COVID19 – Far from Over: Call for Urgent Novel and Advanced Measures

Coronaviruses ◽  
2021 ◽  
Vol 02 ◽  
Author(s):  
Abhigyan Choudhury ◽  
Suprabhat Mukherjee
Keyword(s):  
Chronic Diseases ◽  
Free World ◽  
The Road ◽  
Vaccination Strategies ◽  
Physical Exercises ◽  
Personal Level

: The COVID19 pandemic that started in late 2019 has already killed millions of people, it is yet far from over and the road to the COVID-free world is much tougher than we all imagined; however, it ends at a vaccine functional against all coronaviruses. In this article, we try to present the aetiology behind evolution of superior pathogenicity of SARS-CoV-2 and point out fundamental and highly hazardous loopholes in the current vaccination regimens and propose new vaccination strategies. We also suggest societal and personal level management that are necessary to ensure prevention and better recovery outcomes until the arrival of the vaccine. In turn, we apprise the physician for long-term and stringent management of certain chronic diseases, avoiding prescribing certain drugs and suggesting physical exercises and diets that are fortified with specific micronutrients.

scholarly journals Primary Prevention of Dementia: An Ethical Review

2020 ◽  
pp. 1-10
Author(s):  
Dorothee Horstkötter ◽  
Kay Deckers ◽  
Sebastian Köhler
Keyword(s):  
Synergistic Effects ◽  
Well Being ◽  
Ethical Review ◽  
Medical Risk ◽  
Medical Risk Factors ◽  
Societal Challenges ◽  
Dementia Prevention ◽  
Health Related ◽  
Personal Level

Dementia poses important medical and societal challenges, and of all health risks people face in life, dementia is one of the most feared. Recent research indicates that up to about 40% of all cases of dementia might be preventable. A series of environmental, social, and medical risk-factors have been identified and that should be targeted from midlife onwards when people are still cognitively healthy. At first glance, this seems not merely advisable, but even imperative. However, these new developments trigger a series of new ethical questions and concerns which have hardly been addressed to date. Pro-active ethical reflection, however, is crucial to ensure that the interests and well-being of those affected, ultimately all of us, are adequately respected. This is the goal of the current contribution. Against the background of a concrete case in primary dementia prevention, it provides a systematic overview of the current ethical literature and sketches an ethical research agenda. First, possible benefits of increased well-being must be balanced with the burdens of being engaged in particularly long-term interventions for which it is unclear whether they will ever pay out on a personal level. Second, while knowledge about one’s options to maintain brain health might empower people, it might also undermine autonomy, put high social pressure on people, medicalize healthy adults, and stigmatize those who still develop dementia. Third, while synergistic effects might occur, the ideals of dementia prevention might also conflict with other health and non-health related values people hold in life.

scholarly journals The implications of vehicle collisions for the Endangered endemic Zanzibar red colobus Piliocolobus kirkii

Oryx ◽  
2021 ◽  
pp. 1-9
Author(s):  
Harry Olgun ◽  
Mzee Khamis Mohammed ◽  
Abbas Juma Mzee ◽  
M. E. Landry Green ◽  
Tim R. B. Davenport ◽  
...  
Keyword(s):  
Road Ecology ◽  
Local Population ◽  
Red Colobus ◽  
Vehicle Collisions ◽  
The Road ◽  
Life History Data ◽  
Natural Predation ◽  
Historical Accounts ◽  
The Impact

Abstract Roads affect wildlife in a variety of negative ways. Road ecology studies have mostly concentrated on areas in the northern hemisphere despite the potentially greater impact of roads on biodiversity in tropical habitats. Here, we examine 4 years (January 2016–December 2019) of opportunistic observations of mammalian roadkill along a road intersecting Jozani-Chwaka Bay National Park, Unguja, Zanzibar. In particular, we assess the impact of collisions on the population of an endemic primate, the Endangered Zanzibar red colobus Piliocolobus kirkii. Primates accounted for the majority of roadkill in this dataset. Monthly rainfall was not associated with roadkill frequency for mammals generally, nor for the Zanzibar red colobus. No single age–sex class of colobus was found dead more often than expected given their occurrence in the local population. The overall effect of roadkill on colobus populations in habitats fragmented by roads is unknown given the lack of accurate, long-term life history data for this species. Our findings suggest that mortality from collisions with vehicles in some groups of colobus is within the range of mortality rates other primates experience under natural predation. Unlike natural predators, however, vehicles do not kill selectively, so their impact on populations may differ. Although a comparison with historical accounts suggests that the installation of speedbumps along the road near the Park's entrance has led to a significant decrease in colobus roadkill, further actions to mitigate the impact of the road could bring substantial conservation benefits.

scholarly journals Cardiovascular and musculoskeletal health disorders associate with greater decreases in physical capability in older women

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Juopperi Samuli ◽  
Sund Reijo ◽  
Rikkonen Toni ◽  
Kröger Heikki ◽  
Sirola Joonas
Keyword(s):  
Chronic Diseases ◽  
Musculoskeletal Disorders ◽  
Population Sample ◽  
The Elderly ◽  
Primary Objective ◽  
Baseline Body Mass Index ◽  
Functional Tests ◽  
Physical Capability ◽  
Study Population

Abstract Background Good physical capability is an important part of healthy biological ageing. Several factors influencing physical capability have previously been reported. Long-term reports on physical capability and the onset of clinical disorders and chronic diseases are lacking. Decrease in physical capacity has been shown to increase mortality. This study focuses on the prevalence of chronic diseases. The primary objective of the study was to reveal the association between physical capability and morbidity. Secondary objectives included the validity of self-reported physical capability and the association between baseline physical capability and mortality. Methods The OSTPRE (Kuopio Osteoporosis Risk Factor and Prevention Study) prospective cohort involved all women aged 47–56 years residing in the Kuopio Province, Finland in 1989. Follow-up questionnaires were mailed at five-year intervals. Physical capability questions were first presented in 1994. From these women, we included only completely physically capable subjects at our baseline, in 1994. Physical capability was evaluated with five scale self-reports at baseline and in 2014 as follows: completely physically capable, able to walk but not run, can walk up to 1000 m, can walk up to 100 m and temporarily severely incapable. The prevalences of selected chronic diseases, with a minimum prevalence of 10% in 2014, were compared with the change in self-reported physical capability. Additionally, associations between long-term mortality and baseline physical capability of the whole 1994 study population sample were examined with logistic regression. The correlation of self-reported physical capability with functional tests was studied cross-sectionally at the baseline for a random subsample. Results Our study population consisted of 6219 Finnish women with a mean baseline age of 57.0 years. Self-reported physical capability showed statistically significant correlation with functional tests. Cardiovascular diseases and musculoskeletal disorders show the greatest correlation with decrease of physical capability. Prevalence of hypertension increased from 48.7% in the full physical capability group to 74.5% in the “able to walk up to 100 metres” group (p < 0.001). Rheumatoid arthritis showed a similar increase from 2.1 to 7.4% between these groups. Higher baseline body mass index (BMI) decreases long-term capability (P < 0.001). Women reporting full physical capability at baseline had a mortality rate of 15.1%, in comparison to 48.5% in women within the “able to walk up to 100 m” group (p = 0.357). Mortality increased steadily with worsening baseline physical capability. Conclusions The results of this study show that chronic diseases, particularly cardiovascular and musculoskeletal disorders, correlate with faster degradation of physical capability in the elderly. Similar results are shown for increase in BMI. We also demonstrate that the risk of mortality over a 20-year period is higher in individuals with poor baseline physical capability.

scholarly journals COVID-19: Mechanisms of Vaccination and Immunity

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 404 ◽  
Author(s):  
Daniel E. Speiser ◽  
Martin F. Bachmann
Keyword(s):  
Immune Responses ◽  
Clinical Management ◽  
Neutralizing Antibodies ◽  
Vaccine Development ◽  
Public Life ◽  
High Affinity ◽  
Vaccination Strategies ◽  
Detailed Evaluation ◽  
Pros And Cons

Vaccines are needed to protect from SARS-CoV-2, the virus causing COVID-19. Vaccines that induce large quantities of high affinity virus-neutralizing antibodies may optimally prevent infection and avoid unfavorable effects. Vaccination trials require precise clinical management, complemented with detailed evaluation of safety and immune responses. Here, we review the pros and cons of available vaccine platforms and options to accelerate vaccine development towards the safe immunization of the world’s population against SARS-CoV-2. Favorable vaccines, used in well-designed vaccination strategies, may be critical for limiting harm and promoting trust and a long-term return to normal public life and economy.

The Study on Preventing Users Electic Larceny

2014 ◽  
Vol 602-605 ◽  
pp. 2939-2942
Author(s):  
Ying Ying Yang ◽  
Yi Shan ◽  
Zhi Tong Liu ◽  
Jian Feng Li ◽  
Jing Jin ◽  
...  
Keyword(s):  
Electric Power ◽  
Power Supply ◽  
Economic Loss ◽  
The Road ◽  
Energy Meter ◽  
Power Means ◽  
Long Time

For a long time,users electic larceny has been a headache topic of the electric power department.The users long-term electic larceny has brought great economic loss to the power supply department.In recent years,the stealing power means are emerging in an endless stream,and they have been broght mant difficulties to prevent electic larceny.But the road is high one feet evil spirite is high one a unit of lengh, according to the study on electic energy meter,we will understand the electic larceny means at the sours.Therefore, further study of stealing power means is also our current priority,only the better anti-stealing electic power means, can be completely blocked leak.

scholarly journals The road to achieving the long-term Paris targets: energy transition and the role of direct air capture

2017 ◽  
Vol 144 (2) ◽  
pp. 181-193 ◽  
Author(s):  
Adriana Marcucci ◽  
Socrates Kypreos ◽  
Evangelos Panos
Keyword(s):  
Energy Transition ◽  
The Road ◽  
Direct Air Capture ◽  
Air Capture

scholarly journals A case study of combined winter road snow plowing and de-icer spreading

2017 ◽  
Vol 44 (12) ◽  
pp. 1005-1013 ◽  
Author(s):  
Olivier Quirion-Blais ◽  
André Langevin ◽  
Martin Trépanier
Keyword(s):  
Neighborhood Search ◽  
Problem Analysis ◽  
Winter Maintenance ◽  
The Road ◽  
Snow Plowing ◽  
Winter Road ◽  
Turn Restrictions ◽  
Maintenance Problem

In this article, we address a winter maintenance problem where the streets need to be plowed and gritted in a sequence that depends on the class of the road. The maintenance fleet includes vehicles equipped for plowing, some for spreading, and some for both at once. The objective is to complete the operations as rapidly as possible while considering street hierarchy, turn restrictions, heterogeneous speeds, and street–vehicle compatibility. An adaptive large neighborhood search framework is developed to solve the problem. Analysis of the results obtained can provide both a good basis for vehicle routing and help managers plan long-term policies and investments.

scholarly journals The effects of electronic games on the behaviors of students in elementary stages، their social states and their academic achievements

2019 ◽  
Vol 3 (13) ◽  
Author(s):  
Abdul Rahman Saad Al-Shihri
Keyword(s):  
Real Life ◽  
Modern Technology ◽  
Aggressive Child ◽  
Creative Solutions ◽  
High Knowledge ◽  
Practical Reality ◽  
Personal Level ◽  
Electronic Games ◽  
Two Sides

    The most interesting in electronic games by children let psychologists and experts to study these games and their impact on their users from different perspectives. It has two sides of effects. They have positive aspects that appear in many aspects of the child's life. Besides the education that the child acquires through increasing the concepts، information and skills development، they develop intelligence and speed of thinking. Many games contain puzzles and need mental skills to solve them. On the planning and initiative، and saturation of the imagination of the child in an unprecedented manner، and increase its activity and vitality، and become a high knowledge of modern technology، and good to deal with and use and dedicated to his benefit. It also encourages children to devise creative solutions to adapt to and adapt to the conditions of the game، and extend their impact to the practical reality; it enables him to apply some of the skills he gained through playing on the ground in real life. But on the personal level it develops the child's violence and the sense of crime because the large proportion of these games depends on the child's amusement and enjoyment of killing others، and teach adolescents methods and methods of committing the crime and tricks، As they develop in their minds violence and aggression through the frequent exercise of such games، the result is a violent and aggressive child. These games also make the child live in isolation from others، and the ultimate goal is to satisfy his desires to play. Thus، the child's self-centered personality، self-love and introversion are formed and affected the communities that are widespread. The rate of murder and theft has increased As well as moral crimes، and these games have also been shown to affect the general health of the child in the long term; it leads to the injury of many health diseases and mental disorders، and playing for long periods of the child has the behavior of alcoholism Aloswasi.    

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