scholarly journals Association of Serum Triglycerides in Patients with Ischaemic Stroke Admitted in Hospital with type-2 Diabetes Patients

2013 ◽  
Vol 29 (2) ◽  
pp. 98-107
Author(s):  
Nirmalendu Bikash Bhowmik ◽  
Dilruba Alam ◽  
Md Rashedul Islam ◽  
Rumana Habib ◽  
Aminur Rahman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Triglyceride Level ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Group I ◽  
Stroke Group ◽  
Group Ii ◽  
Type 2 Diabetic

Background and Aims: Diabetes mellitus and dyslipidemia, in particular triglyceridemia pose independent risk factors of stroke. Hypertriglyceridemia implicated in the pathogenesis of ischemic stroke by imparting endothelial dysfunction, oxidative stress and lowering fibrinolytic activity. This study was aimed to explore risk incurred by blood triglyceride level for ischemic stroke in type 2 diabetic patients. Materials and Methods: A total number of 80 [50 with acute ischemic stroke and 30 without stroke] type 2 diabetic patients consecutively admitted in the neurology department, during the period of April to September 2012, fulfilling the recruitment criteria were included in the study. Ischemic stroke was confirmed by CT-scan. Informed written consent from the legal attendant of each patient was obtained. Data regarding clinicobiochemical and images studies were retrieved from patient’s record form. Results: Male to female ratio was 1.2:1 of the study subjects. Mean (±SD) age (yrs) was 61.0±10.6 in patients with ischemic stroke (Group I) and 57.0±12.3 in patients without stroke (Group II). Risk factors like BMI, lifestyle, smoking, alcohol intake did not show any statistical significance with incidence of ischemic stroke. Mean (±SD) triglyceride (mg/ dl) was 241±56 and 217±102 in Group I and Group II respectively (p=0.024). Eighty eight percent patients had triglyceride 150 mg/dl in Group I and 70 percent in Group II. Triglyceride level (mean±SD, mg/dl) was significantly higher (335±101) in overweightobese patients (BMI 25 Kg/m2) compared to those (232±68) with normal body weight (BMI<25 Kg/m2). Triglyceride level did not show statistical difference among patients having habit of smoking or not. Mean (±SD) cholesterol (mg/dl, (±SD) was 197±62 and 165±26 in Group I and Group II respectively (p=0.009). Mean (±SD) LDL-c (mg/dl) was 101±45 and 98±42 in Group I (43.8±34.4) compared to Group II (60.2±15.6) (p=0.017). Patients with atherosclerotic changes had significantly higher triglyceride (mean±SD, mg/dl) level (338±155) compared to those without (228±89) (p=0.047). Conclusions: Data concluded that hypertriglyceridemia is relatively common among the diabetic patients even in patients with apparently good glycemic control and possibly incur added risk for ischemic stroke in these patients. However, further studies are needed involving optimum number of patients to substantiate this finding and conclusively comment on the issue and to design effective prevention program to reduce the cerebrovascular morbidity and mortality. Bangladesh Journal of Neuroscience 2013; Vol. 29 (2) : 98-107

Insulin resistance and classic risk factors in type 2 diabetic patients with different subtypes of ischemic stroke

Diabetes Care ◽  
1999 ◽  
Vol 22 (7) ◽  
pp. 1191-1195 ◽  
Author(s):  
K. Matsumoto ◽  
S. Miyake ◽  
M. Yano ◽  
Y. Ueki ◽  
A. Miyazaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Ischemic Stroke ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Characteristics of the type 2 diabetic patients with hypoglycemia in a tertiary referral hospital

2021 ◽  
Vol 17 (6) ◽  
pp. 472-476
Author(s):  
Satilmis Bilgin ◽  
Gulali Aktas ◽  
Ozge Kurtkulagi ◽  
Burcin M. Atak ◽  
Gizem Kahveci ◽  
...  
Keyword(s):  
Laboratory Data ◽  
Severe Hypoglycemia ◽  
Study Groups ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Group I ◽  
Group Ii ◽  
Diabetic Treatment ◽  
Type 2 Diabetic

Background. Hypoglycemia is an important complication of the treatment of type 2 diabetes mellitus, which constitutes a barrier in stringent diabetic control. Beside it constitutes nearly 10 % of emergency department admissions that caused by adverse drug events, it may also increase morbidities and mortality by inducing, cardiac arrhythmias, neurological impairment and ischemic events. Hypoglycemia is the most common side effect of insulin treatment, however, oral antidiabetic agents may also induce hypoglycemic complications. In present retrospective study, we purposed to observe general characteristics and laboratory data of the type 2 diabetic patients whom presented with mild or moderate/severe hypoglycemia. Materials and methods. Patients with type 2 diabetes mellitus whom presented to our institution with hypoglycemia between January 2019 and January 2020 were retrospectively analyzed. General characteristics and laboratory data of the subjects recorded. Patients grouped into two groups, group I consisted of subjects with mild hypoglycemia and group II consisted of patients with moderate/severe hypoglycemia. Data of the subjects in groups I and II were compared. Results. There were 15 subjects in group I and 23 in group II. HbA1c and other laboratory markers were not significantly different in study groups. Similarly diabetes duration and anti-diabetic treatment were not significantly different in study groups. The rate of geriatric patients was significantly higher in group II compared to group I (p = 0.04). Conclusions. Subjects with moderate/severe hypoglycemia tend to be more frequently in geriatric age and HbA1c not correlates with the degree of the hypoglycemia. Since neither duration of diabetes, nor anti-diabetic treatment were associated with the severity of the hypoglycemia, each case should be evaluated individually to prevent further episodes which could increase morbidity and mortality in diabetic population.

The prevalence and risk factors associated with dyslipidemia in type 2 diabetic patients in the autonomous Region of Cantabria

2020 ◽  
Vol 67 (2) ◽  
pp. 102-112
Author(s):  
Alcibíades Segundo Díaz Vera ◽  
José Abellán Alemán ◽  
Antonio Segura Fragoso ◽  
Juan Pablo Martínez de Esteban ◽  
Francisco Javier Lameiro Couso ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Autonomous Region ◽  
Factors Associated ◽  
Type 2 Diabetic

scholarly journals CNDP1, NOS3, and MnSOD Polymorphisms as Risk Factors for Diabetic Nephropathy among Type 2 Diabetic Patients in Malaysia

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Mohd Jokha Yahya ◽  
Patimah Binti Ismail ◽  
Norshariza Binti Nordin ◽  
Abdah Binti Md Akim ◽  
Wan Shaariah Binti Md Yusuf ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Manganese Superoxide Dismutase ◽  
Multiplicative Model ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic ◽  
Mode Of Inheritance

Type 2 diabetes mellitus (T2DM) is associated with a high incidence of nephropathy. The aim of this study was to investigate the association of a genetic polymorphism of carnosinase (CNDP1-D18S880and -rs2346061), endothelial nitric oxide synthase (NOS3-rs1799983), and manganese superoxide dismutase (MnSOD-rs4880) genes with the development of diabetic nephropathy among Malaysian type 2 diabetic patients. A case-control association study was performed using 652 T2DM patients comprising 227 Malays (without nephropathy = 96 and nephropathy = 131), 203 Chinese (without nephropathy = 95 and nephropathy = 108), and 222 Indians (without nephropathy = 136 and nephropathy = 86). DNA sequencing was performed for theD18S880ofCNDP1, while the rest were tested using DNA Sequenom MassARRAY to identify the polymorphisms. DNA was extracted from the secondary blood samples taken from the T2DM patients. The alleles and genotypes were tested using four genetic models, and the best mode of inheritance was chosen based on the leastpvalue. Thers2346061ofCNDP1was significantly associated with diabetic nephropathy among the Indians only with OR = 1.94 and 95% CI = (1.76–3.20) and fitted best the multiplicative model, whileD18S880was associated among all the three major races with the Malays having the strongest association with OR = 2.46 and 95% CI = (1.48–4.10), Chinese with OR = 2.26 and 95% CI = (1.34–3.83), and Indians with OR = 1.77 and 95% CI = (1.18–2.65) in the genotypic multiplicative model. The best mode of inheritance for bothMnSODandNOS3was the additive model. ForMnSOD-rs4880, the Chinese had OR = 2.8 and 95% CI = (0.53–14.94), Indians had OR = 2.4 and 95% CI = (0.69–2.84), and Malays had OR = 2.16 and 95% CI = (0.54–8.65), while forNOS3-rs1799983, the Indians had the highest risk with OR = 3.16 and 95% CI = (0.52–17.56), followed by the Chinese with OR = 3.55 and 95% CI = (0.36–35.03) and the Malays with OR = 2.89 and 95% CI = (0.29–28.32). The four oxidative stress-related polymorphisms have significant effects on the development of nephropathy in type 2 diabetes patients. The genes may, therefore, be considered as risk factors for Malaysian subjects who are predisposed to T2DM nephropathy.

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