scholarly journals A Predictive Model Based on Machine Learning for the Early Detection of Late-Onset Neonatal Sepsis: Development and Observational Study (Preprint)

2019 ◽  
Author(s):  
Wongeun Song ◽  
Se Young Jung ◽  
Hyunyoung Baek ◽  
Chang Won Choi ◽  
Young Hwa Jung ◽  
...  
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Intensive Care ◽  
High Resolution ◽  
Prediction Model ◽  
Neonatal Sepsis ◽  
Vital Sign ◽  
Prediction Models ◽  
Late Onset ◽  
Model Based

BACKGROUND Neonatal sepsis is associated with most cases of mortalities and morbidities in the neonatal intensive care unit (NICU). Many studies have developed prediction models for the early diagnosis of bloodstream infections in newborns, but there are limitations to data collection and management because these models are based on high-resolution waveform data. OBJECTIVE The aim of this study was to examine the feasibility of a prediction model by using noninvasive vital sign data and machine learning technology. METHODS We used electronic medical record data in intensive care units published in the Medical Information Mart for Intensive Care III clinical database. The late-onset neonatal sepsis (LONS) prediction algorithm using our proposed forward feature selection technique was based on NICU inpatient data and was designed to detect clinical sepsis 48 hours before occurrence. The performance of this prediction model was evaluated using various feature selection algorithms and machine learning models. RESULTS The performance of the LONS prediction model was found to be comparable to that of the prediction models that use invasive data such as high-resolution vital sign data, blood gas estimations, blood cell counts, and pH levels. The area under the receiver operating characteristic curve of the 48-hour prediction model was 0.861 and that of the onset detection model was 0.868. The main features that could be vital candidate markers for clinical neonatal sepsis were blood pressure, oxygen saturation, and body temperature. Feature generation using kurtosis and skewness of the features showed the highest performance. CONCLUSIONS The findings of our study confirmed that the LONS prediction model based on machine learning can be developed using vital sign data that are regularly measured in clinical settings. Future studies should conduct external validation by using different types of data sets and actual clinical verification of the developed model.

scholarly journals A Predictive Model Based on Machine Learning for the Early Detection of Late-Onset Neonatal Sepsis: Development and Observational Study

10.2196/15965 ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. e15965
Author(s):  
Wongeun Song ◽  
Se Young Jung ◽  
Hyunyoung Baek ◽  
Chang Won Choi ◽  
Young Hwa Jung ◽  
...  
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Intensive Care ◽  
High Resolution ◽  
Prediction Model ◽  
Neonatal Sepsis ◽  
Vital Sign ◽  
Prediction Models ◽  
Late Onset ◽  
Model Based

Background Neonatal sepsis is associated with most cases of mortalities and morbidities in the neonatal intensive care unit (NICU). Many studies have developed prediction models for the early diagnosis of bloodstream infections in newborns, but there are limitations to data collection and management because these models are based on high-resolution waveform data. Objective The aim of this study was to examine the feasibility of a prediction model by using noninvasive vital sign data and machine learning technology. Methods We used electronic medical record data in intensive care units published in the Medical Information Mart for Intensive Care III clinical database. The late-onset neonatal sepsis (LONS) prediction algorithm using our proposed forward feature selection technique was based on NICU inpatient data and was designed to detect clinical sepsis 48 hours before occurrence. The performance of this prediction model was evaluated using various feature selection algorithms and machine learning models. Results The performance of the LONS prediction model was found to be comparable to that of the prediction models that use invasive data such as high-resolution vital sign data, blood gas estimations, blood cell counts, and pH levels. The area under the receiver operating characteristic curve of the 48-hour prediction model was 0.861 and that of the onset detection model was 0.868. The main features that could be vital candidate markers for clinical neonatal sepsis were blood pressure, oxygen saturation, and body temperature. Feature generation using kurtosis and skewness of the features showed the highest performance. Conclusions The findings of our study confirmed that the LONS prediction model based on machine learning can be developed using vital sign data that are regularly measured in clinical settings. Future studies should conduct external validation by using different types of data sets and actual clinical verification of the developed model.

scholarly journals Institution-Specific Machine Learning Models for Prehospital Assessment to Predict Hospital Admission: Prediction Model Development Study (Preprint)

2020 ◽  
Author(s):  
Toru Shirakawa ◽  
Tomohiro Sonoo ◽  
Kentaro Ogura ◽  
Ryo Fujimori ◽  
Konan Hara ◽  
...  
Keyword(s):  
Machine Learning ◽  
Hospital Admission ◽  
Prediction Model ◽  
Predictive Factors ◽  
Prediction Models ◽  
Vital Signs ◽  
Chief Complaint ◽  
Gradient Boosting ◽  
Model Based ◽  
Ambulance Transport

BACKGROUND Although multiple prediction models have been developed to predict hospital admission to emergency departments (EDs) to address overcrowding and patient safety, only a few studies have examined prediction models for prehospital use. Development of institution-specific prediction models is feasible in this age of data science, provided that predictor-related information is readily collectable. OBJECTIVE We aimed to develop a hospital admission prediction model based on patient information that is commonly available during ambulance transport before hospitalization. METHODS Patients transported by ambulance to our ED from April 2018 through March 2019 were enrolled. Candidate predictors were age, sex, chief complaint, vital signs, and patient medical history, all of which were recorded by emergency medical teams during ambulance transport. Patients were divided into two cohorts for derivation (3601/5145, 70.0%) and validation (1544/5145, 30.0%). For statistical models, logistic regression, logistic lasso, random forest, and gradient boosting machine were used. Prediction models were developed in the derivation cohort. Model performance was assessed by area under the receiver operating characteristic curve (AUROC) and association measures in the validation cohort. RESULTS Of 5145 patients transported by ambulance, including deaths in the ED and hospital transfers, 2699 (52.5%) required hospital admission. Prediction performance was higher with the addition of predictive factors, attaining the best performance with an AUROC of 0.818 (95% CI 0.792-0.839) with a machine learning model and predictive factors of age, sex, chief complaint, and vital signs. Sensitivity and specificity of this model were 0.744 (95% CI 0.716-0.773) and 0.745 (95% CI 0.709-0.776), respectively. CONCLUSIONS For patients transferred to EDs, we developed a well-performing hospital admission prediction model based on routinely collected prehospital information including chief complaints.

scholarly journals A Self-Care Prediction Model for Children with Disability Based on Genetic Algorithm and Extreme Gradient Boosting

Mathematics ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1590
Author(s):  
Muhammad Syafrudin ◽  
Ganjar Alfian ◽  
Norma Latif Fitriyani ◽  
Muhammad Anshari ◽  
Tony Hadibarata ◽  
...  
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Prediction Model ◽  
Prediction Models ◽  
Self Care ◽  
Gradient Boosting ◽  
Children With Disability ◽  
Study Results ◽  
Extreme Gradient Boosting ◽  
Care Problems

Detecting self-care problems is one of important and challenging issues for occupational therapists, since it requires a complex and time-consuming process. Machine learning algorithms have been recently applied to overcome this issue. In this study, we propose a self-care prediction model called GA-XGBoost, which combines genetic algorithms (GAs) with extreme gradient boosting (XGBoost) for predicting self-care problems of children with disability. Selecting the feature subset affects the model performance; thus, we utilize GA to optimize finding the optimum feature subsets toward improving the model’s performance. To validate the effectiveness of GA-XGBoost, we present six experiments: comparing GA-XGBoost with other machine learning models and previous study results, a statistical significant test, impact analysis of feature selection and comparison with other feature selection methods, and sensitivity analysis of GA parameters. During the experiments, we use accuracy, precision, recall, and f1-score to measure the performance of the prediction models. The results show that GA-XGBoost obtains better performance than other prediction models and the previous study results. In addition, we design and develop a web-based self-care prediction to help therapist diagnose the self-care problems of children with disabilities. Therefore, appropriate treatment/therapy could be performed for each child to improve their therapeutic outcome.

scholarly journals Development of a Machine Learning Model for the Prediction of the Real Time Mortality in Patients in the Intensive Care Unit

2021 ◽  
Author(s):  
Jaeyoung Yang ◽  
Hong-Gook Lim ◽  
Wonhyeong Park ◽  
Dongseok Kim ◽  
Jin Sun Yoon ◽  
...  
Keyword(s):  
Machine Learning ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Prediction Model ◽  
Prediction Models ◽  
External Validation ◽  
Learning Model ◽  
Mortality Prediction ◽  
Machine Learning Model ◽  
Mortality Prediction Model

Abstract BackgroundPrediction of mortality in intensive care units is very important. Thus, various mortality prediction models have been developed for this purpose. However, they do not accurately reflect the changing condition of the patient in real time. The aim of this study was to develop and evaluate a machine learning model that predicts short-term mortality in the intensive care unit using four easy-to-collect vital signs.MethodsTwo independent retrospective observational cohorts were included in this study. The primary training cohort included the data of 1968 patients admitted to the intensive care unit at the Veterans Health Service Medical Center, Seoul, South Korea, from January 2018 to March 2019. The external validation cohort comprised the records of 409 patients admitted to the medical intensive care unit at Seoul National University Hospital, Seoul, South Korea, from January 2019 to December 2019. Datasets of four vital signs (heart rate, systolic blood pressure, diastolic blood pressure, and peripheral capillary oxygen saturation [SpO2]) measured every hour for 10 h were used for the development of the machine learning model. The performances of mortality prediction models generated using five machine learning algorithms, Random Forest (RF), XGboost, perceptron, convolutional neural network, and Long Short-Term Memory, were calculated and compared using area under the receiver operating characteristic curve (AUROC) values and an external validation dataset.ResultsThe machine learning model generated using the RF algorithm showed the best performance. Its AUROC was 0.922, which is much better than the 0.8408 of the Acute Physiology and Chronic Health Evaluation II. Thus, to investigate the importance of variables that influence the performance of the machine learning model, machine learning models were generated for each observation time or vital sign using the RF algorithm. The machine learning model developed using SpO2 showed the best performance (AUROC, 0.89). ConclusionsThe mortality prediction model developed in this study using data from only four types of commonly recorded vital signs is simpler than any existing mortality prediction model. This simple yet powerful new mortality prediction model could be useful for early detection of probable mortality and appropriate medical intervention, especially in rapidly deteriorating patients.

scholarly journals Institution-Specific Machine Learning Models for Prehospital Assessment to Predict Hospital Admission: Prediction Model Development Study

10.2196/20324 ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. e20324
Author(s):  
Toru Shirakawa ◽  
Tomohiro Sonoo ◽  
Kentaro Ogura ◽  
Ryo Fujimori ◽  
Konan Hara ◽  
...  
Keyword(s):  
Machine Learning ◽  
Hospital Admission ◽  
Prediction Model ◽  
Predictive Factors ◽  
Prediction Models ◽  
Vital Signs ◽  
Chief Complaint ◽  
Gradient Boosting ◽  
Model Based ◽  
Ambulance Transport

Background Although multiple prediction models have been developed to predict hospital admission to emergency departments (EDs) to address overcrowding and patient safety, only a few studies have examined prediction models for prehospital use. Development of institution-specific prediction models is feasible in this age of data science, provided that predictor-related information is readily collectable. Objective We aimed to develop a hospital admission prediction model based on patient information that is commonly available during ambulance transport before hospitalization. Methods Patients transported by ambulance to our ED from April 2018 through March 2019 were enrolled. Candidate predictors were age, sex, chief complaint, vital signs, and patient medical history, all of which were recorded by emergency medical teams during ambulance transport. Patients were divided into two cohorts for derivation (3601/5145, 70.0%) and validation (1544/5145, 30.0%). For statistical models, logistic regression, logistic lasso, random forest, and gradient boosting machine were used. Prediction models were developed in the derivation cohort. Model performance was assessed by area under the receiver operating characteristic curve (AUROC) and association measures in the validation cohort. Results Of 5145 patients transported by ambulance, including deaths in the ED and hospital transfers, 2699 (52.5%) required hospital admission. Prediction performance was higher with the addition of predictive factors, attaining the best performance with an AUROC of 0.818 (95% CI 0.792-0.839) with a machine learning model and predictive factors of age, sex, chief complaint, and vital signs. Sensitivity and specificity of this model were 0.744 (95% CI 0.716-0.773) and 0.745 (95% CI 0.709-0.776), respectively. Conclusions For patients transferred to EDs, we developed a well-performing hospital admission prediction model based on routinely collected prehospital information including chief complaints.

scholarly journals Development of Heavy Rain Damage Prediction Model Using Machine Learning Based on Big Data

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Changhyun Choi ◽  
Jeonghwan Kim ◽  
Jongsung Kim ◽  
Donghyun Kim ◽  
Younghye Bae ◽  
...  
Keyword(s):  
Machine Learning ◽  
Big Data ◽  
Prediction Model ◽  
Prediction Models ◽  
Meteorological Data ◽  
Heavy Rain ◽  
Machine Learning Techniques ◽  
Damage Prediction ◽  
Explanatory Variables ◽  
The Republic

Prediction models of heavy rain damage using machine learning based on big data were developed for the Seoul Capital Area in the Republic of Korea. We used data on the occurrence of heavy rain damage from 1994 to 2015 as dependent variables and weather big data as explanatory variables. The model was developed by applying machine learning techniques such as decision trees, bagging, random forests, and boosting. As a result of evaluating the prediction performance of each model, the AUC value of the boosting model using meteorological data from the past 1 to 4 days was the highest at 95.87% and was selected as the final model. By using the prediction model developed in this study to predict the occurrence of heavy rain damage for each administrative region, we can greatly reduce the damage through proactive disaster management.

scholarly journals UAV-Based Hyperspectral and Ensemble Machine Learning for Predicting Yield in Winter Wheat

Agronomy ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 202
Author(s):  
Zhen Chen ◽  
Qian Cheng ◽  
Fuyi Duan ◽  
Xiuqiao Huang ◽  
Honggang Xu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Winter Wheat ◽  
Prediction Model ◽  
Grain Filling ◽  
Yield Prediction ◽  
Spectral Indices ◽  
Learner Model ◽  
Ensemble Machine Learning ◽  
Base Learner

Winter wheat is a widely-grown cereal crop worldwide. Using growth-stage information to estimate winter wheat yields in a timely manner is essential for accurate crop management and rapid decision-making in sustainable agriculture, and to increase productivity while reducing environmental impact. UAV remote sensing is widely used in precision agriculture due to its flexibility and increased spatial and spectral resolution. Hyperspectral data are used to model crop traits because of their ability to provide continuous rich spectral information and higher spectral fidelity. In this study, hyperspectral image data of the winter wheat crop canopy at the flowering and grain-filling stages was acquired by a low-altitude unmanned aerial vehicle (UAV), and machine learning was used to predict winter wheat yields. Specifically, a large number of spectral indices were extracted from the spectral data, and three feature selection methods, recursive feature elimination (RFE), Boruta feature selection, and the Pearson correlation coefficient (PCC), were used to filter high spectral indices in order to reduce the dimensionality of the data. Four major basic learner models, (1) support vector machine (SVM), (2) Gaussian process (GP), (3) linear ridge regression (LRR), and (4) random forest (RF), were also constructed, and an ensemble machine learning model was developed by combining the four base learner models. The results showed that the SVM yield prediction model, constructed on the basis of the preferred features, performed the best among the base learner models, with an R2 between 0.62 and 0.73. The accuracy of the proposed ensemble learner model was higher than that of each base learner model; moreover, the R2 (0.78) for the yield prediction model based on Boruta’s preferred characteristics was the highest at the grain-filling stage.

scholarly journals Machine Learning-Based Prediction Model for Papillary Thyroid Carcinoma Recurrence

2020 ◽  
Author(s):  
Young Min Park ◽  
Byung-Joo Lee
Keyword(s):  
Machine Learning ◽  
Prediction Model ◽  
Tumor Size ◽  
Large Scale ◽  
Prediction Models ◽  
Prognostic Significance ◽  
Disease Recurrence ◽  
Machine Learning Techniques ◽  
Papillary Thyroid ◽  
Recurrence Prediction

Abstract Background: This study analyzed the prognostic significance of nodal factors, including the number of metastatic LNs and LNR, in patients with PTC, and attempted to construct a disease recurrence prediction model using machine learning techniques.Methods: We retrospectively analyzed clinico-pathologic data from 1040 patients diagnosed with papillary thyroid cancer between 2003 and 2009. Results: We analyzed clinico-pathologic factors related to recurrence through logistic regression analysis. Among the factors that we included, only sex and tumor size were significantly correlated with disease recurrence. Parameters such as age, sex, tumor size, tumor multiplicity, ETE, ENE, pT, pN, ipsilateral central LN metastasis, contralateral central LNs metastasis, number of metastatic LNs, and LNR were input for construction of a machine learning prediction model. The performance of five machine learning models related to recurrence prediction was compared based on accuracy. The Decision Tree model showed the best accuracy at 95%, and the lightGBM and stacking model together showed 93% accuracy. Conclusions: We confirmed that all machine learning prediction models showed an accuracy of 90% or more for predicting disease recurrence in PTC. Large-scale multicenter clinical studies should be performed to improve the performance of our prediction models and verify their clinical effectiveness.

scholarly journals Development and Validation of Unplanned Extubation Prediction Models Using Intensive Care Unit Data: Comparative Machine Learning Study (Preprint)

2020 ◽  
Author(s):  
Sujeong Hur ◽  
Ji Young Min ◽  
Junsang Yoo ◽  
Kyunga Kim ◽  
Chi Ryang Chung ◽  
...  
Keyword(s):  
Machine Learning ◽  
Intensive Care Unit ◽  
Patient Safety ◽  
Intensive Care ◽  
Predictive Value ◽  
Prediction Models ◽  
Support Vector ◽  
Unplanned Extubation ◽  
Electronic Health Record Data ◽  
Icu Patients

BACKGROUND Patient safety in the intensive care unit (ICU) is one of the most critical issues, and unplanned extubation (UE) is considered as the most adverse event for patient safety. Prevention and early detection of such an event is an essential but difficult component of quality care. OBJECTIVE This study aimed to develop and validate prediction models for UE in ICU patients using machine learning. METHODS This study was conducted an academic tertiary hospital in Seoul. The hospital had approximately 2,000 inpatient beds and 120 intensive care unit (ICU) beds. The number of patients, on daily basis, was approximately 9,000 for the out-patient. The number of annual ICU admission was approximately 10,000. We conducted a retrospective study between January 1, 2010 and December 31, 2018. A total of 6,914 extubation cases were included. We developed an unplanned extubation prediction model using machine learning algorithms, which included random forest (RF), logistic regression (LR), artificial neural network (ANN), and support vector machine (SVM). For evaluating the model’s performance, we used area under the receiver operator characteristic curve (AUROC). Sensitivity, specificity, positive predictive value negative predictive value, and F1-score were also determined for each model. For performance evaluation, we also used calibration curve, the Brier score, and the Hosmer-Lemeshow goodness-of-fit statistic. RESULTS Among the 6,914 extubation cases, 248 underwent UE. In the UE group, there were more males than females, higher use of physical restraints, and fewer surgeries. The incidence of UE was more likely to occur during the night shift compared to the planned extubation group. The rate of reintubation within 24 hours and hospital mortality was higher in the UE group. The UE prediction algorithm was developed, and the AUROC for RF was 0.787, for LR was 0.762, for ANN was 0.762, and for SVM was 0.740. CONCLUSIONS We successfully developed and validated machine learning-based prediction models to predict UE in ICU patients using electronic health record data. The best AUROC was 0.787, which was obtained using RF. CLINICALTRIAL N/A

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