Breast Milk Stem Cell Survival in Neonate's Gut, Entery into Neonate Circulation and Adaption by the Body

2020 ◽  
Vol 15 (2) ◽  
pp. 98-101 ◽  
Author(s):  
Amit Ghosh
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Breast Milk ◽  
Systemic Circulation ◽  
The Body ◽  
Future Research ◽  
Human Breast Milk ◽  
Human Breast ◽  
Cell Therapies ◽  
Therapeutic Uses

: The stem cell exchange during pregnancy is thought to remain chimeras for life. Few studies recently revealed that maternal transfer of viable stem cells to the offspring continues even after birth during breastfeeding. Some of these stem cells are likely to be integrated into different organs (brain, blood, kidneys, and pancreas) including neurons and insulin-producing cells in the pancreas to become functional cells. This finding opens a new avenue for research on therapeutic uses of breast milk- derived stem cells. : Recently Dr. Foteini Hassiotou used glowing mice, which were genetically modified to express a gene called tdTomato that causes cells to appear red under fluorescence light. These mice were mated, and their babies were swapped with the pups of another, unmodified mother mouse. The new pups suckled the modified mouse and, as a result, obtained glowing red stem cells from breast milk. The study has never been replicated in humans, so it is not clear yet if the findings apply to humans as in the case of mice. However, the results of the study are the jumping-off points for future research on human breast milk stem cells and their possible application in stem cell therapies. Additional studies are necessary to understand the passage of human breast milk stem cells through the neonate’s GI tract, and passage to the systemic circulation.

scholarly journals Differentiation of Human Breast-Milk Stem Cells to Neural Stem Cells and Neurons

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Seyed Mojtaba Hosseini ◽  
Tahere Talaei-khozani ◽  
Mahsa Sani ◽  
Bahareh Owrangi
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Growth Factor ◽  
Breast Milk ◽  
Neural Stem Cells ◽  
Human Breast Milk ◽  
Stem Cell Markers ◽  
Human Breast ◽  
Fetal Bovine ◽  
Endothelial Growth Factor

Objectives.Human breast milk contains a heterogeneous population of cells that have the potential to provide a noninvasive source of cells for cell therapy in many neurodegenerative diseases without any ethical concern. The objectives of this study were to differentiate the breast milk-derived stem cells (BMDSC) toward neural stem cells and then into the neurons and neuroglia.Materials and Methods.To do this, the BMDSC were isolated from human breast milk and cultured in Dulbecco’s modified Eagle medium/F12 (DMEM/F12) containing fibroblast growth factor (bFGF). The cells were then characterized by evaluation of the embryonic and stem cell markers. Then, the cells were exposed to culture medium containing 1% B27 and 2% N2 for 7–10 days followed by medium supplemented with B27, N2, bFGF 10 µg/mL, and endothelial growth factor (EGF) 20 µg/mL. Then, the sphere-forming assay was performed. The spheres were then differentiated into three neural lineages by withdrawing growth factor in the presence of 5% FBS (fetal bovine serum). The immunofluorescence was done forβ-tubulin III, O4, and GFAP (glial fibrillary acidic protein).Results.The results indicated that the cells expressed both embryonic and mesenchymal stem cell (MSC) markers. They also showed neurospheres formation that was nestin-positive. The cells were also differentiated into all three neural lineages.Conclusion.The BMDSC can behave in the same way with neural stem cells. They were differentiated into oligodendrocytes, and astrocytes as well as neurons.

scholarly journals Potential of Ayurvedic Drugs in Differentiating Neuronal Stem Cells from Human Breast Milk: A Review

2019 ◽  
Vol 7 (1) ◽  
pp. 113-123
Author(s):  
Rinki Kumari
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Breast Milk ◽  
Cell Types ◽  
Human Mesenchymal Stem Cell ◽  
Human Breast Milk ◽  
Cell Renewal ◽  
Human Breast ◽  
Neuronal Stem Cells ◽  
Ayurvedic Drugs

Recently, Stem cell therapy has revolutionized excellent clinical therapy with the potential of stem cells to differentiate into various cell types and it may help to replace different cell lines of an organism. Frequent, clinical trials are carried out to merge the new scientific stem cell information and techniques with traditional knowledge and plant extracts that may result in less toxic, affordable, and highly available natural alternative therapeutics. Ayurveda, the traditional Indian system of medicine has given great emphasis to the promotion of health. Ayurveda therapies are based on the restoration of body balance and nourishment of dhatus. Rasayana concept of Ayurveda explains tissue regeneration and cell renewal. Rasayana drugs and therapies provide research opportunities for the biology of regeneration. Specific Medhya Rasayana stimulates and nourishes respective Medha (Dhi, Driti, and Smriti) dhatus. Interpretation of this description offers clues for specific differentiation of neuronal stem cells from human breast milk (HBM) in the presence of some herbal extracts. The previous studies suggest that neuronal stem cells differentiate from Human Breast Milk (Human mesenchymal stem cell) more effectively with Madhya Rasayana drugs. The present review highlights the potential of Ayurveda and its possible contributions in regenerative medicine.

scholarly journals The Therapeutic Potential of Conditioned Medium from Human Breast Milk Stem Cells in Treating Spinal Cord Injury

2020 ◽  
Vol 14 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Maryam Borhani-Haghighi ◽  
Shadan Navid ◽  
Yousef Mohamadi
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Breast Milk ◽  
Conditioned Medium ◽  
Rat Model ◽  
Intrathecal Administration ◽  
Human Breast Milk ◽  
Human Breast ◽  
Cord Injury

Study Design: Experimental animal study.Purpose: This study investigated the therapeutic effects of human breast milk stem cell (BMSC)-conditioned medium (BMSC-CM) in a model of spinal cord injury (SCI) in male Sprague-Dawley rats.Overview of Literature: SCI is one of the leading causes of disability in addition to sensory and motor impairment. So far, there have been no successful treatments for SCI. Given the positive outcomes associated with using stem cells and their derivatives as a treatment for various diseases, there is a growing interest in using them as an SCI treatment. Recent research has demonstrated that CM from stem cells has therapeutic advantages.Methods: Human BMSCs were isolated and characterized, and CM was subsequently collected. Animals received an intrathecal administration of BMSC-CM after SCI. The activity of caspase-3 was measured to assess apoptosis, and levels of tumor necrosis factor-α and interleukin-1β were measured to assess inflammation. Also, sensory and locomotor performances were assessed after SCI and BMSC-CM administration.Results: Administration of CM from BMSC reduced apoptosis and inflammation at the site of injury in a rat model of SCI (p<0.05). Motor, sensory, locomotor, and sensorimotor performances were significantly improved in rats that received BMSC-CM after SCI.Conclusions: Intrathecal administration of BMSC-CM improved recovery in a rat model of SCI.

scholarly journals Stem cells in human breast milk

Human Cell ◽  
2019 ◽  
Vol 32 (3) ◽  
pp. 223-230 ◽  
Author(s):  
Natalia Ninkina ◽  
Michail S. Kukharsky ◽  
Maria V. Hewitt ◽  
Ekaterina A. Lysikova ◽  
Larissa N. Skuratovska ◽  
...  
Keyword(s):  
Stem Cells ◽  
Breast Milk ◽  
Human Breast Milk ◽  
Human Breast

scholarly journals A REPORT ON STEM CELLS AND THEIR APPLICATIONS

2020 ◽  
pp. 1-2
Author(s):  
Shantha A R
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Building Blocks ◽  
Cell Types ◽  
The Body ◽  
Cell Therapies ◽  
Undifferentiated Cells ◽  
The Cost

Stem cells are the building blocks of life. They have remarkable potential to regenerate and develop into many different cell types in the body during early life and growth. They are also a class of undifferentiated cells that are able to be differentiated into specialized cells types. Stem cells are characterized by certain features such as totipotency, pluripotency, multipotency, oligopotent and unipotency. The history of stem cell research had an embryonic beginning in the mid 1800s with the discovery that few cells could generate other cells. In the 1900s the first stem cells were discovered when it was found that cells generate blood cells. Nowadays, stem cell therapy is under research and till now, a very few stem cell therapies have been regarded as safe and successful. It is also found that stem cell therapy cast a number of side effects too. The cost of the procedure too is expensive and is not easily affordable.

scholarly journals Exploring the stem cell and non-stem cell constituents of human breast milk

2012 ◽  
Vol 65 (3) ◽  
pp. 385-393 ◽  
Author(s):  
S. Indumathi ◽  
M. Dhanasekaran ◽  
J. S. Rajkumar ◽  
D. Sudarsanam
Keyword(s):  
Stem Cell ◽  
Breast Milk ◽  
Human Breast Milk ◽  
Human Breast

Novel DRAQ5™/SYTOX® Blue Based Flow Cytometric Strategy to Identify and Characterize Stem Cells in Human Breast Milk

2018 ◽  
Vol 96 (6) ◽  
pp. 480-489 ◽  
Author(s):  
Titus Keller ◽  
Leonie Wengenroth ◽  
Denise Smorra ◽  
Kristina Probst ◽  
Leo Kurian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Breast Milk ◽  
Human Breast Milk ◽  
Human Breast ◽  
Flow Cytometric

Human Breast Milk: Bioactive Components, from Stem Cells to Health Outcomes

2020 ◽  
Vol 9 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Flaminia Bardanzellu ◽  
Diego Giampietro Peroni ◽  
Vassilios Fanos
Keyword(s):  
Stem Cells ◽  
Breast Milk ◽  
Health Outcomes ◽  
Human Breast Milk ◽  
Bioactive Components ◽  
Human Breast

Regulation of Stem Cell-Based Research in India in Comparison with the US, EU and other Asian Countries: Current Issues and Future Perspectives

2020 ◽  
Vol 15 (6) ◽  
pp. 492-508
Author(s):  
Jobin Jose ◽  
Teena George ◽  
Aaron M. Thomas
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Heart Diseases ◽  
The Body ◽  
Regulatory Agencies ◽  
Cell Therapies ◽  
The Us ◽  
Regenerative Medicines

Stem cell therapy is applicable for repair and replacement of damaged cells and tissues. Apart from transplanting cells to the body, the stem cell therapy directs them to grow new and healthy tissues. Stem cells in the area of regenerative medicines hold tremendous promise that may help to regenerate the damaged tissues and heal various diseases like multiple sclerosis, heart diseases, Parkinson’s disease, and so on. To prove the safety, efficacy, and for the requirement of a licence for manufacturing and sale, all the stem cell therapies should pass the required criteria and undergo certain examinations of the regulatory agencies. The regulatory authorities review the manufacturing procedures of products to assure its purity and potency. This review summarizes the comparative critical evaluations of existing regulations and developments on the stem cells research in India, USA, EU and Asian regions and also discusses the challenges that have to be overcome and the important points that should be understood to position India as a source of the perspective nation in stem cells around the world.

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