Pilot, Multicenter and Prospective Trials with an Anti-CEA Antibody

1992 ◽  
Vol 7 (3) ◽  
pp. 189-192 ◽  
Author(s):  
G.L. Buraggi ◽  
M. Gasparini ◽  
E. Seregni ◽  
E. Bombardieri ◽  
E. Regalia ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ct Scan ◽  
Comparative Evaluation ◽  
High Sensitivity ◽  
Multicenter Clinical Trial ◽  
Clinical Role ◽  
Number Of Patients ◽  
Prospective Trials ◽  
A Prospective Study

In this paper we summarize the investigations performed by our group utilizing an anti-CEA monoclonal antibody (F023C5) labelled with different radionuclides in humans. Since 1983 radioimmunoscintigraphy (RIS) was performed on 51 patients with 64 localizations of colorectal carcinoma (pilot study). A multicenter clinical trial in a large number of patients (509 pts of which 284 with gastrointestinal cancer) was subsequently carried out in collaboration with ten nuclear medicine centres. High sensitivity and specificity values were obtained by these studies and many unsuspected lesions were recorded. In order to better define the clinical role of RIS, a prospective study was performed on 59 patients with suspected local relapses of colorectal cancer. A comparative evaluation of RIS, CT scan, US and MRI was done. RIS and MRI had the highest accuracy (86%) followed by CT scan (68%) and US (54%).

Intensive CT scan surveillance for patients who have undergone curative intent treatment for colorectal cancer: The Medstar Washington Hospital Center experience.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e14675-e14675 ◽  
Author(s):  
Konstantinos Leventakos ◽  
Stanlee Santos Lu ◽  
David John Perry
Keyword(s):  
Colorectal Cancer ◽  
Ct Scan ◽  
Survival Data ◽  
Stage I ◽  
First Year ◽  
Curative Intent ◽  
Serial Measurement ◽  
A Prospective Study ◽  
Hospital Center

e14675 Background: The current ASCO guideline for surveillance after curative intent treatment of colorectal cancer is yearly CT scan of the chest, abdomen and pelvis with every 3-6 months history and physical exam and serial measurement of Carcinoembryonic antigen (CEA). The benefit of doing more intensive CT scan surveillance has not been adequately substantiated. Methods: Data of patients with resectable stage I-III colorectal cancer treated at Medstar Washington Hospital Center from January 2000-June 2012 were retrospectively reviewed. Epidemiologic, histopathologic , surveillance schedule (CT scan and CEA), and survival data were analyzed. Our institutional standard was to obtain CT scans every 3 months for the first year, every 6 months for the second year and then yearly for years 3-5. Results: Thirty-three patients with adequate documentation were included. The mean age of the patients was 59.6 years at diagnosis, 55% were female and 78% ethnically African American. 6% were in stage I, 37% were in stage II and 57% in stage III. CT scan was used in 100% of the patients done with a median interval of 7 months. At follow up, 28 (85%) patients had recurrence at a median of 21.6 months from surgery. 67% had recurrence in the liver. 96% of these recurrences were diagnosed primarily by CT scan and only 1 patient (3%) was diagnosed with MRI of the liver following an elevated CEA with a negative CT scan. Only 50% of patients with recurrence had an elevated CEA. 54% of patients with recurrence were able to undergo curative treatment (resection and/or chemotherapy). Conclusions: In this single institution, retrospective review, CT scan surveillance was utilized more frequently than specified in current ASCO guidelines. CEA screening alone would have missed 50% of patients with potentially curable recurrent cancer. Our data shows that more intensive CT scan surveillance led to earlier detection of recurrences that allowed patients to undergo curative intent treatment. A prospective study is warranted to further support this finding.

scholarly journals Role of procalcitonin and high-sensitivity C-reactive protein in sepsis: a prospective study

Critical Care ◽  
2011 ◽  
Vol 15 (S3) ◽  
Author(s):  
S Das ◽  
D Anand ◽  
S Ray ◽  
S Bhargava ◽  
A Manocha ◽  
...  
Keyword(s):  
Prospective Study ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
A Prospective Study

scholarly journals Role of age of incidence, parity, body mass index and socioeconomic class in endometrial carcinoma

2020 ◽  
Vol 9 (2) ◽  
pp. 762
Author(s):  
Neha A. Nimbark
Keyword(s):  
Body Mass Index ◽  
Endometrial Carcinoma ◽  
Body Mass ◽  
Descriptive Statistics ◽  
Age Group ◽  
Socioeconomic Class ◽  
Frequency Table ◽  
Number Of Patients ◽  
A Prospective Study

Background: Endometrial carcinoma is the most common gynecologial malignancy in world. The main aim is to study epidemiological factors of Ca body uterus in our hospital. The present study was designed to evaluate the age of incidence of carcinoma body uterus and study role of parity, body mass index and socioeconomic class in carcinoma body.Methods: This is a prospective study of 50 cases of endometrial carcinoma who were treated in a single unit of the hospital from April 2010 to March 2012 (2 years) conducted at the department of gynaecological oncology G. C. R. I., Ahmedabad. Observational study was done. All these data were combined and tabulated in frequency table simple percentage analysis is used for frequency and percentage analysis is applied to create a contingency table from the frequency distribution and represent the collected data for better understanding. Descriptive statistics were obtained for all variable.Results: Maximum number of patients were in age group of 50-59 years. Mean age was 58 years. Maximum patients were multiparous (54%). 4 patients were nulligravida (9%). 70% were overweight and obese. Majority of patients (72%) belong to middle and higher socio-economic class.Conclusions: It was noted that the incidence for ca endometrium is related to age, parity, BMI and socioeconomic class at our centre.

An updated review of the pre-clinical role of microRNAs and their contribution to colorectal cancer

2021 ◽  
Vol 21 ◽  
Author(s):  
Narges Dastmalchi ◽  
Reza Safaralizadeh ◽  
Shahram Teimourian
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Molecular Targets ◽  
Biological Pathways ◽  
Biological Processes ◽  
Therapeutic Approaches ◽  
Clinical Role ◽  
Related Mortality

: Colorectal cancer (CRC) is one of the main causes of malignancy-related mortality worldwide. It was well-identified that microRNAs (miRNAs) decisively participate in cellular biological pathways; in a way that their deregulated expression causes CRC progression. miRNAs can control the translation and degradation of mRNAs by binding to various molecular targets involved in different biological processes, including growth, apoptosis, cell cycle, autophagy, angiogenesis, metastasis, etc. The functions of these dysregulated miRNAs may be either oncogenic or tumor-suppressive. Therefore, these miRNAs can be contributed to prognostic, diagnostic, and therapeutic approaches in CRC. In this study, we reviewed the tumor-suppressive and oncogenic functions of miRNAs in CRC and assessed their molecular activities in CRC development. However, further investigation for the involvement of dysregulated miRNAs in CRC progression is required.

Clinical role of CT scan-measured pulmonary artery to aorta ratio of acute exacerbation of interstitial lung disease

2017 ◽  
Author(s):  
Mariko Kogo ◽  
Kojiro Otsuka ◽  
Hayato Kawachi ◽  
Ryosuke Hirabayashi ◽  
Ryubu Mori ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Pulmonary Artery ◽  
Lung Disease ◽  
Ct Scan ◽  
Acute Exacerbation ◽  
Clinical Role

scholarly journals Clinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer

2017 ◽  
Vol 18 (8) ◽  
pp. 1632 ◽  
Author(s):  
Kosuke Toda ◽  
Gen Nishikawa ◽  
Masayoshi Iwamoto ◽  
Yoshiro Itatani ◽  
Ryo Takahashi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Role

Better retrieval of lymph nodes in colorectal resection specimens by pathologists’ assistants

2012 ◽  
Vol 66 (1) ◽  
pp. 18-23 ◽  
Author(s):  
C C H J Kuijpers ◽  
H J van Slooten ◽  
W H Schreurs ◽  
G R H M Moormann ◽  
M A Abtahi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Patient Safety ◽  
Adjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Colorectal Resection ◽  
Number Of Patients ◽  
Pathology Reports ◽  
Colorectal Cancer Patients

BackgroundErrors in surgical pathology are partly due to the increasing workload of pathologists. To reduce this workload, ‘pathologists’ assistants’ (PAs) have been trained to take over some of the pathologists’ recurrent tasks. One of these tasks is the precise examination of ≥10 lymph nodes (LNs), which is of paramount importance to reduce the risk of understaging of colorectal cancer patients.AimsTo evaluate the role of PAs in harvesting LNs in colorectal resection specimens and, by doing so, in improving patient safety.MethodsLN harvest was retrospectively reviewed in 557 pathology reports on colorectal resection specimens collected in two Dutch hospitals from 2008 until 2011.ResultsPAs sampled ≥10 LNs in significantly more cases than pathologists did (83.2% vs 60.9% in hospital A and 79.2% vs 67.6% in hospital B) and recovered on average significantly more LNs than pathologists did (18.5 vs 12.2 in hospital A and 16.6 vs 13.2 in hospital B). PAs harvested a significantly higher percentage of LNs <5 mm than pathologists did (64.2% vs 53.7%). The percentages of colon cancer patients eligible for adjuvant chemotherapy due to inadequate LN sampling alone were significantly higher for cases dissected by pathologists than for those dissected by PAs (17.3% vs 1.1% in hospital A and 13.1% vs 3.4% in hospital B)ConclusionsPAs contribute to patient safety since they recover more and, in particular, smaller LNs from colorectal resection specimens than pathologists do. Moreover, they help to reduce costs and morbidity by reducing the number of patients eligible for adjuvant chemotherapy due to inadequate LN sampling alone.

scholarly journals Role of early CT scan in diagnosis of occult scaphoid fractures- a prospective study

2017 ◽  
Vol 5 (9) ◽  
pp. 4072
Author(s):  
Omeshwar Singh ◽  
Anuradha Sen ◽  
Sumeet Singh Charak ◽  
Shakeel Ahmad
Keyword(s):  
Ct Scan ◽  
Tertiary Care ◽  
False Negative ◽  
False Negative Rate ◽  
Scaphoid Bone ◽  
X Rays ◽  
X Ray ◽  
Scaphoid Fractures ◽  
Number Of Patients

Background: Wrists injuries are one of the common presentations to emergency departments and orthopaedic clinics. The scaphoid bone is the most commonly injured of the carpal bones accounting for 50-80% of carpal injuries and predominantly occurs in young healthy individuals. Scaphoid fractures are the most problematic to diagnose in a clinical setting because it can take up to 6 weeks for scaphoid fractures to become conclusive on plain X-ray films. Aim of the study was to retrospective study was carried out to study the role of early CT scan in diagnosis of occult scaphoid fractures.Methods: A total of 123 patients presented with an acute wrist injury with subsequent signs of scaphoid injury in the absence of a diagnostic fracture on plain X-ray within the time period from June 2014 to May 2016 in a tertiary care centre.Results: This study shows that 31% of normal X-rays were pathological on CT scan and out of these; scaphoid fractures (74% of pathologies) represent a large number of patients with fractures that were missed by initial plain films.Conclusions: This study shows an extremely high false-negative rate for plain X-rays and advocate CT at the first attendance to fracture clinic if there is suspicion of scaphoid injury. An earlier diagnosis leads to appropriate management and reduces restrictions to the patient in terms of prolonged immobilization and repeated clinical reviews.

scholarly journals Role of Computed Tomography Scan in Evaluating Children with Seizures

2016 ◽  
Vol 02 (01) ◽  
pp. 015-018
Author(s):  
Vasudha Sipayya ◽  
Shivali Kashikar
Keyword(s):  
Computed Tomography ◽  
Developing Countries ◽  
Ct Scan ◽  
Intravenous Contrast ◽  
Number Of Patients ◽  
Computed Tomography Scans ◽  
The Cost ◽  
Developed World ◽  
Posttraumatic Seizures

Abstract Introduction: Seizures are a common cause of morbidity and mortality in childhood. It is important to establish the cause of seizures to appropriately manage such patients. The etiology of seizures is different in developing countries as compared to the developed world. Computed tomography (CT) scan is easily available, is less sensitive to patient motion, and does not generally require sedation. Also the cost is less as compared to MRI, and this makes it an important screening tool in developing countries like India. Aims: To determine the diagnostic ability of CT to determine the cause of seizures in children. Settings and design: A prospective analytical study. Materials and methods: Computed tomography scans of 84 children presenting with seizures during the period of September 2014 to August 2015 were analyzed. The study was done using 16-slice CT scan. Intravenous contrast was administered as needed. Uncooperative patients were sedated for the scan. Results: Out of 84 scans, 40 scans (47.65%) were found to be abnormal. Maximum number of patients were found to have congenital anomalies (10), followed by hydrocephalus which was found in nine children. Five children had posttraumatic seizures. Four presented with tumors. Four children showed features of hypoxic ischemic encephalopathy. Three each had granuloma and calcification. Two children with seizures had infectious causes, which were clinically diagnosed to be meningitis. Conclusion: Our study indicates that CT is an extremely useful tool for screening the patients of seizures. It is also useful in identifying the treatable causes and monitoring the progression. It is recommended that all children with seizures should be evaluated with CT scan.

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