Effect of Antitubercular Therapy on Endometrial Function in Infertile Women with Female Genital Tuberculosis

2016 ◽  
Vol 16 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Jai Bhagwan Sharma ◽  
Jayaramaiah Sneha ◽  
Urvashi B. Singh ◽  
Sunesh Kumar ◽  
Kallol Kumar Roy ◽  
...  
Keyword(s):  
Antitubercular Therapy ◽  
Genital Tuberculosis ◽  
Infertile Women ◽  
Female Genital Tuberculosis ◽  
Female Genital

HYSTEROSCOPY FOR DIAGNOSIS OF FEMALE GENITAL TUBERCULOSIS IN INFERTILE WOMEN: AN ESSENTIAL TOOL IN MINIMALLY INVASIVE ERA.

2021 ◽  
pp. 73-76
Author(s):  
Vinita Sarbhai ◽  
Aafreen Naaz ◽  
Vikram Sarbhai
Keyword(s):  
Prospective Observational Study ◽  
Uterine Cavity ◽  
Endometrial Biopsy ◽  
Genital Tuberculosis ◽  
Infertile Women ◽  
Female Genital Tuberculosis ◽  
The Common ◽  
Basic Evaluation ◽  
Female Genital

INTRODUCTION: Female genital tuberculosis (FGTB) is difcult to diagnose due to asymptomatic presentation and paucity of denitive investigations. Hysteroscopy can be utilized for the diagnosis of genital tuberculosis in infertile women. This study was done to study the role of hysteroscopy in the diagnosis of genital tuberculosis. METHODS: Prospective observational study was performed on 50 infertile women after basic evaluation of infertility. The women with tubal factors for infertility or unexplained infertility were selected for the study. Premenstrual endometrial biopsy (EB) was done for mycobacteria (AFB) detection. Hysteroscopy was performed in the next cycle if no AFB was detected on EB. ATT was given if genital TB was diagnosed on EB, and hysteroscopy was performed after completion of ATT. Hysteroscopic observations were compared with endometrial biopsy results. RESULTS: A total of 4 (8%) cases were diagnosed as bacteriologically positive for genital tuberculosis in endometrial samples. They were given anti-tubercular treatment. On hysteroscopy, pale endometrium (16%), Intrauterine adhesions (46%), and osteal obliteration (18%) were the common abnormal observations. 12 patients had mild adhesions, 6 had moderate and 5 patients had severe adhesions. Overall, 26 (52%) patients had features of intrauterine brosis, like intra-uterine adhesions or ostial obliteration, which could be suggestive of chronic infection like tuberculosis. Hysteroscopic adhesiolysis was performed in 46% and the cavity was restored. CONCLUSION: Endometrial Biopsy and Hysteroscopy are complementary procedures that together can help in the diagnosis of FGTB. Hysteroscopy is not only the gold standard for diagnosing uterine adhesions, distortion of the uterine cavity and tubal ostia, but it can also be a prognostic and therapeutic tool.

scholarly journals Role of GeneXpert in endometrial biopsy for diagnosis of genital tuberculosis in women presenting with infertility

2021 ◽  
Vol 10 (5) ◽  
pp. 1832
Author(s):  
Aafreen Naaz ◽  
Vikram Sarbhai ◽  
Vinita Sarbhai
Keyword(s):  
Cross Sectional Study ◽  
Endometrial Biopsy ◽  
Genital Tuberculosis ◽  
Cross Sectional ◽  
Infertile Women ◽  
Female Genital Tuberculosis ◽  
Diagnostic Modalities ◽  
Low Sensitivity ◽  
Additional Value ◽  
Female Genital

Background: The diagnosis of female genital TB is challenging due to low sensitivity of conventional diagnostic modalities. The new GeneXpert Test on endometrial biopsy is studied for its role in diagnosis of female genital TB.Methods: This is an observational cross-sectional study on 50 infertile women. Premenstrual endometrial biopsy was performed and sent for AFB Smear, M. TB (LJ) medium culture, CB-NAAT by GeneXpert, and histopathology. The results were compared for diagnosis of FGTB.Results: Endometrial Biopsy (EB) could confirm diagnosis of genital TB in 4 cases (8%) out of 50 infertile women. Amongst these 4 cases, GeneXpert was positive in two, AFB were detected on smear in three while one showed both AFB on smear and positive GeneXpert. GeneXpert adds additional value but surely cannot replace any of the other gold standard investigations.Conclusions: GeneXpert is a rapid diagnostic method which is accurate, feasible and affordable. It is useful adjunct to the existing armamentarium in diagnosis of female genital tuberculosis.

A STUDY ON CO-RELATION BETWEEN INFERTILITY AND FEMALE GENITAL TUBERCULOSIS

2021 ◽  
pp. 11-12
Author(s):  
Bharti Maheshwari ◽  
Srishti Singh
Keyword(s):  
Diagnostic Methods ◽  
Reproductive Age ◽  
Age Group ◽  
Genital Tuberculosis ◽  
Infertile Women ◽  
Female Genital Tuberculosis ◽  
History Of ◽  
High Degree ◽  
Reproductive Age Group ◽  
Female Genital

Background: Female genitourinary tuberculosis (FGTB) is an important cause of infertility in women of reproductive age group. The disease remains undetected due to its asymptomatic nature and lack of sensitive tests. This study was conducted with the aim of detecting the prevalence of genital tuberculosis in infertile women. Aim And Objectives: To evaluate the rate of female genital tuberculosis in patients of infertility. Method And Materials: Questionnaire survey was done among 100 infertile women in 6 months from May 2020 to October 2020. Females of reproductive age group from 18 years to 35 years with the duration of infertility of more than 2 years were included. Results: Total 100 infertile females were included in the study. Out of 100 subjects, 81 cases had primary infertility & 19 had secondary infertility. There was positive history of extra genital TB in past in 30 cases and family history was positive in 26 cases. FGTB was diagnosed in 14 females in past on basis of diagnostic methods used in alone or in combination. Conclusion: FGTB is common in our population and women presenting with infertility should be evaluated for genital tuberculosis. A high degree of suspicion and combination of histopathological and microbiological tests are important methods for the detection of genital tuberculosis

scholarly journals Emerging progress on diagnosis and treatment of female genital tuberculosis

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110149
Author(s):  
Ying Wang ◽  
Ruifeng Shao ◽  
Chihua He ◽  
Ligang Chen
Keyword(s):  
Blood Circulation ◽  
Histopathological Examination ◽  
Epidemiological Data ◽  
Endometrial Biopsy ◽  
Effective Management ◽  
Menstrual Disorders ◽  
Genital Tuberculosis ◽  
Infertile Women ◽  
Female Genital Tuberculosis ◽  
Female Genital

Female genital tuberculosis (FGTB) is an infection caused by Mycobacterium tuberculosis and usually occurs secondary to pulmonary tuberculosis (TB) through the blood circulation, lymph circulation, or direct spreading from abdominal TB. FGTB is an uncommon type of TB that can destroy genital organs, and lead to menstrual disorders and infertility. The diagnosis of FGTB is often made by detection of acid-fast bacilli under microscopy, culture with endometrial biopsy, or histopathological examination of epithelioid granuloma on a biopsy. A multidrug anti-TB regimen is the major management of FGTB, including rifampicin, isoniazid, pyrazinamide, and ethambutol, while surgery is proposed in more deteriorated cases. However, the conception rate in infertile women with FGTB is still low, even after multidrug anti-TB therapy. Additionally, the risk of complications, such as ectopic pregnancy or miscarriage, remains high. In this review, we summarize the characteristics of FGTB, present current epidemiological data, and focus on its early diagnosis and effective management.

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