A Review on Role of Nanosensors in Detecting Cellular miRNA Expression in Colorectal Cancer

2020 ◽  
Vol 20 ◽  
Author(s):  
Koyeli Girigoswami ◽  
Agnishwar Girigoswami
Keyword(s):  
Colorectal Cancer ◽  
General Scheme ◽  
High Sensitivity ◽  
Micro Rna ◽  
Rna Detection ◽  
Piezoelectric Detection ◽  
Current Scenario ◽  
Mirna Detection ◽  
Causes Of Deaths

Background: Colorectal cancer (CRC) is one of the leading causes of deaths due to cancers in the world. Early diagnosis with high sensitivity can prevent the CRC progression, thereby reducing the condition of metastasis. Objective: The purpose of this review is (i) to discuss about miRNA based biomarkers responsible for CRC, (ii) to brief on the different methods used for the detection of miRNA in CRC, (iii) to discuss about different nanobiosensors so far found for the accurate detection of miRNAs in CRC using spectrophotometric detection, piezoelectric detection. Method: The keywords for the review were micro RNA detection in inflammation, colorectal cancer, nanotechnology, were searched in PubMed and the relevant papers on the topics of miRNA related to CRC, nanotechnology based biosensors for miRNA detection were sorted and used appropriately for writing the review. Results: The review comprised of a general introduction explaining the current scenario of CRC, the biomarkers used for detection of different cancers, especially CRC and the importance of nanotechnology and a general scheme of a biosensor. The further subsections discussed about the mechanism of CRC progression, role of miRNA in CRC progression and different nanotechnology based biosensors so far investigated for miRNA detection in other diseases, cancer and CRC. A scheme depicting miRNA detection using gold nanoparticles (AuNPs) is also illustrated. Conclusion: This review may give insight into the different nanostructure like AuNPs, quantum dots, silver nanoparticles, MoS2derived nanoparticles etc. based approach for miRNA detetction using biosensors.

Role of circulating micro-RNA-21 as a noninvasive biomarker for detection of colorectal cancer

2021 ◽  
Vol 34 (1) ◽  
pp. 124
Author(s):  
MohamedH Gohar ◽  
EhabA Abdel-Atti ◽  
El-SayedI El-Shaib ◽  
MohamedA Shehata ◽  
AhmedA Sonbl ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Micro Rna ◽  
Noninvasive Biomarker

Role of Micro-RNA in Colorectal Cancer Screening

2014 ◽  
Vol 92 (10) ◽  
pp. 654-658 ◽  
Author(s):  
José Antonio Rodríguez-Montes ◽  
Pablo Menéndez Sánchez
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Micro Rna

Pilot, Multicenter and Prospective Trials with an Anti-CEA Antibody

1992 ◽  
Vol 7 (3) ◽  
pp. 189-192 ◽  
Author(s):  
G.L. Buraggi ◽  
M. Gasparini ◽  
E. Seregni ◽  
E. Bombardieri ◽  
E. Regalia ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ct Scan ◽  
Comparative Evaluation ◽  
High Sensitivity ◽  
Multicenter Clinical Trial ◽  
Clinical Role ◽  
Number Of Patients ◽  
Prospective Trials ◽  
A Prospective Study

In this paper we summarize the investigations performed by our group utilizing an anti-CEA monoclonal antibody (F023C5) labelled with different radionuclides in humans. Since 1983 radioimmunoscintigraphy (RIS) was performed on 51 patients with 64 localizations of colorectal carcinoma (pilot study). A multicenter clinical trial in a large number of patients (509 pts of which 284 with gastrointestinal cancer) was subsequently carried out in collaboration with ten nuclear medicine centres. High sensitivity and specificity values were obtained by these studies and many unsuspected lesions were recorded. In order to better define the clinical role of RIS, a prospective study was performed on 59 patients with suspected local relapses of colorectal cancer. A comparative evaluation of RIS, CT scan, US and MRI was done. RIS and MRI had the highest accuracy (86%) followed by CT scan (68%) and US (54%).

scholarly journals Identification of microRNA-451a as a Novel Circulating Biomarker for Colorectal Cancer Diagnosis

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Zhen Zhang ◽  
Dai Zhang ◽  
Yaping Cui ◽  
Yongsheng Qiu ◽  
Changhong Miao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Potential Role ◽  
High Sensitivity ◽  
Primary Tumors ◽  
Circulating Biomarker ◽  
Microarray Profiling ◽  
Downstream Analysis ◽  
Microrna Microarray

Background. Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Successful treatment of CRC relies on accurate early diagnosis, which is currently a challenge due to its complexity and personalized pathologies. Thus, novel molecular biomarkers are needed for early CRC detection. Methods. Gene and microRNA microarray profiling of CRC tissues and miRNA-seq data were analyzed. Candidate microRNA biomarkers were predicted using both CRC-specific network and miRNA-BD tool. Validation analyses were carried out to interrogate the identified candidate CRC biomarkers. Results. We identified miR-451a as a potential early CRC biomarker circulating in patient’s serum. The dysregulation of miR-451a was revealed both in primary tumors and in patients’ sera. Downstream analysis validated the tumor suppressor role of miR-451a and high sensitivity of miR-451a in CRC patients, further confirming its potential role as CRC circulation biomarker. Conclusion. The miR-451a is a potential circulating biomarker for early CRC diagnosis.

scholarly journals Prognostic Role of Kras Mutations Detected by High-Sensitivity Taqmelt PCR Assay in Metastatic Colorectal Cancer

2012 ◽  
Vol 23 ◽  
pp. ix187
Author(s):  
J. Garcia Foncillas ◽  
S. Zazo ◽  
C. Carames ◽  
G. Serrano ◽  
A. Leon ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
High Sensitivity ◽  
Prognostic Role ◽  
Pcr Assay ◽  
Kras Mutations

scholarly journals Prognostic role of serum concentrations of high-sensitivity C-reactive protein in patients with metastatic colorectal cancer: results from the ITACa trial

Oncotarget ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 10193-10202 ◽  
Author(s):  
Andrea Casadei Gardini ◽  
Silvia Carloni ◽  
Emanuela Scarpi ◽  
Paolo Maltoni ◽  
Romolo M. Dorizzi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
High Sensitivity ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Prognostic Role ◽  
Reactive Protein

Detector-C: A Blood-based IVD with High Sensitivity and Specificity for Early Detection and Screening of Colorectal Cancer

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
A Rosenthal ◽  
H Köppen ◽  
R Musikowski ◽  
R Schwanitz ◽  
J Behrendt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Detection ◽  
Sensitivity And Specificity ◽  
High Sensitivity

The Contemporary Role of Resection and Ablation in Colorectal Cancer Liver Metastases

2020 ◽  
Vol 04 (03) ◽  
pp. 291-302
Author(s):  
Mariam F. Eskander ◽  
Christopher T. Aquina ◽  
Aslam Ejaz ◽  
Timothy M. Pawlik
Keyword(s):  
Colorectal Cancer ◽  
Portal Vein ◽  
Surgical Oncology ◽  
Portal Vein Ligation ◽  
Safe Alternative ◽  
Colorectal Cancer Liver Metastases ◽  
Liver Remnant ◽  
New Era ◽  
Ablation Therapy

AbstractAdvances in the field of surgical oncology have turned metastatic colorectal cancer of the liver from a lethal disease to a chronic disease and have ushered in a new era of multimodal therapy for this challenging illness. A better understanding of tumor behavior and more effective systemic therapy have led to the increased use of neoadjuvant therapy. Surgical resection remains the gold standard for treatment but without the size, distribution, and margin restrictions of the past. Lesions are considered resectable if they can safely be removed with tumor-free margins and a sufficient liver remnant. Minimally invasive liver resections are a safe alternative to open surgery and may offer some advantages. Techniques such as portal vein embolization, association of liver partition with portal vein ligation for staged hepatectomy, and radioembolization can be used to grow the liver remnant and allow for resection. If resection is not possible, nonresectional ablation therapy, including radiofrequency and microwave ablation, can be performed alone or in conjunction with resection. This article presents the most up-to-date literature on resection and ablation, with a discussion of current controversies and future directions.

Energy Efficiency Analysis in ERA using NFL-BA Algorithm

2020 ◽  
pp. 340-348
Author(s):  
Palky Mehta ◽  
H. L. Sharma
Keyword(s):  
Cluster Head ◽  
Vital Role ◽  
Wireless Sensor ◽  
Energy Usage ◽  
Cluster Heads ◽  
Comparison Results ◽  
Current Scenario ◽  
Energy Efficiency Analysis ◽  
Selection Of

In the current scenario of Wireless Sensor Network (WSN), power consumption is the major issue associated with nodes in WSN. LEACH technique plays a vital role of clustering in WSN and reduces the energy usage effectively. But LEACH has its own limitation in order to search cluster head nodes which are randomly distributed over the network. In this paper, ERA-NFL- BA algorithm is being proposed for selects the cluster heads in WSN. This algorithm help in selection of cluster heads can freely transform from global search to local search. At the end, a comparison has been done with earlier researcher using protocol ERA-NFL, which clearly shown that proposed Algorithm is best suited and from comparison results that ERA-NFL-BA has given better performance.

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