scholarly journals CLINICAL EVALUATION OF MANAGEMENT AND PREVALENCE OF TYPE TWO DIABETES MELLITUS COMPLICATIONS IN SOUTH INDIAN POPULATION

2018 ◽  
Vol 11 ◽  
Author(s):  
Geetha P
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Glycosylated Hemoglobin ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
South Indian Population ◽  
Low Density

Objective: The present study was aimed to assess the prevalence of complications and to assess the targets achieved during the management of diabetes mellitus type 2.Methods: The study was prospective and conducted out in a diabetes center, Chennai, ethical approval was obtained from the Institutional Ethics Committee, case records of the 300 patients diagnosed with type 2 diabetes mellitus and its complications were monitored during March 2017–April 2018. Major result actions are body weight, height, body mass index (BMI), blood pressure, fasting blood sugar (FBS), post-prandial blood sugar (PPBS) levels, glycosylated hemoglobin, serum lipids, and presence of complications of diabetes. Comparison of the average of various biochemical parameters was made in patients with and no diabetic complications.Results: The average age of 300 patients was found to be 55.006±13.04. The average BMI was 27.10±12.81 kg/m2. The average duration of diabetes was 10.48±7.53. The average of systolic (SBP) and diastolic blood pressure was 137±20.88 and 79.95±11.81. The mean glycated hemoglobin, FBS, PPBS, low-density lipoprotein, high-density lipoprotein, and triglyceride, and total cholesterol were found to be 8.5±3.99, 148.85±55.64 mg/dl, 200.98±72.63 mg/dl, 88.06±19.46 mg/dl, 36.20±8.27 mg/dl, 141.22±60.15 mg/dl, and 144.45±29.03 mg/dl, respectively. Among the microvascular complications; neuropathy, nephropathy, and retinopathy were documented in 8.33%, 23.66%, and 17.33% of patients, respectively. The prevalence of peripheral artery disease was 20.66%.Conclusion: The prevalence of diabetic complications is significantly increased with patients age, duration, SBP, low-density lipoprotein,total cholesterol, and post-prandial blood sugar levels. Knowledge concerning the supervision of target blood pressure and lipidparameters is need further than the glycemic manage among diabetes patients type two.

scholarly journals Evaluation of type-2 diabetes mellitus patients for dyslipidemia in a tertiary care centre

2020 ◽  
Vol 7 (4) ◽  
pp. 586
Author(s):  
Janak G. Chokshi ◽  
Apal P. Gandhi ◽  
Ishvarlal M. Parmar ◽  
Dipen R. Damor
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Plasma Glucose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
Low Density ◽  
Increased Risk

Background: Diabetes mellitus (DM) is a syndrome consisting of metabolic, vascular and neuropathic components that are interrelated. Diabetes mellitus is associated with a considerably increased risk of premature atherosclerosis, particularly coronary heart disease (CHD) and peripheral arterial disease. Dyslipidemia is a common feature of diabetes. There is an association between atherosclerotic cardiovascular disease and serum cholesterol and triglyceride levels in both type 1 and type 2 diabetes.Methods: The study was done on 50 adult diabetes mellitus (T2) patients from IPD of General Medicine wards at SMS Hospital, Ahmedabad, Gujarat. 50 healthy age and sex matched healthy volunteers were taken as control. They were evaluated for lipid profile i.e., Total Cholesterol (TC),Triglyceride (TG), Low-density lipoprotein (LDL), High density lipoprotein (HDL), Very low density lipoprotein (VLDL) and glycemic status i.e., Fasting blood glucose (FBS), Postprandial 2 hours blood glucose (PP2BS) & Glycosylated haemoglobin(HbA1C).Results: Diabetic cases had statistically highly significant (p<0.001) elevated levels of total Cholesterol, Triglycerides and VLDL as compared to controls. Serum TG, serum TC, LDL-C and VLDL-C had positive correlation with the postprandial plasma glucose, fasting plasma glucose and HbA1c.Conclusions: Significant correlations between HbA1c levels and lipid levels point towards the usefulness of HbA1c for screening high-risk diabetic patients. High TC, TG, LDL-C and HbA1c with normal or low HDL-C is seen in almost all diabetic patients either alone or in combinations.

scholarly journals Hubungan Antara Tekanan Darah Sistolik Dengan Kadar Ldl (Low Density Lipoprotein) Padapasien Diabetes Melitus Tipe 2 Di Klinik Arafah, Lampung Tengah

2021 ◽  
Vol 1 (3) ◽  
pp. 134-141
Author(s):  
Avi Hurriyatus Sholihah ◽  
Firhat Esfandiari ◽  
Sandhy Arya Pratama ◽  
Resti Arania
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Diabetes Melitus

ABSTRACT: RELATIONSHIP BETWEEN SYSTOLIC BLOOD PRESSURE WITH LDL (LOW DENSITY LIPOPROTEIN) IN DIABETES MELLITUS TYPE 2 PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNG  Background: According to the 2017 World Health Organization (WHO), type 2 diabetes mellitus and hypertension ( HT) is a common disease among older adults aged> 60 years in developing and developed countries. One of the factors of hypertension is high levels of fat at high levels of fat, levels of LDL (Low Density Lipoprotein) are very influential and can lead to atherosclerosis that triggers hypertension. Of the 46 subjects, the frequency distribution of the sexes was male as many as 16 people (34.8%), female 30 people (65.2%). According to age <30 years as many as 2 people (4.3%), 30-50 years as many as 8 people (17.4%),> 50 years as many as 36 (78.3%). According to normal systolic blood pressure <140 mmHg as many as 34 people (73.9%), Height> 140 mmHg as many as 12 people (26.1%). And according to normal LDL levels <100 mg / dl as many as 8 people (17.4%), height> 100 mmHg as many as 38 people (2.6%). Objectives: to determine the relationship between systolic blood pressure and LDL (Low Density Lipoprotein) levels in patients with type 2 diabetes mellitus at the Arafah clinic, Central Lampung, 2020. Methods: This study used a cross sectional approach, namely by collecting data at the same time as one time. The data will be processed and analyzed with the help of a computer using the SPSS for Windows version 20.0 program. Results: Based on the Chi-Square analysis, it was found that there was no relationship with the value of p = 0.336 (p> 0.05). Conclusion: There is no relationship between systolic blood pressure and LDL (Low Density Lipoprotein) levels in patients with type 2 diabetes mellitus.                                                                                                 Keywords: Systolic blood pressure, LDL Levels, Diabetes Mellitus type 2.        INTISARI: HUBUNGAN ANTARA TEKANAN DARAH SISTOLIK DENGAN KADAR LDL (LOW DENSITY LIPOPROTEIN) PADA PASIEN DIABETES MELITUS TIPE 2 DI KLINIK ARAFAH, LAMPUNG TENGAH.Latar Belakang: Menurut World Health Organization tahun 2017 (WHO), diabetes melitus tipe 2 dan hipertensi (HT) adalah penyakit yang umum dikalangan orang dewasa tua berusia > 60 tahun di negara berkembang dan negara maju. Salah satu faktor hipertensi ialah tingginya kadar lemak pada tingginya kadar lemak, kadar LDL (Low Density Lipoprotein) sangat berpengaruh dan dapat mengakibatkan sebuah aterosklerosis pemacu hipertensi. Dari 46 subjek didapatkan distribusi frekuensi jenis kelaminnya laki laki sebanyak 16 orang (34,8%), perempuan 30 orang (65,2%). Menurut umurnya <30 tahun sebanyak 2 orang (4,3%), 30 – 50 tahun sebanyak 8 orang (17,4%), >50 tahun sebanyak 36 (78,3%). Menurut Tekanan darah sistoliknya Normal <140 mmHg sebanyak 34 orang (73,9%), Tinggi >140 mmHg sebanyak 12 orang (26,1%). Dan Menurut Kadar LDLnya normal <100 mg/dl sebanyak 8 orang (17,4%), tinggi >100 mmHg sebanyak 38 orang (2,6%).Tujuan: untuk mengetahui hubunganan antara tekanan darah sistolik dengan kadar LDL (Low Density Lipoprotein) pada pasien diabetes melitus tipe 2 di klinik Arafah, Lampung tengah tahun 2020.Metode: Penelitian ini menggunakan pendekatan cross sectional, yaitu dengan cara pengumpulan data sekaligus pada satu waktu. Data akan diolah dan dianalisa dengan bantuan komputer dengan menggunakan program SPSS for Windows versi 20,0.Hasil: Berdasarkan analisa Chi-Square didapatkan tidak adanya hubungan dengan nilai nilai p =0,336 (p>0,05).Kesimpulan: Tidak terdapat hubungan antara tekanan darah sistolik dengan kadar LDL (Low Density Lipoprotein) pada pasien diabetes melitus tipe 2. Kata Kunci : Tekanan darah sistolik, Kadar LDL, Diabetes Melitus tipe 2.

Jumpstarting Health With a 15-Day Whole-Food Plant-Based Program

2021 ◽  
pp. 155982762110063
Author(s):  
Susan M. Friedman ◽  
Carol Hee Barnett ◽  
Robert Franki ◽  
Bruce Pollock ◽  
Beth Garver ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Blood Sugar ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Food Plant ◽  
Fasting Blood Sugar ◽  
Average Weight ◽  
Low Density ◽  
Average Drop

The 15-day Jumpstart was developed as an evidence-based, affordable, standardized, replicable, and scalable program, designed to demonstrate quickly to patients that changing what they eat can improve their health. The program was designed using the principles of the self-determination theory of motivation and personality. Patients were instructed to eat an Esselstyn-compliant, whole-food plant-based diet consisting of vegetables, fruits, whole grains, and legumes. Of the 389 participants in the program from September 2018 to February 2020, average weight loss was 5.8 pounds (7.3 for those whose body mass index was >30), average systolic blood pressure drop was 6.8 points (16.8 points for those with systolic blood pressure >140), average drop in cholesterol was 26 points (44 points for those with a cholesterol >200), average drop in low-density lipoprotein was 19 points (33 points for those with a low-density lipoprotein >100), and average drop in fasting blood sugar was 5.1 points (28.4 points for those starting in the diabetic range); P value was <.005 for fasting blood sugar and <.001 for all other comparisons. A 15-day program that helps patients adopt an Esselstyn-style whole-food plant-based diet, through education, individualized medical feedback, social support, and facilitated small group work, rapidly improves health.

scholarly journals Impact of Adoption of Directly Measured Low-Density Lipoprotein-Cholesterol (LDL-C) on Targets of Lipid Control and Its Comparison With Friedewald Formula-Calculated LDL Cholesterol in People With Type-2 Diabetes Mellitus

2020 ◽  
pp. 263246362097804
Author(s):  
Rejitha Jagesh ◽  
Mathew John ◽  
Manju Manoharan Nair Jalaja ◽  
Tittu Oommen ◽  
Deepa Gopinath
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Cardiovascular Disease ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Friedewald Formula

Objectives: The accurate and precise measurement of low-density lipoprotein-cholesterol (LDL-C) is important in the assessment of atherosclerotic cardiovascular disease risk (ASCVD) in people with diabetes mellitus. This study aimed at comparing directly measured LDL-C with Friedewald formula (FF)-calculated LDL-C (c-LDL-C) in people with type-2 diabetes. Methods: Fasting lipid profiles of 1905 people with type-2 diabetes, whose LDL-C was estimated by direct LDL assay, were chosen for the study. In the same group, LDL-C was calculated with FF. Correlation and agreement between these methods were analyzed at various strata of triglycerides (TGs). The possibility of misclassifying people at various levels of LDL-C targets proposed in literature was calculated. Results: The mean LDL-C levels were lower in the c-LDL-C group across various TG strata. A significant correlation was found between c-LDL-C and direct LDL-C for all the study samples ( r = 0.948, P < .001) and across all TG strata. Analysis of agreement showed a positive bias for direct LDL-C which increased at higher strata of TGs. c-LDL-C underestimated ASCVD by misclassifying people at various LDL-C target levels. Conclusion: There is a difference between direct LDL-C and c-LDL-C values in people with diabetes and this may result in misclassifying ASCVD especially at lower levels of LDL-C and higher levels of TGs.

scholarly journals Correlation of Serum Low Density Lipoprotein Cholesterol and High Density Lipoprotein Cholesterol with Type 2 Diabetes Mellitus

2018 ◽  
Vol 26 (2) ◽  
pp. 140-147
Author(s):  
Nahid Yeasmin ◽  
Qazi Shamima Akhter ◽  
Sayeeda Mahmuda ◽  
Sultana Yeasmin ◽  
Rumana Afroz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Fasting Serum ◽  
Medical College

Background: Diabetes mellitus is one of the most widespread endocrine disorders in female and its complications are increasing all over the world, leading to life threatening medical problems like cardiovascular diseases, stroke and end stage renal diseases. A correlation between hyperlipidemia and type 2 diabetes mellitus has been identified. The study was carried out to observe the correlation of serum low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) level with type 2 diabetes mellitus in adult female subjects.Method: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. Total sixty female subjects were selected with age ranging from 30 to 50 years. Among them 30 female subjects with diabetes mellitus were included from out-patient department of Endocrinology, Dhaka Medical College Hospital, Dhaka as study group (B) and 30 apparently healthy females were taken as control group (A) for comparison. Estimation of serum fasting serum LDL-C and HDL-C levels was done by enzymatic method in the department of Physiology, Dhaka Medical College Dhaka in both groups. Fasting serum insulin level was measured by ELISA method in the laboratory of National Institute of ENT, Dhaka and fasting blood glucose was estimated by glucose oxidase method in the department of Physiology, Dhaka Medical College in both groups. Data were analyzed by Unpaired Student’s- test and Pearson’s correlation co-efficient (r) test as applicable.Results: The value of fasting serum LDL-C level was significantly higher in study subjects than those of control. Again, fasting serum HDL-C level was significantly lower in study subjects in comparison to controls. In study subjects fasting serum LDL showed positive correlation and fasting serum HDL-C levels showed negative correlation with fasting blood glucose and serum insulin level.Conclusion: Present study reveals that serum insulin and blood glucose level have positive relationship with low density lipoprotein cholesterol (LDL-C) and negative relationship with high density lipoprotein cholesterol (HDL-C) levels.J Dhaka Medical College, Vol. 26, No.2, October, 2017, Page 140-147

scholarly journals Evaluation of lipid profiles and hematological parameters in hypertensive patients: Laboratory-based cross-sectional study

2018 ◽  
Vol 6 ◽  
pp. 205031211875666 ◽  
Author(s):  
Alemu Gebrie ◽  
Natesan Gnanasekaran ◽  
Menakath Menon ◽  
Mekonnen Sisay ◽  
Abriham Zegeye
Keyword(s):  
Blood Pressure ◽  
Blood Cell ◽  
Total Cholesterol ◽  
Hematological Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Low Density ◽  
Blood Cell Count ◽  
Hypertensive Patients

Introduction: Hypertension and dyslipidemia are the two coexisting and synergizing major risk factors for cardiovascular diseases. The cellular constituents of blood affect the volume and viscosity of blood, thus playing a key role in regulating blood pressure. Overweight and obesity are key determinants of adverse metabolic changes including an increase in blood pressure. The aim of this study was to evaluate lipid profiles and hematological parameters in hypertensive patients at Debre Markos Referral Hospital, Northwest Ethiopia. Methods: Laboratory-based cross-sectional study was conducted in 100 eligible hypertensive patients at the hospital. The required amount of blood was withdrawn from the patients by healthcare professionals for immediate automated laboratory analyses. Data were collected on socio-demographic factors, anthropometric measurements, blood pressure, lipid profiles, and hematological parameters. Result: The mean serum levels of triglyceride, total cholesterol, and low-density lipoprotein were significantly higher than their respective cut-off values in the hypertensive patients. Besides, 54%, 52%, 35%, and 11% of the hypertensive patients had abnormal low-density lipoprotein, total cholesterol, triglyceride, and high-density lipoprotein levels, respectively. Higher levels of low-density lipoprotein, hemoglobin, and red blood cell count were observed in the hypertensive patients whose blood pressure had been poorly controlled than the controlled ones ( p < 0.05). Waist circumference had a significant positive association with the serum levels of total cholesterol and white blood cell count ( p < 0.05). Conclusion: Hypertensive patients had a high prevalence of lipid profile abnormalities and poorly controlled blood pressure which synergize in accelerating other cardiovascular diseases. Some hematological parameters such as red blood cell count are also increased as do the severity of hypertension.

Abstract 5054: Apolipoprotein B, but not Low-Density Lipoprotein Cholesterol is Associated with Coronary Atherosclerosis Beyond Total Cholesterol in Diabetics and Non-Diabetics

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Seth S Martin ◽  
Atif N Qasim ◽  
Daniel J Rader ◽  
Muredach P Reilly
Keyword(s):  
Total Cholesterol ◽  
Apolipoprotein B ◽  
Coronary Atherosclerosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Type 2 Diabetics

Introduction: Accumulating evidence suggests that apolipoprotein B (apoB) is superior to low-density lipoprotein cholesterol (LDL-C) in prediction of cardiovascular events. Yet, an important outstanding question is whether apoB, relative to LDL, is an enhanced marker for subclinical atherosclerosis, particularly in diabetics where LDL levels may underestimate atherogenic lipid burden due to increased proportion of small, dense LDL. Hypothesis: We hypothesized that plasma apoB would be a better predictor than LDL-C of coronary artery calcification (CAC) scores in type 2 diabetics and non-type 2 diabetics. Methods: We performed cross-sectional analyses of asymptomatic Caucasians in (1) The Study of Inherited Risk of Coronary Atherosclerosis (434 men and 383 women; median age 48, non-diabetics) and (2) The Penn Diabetes Heart Study (580 men and 261 women; median age 60, type 2 diabetics). Results: Levels of apoB and LDL-C were correlated in diabetics (r=0.78, p<0.001) and non-diabetics (r=0.77, p<0.001). There was no association between LDL-C and CAC in diabetics. In non-diabetics, an association of LDL-C was lost after adjustment for total cholesterol. In contrast, after controlling for age, gender, statin therapy, and total cholesterol, levels of apoB were positively associated with CAC in diabetics [tobit regression ratio for 30 mg/dl increase in apoB 2.94 (95% CI 1.62 – 5.53), p=0.001) and had a more modest association with CAC in non-diabetics [1.67 (95% CI 1.16 – 2.32), p=0.005]. Conclusions: ApoB, but not LDL-C, predicted CAC scores, a measure of coronary atherosclerotic burden. The strength of this association was greater in diabetics than non-diabetics. Relative to LDL-C, plasma apoB levels may be particularly useful in assessing CVD risk in type 2 diabetes.

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