Distinct blue print to restraint neglected tropical diseases

2016 ◽  
Vol 5 (09) ◽  
pp. 4829
Author(s):  
Bhagwati K. Gauni Mehariya* ◽  
Krunal R. Mehariya

Since few decades many developing countries are bearing the strain of Neglected Tropical Diseases (NTDs) and they are the most common infections of the World’s poorest people living in Africa, Asia and Americas. Till date, neglected tropical diseases imitate a group of conditions whose cluster level is obtained from deficiency of efforts directed to their declination. Global efforts have been done to control thirteen parasitic and bacterial infections that affect more than 1.4 billion people. The global usage of drug therapies for reducing the severity of NTDs was introduced few years ago. This singular approach should be elaborate to more extensive set of tools like coordinated community-based programs, vector control, local training, education and environmental change. In more, accelerated schedule is crucially needed to establish adequate diagnostic, preventive and therapeutic interventions to stay one step ahead of the evolutionary adaptation system of disease-causing microorganisms and parasites [1] [2].

2020 ◽  
Vol 21 (12) ◽  
pp. 1250-1263
Author(s):  
Saurabh Shrivastava ◽  
Anshita Gupta ◽  
Chanchal Deep Kaur

Background: Lymphatic filariasis is a pervasive and life-threatening disease for human beings. Currently, 893 million people in 49 countries worldwide affected by lymphatic filariasis as per WHO statistics. The concealed aspects of lymphatic diseases such as delayed disease detection, inappropriate disease imaging, the geographical outbreak of infection, and lack of preventive chemotherapy have brought this epidemic to the edge of Neglected Tropical Diseases. Many medications and natural bioactive substances have seen to promote filaricidal activity against the target parasitic species. However, the majority of failures have occurred in pharmaceutical and pharmacokinetic issues. Objective: The purpose of the study is to focus on the challenges and therapeutic issues in the treatment of filariasis. The review brings novel techniques and therapeutic approaches for combating lymphatic filariasis. It also offers significant developments and opportunities for such therapeutic interventions. Conclusion: Through this review, an attempt has made to critically evaluate the avenues of innovative pharmaceuticals and molecular targeting approaches to bring an integrated solution to combat lymphatic filariasis.


2021 ◽  
Vol 15 (5) ◽  
pp. e0009353
Author(s):  
Jeanne Salje ◽  
Thomas Weitzel ◽  
Paul N. Newton ◽  
George M. Varghese ◽  
Nicholas Day

Rickettsial diseases are a group of vector-borne bacterial infections that cause acute febrile illness with potentially severe or fatal complications. These vector-borne diseases are prevalent in tropical and subtropical regions worldwide and disproportionately affect poorer communities but are scientifically underrecognized. Despite this, they are not included in the World Health Organization’s list of neglected tropical diseases nor were they mentioned in Peter Hotez’s recent reflections on “What constitutes a neglected tropical disease?” in PLOS Neglected Tropical Diseases [1]. Here we present the case that rickettsial infections, as an overlooked cause of morbidity, mortality, and economic losses in marginalized populations, should be recognized as neglected tropical diseases. We describe how this oversight is the result of a number of factors and how it negatively impacts patient outcomes. We then propose measures to address the neglect of rickettsial infections in both scientific research and public health interventions.


2020 ◽  
Vol 114 (10) ◽  
pp. 730-732
Author(s):  
Seid Getahun Abdela ◽  
Johan van Griensven ◽  
Fikre Seife ◽  
Wendemagegn Enbiale

Abstract Countries around the world are facing an enormous challenge due to the COVID-19 pandemic. The pressure that the pandemic inflicts on health systems could certainly impact on the care, control, and elimination of neglected tropical diseases (NTDs). From mid-January 2020, Ethiopia started to prepare for the prevention and treatment of COVID-19. The Federal Ministry of Health pledged to continue essential healthcare, including NTD care, during this pandemic. However, some hospitals have been closed for other healthcare services and have been turned into isolation and treatment centers for COVID-19. In addition to the healthcare facility measures, all community-based health promotion and disease prevention services have been stopped. The current shift in attention towards COVID-19 is expected to have a negative impact on NTD prevention and care.


2016 ◽  
Vol 15 ◽  
pp. 43-55 ◽  
Author(s):  
Saturnino Luz ◽  
Masood Masoodian ◽  
Raquel Rangel Cesario ◽  
Manuel Cesario

2020 ◽  
Author(s):  
Cristhian David Morales-Plaza

Guarantee better clinical practices among clinicians who attend NTDs in developing countries as well as provide education in vector control in hotspot vulnerable communities


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