scholarly journals CLINICAL OUTCOMES OF USE OF HYDROXYCHLOROQUINE IN PARADOXICAL TUBERCULOSIS-IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME IN HIV-INFECTED PATIENTS.

2018 ◽  
Vol 11 (2) ◽  
pp. 439
Author(s):  
Pramod Kumar A ◽  
Parthasarathi G ◽  
Mothi Sn ◽  
Sudheer Ap ◽  
Vht Swamy ◽  
...  
Keyword(s):  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Hiv Care ◽  
Common Condition ◽  
Time Duration ◽  
South Indian ◽  
Definite Improvement ◽  
The Mean ◽  
Inflammatory Syndrome

 Objective: Immune reconstitution inflammatory syndrome (IRIS) is an inflammatory reaction in HIV-infected patients after initiation of antiretroviral therapy (ART) resulting from restored immunity to specific infectious or non-infectious antigens. The most common condition where IRIS has been reported is tuberculosis (TB). Various mechanisms have been proposed and studied to account for the immune regulatory role of hydroxychloroquine (HCQ). This study is done to identify clinical outcome in HIV-TB patients with IRIS after given with HCQ.Methods: An uncontrolled longitudinal study was conducted among HIV-infected patients with TB initiated on ART and developed IRIS between July 2013 and June 2015 in a South Indian HIV care hospital.Results: A total of 40 patients have developed IRIS with mean age of 35.87 years and 77.5 % of them were males. At the time of IRIS occurrence, the mean body mass index was found to be 19.17 kg/m2 and CD4 count was 200 cells/mm3. The time duration took to get improvement in majority of the patients was 4–12 weeks.Conclusion: There was definite improvement seen in patients who received HCQ in TB-IRIS condition.

scholarly journals Cardiovascular Biomarker Profile on Antiretroviral Therapy Is Not Influenced by History of an IRIS Event in People With HIV and Suppressed Viremia

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Aurelie Gouel-Cheron ◽  
Martha Nason ◽  
Adam Rupert ◽  
Virginia Sheikh ◽  
Greg Robby ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Antiretroviral Therapy ◽  
Chronic Inflammation ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Art Initiation ◽  
History Of ◽  
Cardiovascular Biomarker ◽  
Inflammatory Syndrome

Abstract Immune reconstitution inflammatory syndrome (IRIS) is characterized by release of proinflammatory cytokines and tissue inflammation occurring early after antiretroviral therapy (ART) initiation. The role of previous IRIS events in persistent chronic inflammation in people with HIV is currently unclear. In this retrospective analysis of 143 participants who maintained suppression of HIV viremia, we compared biomarkers related to inflammation, coagulation, and cardiovascular risk after 3 years on ART in participants with and without a history of IRIS. There was no evidence of higher levels of persistent chronic inflammation in people with HIV who had a history of an IRIS event. ClinicalTrials.gov Identifier . NCT00286767.

The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome

Immunobiology ◽  
2014 ◽  
Vol 219 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Huyen Thi Thanh Tran ◽  
Rafael Van den Bergh ◽  
Trung Nghia Vu ◽  
Kris Laukens ◽  
William Worodria ◽  
...  
Keyword(s):  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Inflammatory Syndrome

scholarly journals Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163298 ◽  
Author(s):  
Gopalan Narendran ◽  
Dhanasekaran Kavitha ◽  
Ramesh Karunaianantham ◽  
Leonardo Gil-Santana ◽  
Jilson L. Almeida-Junior ◽  
...  
Keyword(s):  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Clinical Severity ◽  
Inflammatory Syndrome

scholarly journals Role of the Interleukin 10 Family of Cytokines in Patients With Immune Reconstitution Inflammatory Syndrome Associated With HIV Infection and Tuberculosis

2013 ◽  
Vol 207 (7) ◽  
pp. 1148-1156 ◽  
Author(s):  
Rebecca Tadokera ◽  
Katalin A. Wilkinson ◽  
Graeme A. Meintjes ◽  
Keira H. Skolimowska ◽  
Kerryn Matthews ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Interleukin 10 ◽  
Inflammatory Syndrome

scholarly journals Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis

Blood ◽  
2012 ◽  
Vol 119 (14) ◽  
pp. 3315-3320 ◽  
Author(s):  
Polidy Pean ◽  
Eric Nerrienet ◽  
Yoann Madec ◽  
Laurence Borand ◽  
Didier Laureillard ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Killer Cell ◽  
Antiretroviral Drugs ◽  
Receptor Expression ◽  
Cell Counts ◽  
Inflammatory Syndrome

Abstract Immune reconstitution inflammatory syndrome (IRIS) is a common and potentially serious complication occurring in HIV-infected patients being treated for tuberculosis (TB) using combined antiretroviral treatment. A role of adaptive immunity has been suggested in the onset of IRIS, whereas the role of natural killer (NK) cells has not yet been explored. The present study sought to examine the involvement of NK cells in the onset of IRIS in HIV-infected patients with TB and to identify predictive markers of IRIS. A total of 128 HIV-infected patients with TB from the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) trial were enrolled in Cambodia. Thirty-seven of the 128 patients developed IRIS. At inclusion, patients had low CD4 cell counts (27 cells/mm3) and high plasma viral load (5.76 and 5.50 log/mL in IRIS and non-IRIS patients, respectively). At baseline, NK-cell degranulation capacity was significantly higher in IRIS patients than in non-IRIS patients (9.6% vs 6.38%, P < .005). At IRIS onset, degranulation capacity did not differ between patients, whereas activating receptor expression was lower in IRIS patients. Patients with degranulation levels > 10.84% had a higher risk of IRIS (P = .002 by log-rank test). Degranulation level at baseline was the most important IRIS predictor (hazard ratio = 4.41; 95% confidence interval, 1.60-12.16). We conclude that NK-degranulation levels identify higher IRIS risk in HIV-infected patients with TB.

scholarly journals Maraviroc Failed to Control Progressive Multifocal Leukoencephalopathy-Associated IRIS in a Patient with Advanced HIV Infection

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Mónica Rodríguez ◽  
Fernando Antonio Silva-Sánchez ◽  
César Luna-Rivero ◽  
Ricardo Vega-Barrientos ◽  
Claudia Alvarado-de la Barrera ◽  
...  
Keyword(s):  
Progressive Multifocal Leukoencephalopathy ◽  
Hiv Infection ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Fatal Outcome ◽  
Therapeutic Options ◽  
Medical Community ◽  
Future Studies ◽  
Inflammatory Syndrome

Due to the lack of therapeutic options for patients with progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-associated IRIS), maraviroc has generated expectations among the medical community. However, we report a patient with advanced HIV infection, who developed PML-associated IRIS and had a fatal outcome despite the addition of maraviroc to suppressive ART. Future studies are required to define the therapeutic role of maraviroc in PML-associated IRIS and differentiate individuals who may benefit from maraviroc from those who may develop neurological deterioration.

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