Evaluation of Risk Factors for Development of Anti-Tubercular Therapy Induced Hepatotoxicity: A Prospective Study

2020 ◽  
Vol 15 (3) ◽  
pp. 198-204
Author(s):  
Malladi V.S. Subbalaxmi ◽  
Radhika Soanker ◽  
Arivittur V. Lakshmi
Keyword(s):  
Risk Factors ◽  
Liver Function ◽  
Pulmonary Tuberculosis ◽  
Female Gender ◽  
Liver Function Tests ◽  
Study Patient ◽  
Control Group ◽  
Study Group ◽  
Cox Regression Analysis ◽  
Function Tests

Background: Incidence of Antitubercular Therapy (ATT)-induced hepatotoxicity is higher in India when compared to Western countries. As the occurrence of ATT-induced hepatotoxicity is unpredictable, serial intensive monitoring of hepatic function is now being recommended by the American Thoracic Society in individuals at high risk. This study was done to evaluate the risk factors for the development of ATT induced hepatotoxicity in India. Methodology: In this prospective, observational study, patient characteristics of microbiologically/ radiologically/ histopathologically confirmed tuberculosis were prospectively compiled. Serial liver function tests were done once a month in all patients. Patients who developed ATT-induced hepatotoxicity were considered as the study group and those who did not develop the event as a control group. The primary outcome measure was to estimate the hazard ratios associated with risk factors for the development of ATT induced hepatotoxicity. Cox Regression Analysis was done using SPSS 20. Results: : A total of 200 patients were enrolled in the study, of them, 14% developed ATT-induced hepatotoxicity and 86% did not develop the event. The baseline liver function tests in the study group and control group were within normal limits. Female gender, alcoholism, HIV co-infection and age >35 yrs were identified to have a higher risk for development of ATT-induced hepatotoxicity, while cases with pulmonary tuberculosis were found to be at lower risk of developing event. Conclusion: Intensive liver function monitoring needs to be done in patients with these risk factors, female gender, alcoholism, HIV co-infection, extra-pulmonary tuberculosis and age >35 yrs.

scholarly journals A cross sectional study of liver function tests in normal pregnancy during third trimester: a treasure from the past

2017 ◽  
Vol 6 (3) ◽  
pp. 1105
Author(s):  
Nirpaul Singh ◽  
Shagufta Yousuf ◽  
Showkat H. Tali
Keyword(s):  
Liver Function ◽  
Pregnant Women ◽  
Serum Alkaline Phosphatase ◽  
Liver Function Tests ◽  
Normal Pregnancy ◽  
The Body ◽  
Control Group ◽  
Study Group ◽  
Third Trimester ◽  
Function Tests

Background: During pregnancy, a lot of changes do occur and affect every organ system in the body. Objective of the study was to find out expected variations, if any, in liver function tests (LFT) in normal pregnancy during the third trimester.Methods: A total of 75 women aged between 20 to 35 years were enrolled in the study of which 25 were non-pregnant women (control group) and 50 were pregnant women in their third trimester (study group).Results: In the study group, there were no changes in SGPT, serum albumen and serum globulin values in any of the subjects. However out of 50 subjects, a rise in serum alkaline phosphatase could be demonstrated in as many as 44 (88%) subjects. In 10 (20%) subject Serum Bilirubin was high and in 6 (12%) subjects each a rise in SGOT and fall in Serum Proteins could be demonstrated.Conclusions: Except for a significant change in serum phosphatase levels, there is no significant variation in any of the liver function tests in third trimester of pregnancy.

Fisher Discrimination of Metabolic Changes in Rats Treated with Aspirin and Ibuprofen

Pharmacology ◽  
2017 ◽  
Vol 100 (3-4) ◽  
pp. 194-200 ◽  
Author(s):  
Jing Zhang ◽  
Huanchun Song ◽  
Shuying Jiang ◽  
Zhibin Chen ◽  
Shuhua Tong ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Gas Chromatography Mass Spectrometry ◽  
Control Group ◽  
Intragastric Administration ◽  
Acetoacetic Acid ◽  
Toxic Reaction ◽  
Function Tests ◽  
Metabolomic Data ◽  
Aspirin Group

Background: Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicities. Methods: A total of 45 rats were randomly divided into Control group, Aspirin group, and Ibuprofen groups. The experiment groups were given intragastric aspirin (15 mg/kg) or ibuprofen (15 mg/kg) for 3 weeks. Liver function tests were performed and blood metabonomics were analyzed by gas chromatography-mass spectrometry. Results: The most important compounds altered were trihydroxybutyric acid and l-alanine in the aspirin group, and acetoacetic acid, l-alanine, and trihydroxybutyric acid in the ibuprofen group. With respect to metabolic profiles, all 3 groups were completely distinct from one another. Fisher discrimination showed that 91.1% of the original grouped cases were correctly classified by the third week. However, only 55.6% of liver function tests were able to classify grouped cases correctly. Conclusion: Trihydroxybutyric acid, l-alanine, and acetoacetic acid were the most significant indicators of altered serum metabolites following intragastric administration of aspirin and ibuprofen in rates. These metabolomic data may be used for classification of aspirin and ibuprofen toxicity.

scholarly journals SYNERGISTIC ANTIOXIDANT ACTION OF MURRAYA KOENIGII AND PLUMERIA RUBRA EXTRACTS ENHANCE HEPATOPROTECTIVE EFFICACY AGAINST METHOTREXATE INDUCED LIVER INJURY

2017 ◽  
Vol 9 (10) ◽  
pp. 152
Author(s):  
Engineer A. S. ◽  
Pal S. ◽  
Desai K. R. ◽  
Highland H. N.
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Control Group ◽  
Liver Protein ◽  
Murraya Koenigii ◽  
Dual Formulation ◽  
Significant Recovery ◽  
Function Tests ◽  
Group I ◽  
Plumeria Rubra

Objective: The present study was focussed on evaluating the hepatoprotective capacity of a combination of leaf extracts of Murraya koenigii and Plumeria rubra on drug-induced toxicity in mice liver.Methods: Hydromethanolic and aqueous extracts were prepared from the leaves of Murraya koenigii and Plumeria rubra. A combination of these extracts was tested as a dual formulation (DF). The extracts were evaluated for their antioxidant activity and phytochemical content. Healthy adult male mice were treated in five groups, for 30 d: Control (Group I-Untreated), Group II (Methotrexate at 10 mg/kg Body weight, intraperitoneally), Group III (Methotrexate+Silymarin), Group IV (Methotrexate+hydromethanolic extract of DF-250 mg/kg b.w., orally), Group V (Methotrexate+aqueous extract of the DF-250 mg/kg b.w. orally). After treatment, the animals were necropsied. Blood was collected for serum parameters such as alanine transaminase (ALT), Aspartate transaminase (AST) and γ glutamyl transpeptidase (GGT). Further liver function tests like Alkaline phosphatase (ALP), Phosphorylase as well as Oxidative stress parameters like Lipid peroxidation (LPO), Superoxide dismutase (SOD), Catalase (CAT), along with the liver protein and cholesterol content were analyzed.Results: Administration of both the DF extracts significantly ameliorated the methotrexate-induced toxic effects on all the aforementioned biochemical parameters. The hydromethanolic extract showed significant recovery in the liver function tests like ALT (p<0.05) and AST (p<0.001). Antioxidant stress enzymes like SOD (p<0.001) and Catalase (p<0.001) also showed significant recovery after administration of both the extracts. The other parameters assayed also followed the same trend. Although both the extracts showed remarkable hepatoprotection, the hydromethanolic extract was found to be significantly more potent than the aqueous extract.Conclusion: The present study concludes that the Dual formulation of the extracts of Murraya koenigii and Plumeria rubra could be an effective hepatoprotective agent due to the synergistic action of the phytoconstituents of both the plants.

Efficiency of enterosorption in comprehensive therapy of viral hepatitis A in children

2020 ◽  
Vol 15 (5) ◽  
pp. 34-38
Author(s):  
R.Kh. Begaidarova ◽  
◽  
Yu.G. Starikov ◽  
G.K. Alshynbekova ◽  
A.E. Dyusembaeva ◽  
...  
Keyword(s):  
Liver Function ◽  
Viral Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Clinical Symptoms ◽  
Liver Function Tests ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Function Tests ◽  
Comprehensive Therapy

Objective. To evaluate therapeutic efficacy and safety of Enterosgel adsorbent and compare it with standard therapy in children with viral hepatitis Patients and methods. This open-label, prospective, randomized, controlled trial was conducted in the Regional Hospital for Infectious Diseases of Karaganda. We examined 98 children (mean age 10.56 ± 0.36 years) diagnosed with hepatitis A. The diagnosis was verified by identification of the marker reflecting active replication of hepatitis A virus (аnti-HAV IgM) using enzyme-linked immunosorbent assay. We evaluated the dynamics of clinical symptoms and liver function tests, including total bilirubin and its fractions, as well as levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The experimental group included 52 patients who received Enterosgel; the control group comprised 46 patients who received standard for hepatitis A therapy. Results. Enterosgel ensured more rapid resolution of clinical symptoms of acute hepatitis A and normalization of liver function tests compared to patients with the control group. This led to a shorter period of intoxication, vomiting, and jaundice, as well as to reduced ALT, and shorter in-hospital stay. Key words: hepatitis A, intoxication, jaundice, enterosorbent, Enterosgel

A young man with bleeding esophageal varices

2018 ◽  
Vol 1 (1) ◽  
pp. 14-16
Author(s):  
Soonthorn Chonprasertsuk
Keyword(s):  
Risk Factors ◽  
Portal Hypertension ◽  
Liver Function ◽  
Physical Examination ◽  
Esophageal Varices ◽  
Liver Function Tests ◽  
Noncirrhotic Portal Hypertension ◽  
Liver Histopathology ◽  
Function Tests ◽  
Bleeding Esophageal Varices

The noncirrhotic portal hypertension is an uncommon cause of bleeding esophageal varices. This condition must be suspected in patients with preserved liver function. We report a 25-year old man with SLE disease who presented with hematemesis. He had no history or risk factors for an underlying liver condition. A huge splenomegaly was detected by physical examination. The EGD found three large varices with red wale sign, whereas liver function tests were unremarkable. The noncirrhotic portal hypertension was diagnosed and confirmed by liver histopathology.

A young man with bleeding esophageal varices

2018 ◽  
Vol 1 (1) ◽  
pp. 14-16
Author(s):  
Soonthorn Chonprasertsuk
Keyword(s):  
Risk Factors ◽  
Portal Hypertension ◽  
Liver Function ◽  
Physical Examination ◽  
Esophageal Varices ◽  
Liver Function Tests ◽  
Noncirrhotic Portal Hypertension ◽  
Liver Histopathology ◽  
Function Tests ◽  
Bleeding Esophageal Varices

The noncirrhotic portal hypertension is an uncommon cause of bleeding esophageal varices. This condition must be suspected in patients with preserved liver function. We report a 25-year old man with SLE disease who presented with hematemesis. He had no history or risk factors for an underlying liver condition. A huge splenomegaly was detected by physical examination. The EGD found three large varices with red wale sign, whereas liver function tests were unremarkable. The noncirrhotic portal hypertension was diagnosed and confirmed by liver histopathology. Figure 1 แสดงผลการส่องกล้องทางเดินอาหารส่วนบน พบ F3 varices with red wale sign

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