.039 ◽

2006 ◽

Vol 119 (8) ◽

pp. 624-638 ◽

Cited By ~ 263

Author(s):

Kenneth R. McQuaid ◽

Loren Laine

Keyword(s):

Systematic Review ◽

Adverse Events ◽

Randomized Controlled Trials ◽

Low Dose ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled ◽

Dose Aspirin ◽

Low Dose Aspirin

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The Effectiveness and Safety of Probiotic Supplements for Psoriasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Preclinical Trials

Journal of Immunology Research ◽

10.1155/2021/7552546 ◽

2021 ◽

Vol 2021 ◽

pp. 1-14

Author(s):

Liuting Zeng ◽

Ganpeng Yu ◽

Yang Wu ◽

Wensa Hao ◽

Hua Chen

Keyword(s):

Systematic Review ◽

Adverse Events ◽

Randomized Controlled Trials ◽

Meta Analysis ◽

Intestinal Flora ◽

Controlled Trials ◽

Skin Thickness ◽

Randomized Controlled ◽

Probiotic Treatment ◽

Preclinical Trials

Background. Patients with psoriasis need long-term medication to control their condition. Recent studies suggest that changing the intestinal flora may be a potential treatment. Methods. The databases were utilized to search the randomized controlled trials (RCTs) and preclinical trials about probiotic supplement in the treatment of psoriasis. The retrieval time is from the establishment of these databases to December 2020. RevMan5.3 was used for the risk assessment of bias and meta-analysis. This systematic review was registered in PROSPERO (CRD42021232756). Results. A total of 3 RCTs involving 164 participants were included. Two RCTs showed that probiotics can improve PASI and thereby improve the condition. For inflammation-related indicators, only one RCT showed that probiotics can improve the levels of CRP and TNF-α but have no obvious improvement effect on IL6. One RCT demonstrated the total effective rate of probiotics in the treatment of psoriasis. For adverse events, one RCT showed that the incidence of adverse events of probiotic treatment was low. Preclinical studies showed that continuous intervention with oral probiotics can significantly improve the progression of psoriasis and reduce the expression of inflammatory factors. The meta-analysis showed that the PASI between two groups was of no statistical significance (SMD 1.83 [-0.41, 4.07], P = 0.11 ). Meanwhile, probiotics may improve skin thickness (SMD -5.87 [-11.34, -0.41], P = 0.04 ) in animal model. Conclusion. Prebiotics may have a positive effect on alleviating the clinical symptoms of psoriasis, but a large sample of RCTs is still needed to support its therapeutic effect in psoriasis.

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Improving Cardiovascular Health through Nudging Healthier Food Choices: A Systematic Review

Nutrients ◽

10.3390/nu11102520 ◽

2019 ◽

Vol 11 (10) ◽

pp. 2520 ◽

Cited By ~ 2

Author(s):

Christine Tørris ◽

Hilde Mobekk

Keyword(s):

Systematic Review ◽

Randomized Controlled Trials ◽

Dietary Habits ◽

Negative Impact ◽

Experimental Studies ◽

Food Choices ◽

Overweight And Obesity ◽

Controlled Trials ◽

Randomized Controlled ◽

The Impact

Obesity and metabolic syndrome are considered major public health problems, and their negative impact on cardiovascular disease (CVD) and diabetes mellitus type 2 (DM2) is profound. Targeting modifiable risk factors such as dietary habits is therefore of great importance. Many of today’s health challenges with overweight and obesity may have behavioral roots, and traditional methods such as regulations and campaigns are often insufficient to improve dietary choices. Nudging or choice architecture might be a viable tool to influence people’s everyday choices and behaviors to better outcomes. This paper reviews the current state of the rapidly expanding number of experimental field studies that investigate the effects/associations of nudging on healthy food choices. A systematic literature search was conducted in PubMed, where 142 citations were identified. Based on selection criteria, six randomized controlled trials and 15 non-randomized controlled trials were ultimately included. The results of this systematic review show that many of the studies included traffic-light labeling, which may be a promising strategy. The reviewed findings, however, also highlight the challenges that confront experimental studies examining the impact of nudging on diet.

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Probiotic Supplementation Has a Limited Effect on Circulating Immune and Inflammatory Markers in Healthy Adults: A Systematic Review of Randomized Controlled Trials

Journal of the Academy of Nutrition and Dietetics ◽

10.1016/j.jand.2019.08.018 ◽

2020 ◽

Vol 120 (4) ◽

pp. 548-564 ◽

Cited By ~ 4

Author(s):

Alex E. Mohr ◽

Anthony J. Basile ◽

Meli’sa S. Crawford ◽

Karen L. Sweazea ◽

Katie C. Carpenter

Keyword(s):

Systematic Review ◽

Randomized Controlled Trials ◽

Inflammatory Markers ◽

Healthy Adults ◽

Controlled Trials ◽

Probiotic Supplementation ◽

Limited Effect ◽

Randomized Controlled

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Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials

American Journal of Ophthalmology ◽

10.1016/j.ajo.2006.11.002 ◽

2007 ◽

Vol 143 (1) ◽

pp. 194

Author(s):

K.R. McQuaid ◽

L. Laine

Keyword(s):

Systematic Review ◽

Adverse Events ◽

Randomized Controlled Trials ◽

Low Dose ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled ◽

Dose Aspirin ◽

Low Dose Aspirin

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Non-Immersive Virtual Reality for Rehabilitation of the Older People: A Systematic Review into Efficacy and Effectiveness

Journal of Clinical Medicine ◽

10.3390/jcm8111882 ◽

2019 ◽

Vol 8 (11) ◽

pp. 1882 ◽

Cited By ~ 7

Author(s):

Bevilacqua ◽

Maranesi ◽

Riccardi ◽

Donna ◽

Pelliccioni ◽

...

Keyword(s):

Systematic Review ◽

Virtual Reality ◽

Older People ◽

Randomized Controlled Trials ◽

Cognitive Abilities ◽

Positive Impact ◽

Data Extraction ◽

Future Research ◽

Controlled Trials ◽

Randomized Controlled

: Objective: the objective of this review is to analyze the advances in the field of rehabilitation through virtual reality, while taking into account non-immersive systems, as evidence have them shown to be highly accepted by older people, due to the lowest “cibersikness” symptomatology. Data sources: a systematic review of the literature was conducted in June 2019. The data were collected from Cochrane, Embase, Scopus, and PubMed databases, analyzing manuscripts and articles of the last 10 years. Study selection: we only included randomized controlled trials written in English aimed to study the use of the virtual reality in rehabilitation. We selected 10 studies, which were characterized by clinical heterogeneity. Data extraction: quality evaluation was performed based on the Physioterapy Evidence Database (PEDro) scale, suggested for evidence based review of stroke rehabilitation. Of 10 studies considered, eight were randomized controlled trials and the PEDro score ranged from four to a maximum of nine. Data synthesis: VR (Virtual Reality) creates artificial environments with the possibility of a patient interaction. This kind of experience leads to the development of cognitive and motor abilities, which usually positively affect the emotional state of the patient, increasing collaboration and compliance. Some recent studies have suggested that rehabilitation treatment interventions might be useful and effective in treating motor and cognitive symptoms in different neurological disorders, including traumatic brain injury, multiple sclerosis, and progressive supranuclear palsy. Conclusions: as it is shown by the numerous studies in the field, the application of VR has a positive impact on the rehabilitation of the most predominant geriatric syndromes. The level of realism of the virtual stimuli seems to have a crucial role in the training of cognitive abilities. Future research needs to improve study design by including larger samples, longitudinal designs, long term follow-ups, and different outcome measures, including functional and quality of life indexes, to better evaluate the clinical impact of this promising technology in healthy old subjects and in neurological patients.

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Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials

European Journal of Clinical Nutrition ◽

10.1038/ejcn.2016.78 ◽

2016 ◽

Vol 70 (11) ◽

pp. 1221-1229 ◽

Cited By ~ 22

Author(s):

T Isomura ◽

S Suzuki ◽

H Origasa ◽

A Hosono ◽

M Suzuki ◽

...

Keyword(s):

Systematic Review ◽

Adverse Events ◽

Randomized Controlled Trials ◽

Green Tea ◽

Case Reports ◽

Intervention Group ◽

Control Group ◽

Controlled Trials ◽

Cochrane Central Register ◽

Randomized Controlled

Abstract There remain liver-related safety concerns, regarding potential hepatotoxicity in humans, induced by green tea intake, despite being supposedly beneficial. Although many randomized controlled trials (RCTs) of green tea extracts have been reported in the literature, the systematic reviews published to date were only based on subjective assessment of case reports. To more objectively examine the liver-related safety of green tea intake, we conducted a systematic review of published RCTs. A systematic literature search was conducted using three databases (PubMed, EMBASE and Cochrane Central Register of Controlled Trials) in December 2013 to identify RCTs of green tea extracts. Data on liver-related adverse events, including laboratory test abnormalities, were abstracted from the identified articles. Methodological quality of RCTs was assessed. After excluding duplicates, 561 titles and abstracts and 119 full-text articles were screened, and finally 34 trials were identified. Of these, liver-related adverse events were reported in four trials; these adverse events involved seven subjects (eight events) in the green tea intervention group and one subject (one event) in the control group. The summary odds ratio, estimated using a meta-analysis method for sparse event data, for intervention compared with placebo was 2.1 (95% confidence interval: 0.5–9.8). The few events reported in both groups were elevations of liver enzymes. Most were mild, and no serious liver-related adverse events were reported. Results of this review, although not conclusive, suggest that liver-related adverse events after intake of green tea extracts are expected to be rare.

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