Kinetic Study of Iodination of Propanone in Different Acidic Medium by using Colorimeter

2021 ◽  
Vol 11 ◽  
Author(s):  
Nitin Sharma ◽  
Tanveer Alam ◽  
Ashok Kumar
Keyword(s):  
Kinetic Study ◽  
Acidic Medium ◽  
Acid Catalyst ◽  
Time Interval ◽  
Iodine Solution ◽  
Yellow Colour ◽  
Rate Law ◽  
Zero Order Reaction ◽  
Standard Solution

Aims: This study aims at the Kinetic Study of Iodination of Propanone in Different Acidic Medium by using Colorimeter. Background: The kinetic experimentation of iodination of propanone has been performed in presence of different acids such as sulphuric acid, hydrochloric acid and acetic acid. The rate law of the iodination of propanone in acidic medium is determined by observing the disappearance of the brownish yellow colour of iodine in aqueous solution. Objective: The objective of this study is the preparation of standard solution, determination of absorbance of iodine solution at λmax= 480 nm, Kinetic study of iodination of propanone with different acidic medium. Method: The kinetic analysis of this reaction has been carried out by colorimetry. The extent of the reaction has been monitored by measuring the absorbance of the reaction mixture after a suitable time interval. Result: The rate law expression is determined to be rate = k [〖"propanone]" 〗_0^0.728 [acid]0. The rates of iodination of propanone in presence of different acidic medium are H2SO4 > HCl > CH3COOH. Conclusion: The rate of the reaction is found to be independent of the concentration of iodine i.e. it is zero order reaction with respect to iodine. However, it depends on the concentration of propanone and acid catalyst. Other: By using this experimental technique, the consumption of chemicals is very less.

Benzyl ethers of methyl α-D-glucopyranoside

1980 ◽  
Vol 45 (7) ◽  
pp. 1959-1963 ◽  
Author(s):  
Dušan Joniak ◽  
Božena Košíková ◽  
Ludmila Kosáková
Keyword(s):  
Kinetic Study ◽  
Spectrophotometric Determination ◽  
Reductive Cleavage ◽  
Ether Bond ◽  
Benzyl Ethers ◽  
Acid Catalyzed ◽  
Model Substances ◽  
Hydrolysis Of

Methyl 4-O-(3-methoxy-4-hydroxybenzyl) and methyl 4-O-(3,5-dimethoxy-4-hydroxybenzyl)-α-D-glucopyranoside and their 6-O-isomers were prepared as model substances for the ether lignin-saccharide bond by reductive cleavage of corresponding 4,6-O-benzylidene derivatives. Kinetic study of acid-catalyzed hydrolysis of the compounds prepared was carried out by spectrophotometric determination of the benzyl alcoholic groups set free, after their reaction with quinonemonochloroimide, and it showed the low stability of the p-hydroxybenzyl ether bond.

scholarly journals Development and validation of a gas chromatography method for the determination of β-caryophyllene in clove extract and its application

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mi Hee Park ◽  
Chul Jin Kim ◽  
Jin Young Lee ◽  
In Seon Kim ◽  
Sung-Kyu Kim
Keyword(s):  
Active Constituent ◽  
Chromatography Method ◽  
Ich Guidelines ◽  
Specificity Test ◽  
Detection Response ◽  
Standard Solution ◽  
Clove Extract ◽  
Pharmaceutical Uses ◽  
Development And Validation

AbstractThe purpose of this study is to check the effectiveness of the analysis method that separates and quantifies β-caryophyllene among clove extracts and validate according to current ICH guidelines. The β-caryophyllene was active constituent of clove buds. The developed method gave a good detection response. In the specificity test, the standard solution was detected at about 17.32 min, and the test solution was detected at 17.32 min. The linearity of β-caryophyllen was confirmed, and at this time, the correlation coefficient (R2) of the calibration curve showed a high linearity of 0.999 or more in the concentration range. The levels of LOD and LOQ were 1.28 ug/mL and 3.89 ug/mL, respectively. The accuracy was confirmed to be 101.6–102.2% and RSD 0.95 ~ 1.31%. As a result of checking the repeatability and inter-tester reproducibility to confirm the precision, the RSD was found to be 1.34 ~ 2.69%. This validated GC method was successfully applied to a soft capsule containing clove extract and other materials for clinical trials. Therefore, this method can be used as an analytical tool for quality control of various samples, including clove extracts and their products of food and pharmaceutical uses.

UV-Visible Spectrophotometric Determination of Lambda-Cyhalothrin Insecticide in Vegetables, Soil and Water Samples

2019 ◽  
Vol 31 (1) ◽  
pp. 1-9
Author(s):  
Deepak Kumar Sahu ◽  
Joyce Rai ◽  
Chhaya Bhatt ◽  
Manish K. Rai ◽  
Jyoti Goswami ◽  
...  
Keyword(s):  
Crop Production ◽  
Limit Of Detection ◽  
Low Cost ◽  
Molar Absorptivity ◽  
Agricultural Field ◽  
Limit Of Quantification ◽  
Yellow Colour ◽  
Modern Age ◽  
Lambda Cyhalothrin

In modern age pesticide is used widely in agriculture. Lambda-cyhalothrin (LCT) is one of the most used pesticides which are used as a insecticide to kill pest, tricks, flies etc in agricultural field and it is also used for crop production. We have developed new method to detect LCT insecticide in agriculture field and reduce its uses. In this method we found the maximum absorbance at 460 nm for yellow colour dye. We also calculated limit of detection and limit of quantification 0.001 mg kg-1 and 0.056 mg kg-1 respectively. Molar absorptivity and Sandell’s sensitivity was also calculated and obtained 1.782 ×107 mol-1 cm-1 and 9.996 ×10-6 µg cm-2 respectively. The obtained yellow colour dye obeyed Beer’s law limit range of 0.5 µg ml -1 to 16 µg ml-1 in 25 ml. This method is less time consuming, selective, simple, sensitive and low cost. Present method is successfully applied in various soil, water and vegetable samples.

scholarly journals Synthesis of Nano-Sized Protonic Acid Catalyst and Initial Kinetic Study of Esterification Reaction of Methanol with Acetic Acid

2014 ◽  
Vol 26 (16) ◽  
pp. 4988-4994
Author(s):  
Jianjun Zhu ◽  
Qiuqing Cui ◽  
Jiangping Peng ◽  
Li Li Zhang ◽  
Zhongqing Jiang ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Kinetic Study ◽  
Acid Catalyst ◽  
Esterification Reaction ◽  
Protonic Acid

High-Performance Liquid Chromatographic Determination of Memantine in Human Urine Following Solid-Phase Extraction and Precolumn Derivatization

2013 ◽  
Vol 96 (6) ◽  
pp. 1302-1307 ◽  
Author(s):  
Karim Michail ◽  
Hoda Daabees ◽  
Youssef Beltagy ◽  
Magdy Abd Elkhalek ◽  
Mona Khamis
Keyword(s):  
Human Urine ◽  
High Performance ◽  
Solid Phase ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Therapeutic Drug ◽  
Time Interval ◽  
Precolumn Derivatization ◽  
Uv Detector

Abstract A validated HPLC-UV method is presented for the quantification of urinary memantine hydrochloride, a novel medication approved to treat moderate and advanced cases of Alzheimer's disease. The drug and amantadine hydrochloride, the internal standard, were extracted from human urine using SPE. The extract was then buffered and derivatized at room temperature using o-phthalaldehyde in the presence of N-acetyl-L-cyteine. Chromatographic separation of the formed derivatives was achieved on a C18 column using methanol–water mobile phase adjusted to pH 7 and pumped isocratically at 1 mL/min. The UV detector was set at 340 nm. The chromatographic run time did not exceed 10 min. The LOD and LOQ were 8 and 20 ng/mL, respectively. The RSDs for intraday and interday precisions did not exceed 5.5%. The method was used to monitor memantine hydrochloride in human urine in order to determine an appropriate sampling interval for future noninvasive therapeutic drug monitoring. The assay could also be applied to the determination of amantadine. The described assay showed that a postdosing time interval of 25–75 h seems adequate for sampling and monitoring memantine in urine.

scholarly journals New Spectrophotometric Method for Determination of Cadmium

2009 ◽  
Vol 6 (s1) ◽  
pp. S496-S500
Author(s):  
K. S. Parikh ◽  
R. M. Patel ◽  
K. N. Patel
Keyword(s):  
Stability Constant ◽  
Spectrophotometric Method ◽  
Basic Medium ◽  
Buffer Solution ◽  
Solution Ph ◽  
Yellow Colour ◽  
Maximum Absorbance ◽  
The Stability

The reagent 2-hydroxy-4-n-butoxy-5-bromopropiophenone thiosemicarbazone (HBBrPT) has been used for the determination of Cd(II) by using spectrophotometric method. The reagent HBBrPT gave an intense yellow colour with Cd(II) solution in basic medium. The maximum absorbance was observed at 440 nm, in basic buffer solution (pH 10.00). The molor absorptivity and Sandell’s sensitivity of Cd(II)-HBBrPT complex were 4035 mol-1cm-1and 0.02765 μg cm-2respectively. The stability constant of 1:2 Cd(II)-HBBrPT complex was 8.46×106. The effect of various iron was also studied.

Determination of Unconjugated and Total N-Acetyl-p-aminophenol (NAPA) in Urine and Serum

1967 ◽  
Vol 13 (3) ◽  
pp. 215-219 ◽  
Author(s):  
Karel P M Heirwegh ◽  
Johan Fevery
Keyword(s):  
Liver Disease ◽  
Acid Hydrolysis ◽  
Azo Dye ◽  
Acidic Medium ◽  
Diazonium Salt ◽  
Accurate Method ◽  
Total N ◽  
Hydrolysis Of ◽  
Urine And Serum

Abstract A sensitive and accurate method is described for the determination of N-acetyl-p-aminophenol (NAPA) and its metabolites in urine and serum. In strongly acidic medium, p-aminophenol (PAP) resulting from differential extraction and acid hydrolysis of total NAPA and unconjugated NAPA, is diazotized and the diazonium salt coupled with N-(1-naphthyl)ethylenediamine (NED) in the presence of ethanol. The blue azo dye formed is determined spectrophotometrically. Application to liver disease is briefly reported.

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