scholarly journals Characteristics of the type 2 diabetic patients with hypoglycemia in a tertiary referral hospital

2021 ◽  
Vol 17 (6) ◽  
pp. 472-476
Author(s):  
Satilmis Bilgin ◽  
Gulali Aktas ◽  
Ozge Kurtkulagi ◽  
Burcin M. Atak ◽  
Gizem Kahveci ◽  
...  
Keyword(s):  
Laboratory Data ◽  
Severe Hypoglycemia ◽  
Study Groups ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Group I ◽  
Group Ii ◽  
Diabetic Treatment ◽  
Type 2 Diabetic

Background. Hypoglycemia is an important complication of the treatment of type 2 diabetes mellitus, which constitutes a barrier in stringent diabetic control. Beside it constitutes nearly 10 % of emergency department admissions that caused by adverse drug events, it may also increase morbidities and mortality by inducing, cardiac arrhythmias, neurological impairment and ischemic events. Hypoglycemia is the most common side effect of insulin treatment, however, oral antidiabetic agents may also induce hypoglycemic complications. In present retrospective study, we purposed to observe general characteristics and laboratory data of the type 2 diabetic patients whom presented with mild or moderate/severe hypoglycemia. Materials and methods. Patients with type 2 diabetes mellitus whom presented to our institution with hypoglycemia between January 2019 and January 2020 were retrospectively analyzed. General characteristics and laboratory data of the subjects recorded. Patients grouped into two groups, group I consisted of subjects with mild hypoglycemia and group II consisted of patients with moderate/severe hypoglycemia. Data of the subjects in groups I and II were compared. Results. There were 15 subjects in group I and 23 in group II. HbA1c and other laboratory markers were not significantly different in study groups. Similarly diabetes duration and anti-diabetic treatment were not significantly different in study groups. The rate of geriatric patients was significantly higher in group II compared to group I (p = 0.04). Conclusions. Subjects with moderate/severe hypoglycemia tend to be more frequently in geriatric age and HbA1c not correlates with the degree of the hypoglycemia. Since neither duration of diabetes, nor anti-diabetic treatment were associated with the severity of the hypoglycemia, each case should be evaluated individually to prevent further episodes which could increase morbidity and mortality in diabetic population.

scholarly journals Association of Serum Triglycerides in Patients with Ischaemic Stroke Admitted in Hospital with type-2 Diabetes Patients

2013 ◽  
Vol 29 (2) ◽  
pp. 98-107
Author(s):  
Nirmalendu Bikash Bhowmik ◽  
Dilruba Alam ◽  
Md Rashedul Islam ◽  
Rumana Habib ◽  
Aminur Rahman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Triglyceride Level ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Group I ◽  
Stroke Group ◽  
Group Ii ◽  
Type 2 Diabetic

Background and Aims: Diabetes mellitus and dyslipidemia, in particular triglyceridemia pose independent risk factors of stroke. Hypertriglyceridemia implicated in the pathogenesis of ischemic stroke by imparting endothelial dysfunction, oxidative stress and lowering fibrinolytic activity. This study was aimed to explore risk incurred by blood triglyceride level for ischemic stroke in type 2 diabetic patients. Materials and Methods: A total number of 80 [50 with acute ischemic stroke and 30 without stroke] type 2 diabetic patients consecutively admitted in the neurology department, during the period of April to September 2012, fulfilling the recruitment criteria were included in the study. Ischemic stroke was confirmed by CT-scan. Informed written consent from the legal attendant of each patient was obtained. Data regarding clinicobiochemical and images studies were retrieved from patient’s record form. Results: Male to female ratio was 1.2:1 of the study subjects. Mean (±SD) age (yrs) was 61.0±10.6 in patients with ischemic stroke (Group I) and 57.0±12.3 in patients without stroke (Group II). Risk factors like BMI, lifestyle, smoking, alcohol intake did not show any statistical significance with incidence of ischemic stroke. Mean (±SD) triglyceride (mg/ dl) was 241±56 and 217±102 in Group I and Group II respectively (p=0.024). Eighty eight percent patients had triglyceride 150 mg/dl in Group I and 70 percent in Group II. Triglyceride level (mean±SD, mg/dl) was significantly higher (335±101) in overweightobese patients (BMI 25 Kg/m2) compared to those (232±68) with normal body weight (BMI<25 Kg/m2). Triglyceride level did not show statistical difference among patients having habit of smoking or not. Mean (±SD) cholesterol (mg/dl, (±SD) was 197±62 and 165±26 in Group I and Group II respectively (p=0.009). Mean (±SD) LDL-c (mg/dl) was 101±45 and 98±42 in Group I (43.8±34.4) compared to Group II (60.2±15.6) (p=0.017). Patients with atherosclerotic changes had significantly higher triglyceride (mean±SD, mg/dl) level (338±155) compared to those without (228±89) (p=0.047). Conclusions: Data concluded that hypertriglyceridemia is relatively common among the diabetic patients even in patients with apparently good glycemic control and possibly incur added risk for ischemic stroke in these patients. However, further studies are needed involving optimum number of patients to substantiate this finding and conclusively comment on the issue and to design effective prevention program to reduce the cerebrovascular morbidity and mortality. Bangladesh Journal of Neuroscience 2013; Vol. 29 (2) : 98-107

scholarly journals Hospital outcomes and cumulative burden from complications in type 2 diabetic sepsis patients: a cohort study using administrative and hospital-based databases

2019 ◽  
Vol 10 ◽  
pp. 204201881987540 ◽  
Author(s):  
Ming-Shun Hsieh ◽  
Sung-Yuan Hu ◽  
Chorng-Kuang How ◽  
Chen-June Seak ◽  
Vivian Chia-Rong Hsieh ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Hospital Mortality ◽  
Laboratory Data ◽  
Diabetic Patients ◽  
Related Complication ◽  
Type 2 Diabetic Patients ◽  
Hospital Outcomes ◽  
Initial Blood ◽  
Type 2 Diabetic

Background: The association between type 2 diabetes and hospital outcomes of sepsis remains controversial when severity of diabetes is not taken into consideration. We examined this association using nationwide and hospital-based databases. Methods: The first part of this study was mainly conducted using a nationwide database, which included 1.6 million type 2 diabetic patients. The diabetic complication burden was evaluated using the adapted Diabetes Complications Severity Index score (aDCSI score). In the second part, we used laboratory data from a distinct hospital-based database to make comparisons using regression analyses. Results: The nationwide study included 19,719 type 2 diabetic sepsis patients and an equal number of nondiabetic sepsis patients. The diabetic sepsis patients had an increased odds ratio (OR) of 1.14 (95% confidence interval 1.1–1.19) for hospital mortality. The OR for mortality increased as the complication burden increased [aDCSI scores of 0, 1, 2, 3, 4, and ⩾5 with ORs of 0.91, 0.87, 1.14, 1.25, 1.56, and 1.77 for mortality, respectively (all p < 0.001)]. The hospital-based database included 1054 diabetic sepsis patients. Initial blood glucose levels did not differ significantly between the surviving and deceased diabetic sepsis patients: 273.9 ± 180.3 versus 266.1 ± 200.2 mg/dl ( p = 0.095). Moreover, the surviving diabetic sepsis patients did not have lower glycated hemoglobin (HbA1c; %) values than the deceased patients: 8.4 ± 2.6 versus 8.0 ± 2.5 ( p = 0.078). Conclusions: For type 2 diabetic sepsis patients, the diabetes-related complication burden was the major determinant of hospital mortality rather than diabetes per se, HbA1c level, or initial blood glucose level.

scholarly journals The study of Mean Platelet Volume (MPV) as a Potential Risk Factor for Macrovascular Complications (Ischemic Heart Disease and Cerebrovascular Stroke) in Type 2 Diabetes Mellitus

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H M Amer ◽  
K M Makboul ◽  
B M Mostafa ◽  
C A Girgis ◽  
Y A Mohammed
Keyword(s):  
Myocardial Infarction ◽  
Diabetic Patients ◽  
Hypertensive Patients ◽  
Statistical Significant Difference ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Cerebrovascular Stroke ◽  
Type 2 Diabetic

Abstract Background Type 2 diabetes mellitus (T2DM) has reached global epidemic proportions, with more than 382 million people affected according to 2013 estimate. By 2035, its prevalence is expected to reach 471 million, meaning that 10% of the world’s population will have diabetes. Patients with diabetes often suffer from metabolic abnormalities, poor glycemic control, oxidative stress, insulin resistance, and low-grade inflammation. These conditions trigger vascular dysfunction, which predisposes them to atherothrombosis Objective The present study aimed to study the mean platelet volume (MPV) as a potential risk factor for ischemic heart disease and cerebrovascular stroke in type 2 diabetes. Methods The study was conducted on 150 subjects there ages ranged from 40 to 60 years old. They were divided into 4 groups: Group 1: included30 type 2 diabetic overweight or obese patients without previous history of myocardial infarction or cerebrovascular stroke. Then, they were subdivided into 2 subgroups: 1a) 15 diabetic non hypertensive patients. 1b) 15 diabetic hypertensive patients. Group 2: included A) 30 type 2 diabetic overweight or obese patients with recent cerebrovascular stroke. Then, they were subdivided into 2 subgroups: 2Aa) 15 diabetic non hypertensive patients. 2Ab) 15 diabetic hypertensive patients. B) 30 type 2 diabetic overweight or obese patients with acute myocardial infarction. Then, they were subdivided into 2 subgroups: 2Ba) 15 diabetic non hypertensive patients. 2Bb) 15 diabetic hypertensive patients. Group 3: 30 overweight or obese non-diabetic patients with acute myocardial infarction or recent cerebrovascular stroke. Then, they were subdivided into 3a) 15 patients with acute myocardial infarction. 3b) 15 patients with recent cerebrovascular stroke. Group 4: 30 Healthy control with matching age and sex and were subdivided into 2 subgroups: Control a) 15 lean subjects. Control b) 15 overweight or obese subjects. All subjects in this study were subjected to Full medical history taking. Thorough clinical examination (including weight, height, BMI, blood pressure). The following laboratory investigations were done: Fasting blood glucose, Two hour post prandial, HbA1c, Fasting insulin (for HOMA IR), Lipid profile (Total cholesterol-LDL-HDL-Triglycerides), Mean platelet volume and Liver and kidney function test. The following radiological investigation were done: Carotid ultrasonography for estimation of intima-media thickness and abdominal ultrasonography. Results As regards MPV, there was a high statistical significant difference between the studied groups (p-value&lt;0.01), being the highest in group II (mean 11.93 ± 0.37 fl) followed by group III (10.77±1.69 fl), group I (10.67±1.98 fl) and group IV (8.83±0.98 fl). On comparing between every other groups there was a high statistical significant difference between group (I) & (II) being higher in group II, (I) & (IV) being higher in group I, (II) & (III) being higher in group II, (II) & (IV) being higher in group II and (III) & (IV) being higher in group III (P value&lt;0.01). However, there was a non-statistical significant difference between group (I) & (III) regarding the MPV (P value&gt;0.05). On comparing between hypertensive and non-hypertensive patients in each group as regard MPV, there were non-significant statistical difference. Conclusion MPV was higher in type 2 diabetic patients than healthy control. Moreover, MPV was significantly higher in type 2 diabetic patients with macrovascular complications. There was no significant difference between hypertensive and non hypertensive patients as regard MPV. There was no significant difference between obese and lean subjects as regard MPV. There was a positive significant correlation between MPV and markers of glycemic control in T2DM.

scholarly journals Cost Analysis of Severe Hypoglycemia in Treated Type 2 Diabetic Patients According to Anti-Hyperglycemic Agent Therapy

2014 ◽  
Vol 17 (7) ◽  
pp. A352-A353
Author(s):  
P. Laires ◽  
J. Conceição ◽  
J. Dores ◽  
F. Araújo ◽  
C. Silva ◽  
...  
Keyword(s):  
Cost Analysis ◽  
Severe Hypoglycemia ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Costs of Hospitalization of Type 2 Diabetic Patients Associated with Severe Hypoglycemia

2014 ◽  
Vol 17 (7) ◽  
pp. A352
Author(s):  
P. Laires ◽  
J. Conceição ◽  
F. Araújo ◽  
J. Dores ◽  
C. Silva ◽  
...  
Keyword(s):  
Severe Hypoglycemia ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Secular Trends in the Clinical Characteristics of Type 2 Diabetic Patients With Severe Hypoglycemia Between 2008 and 2013

2016 ◽  
Vol 8 (10) ◽  
pp. 710-714 ◽  
Author(s):  
Hiroyuki Ito ◽  
Emiko Tsugami ◽  
Shigenori Ando ◽  
Ayano Imai ◽  
Suzuko Matsumoto ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Severe Hypoglycemia ◽  
Secular Trends ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Assessment of Periodontal Inflamed Surface Area and Its Relationship with Glycemic Control in Type 2 Diabetes

2016 ◽  
Vol 7 (1) ◽  
pp. 6-11
Author(s):  
Sakthi Devi ◽  
Mythili Swaminathan ◽  
Senthil Murugappan ◽  
Karthikeyan Ilangovan ◽  
Anitha Kannaiyan
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Surface Area ◽  
Tamil Nadu ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Pocket Depth ◽  
Group I ◽  
Type 2 Diabetic

ABSTRACT Introduction The objective of this study is to assess the periodontal inflamed surface area (PISA) and its relationship with glycemic control in type 2 diabetes with and without periodontitis. Materials and methods A study was performed on 60 out-patients (males and females) reporting to the Department of Periodontics, Rajah Muthiah Dental College and Hospital and the Diabetic Clinic, Rajah Muthiah Medical College, Annamalai Nagar, Chidambaram, Tamil Nadu. The age of the study subjects ranged from 40 to 60 years. Patients having HbA1c levels > 7 mg/dl were diagnosed as type 2 diabetes mellitus and were enrolled in the study. The selected patients were divided into two groups of 30 patients each, with at least eight remaining teeth present: Group I - Diabetic patients with periodontitis (test) with probing pocket depth (PPD) of 3 to 10 mm and bleeding on probing (BOP), and Group II - Diabetic patients without periodontitis (periodontally healthy as control) with PPD not exceeding 3 mm and limited BOP. Subjects were excluded if they were under systemic antibiotics 3 months prior and during the study and if they have undergone periodontal treatment 6 months prior to the study. Results When HbA1c increased, the PISA values also increased in type 2 diabetic patients with and without periodontitis. Conclusion The cross-sectional clinical study reveals that there is a linear association between diabetes and PISA in type 2 diabetic patients with and without periodontitis. How to cite this article Devi S, Murugappan S, Swaminathan M, Ilangovan K, Mangalekar SB, Kannaiyan A. Assessment of Periodontal Inflamed Surface Area and Its Relationship with Glycemic Control in Type 2 Diabetes. J Health Sci Res 2016;7(1):6-11.

scholarly journals Biochemical Study on Anti Thyroid Peroxidase in Type 2 Diabetic patients with thyroid disorders

2016 ◽  
Vol 13 (4) ◽  
pp. 753-761
Author(s):  
Baghdad Science Journal
Keyword(s):  
Type 2 Diabetes ◽  
Biochemical Study ◽  
Study Groups ◽  
Enzyme Linked Immunosorbent Assay ◽  
Thyroid Peroxidase ◽  
Diabetic Patients ◽  
Thyroid Disorders ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Type 2 diabetes mellitus (T2DM) is the most frequent endocrinal disease commonly associated with thyroid disorders .The study is conducted at the Specialized Center for Endocrinology and Diabetes in Baghdad ,during December 2014 up to October 2015.This study was done to investigate the prevalence of anti- thyroid peroxidase (Anti-TPO) antibody in patients suffered from type 2 diabetes with thyroid disorders .The study groups included a total number of 80 subjects consisting of 60 type 2 diabetic patients divided into 20 hyperthyroidism subjects (group 1) ,20 hypothyroidism subjects (group 2), 20 euthyroidism subjects (group 3) and 20 healthy controls (group 4) . The fasting blood samples were analyzed for (T3,T4,TSH) by using Vitek Immuno diagnstic Assay System (VIDAS). Enzyme Linked Immunosorbent Assay (ELISA) is used to detect anti-thyroid peroxidase (Anti-TPO) antibody .The results show that age, gender and BMI (body mass index) have significantly higher levels in the patients groups as compared to the healthy group at (p

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