TRIM65 in White Matter Lesions, Innate Immunity and Tumor

2021 ◽  
Vol 14 ◽  
Author(s):  
Bingxue Liu ◽  
Yunlian Tang ◽  
Ping Yang ◽  
Chu Wu ◽  
Yue Huang
Keyword(s):  
Signal Transduction ◽  
Innate Immunity ◽  
White Matter ◽  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
White Matter Lesions ◽  
Intracellular Signal Transduction ◽  
Cellular Processes ◽  
Tripartite Motif ◽  
Intracellular Signal

Abstract: Most of the tripartite motif (TRIM) family proteins have E3 ubiquitin ligase activities and also have a variety of functions in cellular processes such as intracellular signal transduction, apoptosis, innate immunity and carcinogenesis. TRIM65 is a member of the TRIM family. More and more evidences have shown a unique and importance of TRIM65 protein in the occurrence and development of some diseases. In this review, the importance on TRIM65 in white matter lesions, innate immunity and the effect of tumors was mainly reviewed.

scholarly journals The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development

Acta Naturae ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 65-76
Author(s):  
Oleg A. Kuchur ◽  
Daria O. Kuzmina ◽  
Marina S. Dukhinova ◽  
Alexandr A. Shtil
Keyword(s):  
Signal Transduction ◽  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Tumor Cells ◽  
P53 Protein ◽  
Intracellular Signal Transduction ◽  
Radiation Problem ◽  
The Family ◽  
Intracellular Signal ◽  
Survival Mechanisms

Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatments effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the development of radioresistance. This review analyzes the p53-dependent and p53-independent mechanisms involved in overcoming the resistance of tumor cells to radiation exposure.

INTRACELLULAR SIGNAL TRANSDUCTION IN EOSINOPHILS AND ITS CLINICAL SIGNIFICANCE

2002 ◽  
Vol 24 (2) ◽  
pp. 165-186 ◽  
Author(s):  
Chun Kwok Wong ◽  
Jiping Zhang ◽  
Wai Ki Ip ◽  
Christopher Wai Kei Lam
Keyword(s):  
Signal Transduction ◽  
Clinical Significance ◽  
Intracellular Signal Transduction ◽  
Intracellular Signal
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