Human Papillomavirus Infection and Transmission Among Couples Through Heterosexual Activity (HITCH) Cohort Study: Protocol Describing Design, Methods, and Research Goals (Preprint)

BACKGROUND Human papillomavirus (HPV) epidemiological research has generally been individual based, typically focusing on women, with couple-based research mostly consisting of cross-sectional assessment of prevalent HPV infection in both partners. OBJECTIVE The HPV Infection and Transmission among Couples through Heterosexual activity (HITCH) study was set up to investigate the transmissibility of HPV among young, recently formed couples in Montreal, Canada. This paper provides an overview of the HITCH cohort study design and procedures as well as a narrative summary of the most important findings. METHODS HITCH is a longitudinal investigation of HPV transmission in recently formed heterosexual partnerships initiated within 6-month pre-enrollment, a time at which considerable transmission is believed to occur. A total of 549 newly formed dyads were recruited (2005-2011) from postsecondary institutions, including 502 young women and their male partners. An additional 46 males were enrolled at follow-up, as some women enrolled a subsequent partner at follow-up. Women aged 18-24 years were followed for 24 months for acquisition of HPV types not present at enrollment, whereas men returned for a single follow-up visit at month 4, for a sum total of 3361 clinic visits. The last follow-up visit occurred in January 2014. Extensive sociodemographic, sexual behavioral, and medical history data were collected every 2-4 months using computer-assisted, self-administered questionnaires. Furthermore, participants provided genital, blood, oral, and hand specimens for HPV assessment. RESULTS Although in its early analysis stage, HITCH has produced important publications. Findings from HITCH have increased the available knowledge about the natural history of HPV transmission and its determinants, provided further evidence regarding oral-oral and oral-genital routes of HPV transmission, and supplied empirically valid epidemiological parameters of HPV transmission to assist mathematical modelers in health economic assessments. In addition, HITCH data were made available to several multistudy collaborations evaluating new HPV detection assays and evidence for-or-against HPV type replacement following the introduction of HPV vaccination. CONCLUSIONS HITCH will continue to offer a unique resource for research on HPV transmission. INTERNATIONAL REGISTERED REPOR RR1-10.2196/11284

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Human Papillomavirus Infection and Prevention In The Adolescent

10.2310/obg.19119 ◽

2020 ◽

Author(s):

Alexandria Richards ◽

Joanna Stacey

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccination ◽

Transmitted Disease ◽

Cervical Dysplasia ◽

Vaccine Safety ◽

Genital Warts ◽

Hpv Infection ◽

Sexually Transmitted ◽

Papillomavirus Infection

Human papillomavirus, or HPV, is a common sexually transmitted disease, most often acquired during the adolescence or the early 20s. It can be divided into oncogenic and nononcogenic serotypes. It is responsible for genital warts as well as pathologic diseases that can lead to genital cancers and cancers of the oropharyngeal tract in both males and females. The majority of adolescents who acquire HPV infections do not go on to develop cancer. New discoveries about the virus’ persistence and latency direct how we treat adolescents with HPV infections. Recommendations for prevention of HPV include use of the 9-valent vaccine against the most common oncogenic HPV serotypes. Screening should be delayed until the age of 21, with the exception of immunocompromised women. The HPV vaccination is safe and effective, and does not encourage sexual activity among adolescents. Both boys and girls should be vaccinated against HPV at 11 to 12 years of age but may receive the vaccination as early as 9 or as late as 21 (males) or 26 (females) years of age. The vaccine may now also be given in only two doses if the series was started before the age of 15. Follow-up studies in the years after the vaccine’s introduction have shown large decreases in HPV infection rates. This review contains 7 figures, 7 tables and 63 references Key Words: Oncogenic subtype, Oropharyngeal cancer, Infection persistence, Immune tolerance, Cervical dysplasia, Genital warts, 9-valent vaccine, Vaccine safety

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Human papillomavirus vaccination coverage among working women

Asian Journal of Medical and Biological Research ◽

10.3329/ajmbr.v6i4.51238 ◽

2021 ◽

Vol 6 (4) ◽

pp. 714-722

Author(s):

Sajeda Khatun ◽

Ashees Kumar Saha ◽

Irtiza Ahmed Chowdhury ◽

Arifa Sultana ◽

Mst Wazeda Begum ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Vaccination Coverage ◽

Hpv Vaccination ◽

Working Women ◽

Hpv Infection ◽

Cross Sectional Study ◽

P Value ◽

Human Papillomavirus Vaccination ◽

Cross Sectional

Human papillomavirus (HPV) infection is one of the causes of cervical cancer which is preventable. The study was a cross-sectional study with the objective was to determine the Human papillomavirus (HPV) vaccination coverage among working women. A total 236 educated working women were selected purposively from different working places in Dhaka city. A pretested semi- structured questionnaire was used for data collection. The knowledge was assessed by using modified Blooms cut off points which was developed with cervical cancer and vaccine knowledge related questions. The study result revealed that among 236 working women 71.2% knew about the risk factor of cervical cancer. It was found that 92.8% knew about the way of prevention of cervical cancer respectively. The overall knowledge on cervical cancer and vaccine was found to be having good knowledge 21.2%, satisfactory knowledge 41.9% and poor knowledge 36.9%. Out of the total working women only 5.1% had HPV vaccination coverage. Reason behind non vaccinations, 50% mentioned had no knowledge about vaccine, 35.3% mentioned can’t decide and 8.9% mentioned high cost of vaccine. Significant association has been observed in between vaccination coverage with over all knowledge of cervical cancer (p value .04). It may be concluded that HPV vaccination coverage is very low which needs awareness program on this issues through mass media, educational session, counseling and so on to reduce human papillomavirus associated cancers as well as economic burden. Asian J. Med. Biol. Res. December 2020, 6(4): 714-722

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Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination

Vaccines ◽

10.3390/vaccines8030425 ◽

2020 ◽

Vol 8 (3) ◽

pp. 425

Author(s):

Masayuki Sekine ◽

Manako Yamaguchi ◽

Risa Kudo ◽

Sharon J. B. Hanley ◽

Megumi Hara ◽

...

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccination ◽

Pap Test ◽

Hpv Infection ◽

Infection Rates ◽

Human Papillomavirus Vaccination ◽

Papillomavirus Infection ◽

Vaccination Recommendation ◽

Epidemiologic Profile ◽

The Government

Organized human papillomavirus vaccination (OHPV) in Japan was introduced in 2010 for girls aged 12–16 years who were born in 1994 or later. The rate of OHPV coverage was 70–80%. However, after suspension of the government vaccination recommendation, the coverage dramatically decreased. We aim to investigate the change in prevalence of HPV infection after the initiation of HPV vaccination. We recruited females aged 20–21 years attending public cervical cancer screening from 2014 to 2017 fiscal years (April 2014 to March 2018). Residual Pap test specimens were collected for HPV testing. We compared the prevalence of HPV type-specific infection between women registered in 2014 (born in 1993–1994, including the pre-OHPV generation) and registered in 2015–2017 (born in 1994–1997, the OHPV generation). We collected 2379 specimens. The vaccination coverage figures were 30.7%, 86.6%, 88.4% and 93.7% (p < 0.01) from 2014 to 2017, respectively. The prevalence of HPV16/18 infection significantly decreased from 1.3% in 2014 to 0% in 2017 (p = 0.02). The three most prevalent types were HPV52, 16 and 56 in 2014, and HPV52, 58 and 56 in 2015–2017, respectively. HPV16 and 33 infection rates decreased. On the other hand, the HPV58 infection rate was obviously increased after OHPV from 0.3% to 2.1%. Our study demonstrates that the prevalence of HPV16/18 infection dramatically decreased and the profile of type-specific HPV infection was changed after OHPV.

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Is stress related to the presence and persistence of oncogenic human papillomavirus infection in young women?

BMC Cancer ◽

10.1186/s12885-021-08010-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ulrike Kuebler ◽

Susanne Fischer ◽

Laura Mernone ◽

Christian Breymann ◽

Elvira Abbruzzese ◽

...

Keyword(s):

Human Papillomavirus ◽

Chronic Stress ◽

Salivary Cortisol ◽

Positive Association ◽

Hpv Infection ◽

Cortisol Awakening Response ◽

Diurnal Cortisol ◽

Papillomavirus Infection ◽

Hpv Status

Abstract Background Persistent infection with high-risk human papillomavirus (HR-HPV) is the most important risk factor for the development of cervical cancer, but factors contributing to HR-HPV persistence are incompletely understood. The objective of this study was to test for associations of chronic stress and two aspects of diurnal cortisol secretion (i.e., the cortisol awakening response [CAR] and total cortisol output over the day [AUCgday]) with HR-HPV status at baseline and 12 months later (follow-up). Methods We evaluated 188 women (25 ± 3 years) at baseline. Follow-up investigation was restricted to HR-HPV infected women at baseline. Of the initial 48 HR-HPV positive participants, 42 completed the follow-up (16 HR-HPV positive and 26 HR-HPV negative). At baseline and follow-up, we determined HR-HPV status in cervical smears, assessed chronic stress, and repeatedly measured salivary cortisol over the day. At baseline, we analyzed salivary cortisol only in a subgroup of 90 participants (45 HR-HPV negative and 45 HR-HPV positive). Results At baseline, higher chronic stress (excessive demands at work: p = .022, chronic worrying: p = .032), and a higher CAR (p = .014) were related to baseline HR-HPV positivity. At follow-up, there was a statistical trend for a positive association between the CAR and HR-HPV positivity (p = .062). Neither the CAR nor the AUCgday mediated the associations between chronic stress and HR-HPV status. Conclusions Our findings suggest that both chronic stress and diurnal cortisol are related to the presence of HR-HPV infection and may thus play a role in HPV-associated cervical carcinogenesis.

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Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan

Scientific Reports ◽

10.1038/s41598-021-98720-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Daisuke Shiojiri ◽

Daisuke Mizushima ◽

Misao Takano ◽

Koji Watanabe ◽

Naokatsu Ando ◽

...

Keyword(s):

Human Papillomavirus ◽

Hiv Infection ◽

Hpv Vaccination ◽

Epidemiological Data ◽

Hpv Infection ◽

Exclusion Criterion ◽

Abnormal Cytology ◽

Papillomavirus Infection ◽

Hpv Genotypes ◽

History Of

AbstractAnal high-risk human papillomavirus (hr-HPV) infection is widely considered a cause of anal cancer. However, epidemiological data are quite limited in Japan. This study investigated anal HPV infections and cytological abnormalities among MSM with or without HIV infection. Anal swabs were obtained, and cytological results were examined. Hybrid capture-based methodology was used for hr-HPV genotyping. The exclusion criterion was a history of vaccination against HPV. 644 subjects participated, and the overall prevalence of hr-HPV was 59.7% (95% CI 54.7–62.3), HIV-infected had higher prevalence than HIV-uninfected (68.9% vs 40.6%) p < .001. Among hr-HPV-infected participants, 82.8% (312/377) were infected with at least one of 9 valent vaccine-covered hr-HPV genotypes. From regression analysis, detection of abnormal cytology correlated positively with HIV infection (OR 2.17 [95% CI 1.51–3.13]), number of hr-HPV genotypes infected (OR 1.83 [1.59–2.10]), history of STI (OR 1.58 [1.14–2.22]) and No. of lifetime sexual partners (OR 1.56 [1.10–2.21]), albeit multivariate analysis identified the number of detected hr-HPV genotypes (adjusted OR 1.78 [1.54–2.06]) as the independent risk factor for abnormal cytology. High rates of anal hr-HPV infection, especially 9-valent HPV vaccine-preventable hr-HPV were detected among our MSM participants in Japan. HPV vaccination should also be encouraged for MSM in Japan.

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YouTube™ videos related to human papillomavirus: the need for professional communication

International Journal of Adolescent Medicine and Health ◽

10.1515/ijamh-2015-0122 ◽

2016 ◽

Vol 30 (1) ◽

Cited By ~ 18

Author(s):

Corey H. Basch ◽

Grace Clarke Hillyer ◽

Alyssa Berdnik ◽

Charles E. Basch

Keyword(s):

Human Papillomavirus ◽

Public Awareness ◽

Hpv Vaccination ◽

Hpv Infection ◽

Cross Sectional Study ◽

General Information ◽

Professional Communication ◽

Cross Sectional ◽

Search Terms ◽

Health Related

Abstract YouTube™ is a frequently visited website that contains a large and diverse collection of health-related videos. The aim of this study was to identify the most popular videos on YouTube™.com related to human papillomavirus (HPV) and describe their content. This cross-sectional study involved using the search terms “HPV” and “human papillomavirus” to determine a purposive sample composed of an equal number of the most popular “professional” (n=35) and “consumer” (n=35) videos identified. Video content was analyzed and those videos related to HPV vaccination in any way were analyzed further to denote the nature of the message. The majority of videos (81.4%) provided general information related to HPV, discussed the association of HPV infection and the development of cancer (81.4%), and addressed HPV screening (64.3%). Just under one-half (n=34) of the videos addressed vaccination. Fifteen of these were neutral, while six were encouraging and 13 were discouraging. The videos included in this study were viewed ~17 million times, which indicates their potential for influencing public awareness and opinions. Of the videos devoted to HPV vaccination, few were encouraging. These videos may impede efforts to increase rates of HPV vaccination, which are already far below target levels.

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Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort

BMJ Open ◽

10.1136/bmjopen-2020-046928 ◽

2021 ◽

Vol 11 (6) ◽

pp. e046928

Author(s):

Lisa M Jamieson ◽

Gail Garvey ◽

Joanne Hedges ◽

Cathy Leane ◽

Isaac Hill ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

Hpv Vaccination ◽

Hpv Infection ◽

Indigenous Australians ◽

Health State ◽

Hpv 16 ◽

Oral Hpv ◽

Hpv Types

PurposeOur aims are to: (1) estimate prevalence, incidence, clearance and persistence of oral human papillomavirus (HPV) infection among Indigenous Australians; (2) identify risk factors associated with oropharyngeal squamous cell carcinoma (OPSCC)-related HPV types (HPV 16 or 18); (3) develop HPV-related health state valuations and; (4) determine the impact on OPSCC and cervical cancers, and the cost-effectiveness of extending publicly-funded HPV vaccination among Indigenous Australians.ParticipantsParticipants were recruited from February 2018 to January 2019. Twelve-month follow-up occurred from March 2019 to March 2020. Participants provided socio-demographic characteristics, health-related behaviours including tobacco and alcohol use and sexual history. Health state preferences in regard to HPV vaccination, knowledge regarding HPV infection, OPSCC and cervical cancer were collected using a two-stage standard gamble approach. Participants provided saliva samples and DNA for microbial genotyping was extracted.Findings to dateOf the 910 participants who were positive for β-globin at baseline, 35% had any oral HPV infection. The most prevalent HPV types were 13 or 32 (Heck’s disease; 23%). The second most prevalent types were associated with OPSCC (HPV 16 or 18; 3.3%). Of the 645 participants who were positive for β-globin at 12-month follow-up, 43% had any HPV infection. Of these, 33% were HPV types 13 or 32 and 2.5% were HPV 16 or 18. Some 588 participants had β-globin positive oral samples at baseline and 12-month follow-up. The prevalence of any oral HPV infection increased from 34% at baseline to 44% at 12-month follow-up; due to increases in HPV types 13 or 32 (20% at baseline and 34% at 12-month follow-up).Future plansFurther funding will be sought to continue follow-up of this cohort, and to include (after a full medical history) a thorough clinical examination of the external head and neck; a complete oral examination and examination of the oropharynx. Blood tests for early stage OPSCC will also be undertaken.

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Human papillomavirus infection and disease in men: Impact of HIV

Southern African Journal of HIV Medicine ◽

10.4102/sajhivmed.v14i4.55 ◽

2013 ◽

Vol 14 (4) ◽

pp. 183-188 ◽

Cited By ~ 4

Author(s):

Sinead Delany-Moretlwe ◽

A Chikandiwa ◽

J Gibbs

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccination ◽

Hpv Infection ◽

Sub Saharan Africa ◽

Anogenital Warts ◽

African Countries ◽

Hpv Prevalence ◽

Papillomavirus Infection ◽

Significant Burden ◽

Sub Saharan

There is growing evidence of a significant burden of human papillomavirus (HPV) infection and associated disease in men. High rates of HPV infection have been observed in men from sub-Saharan Africa where HIV prevalence is high. HIV infection increases HPV prevalence, incidence and persistence and is strongly associated with the development of anogenital warts and anal, penile and head and neck cancers in men. Despite increasing access to antiretroviral therapy, there appears to be little benefit in preventing the development of these cancers in HIV-positive men, making prevention of infection a priority. New prevention options that are being introduced in many African countries include male circumcision and HPV vaccination. However, more data are needed on the burden of HPV disease in men before boys are included in HPV vaccination programmes.

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Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Vaccines ◽

10.3390/vaccines8020175 ◽

2020 ◽

Vol 8 (2) ◽

pp. 175

Author(s):

Song Fan ◽

Peiyang Li ◽

Lin Ouyang ◽

Tanwei Yuan ◽

Hui Gong ◽

...

Keyword(s):

Human Papillomavirus ◽

Sexual Behaviors ◽

Hpv Vaccination ◽

Northern China ◽

Hpv Infection ◽

High Risk Population ◽

Online Questionnaire ◽

Vaccination Programs ◽

Papillomavirus Infection ◽

Sex With Men

Men who have sex with men (MSM) attending university are a high-risk population for human papillomavirus (HPV) infection and are a neglected population of HPV vaccination programs in China. To provide evidence for HPV vaccination policies, we conducted this study to examine the prevalence and factors associated with anal HPV infection among MSM attending university in China. A self-administered online questionnaire was conducted to collect information on social demographics and sexual behaviors. A self-collected rectal swab specimen was collected to test for 37 HPV types. A total of 426 participants were tested for HPV. The median age was 20 years. HPV prevalence was 37.5% for any type, 29.8% for nine-valent vaccine types, 24.6% for four-valent vaccine types, 11.5% for HPV-16/18, and 15.7% for HPV-6/11. Men enrolled in a technical diploma, living in Northern China, having more than two sex partners, being bottom or versatile in anal sex, and having a human immunodeficiency virus (HIV) testing history were more likely to have positive anal HPV of any type. Our study found a high prevalence of anal HPV infection among MSM attending university in China, with HPV vaccine-preventable types being the most popular types in this group. Thus, our findings highlight the urgency of promoting HPV vaccination among teenage MSM.

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Quality of Life for Women with Human Papillomavirus-induced Lesions

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0040-1709192 ◽

2020 ◽

Vol 42 (04) ◽

pp. 211-217

Author(s):

Natália Maria Vieira Pereira-Caldeira ◽

Fernanda Garcia Bezerra Góes ◽

Maria Cristina Mendes de Almeida-Cruz ◽

Juliano de Souza Caliari ◽

Fernanda Maria Vieira Pereira-Ávila ◽

...

Keyword(s):

Quality Of Life ◽

Human Papillomavirus ◽

Social Relationships ◽

Hpv Infection ◽

Cross Sectional ◽

Face To Face ◽

Papillomavirus Infection ◽

Thematic Units ◽

Sources Of Support

Abstract Objective To reveal the changes in the quality of life reported by women with Human papillomavirus (HPV)-induced lesions. Methods This is a cross-sectional, descriptive-exploratory study of a qualitative approach performed from June to August 2016. Semi-structured face-to-face interviews based on five questions on the concept of quality of life were used. The data were submitted to thematic analysis. All ethical aspects have been contemplated. Results A total of 20 women aged between 25 and 59 years old were interviewed. From the analysis of the data, the following thematic units emerged: physical and emotional changes, especially complaints of pruritus, discharge and pain, worry, fear, shame and sadness; changes in sexual and affective relationships with decreased libido, dyspareunia and interruption of sexual activity; changes in social relationships resulting in absenteeism at work. Conclusion Human papillomavirus infection impairs the quality of life of women as it significantly affects sexual, affective, physical, emotional, and everyday habits. Therefore, HPV infection can lead to exponential changes in the quality of life of women, which can be mitigated by the availability of sources of support such as family, friends and the multi-professional team, helping to improve knowledge and cope with HPV.

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