The seroprevalence of cystic echinococcosis in a rural normal population, southwestern Iran

2018 ◽  
Vol 18 ◽  
Author(s):  
Molouk Beiromvand ◽  
Abdollah Rafiei ◽  
Esmat Panabad
Keyword(s):  
Cystic Echinococcosis ◽  
Normal Population ◽  
Southwestern Iran

scholarly journals Human cystic echinococcosis in southwest Iran: a 15-year retrospective epidemiological analysis of 501 consecutive hospitalized cases (2004-2018)

2019 ◽  
Author(s):  
Reza Shahriarirad ◽  
Amirhossein Erfani ◽  
Mehrdad Eskandarisani ◽  
Mohammad Rastegarian ◽  
Hajar Taghizadeh ◽  
...  
Keyword(s):  
Clinical Features ◽  
Cystic Echinococcosis ◽  
Fars Province ◽  
Epidemiological Analysis ◽  
Mortality And Morbidity ◽  
Average Annual Incidence ◽  
Southwestern Iran ◽  
Southwest Iran ◽  
Human Cystic Echinococcosis ◽  
Significant Mortality

Abstract Background: Cystic echinococcosis (CE) is considered a neglected disease with significant mortality and morbidity in most of the developing countries. The current study aimed to retrospectively assess the epidemiologic and clinical features of human CE in a 15-year period in Fars province, southwestern Iran. Methods: Hospital records of patients undergone surgeries for CE in two main hospitals in Fars Province, southwestern Iran in a 15-year period (2004-2018) were reviewed and data concerning the patients' demographical and clinical features were retrieved from each record. Results: A total of 501 CE surgical cases were recorded during a 15-year period, giving an average annual incidence of 33.4 cases in which 242 (48.6%) were male and 256 (52.4%) were female. Patients' age ranged from 2 to 96 years, with a mean age of 34.92 (±19.87) years. A significantly higher rate of CE cases was noted in subjects ≥ 50 years of age. The highest frequency of cases (62: 12.5%) was recorded in the year 2017. The most commonly involved organs were liver (339 cases; 57.8%), and lung (279 cases; 47.6%). Concurrent involvement of two organs was seen in 58 (9.9%) cases of both lung and liver, 10 (1.6%) cases of lung and other locations (but not liver) and 23 (3.9%) cases of liver and other locations (but not lung). Recurrence was noted in 67 (13.37%) of the cases. The size of the lung hydatid cyst varied, ranging between 2 to 24 cm (mean = 7.33, SD= 3.737). The size of liver hydatid cysts ranged from 1 to 26 cm (mean: 9.04, SD= 4.275). Conclusion: The findings of the current study demonstrated a nearly constant prevalence of CE during the last 15 years in southern Iran. Further studies are needed to find out the reasons behind the recurrence of the disease, which is substantial, in surgically-treated patients.

scholarly journals Screening municipal waste collectors for cystic echinococcosis and toxocariasis in southwestern Iran

2019 ◽  
Vol 13 (02) ◽  
pp. 154-161
Author(s):  
Molouk Beiromvand ◽  
Abdollah Rafiei ◽  
Mehdi Tavalla ◽  
Roya Daneshbakhtyar
Keyword(s):  
Cystic Echinococcosis ◽  
Prolonged Exposure ◽  
Elisa Test ◽  
Zoonotic Diseases ◽  
Municipal Waste ◽  
High Rate ◽  
Protective Equipment ◽  
Larval Stages ◽  
Southwestern Iran ◽  
The City

Introduction: Cystic Echinococcosis (CE) and toxocariasis caused by the larval stages of intestinal dog worms including Echinococcus granulosus and Toxocara spp. are among the most widespread zoonotic diseases. Methodology: Four hundred municipal waste collectors were serologically evaluated for CE and toxocariasis. To identify the seropositive cases of CE, an ELISA test was performed using native AgB. Toxocara IgG detection was carried out using ELISA DRG kit (USA), and the seropositive cases were then examined by a Western blot kit (LDBIO, France) to confirm the positive ELISA results. Results: 15 (3.7%) workers were seropositive for CE according to the ELISA. A significant relationship was observed between being seropositive and having contact with soil and dogs. No significant correlations were observed between education and the prevalence of these diseases. Of the 15 seropositive workers for CE, ten worked in district 5 of Ahvaz. Toxocara IgG was identified in 11 (2.7%) cases using the ELISA; however, none of them were confirmed by Western blotting. Conclusion: The 3.7% rate of seroprevalence for CE in asymptomatic municipal waste collectors living in urban regions of Ahvaz suggests a high rate. The higher rate of infection among workers in district 5 is likely associated with the presence of stray and owned dogs in that area of the city. A prolonged exposure to contaminated soil, the lack of awareness about the risk of diseases that can be transmitted through waste and the lack of general availability of suitable personal protective equipment for waste collectors might cause infectious diseases.

Personality of Clown Doctors

2016 ◽  
Vol 37 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Alberto Dionigi
Keyword(s):  
General Population ◽  
Personality Traits ◽  
Big Five ◽  
Normal Population ◽  
Big Five Personality Traits ◽  
Published Data ◽  
Big Five Personality

Abstract. In recent years, both professional and volunteer clowns have become familiar in health settings. The clown represents a peculiar humorist’s character, strictly associated with the performer’s own personality. In this study, the Big Five personality traits (BFI) of 155 Italian clown doctors (130 volunteers and 25 professionals) were compared to published data for the normal population. This study highlighted specific differences between clown doctors and the general population: Clown doctors showed higher agreeableness, conscientiousness, openness, and extraversion, as well as lower neuroticism compared to other people. Moreover, specific differences emerged comparing volunteers and professionals: Professional clowns showed significantly lower in agreeableness compared to their unpaid colleagues. The results are also discussed with reference to previous studies conducted on groups of humorists. Clowns’ personalities showed some peculiarities that can help to explain the facility for their performances in the health setting and that are different than those of other groups of humorists.

High Prevalence of Factor V R506Q Mutation in German Thrombophilic and Normal Population

1998 ◽  
Vol 79 (03) ◽  
pp. 684-685 ◽  
Author(s):  
Birga Zwinge ◽  
Inge Scharrer ◽  
Silke Ehrenforth
Keyword(s):  
Normal Population ◽  
Factor V ◽  
High Prevalence

Application of Two Neutral Mspl DNA Polymorphisms in the Analysis of Hereditary Protein C Deficiency

1990 ◽  
Vol 64 (02) ◽  
pp. 239-244 ◽  
Author(s):  
P H Reitsma ◽  
W te Lintel Hekkert ◽  
E Koenhen ◽  
P A van der Velden ◽  
C F Allaart ◽  
...  
Keyword(s):  
Protein C ◽  
Stop Codon ◽  
Normal Population ◽  
Amino Acid Position ◽  
Rare Allele ◽  
Dna Polymorphisms ◽  
Type I ◽  
Protein C Deficiency ◽  
Gene Deletions ◽  
Allelic Frequencies

SummaryScreening of restriction erzyme digested DNA from normal and protein C deficient individuals with a variety of probes derived from the protein C locus has revealed the existence of two neutral MspI polymorphism. One polymorphism (MI), which is located ≈7 kb upstream of the protein C gene, has allelic frequencies of 69 and 31%, and was used to exclude extensive gene deletions as a likely cause of type I protein C deficiency in 50% of cases in a panel of 22 families. Furtherrnore, the same polymorphism has been used in 5 doubly affected individuals establishing compound heterozygosity in 3 of these.The second, intragenic, polymorphism (MII) has allelic frequencies of 99 and 1% in the normal population. The frequency of the rare allele of this RFLP was with 7% much higher in a panel of 22 Dutch families with protein C deficiency. Interestingly, in all three probands that were heterozygous for MII the rare allele of MII coincided with a point mutation that leads to a stop codon in amino acid position 306 of the protein C coding sequence. This mutation may account for 14% of the protein C deficient individuals in The Netherlands.

Factor V Leiden: An Additional Risk Factor for Thrombosis in Protein S Deficient Families?

1995 ◽  
Vol 74 (02) ◽  
pp. 580-583 ◽  
Author(s):  
B P C Koeleman ◽  
D van Rumpt ◽  
K Hamulyák ◽  
P H Reitsma ◽  
R M Bertina
Keyword(s):  
Protein C ◽  
Normal Population ◽  
Factor V Leiden ◽  
Protein S ◽  
Reliable Estimate ◽  
Additional Risk Factor ◽  
Protein S Deficiency ◽  
S Deficiency ◽  
High Prevalence ◽  
Fv Leiden

SummaryWe recently reported a high prevalence of the FV Leiden mutation (R506Q, responsible for Activated Protein C resistance) among symptomatic protein C deficient probands (19%), and the involvement of the FV Leiden mutation in the expression of thrombophilia in six protein C deficient families. Here, we report the results of a similar study in protein S deficient probands and families. Among 16 symptomatic protein S deficient probands the prevalence of the FV Leiden mutation was high (38%). This high prevalence is significantly different from that in the normal population, and is probably caused by the selection of probands for familial thrombosis and protein S deficiency. In 4 families, the segregation of the FV Leiden mutation and the protein S deficiency could be studied. In sibships where both abnormalities were segregating, the percentage of symptomatic individuals with both abnormalities was 80%. Three of the seven subjects with only the FV Leiden mutation, and two out of the three subjects with only protein S deficiency had developed thrombosis. These results indicate that in the families presented here the combination of the FV Leiden mutation and the protein S deficiency is associated with a high risk for thrombosis. A reliable estimate of the penetrance of the single defects is not possible, because the number of individuals with a single defect is too low.

Detection of Circulating Tissue Factor and Factor VII in a Normal Population

1996 ◽  
Vol 75 (05) ◽  
pp. 772-777 ◽  
Author(s):  
Sybille Albrecht ◽  
Matthias Kotzsch ◽  
Gabriele Siegert ◽  
Thomas Luther ◽  
Heinz Großmann ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Normal Population ◽  
Mean Value ◽  
Factor Vii ◽  
Significant Difference ◽  
Age Dependent ◽  
The Mean ◽  
Highly Correlated ◽  
And Gender

SummaryThe plasma tissue factor (TF) concentration was correlated to factor VII concentration (FVIIag) and factor VII activity (FVIIc) in 498 healthy volunteers ranging in age from 17 to 64 years. Immunoassays using monoclonal antibodies (mAbs) were developed for the determination of TF and FVIIag in plasma. The mAbs and the test systems were characterized. The mean value of the TF concentration was 172 ± 135 pg/ml. TF showed no age- and gender-related differences. For the total population, FVIIc, determined by a clotting test, was 110 ± 15% and the factor VIlag was 0.77 ± 0.19 μg/ml. FVII activity was significantly increased with age, whereas the concentration demonstrated no correlation to age in this population. FVII concentration is highly correlated with the activity as measured by clotting assay using rabbit thromboplastin. The ratio between FVIIc and FVIIag was not age-dependent, but demonstrated a significant difference between men and women. Between TF and FVII we could not detect a correlation.

F.VIII R:Ag in Hepatitis

1979 ◽  
Author(s):  
R. Kotitschke ◽  
J. Scharrer
Keyword(s):  
Chronic Hepatitis ◽  
Blood Donors ◽  
Blood Donation ◽  
Normal Population ◽  
Rabbit Antiserum ◽  
Two Dimensional ◽  
Plastic Plate ◽  
Significant Difference ◽  
Acute Hepatitis B ◽  
The One

F.VIII R:Ag was determined by quantitative immunelectrophoresis (I.E.) with a prefabricated system. The prefabricated system consists of a monospecific f.VIII rabbit antiserum in agarose on a plastic plate for the one and two dimensional immunelectrophoresis. The lognormal distribution of the f.VIII R:Ag concentration in the normal population was confirmed (for n=70 the f.VIII R:Ag in % of normal is = 95.4 ± 31.9). Among the normal population there was no significant difference between blood donors (one blood donation in 8 weeks; for n=43 the f.VIII R:Ag in % of normal is = 95.9 ± 34.0) and non blood donors (n=27;f.VIII R:Ag = 94.6 ± 28.4 %). The f.VIII R:Ag concentration in acute hepatitis B ranged from normal to raised values (for n=10, a factor of 1.8 times of normal was found) and was normal again after health recovery (n=10, the factor was 1.0). in chronic hepatitis the f.VIII R:Ag concentration was raised in the majority of the cases (for n=10, the factor was 3.8). Out of 22 carrier sera 20 showed reduced, 2 elevated levels of the f.VIII R:Ag concentration. in 5 sera no f.VIII R:Ag could be demonstrated. The f.VIII R:Ag concentration was normal for n=10, reduced for n=20 and elevated for n=6 in non A-non B hepatitis (n=36). Contrary to results found in the literature no difference in the electrophoretic mobility of the f.VIII R:Ag was found between hepatitis patients sera and normal sera.

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