scholarly journals Efficacy of the R(+)-enantiomer of alpha-lipoic acid in clinical practice

2021 ◽  
Vol 17 (8) ◽  
pp. 633-636
Author(s):  
N.О. Kravchun ◽  
I.P. Dunaieva
Keyword(s):  
Lipoic Acid ◽  
Clinical Situation ◽  
Current Data ◽  
Gradual Transition ◽  
Alpha Lipoic Acid ◽  
Positive Effects ◽  
Personalized Approach ◽  
Factor Α ◽  
Effective Use ◽  
Continuous Use

The article presents current data from the scientific medical literature on the effective use of the R(+)-enantiomer of α-lipoic acid in various pathological conditions. The authors analyze the literature data on the comparative assessment of the activity of racemic and dextrorotatory forms of thioctic (alpha-lipoic) acid in low back pain, the effect of the R(+)-enantiomer in combination with hyperbaric oxygen therapy on the production of interleukin-6, tumor necrosis factor α and vascular endothelial growth factor in the healing of chronic ulcers of the lower extremities, as well as the use of R-α-lipoic acid in patients with mild to moderate carpal tunnel syndrome. It should be noted that recently around the world there is a tendency to gradual transition from the course treatment of diabetic neuropathy towards long-term and continuous use of pathogenetic therapies in order to maintain their positive effects. Alpha-lipoic acid is widely used in neurological practice, as evidenced by our data. Also, α-lipoic acid is actively used in gastroenterology in the treatment of chronic liver diseases. Currently, the action of α-lipoic acid is being actively studied in terms of the prevention and treatment of atherosclerosis. Based on the analyzed data, the authors concluded that it is the R(+)-enantiomer of α-lipoic acid that has a positive biological effect, and treatment with it should be carried out almost constantly, taking breaks in its intake. The duration of R-α-lipoic acid use depends on the specific clinical situation, and given the current personalized approach to treatment, as shown by the analysis of modern medical sources, people with diabetes in a state of decompensation of carbohydrate metabolism should be prescribed it for 6 months continuously with a break of 2 months and repeated courses.

scholarly journals Effect of Alpha-lipoic Acid Supplementation on Glycemic Control in the Patients with Metabolic Syndrome: A Randomized Clinical Trial

2020 ◽  
Author(s):  
Nafiseh Kaviyani ◽  
Seyed Ali Keshavarz ◽  
Behnood Abbasi
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Clinical Trial ◽  
Glycemic Control ◽  
Lipoic Acid ◽  
Serum Insulin ◽  
Alpha Lipoic Acid ◽  
Acid Supplementation ◽  
Positive Effects ◽  
Significant Difference

Abstract BackgroundMetabolic syndrome is a collection of metabolic disorders. It is an important risk factor for progression towards type 2 diabetes and coronary artery diseases. Alpha-lipoic acid also plays a role as a co-factor for multi-enzyme complexes catalyzing oxidative. Antioxidant properties of alpha-lipoic acid (ALA) are associated with insulin-like effects. The present study examined the effect of alpha-lipoic acid supplementation on glycemic control in the patients with metabolic syndrome.MethodsA total of 46 patients with metabolic syndrome have participated in this double-blind randomized parallel-group clinical trial, 23 patients in one group received 600 mg of alpha-lipoic acid supplement and 23 patients in another group received the placebo for 12 weeks. RCT protocol was registered at ClinicalTrials.gov and it is available using NCT03589690 code. Fasting blood sugar (FBS), Serum insulin, Hemoglobin A1c (HbA1c), insulin resistance, were measured at the beginning and the end of the study. Dietary intake of participants was examined at the beginning of the study and this information was evaluated using Nutritionist 4 (N4) software. Studied information was analyzed by SPSS-24 software.ResultsThere were significant decreases in FBS levels (P = 0.009), serum insulin (P = 0.02), and insulin resistance (P = 0.001) between the two groups. Also, the HbA1c levels (P = 0.16) had no significant difference between the two groups.ConclusionALA is a potent antioxidant that it might be able to improve the blood glucose levels, serum insulin and insulin resistance; thus it will have positive effects on promoting the health levels in the patients with metabolic syndrome.Trial registrationNCT03589690

scholarly journals A Case for Alpha-Lipoic Acid as an Alternative Treatment for Diabetic Polyneuropathy

2018 ◽  
Vol 21 (1s) ◽  
pp. 192s-199s ◽  
Author(s):  
Ngoc Nguyen ◽  
Jody K Takemoto
Keyword(s):  
Lipoic Acid ◽  
Diabetic Polyneuropathy ◽  
The United States ◽  
Current Data ◽  
Current Evidence ◽  
Future Research ◽  
Alpha Lipoic Acid ◽  
Open Label ◽  
The Us ◽  
Meta Analyses

Purpose: The aim of this systematic review is to evaluate current evidence of alpha-lipoic acid (ALA) regarding efficacy, safety, and cost to accurately compare it with other diabetic polyneuropathy (DPN) treatments. The intention is to provide recommendations on future research and to promote utilization of ALA in the United States (US). Methods: A literature search was conducted on three databases: Scopus, PubMed, and Web of Science. The following criteria were used to select studies: (1) randomized controlled trials (RCTs) and open-label trials on ALA, (2) review articles and meta-analyses of RCTs on ALA, (3) study population consisting of patients with diabetes mellitus, peripheral neuropathic pain, and/or metabolic syndrome. Results: Twenty-five publications were selected including five RCTs and three open-label studies. Most clinical trials were conducted outside of the US. Current data provides evidence for the benefits of ALA in DPN treatment at a dose of 600 mg per day, either intravenously (IV) or orally, for a duration of at least 3 weeks with minimal side effects. Conclusions: ALA demonstrates effectiveness in treating DPN through multiple mechanisms to modulate pathophysiology and control symptoms. In addition, ALA exhibits activity in weight management and insulin sensitivity. The use of ALA for DPN in the US is worth considering because commonly prescribed medications have unclear mechanisms, more pronounced adverse effects, and are more expensive than ALA.  Further research needs to be conducted to assess long-term efficacy of ALA in US patients.

Effect of the alpha-lipoic acid on apoptosis in HIT-T15 cells induced by high glucose

2010 ◽  
Vol 34 (8) ◽  
pp. S14-S14
Author(s):  
Yi Yang ◽  
Wei‑Ping Wang ◽  
Yi‑Nan Liu ◽  
Ting Guo ◽  
Ping Chen ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
High Glucose ◽  
Alpha Lipoic Acid

Evaluation of dissolution profiles of alpha lipoic acid soft gelatin capsules and tablets

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
A Uzunovic ◽  
S Hadzidedic ◽  
A Elezovic ◽  
S Pilipovic ◽  
A Sapcanin
Keyword(s):  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Gelatin Capsules ◽  
Soft Gelatin Capsules

Secunder prevention with alpha-lipoic acid and vitamin E in porphyria cutanea tarda patients

2008 ◽  
Vol 46 (05) ◽  
Author(s):  
E Székely ◽  
K Szentmihályi ◽  
M Bor ◽  
Á Pusztai ◽  
T Kurucz ◽  
...  
Keyword(s):  
Vitamin E ◽  
Lipoic Acid ◽  
Porphyria Cutanea Tarda ◽  
Alpha Lipoic Acid

Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells

Diabetes ◽  
1997 ◽  
Vol 46 (9) ◽  
pp. 1481-1490 ◽  
Author(s):  
A. Bierhaus ◽  
S. Chevion ◽  
M. Chevion ◽  
M. Hofmann ◽  
P. Quehenberger ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Cultured Endothelial Cells ◽  
Nf Kappab

The use of rosuvastatin and alpha lipoic acid in patients with unstable angina

2017 ◽  
Vol 23 (1-2) ◽  
pp. 9-14
Author(s):  
E.H. Zaremba ◽  
◽  
O.V. Smalyukh ◽  
O.V. Zaremba-Fedchyshyn ◽  
O.V. Zaremba ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid

EVALUATION OF THE EFFECT OF CARNOSINE AND ALPHA-LIPOIC ACID ON THE HEMATOLOGICAL PARAMETERS OF WISTAR RATS WITH INDUCED FATTY LIVER DISEASE

2020 ◽  
Author(s):  
Оксана Константиновна Мустафина ◽  
Элеонора Николаевна Трушина ◽  
Николай Александрович Ригер ◽  
Илья Владимирович Аксенов
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Lipoic Acid ◽  
Fatty Liver Disease ◽  
Hematological Parameters ◽  
Biologically Active ◽  
Alpha Lipoic Acid ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Significant Protective Effect

В исследовании установлено, что использование высококалорийного холинодефицитного рациона (ВКХДР) у крыс привело к снижению уровня гемоглобина и эритроцитарных показателей, лейкоцитозу. Не выявлено достоверного влияния ВКХДР на общее количество тромбоцитов и эритроцитов. Добавление в рационы крыс карнозина и альфа-липоевой кислоты не оказало протективного влияния на изменения гематологического статуса в условиях развития НАЖБП. Studies on the effect of minor biologically active substances on the hematological parameters of rats against the background of induced fatty liver dystrophy. The addition of carnosine and alpha-lipoic acid to rat diets did not have a significant protective effect on changes in the hematological status in conditions of non-alcoholic fatty liver disease.

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