scholarly journals Exploring the Role of Interleukin-6 Receptor Inhibitor Tocilizumab in Patients with Active Rheumatoid Arthritis and Periodontal Disease

2021 ◽  
Vol 10 (4) ◽  
pp. 878
Author(s):  
Codrina Ancuța ◽  
Rodica Chirieac ◽  
Eugen Ancuța ◽  
Oana Țănculescu ◽  
Sorina Mihaela Solomon ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Interleukin 6 ◽  
Gingival Index ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Bleeding On Probing ◽  
Periodontal Status ◽  
Probing Pocket Depth ◽  
Receptor Inhibitor

Background: The aim of our study was to explore the influence of weekly subcutaneous administration of interleukin-6 (IL-6) receptor inhibitor tocilizumab (TCZ) on periodontal status in a local longitudinal study of patients with rheumatoid arthritis (RA) and periodontal disease (PD). Methods: We performed a 6-month prospective study in 51 patients with chronic periodontitis and moderate-to-severe RA starting TCZ in accordance with local recommendations. Extensive rheumatologic (clinical activity, inflammatory, serological biomarkers) and periodontal (visible plaque index, gingival index, bleeding on probing, probing pocket depth, clinical attachment loss) assessments were done. Changes in RA activity and periodontal status were reassessed after 3 and 6 months. Results: We demonstrated significant correlations between periodontal status, disease activity, and serologic biomarkers (p < 0.05). Tocilizumab significantly improved the gingival index scores and decreased the number of sites with bleeding on probing after only 3 months (p < 0.05), while the probing pocket depth significantly decreased after 6 months; overall, clinical attachment loss presented only slight changes without any statistical significance as well as teeth count and plaque levels (p > 0.05). Conclusion: IL-6 inhibition is able to improve periodontal outcomes in patients with RA and concomitant PD, which is essentially related to a dramatic decrease in serum inflammatory mediators.

scholarly journals CORRELATION BETWEEN PERIODONTAL DISEASE INDICES AND LUNG CANCER IN GREEK ADULTS: A CASE — CONTROL STUDY

2016 ◽  
Vol 38 (1) ◽  
pp. 49-53 ◽  
Author(s):  
N A Chrysanthakopoulos
Keyword(s):  
Lung Cancer ◽  
Periodontal Disease ◽  
Case Control Study ◽  
Case Control ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Bleeding On Probing ◽  
Attachment Loss ◽  
Probing Pocket Depth ◽  
Control Study

Aim: The aim of the present case — control study was to examine the possible associations between periodontal disease indices and the risk of lung cancer development in a sample of Greek out-patients referred to a medical and a dental private practice. Materials and Methods: A total of 200 individuals were interviewed and underwent an oral clinical examination, and 64 of them were suffered from several histological types of lung cancer. The estimation of the possible associations between lung cancer as a dependent variable and periodontal disease indices as independent ones was carried out by using a multiple regression analysis model. Results: Probing pocket depth (odds ratio (OR) = 2.72, 95% confidence interval (CI) 1.05–7.06), clinical attachment loss (OR = 3.51, 95% CI 1.30–9.47) bleeding on probing (OR = 1.93, 95% CI 0.98–3.81) were significantly associated with the risk of developing lung cancer. Smoking (OR = 2.49, 95% CI 1.20–5.17) was significantly associated with the mentioned risk, whereas it was consisted as a confounder regarding the estimated associations between moderate/severe clinical attachment loss and presence of bleeding on probing with the risk of developing lung cancer. Conclusion: Probing pocket depth as an index for periodontal disease severity was statistically significantly associated with the risk of developing lung cancer.

scholarly journals Application of Lactoferrin andα1-Antitrypsin in Gingival Retention Fluid to Diagnosis of Periodontal Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Ryosuke Koshi ◽  
Kazuhiko Kotani ◽  
Mariko Ohtsu ◽  
Naoto Yoshinuma ◽  
Naoyuki Sugano
Keyword(s):  
Clinical Practice ◽  
Periodontal Disease ◽  
Area Under The Curve ◽  
Pocket Depth ◽  
Bleeding On Probing ◽  
Periodontal Status ◽  
Positive Correlation ◽  
Probing Pocket Depth ◽  
The Relationship

Objectives.Periodontal disease is prevalent and has an inflammation associated with not only oral but also systemic pathologies. The diagnosis by biomarkers is required for clinical practice on periodontal disease. The lactoferrin andα1-antitrypsin were both inflammation-related molecules. The present study investigated the relationship between the periodontal status and the two biomarkers in gingival retention fluid (GRF).Patients and Methods. In 63 subjects with periodontitis, the GRF was sampled from maxillary anterior gingiva using a microbrush for 30 seconds. The lactoferrin andα1-antitrypsin levels in GRF were measured by an enzyme-link solvent immunoassay. Periodontal status was evaluated by probing pocket depth (PD) and bleeding on probing (BOP).Results. There was a higher level of these biomarkers in saliva (median (ng/mL), lactoferrin: 3611.9,α1-antitrypsin: 4573.3) than in GRF (lactoferrin: 61.0,α1-antitrypsin: 54.7). There was a mild-to-moderate but significantly positive correlation in lactoferrin orα1-antitrypsin between GRF and saliva. There was a positively mild-to-moderate accuracy (area under the curve: 0.60–0.81) of lactoferrin orα1-antitrypsin in GRF or in saliva to distinguish the severity of periodontal status. The cutoff level (ng/mL) of lactoferrin in GRF for detecting ≥30% of PD ≥ 4 mm (moderate periodontitis) was 68.6 and for detecting ≥20% of BOP (clinically active periodontitis) was 61.2. The cutoff level (ng/mL) ofα1-antitrypsin in GRF for detecting ≥30% of PD ≥ 4 mm was 54.5 and for detecting ≥20% of BOP was 35.3.Conclusions.The data can promote an application of the measurements of lactoferrin andα1-antitrypsin in GRF to clinical practice on periodontal disease.

scholarly journals Estimation of interleukin-17 levels in gingival crevicular fluid from healthy individuals, chronic gingivitis and chronic periodontitis patients using enzyme linked immunosorbent assay

2020 ◽  
Vol 8 (10) ◽  
pp. 3605
Author(s):  
Neha Nainee ◽  
Sheetal Sanikop ◽  
Abhilasha Jha
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Strong Association ◽  
Enzyme Linked Immunosorbent Assay ◽  
Interleukin 17 ◽  
Gingival Index ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Probing Pocket Depth

Background: Chronic Periodontitis (CP) is an infectious disease resulting in inflammation of supporting tissues of the teeth. A number of pro-inflammatory cytokines are formed against periodontopathogenic microorganisms. Interleukin-17 (IL-17) is a pro-inflammatory cytokine, implicated in numerous inflammatory and autoimmune conditions.Methods: A total of 25 periodontally healthy subjects (Group 1), 25 patients with gingivitis (Group 2) and 25 patients with CP (Group 3) were included for the study based on clinical examination. Gingival index, probing pocket depth and clinical attachment loss were recorded in all subjects.Results: The levels of IL-17 increased from healthy to gingivitis to periodontitis patients. A positive correlation was found with the IL-17 and the clinical parameters like gingival index, probing pocket depth and clinical attachment loss.Conclusions: There is a strong association between the levels of IL-17 with periodontal disease as well as with its severity and its possible use as a biomarker for inflammatory periodontal disease.

scholarly journals Comparison of Periodontal Status Between Male Exclusive Narghile Smokers and Male Exclusive Cigarette Smokers

2019 ◽  
Vol 13 (2) ◽  
pp. 155798831983987
Author(s):  
Mehdi Khemiss ◽  
Dalila Ben Fekih ◽  
Mohamed Ben Khelifa ◽  
Helmi Ben Saad
Keyword(s):  
Periodontal Disease ◽  
Plaque Index ◽  
Gingival Index ◽  
Tobacco Exposure ◽  
Chi Square ◽  
Pocket Depth ◽  
Cigarette Smokers ◽  
Periodontal Status ◽  
Probing Pocket Depth ◽  
Student’S T

Studies evaluating the effects of narghile use on the periodontium present conflicting conclusions. This study aimed to compare the periodontal status of exclusive narghile smokers (ENSs, n = 74) to that of exclusive cigarette smokers (ECSs, n = 74). Males aged 20–40 years were recruited to participate in this comparative study. Information concerning oral health habits (number of yearly visits to the dentist, daily toothbrushing frequency) and tobacco exposure were obtained. Clinical measurements were performed on all the existing teeth, except the third molars. The number of remaining teeth and decayed/missing/filled teeth (DMFT) were noted. The plaque levels were recorded using the plaque index of Löe and Silness. The gingival index modified by Löe was used to evaluate gingival inflammation. Teeth mobility was measured using bidigital mobility. The probing pocket depth was measured using a periodontal probe. Periodontal disease was defined as the presence of at least 10 sites with a probing depth ≥5 mm. Student’s t and chi-square tests were used to compare, respectively, the two groups’ quantitative and qualitative data. The two groups were matched for quantities of used tobacco, age, daily toothbrushing frequency, teeth mobility, number of remaining teeth, plaque index, and DMFT. Compared to the ECS group, the ENS group had a significantly lower number of yearly visits to the dentist (mean ± SD: 0.2 ± 0.5 vs. 0.1 ± 0.2), lower probing pocket depth (mean ± SD: 2.33 ± 0.63 vs. 2.02 ± 0.80 mm), and gingival index (median [interquartile]: 0.46 [0.10–0.89] vs. 0.00 [0.00–0.50]), and it included significantly lower percentages of smokers with periodontal disease (24.3% vs. 9.5%). In conclusion, chronic exclusive narghile smoking has fewer adverse effects on the periodontium than chronic exclusive cigarette smoking.

scholarly journals Validating gingival surface temperature as an alternative tool in the diagnosis of periodontal disease activity: An observational clinical trial

2019 ◽  
Vol 13 (2) ◽  
pp. 123-127
Author(s):  
Sumanth Gunupati ◽  
Hasya Sappiti ◽  
Sreenivas Nagarakanti ◽  
BV Ramesh Reddy ◽  
Vijay Kumar Chava
Keyword(s):  
Pilot Study ◽  
Periodontal Disease ◽  
Surface Temperature ◽  
Disease Activity ◽  
Diagnostic Tool ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Probing Pocket Depth ◽  
Pilot Clinical Study

Background. Elevated temperature has been recognized as an inflammatory sign. It is the only indication that can be both objectively and quantitatively evaluated and is considered as a potential indicator of periodontal disease. Assessing gingival surface temperature (GST) could be a diagnostic parameter to determine periodontal health. This pilot clinical study aimed to validate gingival surface temperature (GST) as a clinical diagnostic tool to measure periodontal disease activity by correlating with the periodontal inflamed surface area (PISA). Methods. A cross-sectional mono-center pilot study was conducted with a convenient sample of 50 participants with a mean age of 34.14±13.7 years. Clinical parameters such as probing pocket depth (PPD) clinical attachment loss (CAL) and bleeding on probing (BOP) were measured. GST was recorded with a single lead of the bedside patient monitor and correlated with PISA. Results. The results showed a positive correlation between PISA and GST (P=0.46). Conclusion. This study showed a rise in GST of inflamed sites, but the results did not support the hypothesis that increased GST is an indicator of periodontal disease. As this is a pilot study, further studies with more larger sample sizes need to be undertaken to confirm its use as a diagnostic tool in clinical trials.

scholarly journals Effectiveness of non-surgical treatment to reduce il-18 levels in the gingival crevicular fluid of patients with periodontal disease

2012 ◽  
Vol 23 (4) ◽  
pp. 428-432 ◽  
Author(s):  
Bernardo Oliveira de Campos ◽  
Ricardo Guimarães Fischer ◽  
Anders Gustafsson ◽  
Carlos Marcelo da Silva Figueredo
Keyword(s):  
Surgical Treatment ◽  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Gingival Index ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Crevicular Fluid ◽  
Attachment Level ◽  
Gingival Fluid ◽  
Non Surgical Treatment

The aim of this study was to evaluate the effectiveness of the non-surgical periodontal treatment in reducing the gingival crevicular fluid (GCF) levels of IL-18 from inflamed periodontal sites. Fourteen patients with periodontal disease were included, being 9 patients with chronic periodontitis (mean age: 48.8 SD ± 7.4 years) and 5 patients with gingivitis (mean age: 43.6 SD ± 11.8). The patients were divided in the following groups: gingivitis sites from periodontitis patients (sites GP), periodontitis sites from periodontitis patients (sites PP), and gingivitis sites from gingivitis patients (sites GG). Probing pocket depth (PPD), probing attachment level (AL), plaque index (PI) and gingival index (GI) were recorded, and gingival fluid samples were collected. The subjects received non-surgical treatment and were re-evaluated 30 days after treatment (day 30 AT). There was a significant reduction in PI in GG (1.0 ± 0.4 to 0.5 ± 0.2), GP (1.2 ± 0.3 to 0.5 ± 0.3), and in PP (1.3 ± 0.4 to 0.7 ± 0.3) 30 AT. There was also a significant reduction in the GI in GG (1.3 ± 0.3 to 0.7 ± 0.4). PPD reduced significantly in GG (2.4 ± 0.6 to 1.9 ± 0.1), and PP (6.7 ± 1.1 to 5.2 ± 0.9) 30 AT. When all the samples were analyzed together, there was a significant reduction in IL-18 (12.9 ± 7.2 to 10.0 ± 3.1). This study showed that non-surgical treatment was effective in reducing GCF levels of IL-18 from inflamed periodontal sites.

scholarly journals Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252859
Author(s):  
Nik-Madihah Nik-Azis ◽  
Nurulhuda Mohd ◽  
Fazalina Mohd Fadzilah ◽  
Nor Hazla Mohamed Haflah ◽  
Mohd Shahrir Mohamed Said ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Health Assessment ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Probing Pocket Depth ◽  
Probing Depth ◽  
Disease Modifying ◽  
And Control ◽  
The Relationship ◽  
Periodontal Probing

Patients with rheumatoid arthritis (RA) experience a higher prevalence of periodontitis. This study aimed to examine the variation of periodontitis experienced with different serotypes suffered by RA patients and to examine the relationship between the different medications taken for RA that may influence this relationship. Two hundred and sixty RA and control participants underwent standardized periodontal examinations. Medical, serological and radiological (Sharp/van der Heijde) records were assessed. Functional status was assessed using the administered Health Assessment Questionnaire. Moreover, disease parameters, including disease activity (DAS28-ESR) and anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) seropositivity were evaluated. Periodontitis was higher in RA (71.54%) compared with controls (54.62%). The stage of periodontitis experienced by ACPA-positive participants were higher than APCA-negative participants. The probing pocket depth and recession experienced by RF-positive participants were higher than those who were RF-negative. RA participants on methotrexate had lower clinical attachment loss and lower periodontal probing depth compared with participants on a combination methotrexate and other disease-modifying antirheumatic drugs. Participants taking corticosteroids had lower gingival index scores. The association between seropositivity and the type of medications taken with periodontal health parameters in this group of patients suggests that both seropositivity and medications taken are important modifiers in the relationship between periodontitis and RA.

scholarly journals Association of Periodontal Disease and Polycystic Ovarian Syndrome: A Systematic Review and Meta-analysis with Trial Sequential Analysis

2019 ◽  
Vol 13 (1) ◽  
pp. 478-487 ◽  
Author(s):  
Fathima F. Farook ◽  
Ka Ting Ng ◽  
Nuzaim MNM ◽  
Wen J. Koh ◽  
Wan Y. Teoh
Keyword(s):  
Periodontal Disease ◽  
Polycystic Ovarian Syndrome ◽  
Plaque Index ◽  
Gingival Index ◽  
Clinical Attachment Loss ◽  
Bleeding On Probing ◽  
Attachment Loss ◽  
Probing Depth ◽  
Healthy Cohort ◽  
Ovarian Syndrome

Introduction: Several articles have suggested a potential synergistic relationship between periodontal disease and systemic inflammatory diseases, such as Polycystic Ovarian Syndrome (PCOS) and diabetes mellitus. However, the associations between periodontal disease and PCOS population remain unclear in the literature. Objective: The primary aim of this review is to examine the associations between periodontal disease and PCOS with different scoring methods, namely clinical attachment loss, probing depth, gingival index, percentage of bleeding on probing and plaque index. Methods: MEDLINE, EMBASE and CENTRAL were systematically searched for observational studies and case-control studies from its inception until 2nd June, 2019. Case reports, case series, non-systematic reviews and trials published as abstracts were excluded. Results: Four articles (614 subjects) were included for analysis. Out of 614 subjects, 329 PCOS patients were compared to 285 healthy subjects. In comparison to healthy cohort, women with PCOS had a statistically significant increase in clinical attachment loss (MD: 0.34, 95% CI: 0.13-0.55, ρ=0.002), probing depth (MD: 0.35, 95%CI: 0.21-0.48, ρ<0.001), gingival index (MD: 0.70, 95% CI: 0.70-1.11, ρ<0.001) and percentage of bleeding on probing (MD: 34.41, 95% CI: 20.23-48.59, ρ<0.001). No difference was demonstrated in plaque index (MD: 0.42, 95% CI: -0.29-1.12, ρ=0.24) for both PCOS and healthy cohort. Conclusion: PCOS is significantly associated with a higher severity of the periodontal disease. This association should be emphasized during the management of PCOS patients, by including referral to dentists or periodontists for regular mechanical debridement of plaque and periodontal maintenance.

scholarly journals The Relationship Between Bleeding on Probing and Subgingival Deposits. An Endoscopical Evaluation

2009 ◽  
Vol 3 (1) ◽  
pp. 154-160 ◽  
Author(s):  
Luigi Checchi ◽  
Marco Montevecchi ◽  
Vittorio Checchi ◽  
Franco Zappulla
Keyword(s):  
Physical State ◽  
New Technology ◽  
Scaling And Root Planing ◽  
Gingival Index ◽  
Pocket Depth ◽  
Bleeding On Probing ◽  
Probing Pocket Depth ◽  
Low Sensitivity ◽  
High Level ◽  
The Relationship

Background: Bleeding on probing (BOP) is an indicator of tissue inflammatory response to bacterial pathogens. Due to anatomical limitations, the entity and physical state of microbial aggregations located under the gingival margin and their relations to BOP have been hardly investigated till now. The recent introduction of the endoscopy has allowed clinicians to observe the subgingival environment in a non-traumatic way. The aim of this study is to evaluate the correlation between BOP and subgingival deposits by using this new technology. Methods: 107 teeth (642 individual sites) from 16 periodontal patients, treated with scaling and root planing, were evaluated for plaque index (PI), gingival index (GI), probing pocket depth (PPD), bleeding on probing (BOP), endoscopic biofilm index (EBI), and endoscopic calculus index (ECI) at one-month revaluation. Results: A linear association between BOP and PD, EBI, and ECI was detected. The BOP provided a high level of specificity but quite low sensitivity values both for ECI (sensitivity 40%, specificity 86%) and EBI (sensitivity 37%, specificity 89%). The BOP sensitivity was directly linked to the amount of subgingival deposits. Conclusions: This study demonstrates a direct relationship between BOP and presence/amount of subgingival deposits. More investigations on larger samples are, however, needed.

scholarly journals Association between chronic periodontitis and herpes viruses: A review of the literature.

2020 ◽  
Vol 9 (3) ◽  
pp. 234-244
Author(s):  
Héctor Oñate ◽  
◽  
Alejandra Bravo ◽  
Carolina Arancibia ◽  
Paola Bustos ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Insertion Loss ◽  
Chronic Periodontitis ◽  
Data Matrix ◽  
Pocket Depth ◽  
Bleeding On Probing ◽  
Barr Virus ◽  
Probing Pocket Depth ◽  
Epstein Barr ◽  
Simplex Virus

Objective: This research aims to analyze the available spe-cialized literature concerning the association between Herpesviruses [Cytomegalovirus (CMV), Epstein Barr virus (EBV), Herpes Simplex virus (HSV)] and chronic periodontitis to clarify the possible role of these microorganisms in the progression and severity of the disease. Materials and Methods: A search for scientific articles was carried out in March 2019 in the main metasearch engines: PubMed /MEDLINE, SciELO, EBSCO, and the Trip search engine, to select articles according to the exclusion and inclusion criteria. The analysis of the articles was carried out through a data matrix expressed in frequency tables using descriptive statistics with measures of central tendency, dispersion, and correlation. Results: The results of this study show that the presence of CMV, EBV, and HSV in patients with chronic periodontitis is related to an increase in clinical parameters such as probing pocket depth (PD), clinical insertion loss (CIL) and bleeding on probing (BOP), in 96%, 60% and 40% of the studies, respectively, for HCMV; 96.55% (PD), 51.72% (CIL), and 48.28% (BOP) for EBV, and 80% (PD), 90% (CIL), and 60% (BOP) for HSV. The average prevalence of EBV, HCMV, and HSV was 46.3%, 35.4%, and 40.1%, respectively. Conclusions: EBV, CMV, and HSV could be associated with the progression and severity of periodontal disease as they are related to a greater probing depth, greater clinical insertion loss, and greater bleeding on probing. EBV presented a higher prevalence in the reviewed literature. More clinical studies are needed to verify a direct relationship between EBV, HSV, CMV, and periodontal disease, to confirm the trends observed in this work.

Sign in / Sign up

Export Citation Format

Share Document