scholarly journals THE EMERGING ROLE OF SERRATIOPEPTIDASE IN ORAL SURGERY: LITERATURE UPDATE

2018 ◽  
Vol 11 (3) ◽  
pp. 19 ◽  
Author(s):  
Santhosh Kumar Mp
Keyword(s):  
Proteolytic Enzyme ◽  
Therapeutic Agent ◽  
Oral Surgery ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Medical Field ◽  
Enzyme Preparations ◽  
Inflammatory Agent ◽  
Anti Inflammatory

 Serratiopeptidase, a proteolytic enzyme derived from Serratia E-15 species enterobacteria, is widely used in medical field for its anti-inflammatory, anti-edemic properties, and analgesic properties. It is being used commonly in various specialties such as orthopedics, otolaryngology, gynecology, surgery, pulmonology, ophthalmology, and dentistry. Research has shown that serratiopeptidase is the most effective anti-inflammatory agent compared to other enzyme preparations. This article reviews the efficacy, safety, and applications of serratiopeptidase in oral surgery. This article also discusses the mechanism of action of serratiopeptidase, its contraindications and complications. From the recently published literature, it is clear that the role of serratiopeptidase as a therapeutic agent in oral and maxillofacial surgery is expanding and they hold a promising future as a broad-spectrum anti-inflammatory drug with minimal side effects and complications. Further, research will broaden their applications in the field of medicine and dentistry.

scholarly journals The Role of Chemical Agents in the Microbial Flora with Major Risk of Interventios in Maxilo-facial Surgery

2019 ◽  
Vol 70 (6) ◽  
pp. 1988-1991
Author(s):  
Carmen Gabriela Stelea ◽  
Iulian Constantin ◽  
Cristian Budacu ◽  
Alexandra Lorina Platon ◽  
Mihail Balan ◽  
...  
Keyword(s):  
Oral Surgery ◽  
Maxillofacial Surgery ◽  
The Body ◽  
Small Scale ◽  
Oral And Maxillofacial Surgery ◽  
Periodontal Surgery ◽  
Facial Surgery ◽  
Chemical Agents ◽  
Infectious Etiology

The pathology of the oro-maxilo-facial territory comprises a vast chapter of diseases with primary or secondary infectious etiology, the mouth being the natural cavity of the organism with the most varied and variable flora of bacterial contamination. By the continuity solutions created by the mechanical act of mastication, decubitus of defective prosthetic works, local dento-periodontal infectious processes, but especially of dental or small-scale interventions, open gates and possibilities of penetration into the blood circulation of the microorganisms, which cause the transient bacteria. The study included 243 randomly selected patients, with the address of the Oral and Maxillofacial Surgery Clinic in the period 2016-2018. The inoculation of microorganisms in the oral cavity in circulating blood as a result of oral surgery or dental care procedures is much more common than in other areas of the body. Aggressive dental maneuvers that create solutions of continuity of oral mucosa, gingiva, periodontal surgery, periodontal surgery techniques can cause bacteria.

scholarly journals Effect of educational intervention on the appropriate use of oral antimicrobials in oral and maxillofacial surgery: a retrospective secondary data analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Junya Kusumoto ◽  
Atsushi Uda ◽  
Takeshi Kimura ◽  
Shungo Furudoi ◽  
Ryosuke Yoshii ◽  
...  
Keyword(s):  
Educational Intervention ◽  
Oral Surgery ◽  
Maxillofacial Surgery ◽  
Antibiotic Use ◽  
Oral And Maxillofacial Surgery ◽  
Third Generation ◽  
Oral Antibiotics ◽  
Appropriate Use ◽  
Before And After ◽  
Third Generation Cephalosporins

Abstract Background In Japan, oral third-generation cephalosporins with broad-spectrum activity are commonly prescribed in the practices of dentistry and oral surgery. However, there are few reports on the appropriate use of antibiotics in the field of oral surgery. This study aimed to evaluate the appropriateness of antibiotic use before and after an educational intervention in the Department of Oral and Maxillofacial Surgery, Kobe University Hospital. Methods The use of oral antibiotics was investigated among inpatients and outpatients before and after an educational intervention conducted by the antimicrobial stewardship team. Additionally, the frequency of surgical site infection after the surgical removal of an impacted third mandibular molar under general anesthesia and the prevalence of adverse effects of the prescribed antibiotics were comparatively evaluated between 2013 and 2018. Results After the educational intervention, a remarkable reduction was noted in the prescription of oral third-generation cephalosporins, but increased use of penicillins was noted among outpatients. There was reduced use of macrolides and quinolones in outpatients. Although a similar trend was seen for inpatients, the use of quinolones increased in this population. Despite the change in the pattern of antibiotic prescription, inpatients who underwent mandibular third molar extraction between 2013 and 2018 did not show a significant increase in the prevalence of surgical site infections (6.2% vs. 1.8%, p = .336) and adverse effects of drugs (2.1% vs. 0%, p = .466). Conclusions This study suggests that the judicious use of oral antibiotics is possible through conscious and habitual practice of appropriate antibiotic use. However, further investigation is required to develop measures for appropriate use of oral antibiotics.

scholarly journals Pharmacotherapy in Oral and Maxillofacial Surgery

2021 ◽  
pp. 195-215
Author(s):  
Latha P. Rao
Keyword(s):  
Literature Search ◽  
Maxillofacial Surgery ◽  
Medical Professionals ◽  
Oral And Maxillofacial Surgery ◽  
Pharmacological Properties ◽  
Review Of Literature ◽  
Surgical Practice ◽  
Inflammatory Drugs ◽  
Prescribed Medicines ◽  
Anti Inflammatory

AbstractThe field of pharmacology has always fascinated medical professionals—the ability to cure a disease by prescribing medicine is very tempting. Medical and surgical specialties benefit from the correct use of drugs, and oral and maxillofacial surgery (OMFS) is no exception. Antibiotics, analgesics, and anti-inflammatory drugs are among commonly prescribed medicines in a maxillofacial surgical practice. Umpteen number of literature studies are available on the usage of these medicines in maxillofacial surgery. A review of literature is attempted in this chapter to reach a consensus in matters pertaining to these drugs. The task was in no way an easy one as no two studies compared the same group of medicines or similar pharmacological properties. The key facts, which have emerged from this literature search, have been projected in this chapter.

scholarly journals Rare Iatrogenic Oronasal Communication after Superior Canine Odontectomy Attempt

2021 ◽  
Vol 2020 (2) ◽  
pp. 1
Author(s):  
Ciprian Roi ◽  
Emilia Ianeș ◽  
Diana Nica ◽  
Alexandra Roi ◽  
Laura Cristina Rusu ◽  
...  
Keyword(s):  
Case Report ◽  
Scientific Literature ◽  
Oral Surgery ◽  
Healing Process ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Unsuccessful Attempt ◽  
One Year ◽  
General Dentist

(1) Background: Oronasal communication is described in the scientific literature as a common complication that occurs after a cleft palate surgery. In some cases, it can also be a consequence of oral surgery procedures; the main problem of this type of rare accident is related to the correct healing process and treatment option. (2) Case report: A patient with oronasal communication caused by an unsuccessful attempt of a superior canine odontectomy presented at the Emergency Department of the Oral and Maxillofacial Surgery Hospital, Timișoara. The case management is described from the first consult to one-year follow-up. We consider that this pathology was optimally treated surgically, and the results are more than satisfactory, taking into consideration the high rates of recurrence. (3) Conclusion: This case report can be a useful to a general dentist who is trying to decide whether to perform the canine odontectomy or refer to a specialist surgeon due to the accidents and complications of this procedure.

Role of a nonsteroidal anti-inflammatory agent, ibuprofen, in coronary revascularization after acute myocardial infarction

1990 ◽  
Vol 85 (1) ◽  
pp. 55-70 ◽  
Author(s):  
R. Clement ◽  
D. K. Das ◽  
R. M. Engelman ◽  
H. Otani ◽  
D. Bandhyopadhyay ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Revascularization ◽  
Inflammatory Agent ◽  
Anti Inflammatory

scholarly journals Antiplatelet drugs: a review of pharmacology and the perioperative management of patients in oral and maxillofacial surgery

2020 ◽  
Vol 102 (1) ◽  
pp. 9-13
Author(s):  
H Mahmood ◽  
I Siddique ◽  
A McKechnie
Keyword(s):  
Antiplatelet Therapy ◽  
Oral Surgery ◽  
Safety Concern ◽  
Maxillofacial Surgery ◽  
Antiplatelet Agents ◽  
Antiplatelet Drugs ◽  
Current Evidence ◽  
Bleeding Complications ◽  
Oral And Maxillofacial Surgery ◽  
Number Of Patients

Introduction An increasing number of patients are taking oral antiplatelet agents. As a result, there is an important patient safety concern in relation to the potential risk of bleeding complications following major oral and maxillofacial surgery. Surgeons are increasingly likely to be faced with a dilemma of either continuing antiplatelet therapy and risking serious haemorrhage or withholding therapy and risking fatal thromboembolic complications. While there are national recommendations for patients taking oral antiplatelet drugs undergoing invasive minor oral surgery, there are still no evidence-based guidelines for the management of these patients undergoing major oral and maxillofacial surgery. Methods MEDLINE and EMBASE databases were searched to retrieve all relevant articles published to 31 December 2017. Findings A brief outline of the commonly used antiplatelet agents including their pharmacology and therapeutic indications is discussed, together with the haemorrhagic and thromboembolic risks of continuing or altering the antiplatelet regimen in the perioperative period. Finally, a protocol for the management of oral and maxillofacial patients on antiplatelet agents is presented. Conclusions Most current evidence to guide decision making is based upon non-randomised observational studies, which attempts to provide the safest possible management of patients on antiplatelet therapy. Large randomised clinical trials are lacking.

scholarly journals Curcumin and Endometriosis

2020 ◽  
Vol 21 (7) ◽  
pp. 2440 ◽  
Author(s):  
Alexandre Vallée ◽  
Yves Lecarpentier
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Responses ◽  
Uterine Cavity ◽  
Main Role ◽  
Oxygen Species ◽  
Inflammatory Agent ◽  
Gynecological Disorders ◽  
Anti Oxidant ◽  
Anti Inflammatory

Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.

scholarly journals A szellemi fogyatékosok fogászati-szájsebészeti ellátásának múltja, jelene és remélt jövője Magyarországon

2019 ◽  
Vol 160 (35) ◽  
pp. 1380-1386
Author(s):  
Ilona Szmirnova ◽  
Emese Gellérd ◽  
Gábor Tamás Pintér ◽  
György Szmirnov ◽  
Zsolt Németh ◽  
...  
Keyword(s):  
Dental Care ◽  
Oral Surgery ◽  
Demographic Data ◽  
Maxillofacial Surgery ◽  
Mental Disability ◽  
Oral And Maxillofacial Surgery ◽  
Disabled People ◽  
Care Needs ◽  
Mentally Disabled ◽  
The Past

Abstract: Introduction: Dental care for mentally disabled people poses a growing challenge for healthcare. In Hungary, the number of mentally disabled people needing special dental care is ca. 100 000. Aim: The aim of our retrospective analysis is to provide a summary of the demographic data and the treatment outcomes of patients with mental disorders treated at the Department of the Oral and Maxillofacial Surgery of the Semmelweis University in the past five years. Method: Dental care for patients with a severe level of mental disability can be carried out in general anaesthesia only. At Semmelweis University, in the Oral and Maxillofacial Department, 1717 mentally disabled adults received dental care during the past five years. (Patients included people with a mild, medium or severe level of mental disability, patients with Down’s syndrome, autism, epilepsy or panic disorder.) Results: The single biggest achievement seems to be the fact that the issue of acute dental care and oral surgery has basically been settled. A workable relationship has been forged with foundations and organizations dealing with the problems of these patients. It has been realized, however, that in the case of mentally disabled patients there is an enormous need for prevention and ongoing care. Conclusions: Up to now no survey has been carried out in Hungary with the aim of objectively revealing the dental care needs of these patients. Internationally, however, several surveys have been published. It can be stated on the basis of these that both caries frequency and the presence of parodontal diseases increase in correlation with age and the level of disability. Oral hygiene is insufficient, patients or their caretakers do not get proper information, only a few of them receive adequate training and they are not motivated to keep up oral health. Dental care, except for tending acute cases, is not satisfactory. For the sake of prevention, cooperation is needed with non-governmental organizations, foundations, special education teachers and psychiatrists specialized in this field. Orv Hetil. 2019; 160(35): 1380–1386.

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