scholarly journals Association of Periodontal Disease and Polycystic Ovarian Syndrome: A Systematic Review and Meta-analysis with Trial Sequential Analysis

2019 ◽  
Vol 13 (1) ◽  
pp. 478-487 ◽  
Author(s):  
Fathima F. Farook ◽  
Ka Ting Ng ◽  
Nuzaim MNM ◽  
Wen J. Koh ◽  
Wan Y. Teoh

Introduction: Several articles have suggested a potential synergistic relationship between periodontal disease and systemic inflammatory diseases, such as Polycystic Ovarian Syndrome (PCOS) and diabetes mellitus. However, the associations between periodontal disease and PCOS population remain unclear in the literature. Objective: The primary aim of this review is to examine the associations between periodontal disease and PCOS with different scoring methods, namely clinical attachment loss, probing depth, gingival index, percentage of bleeding on probing and plaque index. Methods: MEDLINE, EMBASE and CENTRAL were systematically searched for observational studies and case-control studies from its inception until 2nd June, 2019. Case reports, case series, non-systematic reviews and trials published as abstracts were excluded. Results: Four articles (614 subjects) were included for analysis. Out of 614 subjects, 329 PCOS patients were compared to 285 healthy subjects. In comparison to healthy cohort, women with PCOS had a statistically significant increase in clinical attachment loss (MD: 0.34, 95% CI: 0.13-0.55, ρ=0.002), probing depth (MD: 0.35, 95%CI: 0.21-0.48, ρ<0.001), gingival index (MD: 0.70, 95% CI: 0.70-1.11, ρ<0.001) and percentage of bleeding on probing (MD: 34.41, 95% CI: 20.23-48.59, ρ<0.001). No difference was demonstrated in plaque index (MD: 0.42, 95% CI: -0.29-1.12, ρ=0.24) for both PCOS and healthy cohort. Conclusion: PCOS is significantly associated with a higher severity of the periodontal disease. This association should be emphasized during the management of PCOS patients, by including referral to dentists or periodontists for regular mechanical debridement of plaque and periodontal maintenance.

2016 ◽  
Vol 38 (1) ◽  
pp. 49-53 ◽  
Author(s):  
N A Chrysanthakopoulos

Aim: The aim of the present case — control study was to examine the possible associations between periodontal disease indices and the risk of lung cancer development in a sample of Greek out-patients referred to a medical and a dental private practice. Materials and Methods: A total of 200 individuals were interviewed and underwent an oral clinical examination, and 64 of them were suffered from several histological types of lung cancer. The estimation of the possible associations between lung cancer as a dependent variable and periodontal disease indices as independent ones was carried out by using a multiple regression analysis model. Results: Probing pocket depth (odds ratio (OR) = 2.72, 95% confidence interval (CI) 1.05–7.06), clinical attachment loss (OR = 3.51, 95% CI 1.30–9.47) bleeding on probing (OR = 1.93, 95% CI 0.98–3.81) were significantly associated with the risk of developing lung cancer. Smoking (OR = 2.49, 95% CI 1.20–5.17) was significantly associated with the mentioned risk, whereas it was consisted as a confounder regarding the estimated associations between moderate/severe clinical attachment loss and presence of bleeding on probing with the risk of developing lung cancer. Conclusion: Probing pocket depth as an index for periodontal disease severity was statistically significantly associated with the risk of developing lung cancer.


2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Jeanne Freeland-Graves ◽  
Mahsa Babaei ◽  
Prageet Sachdev

Abstract Objectives To examine the relationships between food security and prevalence and severity of periodontal disease in low-income women. Methods This cross-sectional study involved 220 women, 18–50 years of age, who were recruited from dental clinics and low-income households in Central Texas. On one visit, women completed a Demographic Survey and the United States Household Food Security Survey Module. Two trained dentists conducted dental screenings for evaluation of periodontal status, using two indices: Clinical Attachment Loss (CAL) and Bleeding on Probing (BOP) to discern severity of periodontitis. Multiple regression analysis was used to assess the effect of food insecurity on the status of periodontal disease, after adjustment for socioeconomic status. Results The mean age of participants was 38.13 ± 9.43 years. The majority were Hispanic, had completed a high school education, and had a mean income of <$25,000/year. Over half of the sample (54.55%) was food insecure, followed by marginally food secure (24.09%) and highly food secure (21.36%), based on cut off values of the Household Food Security Survey Module. Mean values for Clinical Attachment Loss and Bleeding on Probing were 1.742 ± 0.75 and 1.632 ± 2.23 respectively. These results indicated that the women exhibited periodontal disease, with stages of mild (56.83%), moderate (26.36%) and severe periodontitis (16.81%). Food insecurity was directly related to the severity of periodontal disease, as illustrated by the Clinical Attachment Loss (β-coefficient = 0.170, p value = 0.01) and Bleeding on Probing (β coefficient = 0.380, p value = 0.00), after adjustment for socioeconomic status. Conclusions Food insecure individuals appear to be at a great risk for periodontal disease. Whether this relationship is due to lack of food resources, improper dental equipment or hygiene, or nutrition knowledge will be explored as the study progresses. This health risk for periodontal disease should be incorporated into public health policies concerning food insecurity. Funding Sources Bess Heflin Centennial Professorship.


2014 ◽  
Vol 40 (2) ◽  
pp. 169-173 ◽  
Author(s):  
Flaviana Soares Rocha ◽  
Rainde Naiara Rezende Jesus ◽  
Fabiana Maria Soares Rocha ◽  
Camilla Cristhian Gomes Moura ◽  
Darceny Zanetta-Barbosa

The aim of this study was to investigate the potential use of salivary IL1β in early-stage diagnostics of peri-implant inflammation in partially and totally edentulous patients rehabilitated with dental implants. Patients were classified according to peri-implant probing depth and bleeding upon probing in groups of healthy individuals or in groups of individuals with peri-implant inflammation. Data on plaque index, clinical attachment loss, suppuration, and mobility were also assessed. Saliva was collected without stimulation, and the levels of IL-1β were determined by ELISA. Healthy groups demonstrated significantly lower levels of IL-1β compared with the inflammation groups. No difference in IL-1β levels was observed between partially edentulous or totally edentulous patients. Salivary IL-1β may be useful for the diagnosis and monitoring of early peri-implant inflammation, particularly in edentulous patients.


2010 ◽  
Vol 17 (1) ◽  
pp. 53-64 ◽  
Author(s):  
Hind A. Aljohani

The aim of this study is to investigate the association between hemoglobin level and the severity of chronic periodontitis. Data were collected from 124 systemically healthy chronic periodontitis patients, referred to the Division of Periodontology, Faculty of Dentistry, King Abdulaziz University. Medical history, dental history, and periodontal parameters such as bleeding on probing. Plus probing depth, clinical attachment loss and distance from cement-enamel junction to gingival margin, furcations, mobility and number of missing teeth] were recorded. Blood samples were collected to measure the hemoglobin level. The correlation between hemoglobin and the means of clinical attachment loss and bleeding on probing was insignificant. There was no significant difference in the mean hemoglobin level for individuals with different severity of periodontitis among male and females. The mean hemoglobin found to be insignificantly correlated with the number of missing teeth. No association between hemoglobin levels and periodontal status was found. Further longitudinal studies with larger sample size are needed to investigate this association, and the effect of periodontal treatment on hemoglobin level.


2009 ◽  
Vol 35 (5) ◽  
pp. 232-237 ◽  
Author(s):  
Mehdi Adibrad ◽  
Mohammad Shahabuei ◽  
Mahasti Sahabi

Abstract Our objective was to determine the association between keratinized mucosa width and the health status of the supporting tissue around implants supporting overdentures. Sixty-six functioning dental implants were examined. Periodontal parameters measured included gingival index, plaque index, bleeding on probing, probing depth, mucosal recession, periodontal attachment level, radiographic bone level, and width of keratinized mucosa. A negative correlation was found between keratinized mucosa width and mucosal recession and periodontal attachment level. When data were dichotomized by keratinized mucosa width, the mean gingival index score, plaque index score, and bleeding on probing were significantly higher for those implants with a narrow zone (&lt;2 mm) of keratinized mucosa. A wider mucosal band (≥2 mm) was associated with less mucosal recession and periodontal attachment loss compared with a narrow (&lt;2 mm) band. The absence of adequate keratinized mucosa around implants supporting overdentures was associated with higher plaque accumulation, gingival inflammation, bleeding on probing, and mucosal recession.


2021 ◽  
Vol 10 (4) ◽  
pp. 878
Author(s):  
Codrina Ancuța ◽  
Rodica Chirieac ◽  
Eugen Ancuța ◽  
Oana Țănculescu ◽  
Sorina Mihaela Solomon ◽  
...  

Background: The aim of our study was to explore the influence of weekly subcutaneous administration of interleukin-6 (IL-6) receptor inhibitor tocilizumab (TCZ) on periodontal status in a local longitudinal study of patients with rheumatoid arthritis (RA) and periodontal disease (PD). Methods: We performed a 6-month prospective study in 51 patients with chronic periodontitis and moderate-to-severe RA starting TCZ in accordance with local recommendations. Extensive rheumatologic (clinical activity, inflammatory, serological biomarkers) and periodontal (visible plaque index, gingival index, bleeding on probing, probing pocket depth, clinical attachment loss) assessments were done. Changes in RA activity and periodontal status were reassessed after 3 and 6 months. Results: We demonstrated significant correlations between periodontal status, disease activity, and serologic biomarkers (p < 0.05). Tocilizumab significantly improved the gingival index scores and decreased the number of sites with bleeding on probing after only 3 months (p < 0.05), while the probing pocket depth significantly decreased after 6 months; overall, clinical attachment loss presented only slight changes without any statistical significance as well as teeth count and plaque levels (p > 0.05). Conclusion: IL-6 inhibition is able to improve periodontal outcomes in patients with RA and concomitant PD, which is essentially related to a dramatic decrease in serum inflammatory mediators.


2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 524.1-524
Author(s):  
R. Dos-Santos ◽  
F. Otero ◽  
E. Perez-Pampín ◽  
A. Mera Varela

Background:Periodontal disease (PD) has been widely studied in the pathogenesis of rheumatoid arthritis (RA). As well, its relationship with severity and disease activity, has also been investigated with ambiguous results. It has been suggested that the improvement of oral health could enhance disease activity scores.1 PD prevalence worldwide stands around 60% in older adults (>65 years) and its frequency increases with aging.2Objectives:To asses oral health in RA patients and to identify predictors of PD in this population.Methods:Patients diagnosed of RA at treatment with biological, classical or targeted synthetic disease modifying anti-rheumatic drugs (b/cs/tsDMARDs) in the aforementioned hospital during 2020 performed a dental review with a specialized periodontal odontologist. Oral health patterns were given for all patients, following criteria of American Academy of Periodontology, and reevaluation of disease activity was made 2 months later.Clinical, demographic and treatment data were collected from participants.Univariable logistic regression was performed to identify predictors of PD. Variables with p<0.20 were selected for multivariable analysis.Stata 15.1 was used to perform statistical analysis.Results:81 patients were recruited. 82.72% were female. Mean age was 56.17 years (SD 14.15) and mean time since diagnosis was 15.58 years (SD 8.17). 25% were current or past smokers. 21 patients had comorbidities (arterial hypertension the most frequent). 66.67% were rheumatoid factor (RF) positive and 72.73% anti-citrullinated peptide autoantibody (ACPA) positive. Median erythrocyte sedimentation rate (ESR) was 12 mm (IQR 6;23) and mean C-reactive protein (CRP) was 0.48 mg/dl (SD 1.18). Mean disease activity score (DAS28-VSG) at the testing time was 2.62 (SD 1.21) and after 2 months was 2.39 (SD 0.97). 96.30% of patients were at treatment with csDMARDs, 64.20% with glucocorticoids, 96.30% with bDMARDs and 6 patients with tsDMARDs.Univariable analysis identified higher age, at least one autoantibody positive and ESR/CRP as potential predictors of medium/severe PD (p<0.20). Multivariable testing including these variables pointed out higher age, lower ESR and at least one autoantibody positive (OR 1.09 [CI95% 1.04-1.14] p=0.001, OR 0.18 [CI95% 0.04-0.95] p=0.044 and OR 0.94 [CI95% 0.88-1.00] p=0.042, respectively) as predictors of medium or severe PD (≥3 mm interdental clinical attachment loss).Univariable analysis identified higher age, the presence of any comorbidity and anti tumour-necrosis factor alpha treatment (anti-TNF) as potential predictors of severe PD (p<0.20). Multivariable testing including these variables pointed out higher age (OR 1.15 [CI95%1.02-1.30] p=0.026) as predictor of severe PD (≥5 mm interdental clinical attachment loss).Conclusion:Periodontal disease is still an extended health problem among the entire population. Its prevalence in RA is increased, therefore higher age and RF or ACPA positive are risk factors for developing severe PD. This analysis might suggest that an aggressive management of PD could implement better responses in DAS28. Also anti-TNF treatment could delimit a “penumbra” group of patients at risk of developing severe PD, where intensive manage could modify the final outcome.References:[1]C O Bingham, M Moni. Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions. Curr Opin Rheumatol. 2013;25(3):345-353.[2]P Carvajal. Periodontal disease as a public health problem: the challenge for primary health care. Rev Clin Periodoncia inplantol. 2016;9(2):177-183.Disclosure of Interests:None declared


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Miren Vilor-Fernández ◽  
Ana-María García-De-La-Fuente ◽  
Xabier Marichalar-Mendia ◽  
Ruth Estefanía-Fresco ◽  
Luis-Antonio Aguirre-Zorzano

Abstract Background Oral implants have helped clinicians to improve the quality of life for many patients. The material of choice for dental implants currently remains titanium type IV, whose mechanical and biological properties have been proven throughout the history of implantology. Yet, this material is not exempt from complications. For these reasons, ceramic alternatives to titanium have emerged. Thus, the purpose of this study is to evaluate peri-implant hard and soft tissue stability with the use of a one-piece ceramic implant (Straumann® PURE Ceramic Implant) during 1 year of follow-up. Study design One-piece all-ceramic zirconia (ZrO2) implants were placed to replace single missing teeth in the esthetic zone. Six to 8 weeks after the procedure, the definitive prosthesis was fabricated. At the time of prosthesis, placement (T0) photographs and periapical radiographs were taken, and the following clinical parameters were recorded: probing depth (PD), plaque index (PI), bleeding on probing (BOP), suppuration on probing (SOP), distance from gingival margin to incisal edge (GM-IE), and Jemt papilla index (JPI). Follow-up appointments were scheduled at 4 (T4), 8 (T8), and 12 (T12) months, when the same parameters were recorded. In addition, plaque control was reinforced and prophylaxis was carried out. In this last appointment, a final periapical radiograph was taken to assess marginal bone loss. Results A total of 32 zirconia implants were placed in 28 patients (16 women and 12 men, aged between 34 and 67 years). The survival and success rate were 96.9%. The increase in probing depth from baseline to 12 months was 0.78 mm. Assessments of plaque index and bleeding on probing showed a slight increase throughout the study. Conclusions The results obtained with the Straumann® PURE Ceramic implants show them to exhibit very good clinical behavior. The survival rate of the implants of our pilot study was 96.9%. For these reasons, we can say that zirconia implants could be an alternative to titanium implants in the esthetic zone.


Author(s):  
Shreeya Aryal ◽  
Ameena Pradhan ◽  
Shilu Shrestha ◽  
Surendra Man Shrestha

Introduction: Obesity is regarded as unnecessary body fat in ratio to lean body mass. Besides being an established risk factor for cardiovascular and other systemic diseases, obesity has been suggested to be a potential threat for periodontitis as well. Objective: The objective of the study was to learn relationship between body mass index (BMI) and periodontal disease. Methods: This analytical cross-sectional study was conducted at People’s Dental College from February 16 to April 15, 2021 after ethical approval. Seventy-two participants were selected conveniently who, on the basis of calculation of weight and height were allocated into two groups: Group A: participants with normal BMI, Group B: Obese/ overweight individuals. Plaque index, gingival index, periodontal pocket, and clinical attachment loss were recorded in both the groups to assess the periodontal disease status. On basis of findings, the two groups were statistically compared. Results: The result showed clinical attachment loss was significantly higher (P <0.001) in overweight/obese group than in normal BMI group (P =0 .001). Conclusion: The findings of this study suggest that obesity and overweight can be a possible predisposing factor for periodontal disease.


2007 ◽  
Vol 77 (6) ◽  
pp. 1085-1089 ◽  
Author(s):  
Zuhal Yetkin Ay ◽  
Mözgür Sayın ◽  
Yener Özat ◽  
Tuba Goster ◽  
A. Onur Atilla ◽  
...  

Abstract Objective: To determine the most appropriate oral hygiene motivation method (OHMM) for orthodontic patients with fixed appliances. Materials and Methods: A total of 150 orthodontic patients, scheduled for their regular controls, were included in this study. The patients were divided into five groups (n = 30) according to the verbal OHMM and instructed as follows: only verbal information (V), verbal information with demonstration on model (M), verbal information with demonstration on model and self application by the patient (M+A), verbal information using the illustration catalog (I), and verbal information using the illustration catalog and self application by the patient (I+A). All of the applications of the patients were made under the supervision of the clinicians. The periodontal parameters (plaque index [PI], gingival index [GI], and bleeding on probing [BOP]) were recorded at the baseline (before the instructions of the OHMM), 1 week later, and 4 weeks after the OHMM. Results: All periodontal parameters showed significant decreases after 4 weeks in all OHMM groups (P &lt; .05). I+A group has significantly lower PI scores and BOP percentages than the other groups (P &lt; .05) after 4 weeks. The difference between the V group and M+A, I, and I+A groups in the GI scores were significant (P &lt; .05), and the I+A group has presented the lowest GI score. Conclusions: The OHMM applied by the patients under the supervision of the clinician seemed to be more successful in the elimination of plaque and inflammatory symptoms in patients with fixed appliances.


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