Multiple Sclerosis and Schizophrenia: A Case Report

1972 ◽  
Vol 3 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Marc H. Hollender ◽  
Philip P. Steckler
Keyword(s):  
Multiple Sclerosis ◽  
Psychiatric Disorder ◽  
Central Nervous System Disease ◽  
Dramatic Improvement ◽  
Healthy Children ◽  
System Disease ◽  
Essential Questions ◽  
Sodium Amobarbital ◽  
Relationship Of ◽  
The Relationship

In the borderland between psychiatry and neurology the clinician occasionally encounters patients with diseases which challenge diagnostic skills and treatment methods. A case is presented in which the coexistence of multiple sclerosis and schizophrenia raises essential questions about the relationship of mind and brain. A young woman with multiple sclerosis developed a clinical picture of schizophrenia in the initial stages of her disease. During sodium amobarbital interviews the patient's mental functioning cleared temporarily, although tranquilizers failed to control disruptive behavior. Electroconvulsive therapy was administered with dramatic improvement of her psychiatric disorder and no worsening of her neurological disease. In the seven years since recovery she has married and raised two healthy children without recurrence of either neurological or psychiatric disorder. While no cause-and-effect relationship can be defined, such cases emphasize the need for further studies of the relationship of central nervous system disease to psychiatric disorder.

scholarly journals Traveled Distance Is a Sensitive and Accurate Marker of Motor Dysfunction in a Mouse Model of Multiple Sclerosis

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Takako Takemiya ◽  
Chisen Takeuchi
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System Disease ◽  
Motor Dysfunction ◽  
Coefficient Of Determination ◽  
Autoimmune Encephalomyelitis ◽  
System Disease ◽  
The Relationship ◽  
Early Phases ◽  
Sensitive Marker ◽  
Experimental Autoimmune

Multiple sclerosis (MS) is a common central nervous system disease associated with progressive physical impairment. To study the mechanisms of the disease, we used experimental autoimmune encephalomyelitis (EAE), an animal model of MS. EAE is induced by myelin oligodendrocyte glycoprotein35–55 peptide, and the severity of paralysis in the disease is generally measured using the EAE score. Here, we compared EAE scores and traveled distance using the open-field test for an assessment of EAE progression. EAE scores were obtained with a 6-step observational scoring system for paralysis, and the traveled distance was obtained by automatic trajectory analysis of natural exploratory behaviors detected by a computer. The traveled distance of the EAE mice started to decrease significantly at day 7 of the EAE process, when the EAE score still did not reflect a change. Moreover, in the relationship between the traveled distance and paralysis as measured by the EAE score after day 14, there was a high coefficient of determination between the distance and the score. The results suggest that traveled distance is a sensitive marker of motor dysfunction in the early phases of EAE progression and that it reflects the degree of motor dysfunction after the onset of paralysis in EAE.

scholarly journals Supplementation and therapeutic use of vitamin D in patients with multiple sclerosis: Consensus of the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology

2014 ◽  
Vol 72 (2) ◽  
pp. 152-156 ◽  
Author(s):  
Doralina Guimarães Brum ◽  
Elizabeth Regina Comini-Frota ◽  
Claúdia Cristina F. Vasconcelos ◽  
Elza Dias-Tosta
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trial ◽  
Vitamin D ◽  
Environmental Factors ◽  
Scientific Evidence ◽  
Hypovitaminosis D ◽  
Central Nervous System Disease ◽  
Keywords Multiple Sclerosis ◽  
System Disease ◽  
Genetic And Environmental Factors

Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating, and degenerative central nervous system disease. Even though the etiology of MS has not yet been fully elucidated, there is evidence that genetic and environmental factors interact to cause the disease. Among the main environmental factors studied, those more likely associated with MS include certain viruses, smoking, and hypovitaminosis D. This review aimed to determine whether there is evidence to recommend the use of vitamin D as monotherapy or as adjunct therapy in patients with MS. We searched PUBMED, EMBASE, COCHRANNE, and LILACS databases for studies published until September 9 th , 2013, using the keywords “multiple sclerosis”, “vitamin D”, and “clinical trial”. There is no scientific evidence up to the production of this consensus for the use of vitamin D as monotherapy for MS in clinical practice.

Еarly diagnosis of multiple sclerosis: experience with the use of class G oligoclonal immunoglobulin

2021 ◽  
Vol 26 (3) ◽  
pp. 34-39
Author(s):  
Z. A. Goncharova ◽  
Y. Y. Pogrebnova ◽  
N. M. Yarosh ◽  
S. M.M. Sehweil
Keyword(s):  
Multiple Sclerosis ◽  
Early Diagnosis ◽  
Literature Review ◽  
Demyelinating Disease ◽  
Mcdonald Criteria ◽  
Mri Features ◽  
Oligoclonal Igg ◽  
Relationship Of ◽  
The Relationship

The article presents the literature review and our experience in early diagnosis of multiple sclerosis based on the updated McDonald criteria of 2017. The study included 256 patients with clinic symptoms of probable idiopathic infl ammatory demyelinating disease, including rare and atypical forms of demyelination. As a result of the study the sensitivity and specifi city of the determination of oligoclonal immunoglobulin G in the population of Rostov-on-Don was described for the fi rst time, including dependence of the duration of the disease. The relationship of clinical and MRI features of the fi rst attack of the disease with the probability of determining oligoclonal IgG in the cerebrospinal fl uid is refl ected

scholarly journals Multiple Sclerosis in French Canadians: Evidence for HLA Class II Susceptibility and Resistance Genes

1990 ◽  
Vol 17 (4) ◽  
pp. 382-386 ◽  
Author(s):  
D.G. Haegert ◽  
M. Michaud ◽  
G.S. Francis
Keyword(s):  
Multiple Sclerosis ◽  
Resistance Genes ◽  
Rflp Analysis ◽  
Class Ii ◽  
Hla Class Ii ◽  
Extended Haplotype ◽  
Allele Specific ◽  
Relationship Of ◽  
The Relationship ◽  
Susceptibility And Resistance

ABSTRACT:HLA class II DRBI, DQB1 and DQA1 gene probes were used to study DNA from unrelated French Canadian multiple sclerosis (MS) patients and controls by restriction fragment length polymorphism (RFLP) analysis. An MS-associated and linked series of allele-specific RFLPs or allogenotypes was identified among this relatively homogeneous ethnic group; the allogenotypes include DRwl5, DQw6 and a DQA1 allogenotype termed DQαlb. An additional allogenotype which cross-hybridizes with DQA1 and is termed DQA2 upper (DQA2U), was shown not only to be part of the MS-associated extended haplotype, but also to be independently associated with MS in DRwl5-negative patients. Conversely a second DQA2 allogenotype, termed DQA2 lower (DQA2L) and a DQB1 allogenotype (DQw7) linked to DQA2L showed negative correlations with MS. It seems likely that the relationship of the HLA class II gene region to MS is complex and that MS susceptibility may reflect interaction between disease susceptibility and resistance genes.

Relationship of cognitive impairment to psychiatric symptoms in multiple sclerosis

2008 ◽  
Vol 14 (8) ◽  
pp. 1084-1090 ◽  
Author(s):  
N Figved ◽  
R Benedict ◽  
G Klevan ◽  
KM Myhr ◽  
HI Nyland ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Verbal Memory ◽  
Psychiatric Symptoms ◽  
Cognitive Tests ◽  
Cognitive Changes ◽  
Impaired Performance ◽  
Impaired Memory ◽  
Healthy Control ◽  
Relationship Of ◽  
The Relationship

Psychiatric and cognitive changes are common in patients with multiple sclerosis (MS), but their relationship has not received much attention. We studied the relationship between psychiatric symptoms and verbal memory, working memory, and mental speed in 78 patients with MS and 40 healthy control subjects using linear regression analyses. The MS group exhibited impaired performance on all cognitive tests. Apathy was associated with intrusions and depression with impaired memory and mental speed. The association between apathy and intrusions supports the hypothesis that lesions in frontal areas or frontal connections contribute to a specific neuropsychiatric syndrome in patients with MS.

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