scholarly journals Qualitative Evidence Synthesis on Self-Collection for Human Papillomavirus–Based Cervical Screening: Protocol for Systematic Review

10.2196/21093 ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. e21093
Author(s):  
Hawa Camara ◽  
Ye Zhang ◽  
Lise Lafferty ◽  
Andrew Vallely ◽  
Rebecca Guy ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Evidence Synthesis ◽  
Cervical Screening ◽  
Screening Method ◽  
The Self ◽  
Synthesis Process ◽  
Qualitative Evidence Synthesis ◽  
Screening Programs ◽  
Qualitative Evidence

Background Cervical cancer is the fourth most common cancer affecting women worldwide. In the 1980s, it was found that the sexually transmitted disease human papillomavirus causes over 90% of all cervical cancer cases. Since that discovery, diagnostic technologies have been developed for the detection of human papillomavirus DNA in cervical samples. However, significant sociocultural and structural barriers remain. Considerable strides have taken place in recent years to address these barriers, such as the self-collection for human papillomavirus–based cervical screening method. Objective The purpose of this review is to synthesize qualitative evidence around the self-collection method and identify strategies to increase acceptability and feasibility in different settings. This qualitative synthesis will be used to better understand how to conceptualize and implement more effective, accessible, and socially and culturally acceptable cervical screening programs and policies globally. Methods A systematic search will be conducted in Global Health, Cochrane, CINAHL (Cumulative Index to Nursing and Allied Health Literature), ProQuest, ScienceDirect, EMBASE, EMCARE, Medline (OVID), Scopus, and Web of Science. Published and peer-reviewed articles will be included. Two reviewers will independently screen and assess the studies. The data will be coded and analyzed using a thematic synthesis process. The socioecological model will be used to organize emergent themes at the micro and macro levels. The results will be presented in narrative and tabular form. Results The article search and data extraction were completed in May 2020. The data were analyzed in June 2020. The review will be submitted for publication in Fall 2020. Conclusions This review will present the global evidence of the perspectives and experiences of various key stakeholders and how these perspectives and experiences impact their decision-making process to perform or accept self-collection for human papillomavirus–based cervical screening. The review will provide guidance to implementation researchers as well as implications for future research. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42019109073; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=109073 International Registered Report Identifier (IRRID) DERR1-10.2196/21093

scholarly journals Qualitative Evidence Synthesis on Self-Collection for Human Papillomavirus–Based Cervical Screening: Protocol for Systematic Review (Preprint)

2020 ◽  
Author(s):  
Hawa Camara ◽  
Ye Zhang ◽  
Lise Lafferty ◽  
Andrew Vallely ◽  
Rebecca Guy ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Evidence Synthesis ◽  
Cervical Screening ◽  
Screening Method ◽  
The Self ◽  
Synthesis Process ◽  
Qualitative Evidence Synthesis ◽  
Screening Programs ◽  
Qualitative Evidence

BACKGROUND Cervical cancer is the fourth most common cancer affecting women worldwide. In the 1980s, it was found that the sexually transmitted disease human papillomavirus causes over 90% of all cervical cancer cases. Since that discovery, diagnostic technologies have been developed for the detection of human papillomavirus DNA in cervical samples. However, significant sociocultural and structural barriers remain. Considerable strides have taken place in recent years to address these barriers, such as the self-collection for human papillomavirus–based cervical screening method. OBJECTIVE The purpose of this review is to synthesize qualitative evidence around the self-collection method and identify strategies to increase acceptability and feasibility in different settings. This qualitative synthesis will be used to better understand how to conceptualize and implement more effective, accessible, and socially and culturally acceptable cervical screening programs and policies globally. METHODS A systematic search will be conducted in Global Health, Cochrane, CINAHL (Cumulative Index to Nursing and Allied Health Literature), ProQuest, ScienceDirect, EMBASE, EMCARE, Medline (OVID), Scopus, and Web of Science. Published and peer-reviewed articles will be included. Two reviewers will independently screen and assess the studies. The data will be coded and analyzed using a thematic synthesis process. The socioecological model will be used to organize emergent themes at the micro and macro levels. The results will be presented in narrative and tabular form. RESULTS The article search and data extraction were completed in May 2020. The data were analyzed in June 2020. The review will be submitted for publication in Fall 2020. CONCLUSIONS This review will present the global evidence of the perspectives and experiences of various key stakeholders and how these perspectives and experiences impact their decision-making process to perform or accept self-collection for human papillomavirus–based cervical screening. The review will provide guidance to implementation researchers as well as implications for future research. CLINICALTRIAL PROSPERO International Prospective Register of Systematic Reviews CRD42019109073; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=109073 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/21093

Promising strategies for cervical cancer screening in the post-human papillomavirus vaccination era

Sexual Health ◽  
2010 ◽  
Vol 7 (3) ◽  
pp. 376 ◽  
Author(s):  
Joseph Tota ◽  
Salaheddin M. Mahmud ◽  
Alex Ferenczy ◽  
François Coutlée ◽  
Eduardo L. Franco
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Human Error ◽  
Pap Smear ◽  
Cervical Screening ◽  
Screening Tests ◽  
Hpv Testing ◽  
Human Papillomavirus Vaccination ◽  
Screening Programs

Human papillomavirus (HPV) vaccination is expected to reduce the burden of cervical cancer in most settings; however, it is also expected to interfere with the effectiveness of screening. In the future, maintaining Pap cytology as the primary cervical screening test may become too costly. As the prevalence of cervical dysplasias decreases, the positive predictive value of the Pap test will also decrease, and, as a result, more women will be referred for unnecessary diagnostic procedures and follow-up. HPV DNA testing has recently emerged as the most likely candidate to replace cytology for primary screening. It is less prone to human error and much more sensitive than the Pap smear in detecting high-grade cervical lesions. Incorporating this test would improve the overall quality of screening programs and allow spacing out screening tests, while maintaining safety and lowering costs. Although HPV testing is less specific than Pap cytology, this issue could be resolved by reserving the latter for the more labour-efficient task of triaging HPV-positive cases. Because most HPV-positive smears would contain relevant abnormalities, Pap cytology would be expected to perform with sufficient accuracy under these circumstances. HPV Pap triage would also provide a low-cost strategy to monitor long-term vaccine efficacy. Although demonstration projects could start implementing HPV testing as a population screening tool, more research is needed to determine the optimal age to initiate screening, the role of HPV typing and other markers of disease progression, and appropriate follow-up algorithms for HPV-positive and Pap-negative women.

scholarly journals A pilot study of risk-stratified cervical cancer screening

2021 ◽  
Vol 1 ◽  
pp. 84
Author(s):  
Jiangrong Wang ◽  
K. Miriam Elfström ◽  
Christer Borgfeldt ◽  
Joakim Dillner
Keyword(s):  
Cervical Cancer ◽  
Pilot Study ◽  
Cancer Risk ◽  
Cervical Screening ◽  
Screening Method ◽  
Screening Tests ◽  
Individual Risk ◽  
Horizon 2020 ◽  
Screening Programs

Background: Cervical screening programs target entire populations, although it is well established that cervical cancer risks can vary >100-fold based, in particular, on the woman’s screening history. Since cervical screening switched to Human Papillomavirus (HPV) testing as the primary screening method, the risk differences are even larger as different HPV types may vary in associated cancer risk by 100 times. Furthermore, HPV infections with the most oncogenic types are declining dramatically because of HPV vaccination programs. Tailoring screening intensity based on the known cancer risk of the individual (risk-stratified screening) therefore has great potential to increase both the sensitivity and specificity. Within Horizon 2020 a major project for RIsk-stratified Screening for Cervical Cancer (RISCC) has therefore been launched. We performed a pilot study of risk-stratified screening to evaluate feasibility and acceptability of offering vaginal HPV self-sampling tests to women with a higher risk of cervical cancer. Methods: We identified resident women who had had either i) atypical glandular cells in screening tests during the past six years (risk >150/100,000 woman-years) or ii) abnormal screening findings above the age of 50, but without sufficient follow-up (risk >65/100,000). The women were invited, either by short message service (SMS) or physical letters, to order an HPV self-sampling kit via the study web-platform. The returned self-collected samples were tested for HPV. If positive, women were invited for clinical follow-up. Results: Among 920 targeted women, 191 (21%) placed an order and 163 (18%) returned a self-collected sample. Among all tested samples, 19 (12%) were positive for hrHPV and 18 of these women attended clinical follow-up. Conclusions: We found that SMS invitations to high-risk women are feasible and result in substantial requests for kits and submission of samples. Future work will focus on improving the efficiency of the procedure and further increasing attendance.

Possibilities of the self-sampling method application in the cervical cancer screening (review)

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (3) ◽  
pp. 57-60 ◽  
Author(s):  
I A Apolikhina ◽  
L K Bashirova ◽  
E A Gorbunova
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Screening ◽  
Sampling Method ◽  
Sampling Methods ◽  
The Self ◽  
Technical Aspects ◽  
Screening Programs ◽  
Slow Progression ◽  
Relative Accessibility

It was performed an analysis of literature data on the possibility of using self-sampling methods for the screening of cervical cancer. It is indicated that the slow progression of the disease, the presence of several stages of precancerous conditions and the relative accessibility of the tumor for manipulation provide opportunities for timely diagnosis and prevention of the tumor. It is reported that a number of specialists believe that an independent sampling of material for human papillomavirus analysis can be considered as an alternative method for screening cervical cancer. Using this approach will significantly increase the coverage of the population participating in screening programs. The need for further research on improving the technical aspects and assessing the clinical and economic characteristics of the application of the method of self-sampling of cervical-vaginal material to be separated in clinical and epidemiological practice was noted.

scholarly journals Clinical validation of full genotyping CLART® HPV4S assay on SurePath and ThinPrep collected screening samples according to the International Guidelines for Human Papillomavirus Test Requirements for Cervical Screening

2020 ◽  
Author(s):  
Ditte Møller Ejegod ◽  
Camilla Lagheden ◽  
Ramya Bhatia ◽  
Helle Pedersen ◽  
Elia Alcañiz Boada ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Cervical Screening ◽  
Screening Methods ◽  
International Guidelines ◽  
Screening Programs ◽  
Test Requirements

Abstract Background To ensure the highest quality of human papillomavirus (HPV) testing in primary cervical cancer screening, novel HPV assays must be evaluated in accordance with the international guidelines. Furthermore, HPV assay with genotyping capabilities are becoming increasingly important in triage of HPV positive women in primary HPV screening. Here we evaluate a full genotyping HPV assay intended for primary screening. Methods The CLART® HPV4S (CLART4S) assay is a newly developed full-genotyping assay detecting 14 oncogenic (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68) and two non-oncogenic HPV genotypes (6, 11). It was evaluated using SurePath and ThinPrep screening samples collected from the Danish and Swedish cervical cancer screening programs, respectively. For calculation of sensitivity, 81 SurePath and 80 ThinPrep samples with confirmed ≥CIN2 were assessed. For clinical specificity analysis, 1,184 SurePath and 1,169 ThinPrep samples from women with

scholarly journals Cervical pap smear study and its utility in cervical cancer detection and prevention

2021 ◽  
Vol 8 (4) ◽  
pp. 470-475
Author(s):  
Boinapalli Sudhakar ◽  
Vijaya Karra ◽  
Pamu Shiva Ramulu
Keyword(s):  
Cervical Cancer ◽  
Early Identification ◽  
Pap Smear ◽  
Precancerous Lesions ◽  
Cervical Screening ◽  
Screening Method ◽  
Pap Smear Test ◽  
Screening Programs ◽  
Cervical Cancers ◽  
Smear Test

The objective of present study to find out women for precancerous lesions with the help of pap smear test as early identification marker. Determine the percentage of cervical cancer in relationship with demographic, education and occupation. To find out pap smear effectiveness in various infections. To find out correlation pap smear findings with symptoms.This is a cross-sectional study involving the screening of women from the rural population of Siddipet district for the assessment of health status using pap smear test who have attended the outpatient department of Obstetrics and Gynecology conducted during the period of August 2019 to May 2021. The present study included 1500 Pap smears, of which the most common abnormality was inflammatory smear, which is followed by atrophic smear. Among all the study respondent’s majority (64.5%) of the women were home makers and not working, remaining participants were either self employed or working women. Percentage of abnormal smear reports was reported in group 2 (31-40 years) subjects followed by group 3 (41-50 years) women. In 22 patients, Atypical Squamous Cell of Undetermined Significance (ASCUS) was observed. The present study reported very less cervical cancer prevalence in our study population.Pap smear testing is a sensitive and effective screening test which can be used for identification of precancerous epithelial lesions. Pap smear test should be recognized as a routine screening method to decrease Mortality and Morbidity due to the cervical cancer. This study also regard us as paps smear is a gold standard for cervical screening. This study also suggests that every woman above the age 30 years should undergo screening programs for cervical cancers. So Morbidity and Mortality due to cervical cancers can be prevented by early identification of cervical cancer by doing screening at regular intervals.

Human Papillomavirus Selected Properties and Related Cervical Cancer Prevention Issues

2020 ◽  
Vol 26 (18) ◽  
pp. 2073-2086
Author(s):  
Saule Balmagambetova ◽  
Andrea Tinelli ◽  
Ospan A. Mynbaev ◽  
Arip Koyshybaev ◽  
Olzhas Urazayev ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Prevention ◽  
Screening Program ◽  
Hpv Infection ◽  
Cervical Cancer Prevention ◽  
Point Of View ◽  
Prevention Strategies ◽  
Middle Income ◽  
Screening Programs

High-risk human papillomavirus strains are widely known to be the causative agents responsible for cervical cancer development. Aggregated damage caused by papillomaviruses solely is estimated in at least 5% of all malignancies of the human body and 16% in cancers that affect the female genital area. Enhanced understanding of the complex issue on how the high extent of carcinogenicity is eventually formed due to the infection by the Papoviridae family would contribute to enhancing current prevention strategies not only towards cervical cancer, but also other HPV associated cancers. This review article is aimed at presenting the key points in two directions: the current cervical cancer prevention and related aspects of HPV behavior. Virtually all applied technologies related to HPV diagnostics and screening programs, such as HPV tests, colposcopy-based tests (VIA/VILI), conventional and liquid-based cytology, currently available are presented. Issues of availability, advantages, and drawbacks of the screening programs, as well as vaccination strategies, are also reviewed in the article based on the analyzed sources. The current point of view regarding HPV is discussed with emphasis on the most problematic aspect of the HPV family concerning the observed increasing number of highly carcinogenic types. Present trends in HPV infection diagnostics throughout the human fluids and tissues are also reported, including the latest novelties in this field, such as HPV assay/self-sample device combinations. Besides, a brief outline of the related prevention issues in Kazakhstan, the leading country of Central Asia, is presented. Kazakhstan, as one of the post-soviet middle-income countries, may serve as an example of the current situation in those terrains, concerning the implementation of globally accepted cervical cancer prevention strategies. Along with positive achievements, such as the development of a nationwide screening program, a range of drawbacks is also analyzed and discussed.

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