scholarly journals Evaluation of lipid profiles and hematological parameters in hypertensive patients: Laboratory-based cross-sectional study

2018 ◽  
Vol 6 ◽  
pp. 205031211875666 ◽  
Author(s):  
Alemu Gebrie ◽  
Natesan Gnanasekaran ◽  
Menakath Menon ◽  
Mekonnen Sisay ◽  
Abriham Zegeye
Keyword(s):  
Blood Pressure ◽  
Blood Cell ◽  
Total Cholesterol ◽  
Hematological Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Low Density ◽  
Blood Cell Count ◽  
Hypertensive Patients

Introduction: Hypertension and dyslipidemia are the two coexisting and synergizing major risk factors for cardiovascular diseases. The cellular constituents of blood affect the volume and viscosity of blood, thus playing a key role in regulating blood pressure. Overweight and obesity are key determinants of adverse metabolic changes including an increase in blood pressure. The aim of this study was to evaluate lipid profiles and hematological parameters in hypertensive patients at Debre Markos Referral Hospital, Northwest Ethiopia. Methods: Laboratory-based cross-sectional study was conducted in 100 eligible hypertensive patients at the hospital. The required amount of blood was withdrawn from the patients by healthcare professionals for immediate automated laboratory analyses. Data were collected on socio-demographic factors, anthropometric measurements, blood pressure, lipid profiles, and hematological parameters. Result: The mean serum levels of triglyceride, total cholesterol, and low-density lipoprotein were significantly higher than their respective cut-off values in the hypertensive patients. Besides, 54%, 52%, 35%, and 11% of the hypertensive patients had abnormal low-density lipoprotein, total cholesterol, triglyceride, and high-density lipoprotein levels, respectively. Higher levels of low-density lipoprotein, hemoglobin, and red blood cell count were observed in the hypertensive patients whose blood pressure had been poorly controlled than the controlled ones ( p < 0.05). Waist circumference had a significant positive association with the serum levels of total cholesterol and white blood cell count ( p < 0.05). Conclusion: Hypertensive patients had a high prevalence of lipid profile abnormalities and poorly controlled blood pressure which synergize in accelerating other cardiovascular diseases. Some hematological parameters such as red blood cell count are also increased as do the severity of hypertension.

scholarly journals Status of Lipid Profile among the Hypertensive Patients in Bangladesh

2014 ◽  
Vol 9 (1) ◽  
pp. 13-17 ◽  
Author(s):  
CM Reza ◽  
ASMA Kabir ◽  
Tuhin Biswas ◽  
Kamrun Nahar Choudhury ◽  
Md Zahidur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Hypertensive Patients

Back ground: Hypertension and dyslipidemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. It is widely accepted that cardiovascular disease is associated with hypertension and increased blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides. In contrast, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Hypertension is a major public health problem in developed and developing countries. Methods: This study was a cross sectional study in which 159 diagnosed hypertensive patient and 75 with normal blood pressure (normotensive) were enrolled. These patients sought a through health cheek up including blood pressure assessment between May 2012 to April 2013 in Tairunnessa Memorial Medical College and Hospital. Lipid parameter total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by enzymatic colorimetric test. Results: The mean of Systolic blood pressure and Diastolic blood pressure of hypertensive were higher than normotensive (p<0.001). The serum levels of total cholesterol, triglyceride and LDL-C in hypertensive subject were higher than normotensive and statistically significant (p<0.001). Serum HDL-C was significantly lower (p<0.001) in hypertensive patients than in normotensive. Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke. DOI: http://dx.doi.org/10.3329/uhj.v9i1.19505 University Heart Journal Vol. 9, No. 1, January 2013; 13-17

scholarly journals Association of Metabolic Syndrome and Blood Pressure in Patients with Essential Hypertension

2021 ◽  
Vol 8 (7) ◽  
pp. 453-457
Author(s):  
Abhishek Kumar Chandra ◽  
Anurag Kumar ◽  
Ansuman Dalbehera
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Essential Hypertension ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Male And Female ◽  
Hypertensive Patients

Objective: In Indian hypertensive patients, to investigate the prevalence and characteristics of the MS was the main objective of the present study. Material and Method: Current study was conducted in a tertiary care OPD among 130 patients who were diagnosed with essential hypertension. Any patients who were more that 18 years of age and diagnosed with essential hypertension and willing to participate in the study were included. By routine laboratory techniques which is generally used at NABL accredited private or government testing laboratories for analysis of lipid profile total cholesterol, total triglycerides, low-density lipoprotein cholesterol and high density lipoprotein cholesterol were assayed. Result: Average MS score were high in both the male and female group. Both male and female groups patients receives adequate blood pressure lowering treatment. In both the groups maximum patients were in ARB therapy. All parameters which are related to occurrence of metabolic syndrome like, abdominal obesity, Total Cholesterol (TC), Triglycerides (TG), Low Density Lipoprotein (LDL), fasting blood glucose (FBG) and uric acids were significantly higher in both male and female patients than the control one. Conclusion: Current study conclude that, in Indian hypertensive patients, especially in females, metabolic syndrome was highly prevalent. Keywords: Metabolic syndrome, metabolic risk factors, hhypertension,

scholarly journals Status of Lipid Profile among the Hypertensive Patients in Bangladesh

2015 ◽  
Vol 10 (2) ◽  
pp. 73-77
Author(s):  
CM Reza Qureshi Forhad ◽  
Asma Kabir ◽  
Tuhin Biswas ◽  
Kamrun Nahar Choudhury ◽  
Md Zahidur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Hypertensive Patients

Back ground: Hypertension and dyslipidemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. It is widely accepted that cardiovascular disease is associated with hypertension and increased blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides. In contrast, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Hypertension is a major public health problem in developed and developing countries. Methods: This study was a cross sectional study in which 159 diagnosed hypertensive patient and 75 with normal blood pressure (normotensive) were enrolled for compare. These patients sought a through health cheek up including blood pressure assessment between May 2012 to April 2013 in Tairunnessa Memorial Medical College and Hospital. Lipid parameters total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by enzymatic colorimetric test. Results: The mean of Systolic blood pressure and Diastolic blood pressure of hypertensive were higher than normotensive (p<0.001). The serum levels of total cholesterol, triglyceride and LDL-C in hypertensive subject were higher than normotensive and statistically significant (p<0.001). Serum HDL-C was significantly lower (p<0.001) in hypertensive patients than in normotensive. Age, waist circumference (WC), body mass index (BMI) showed significant association with hypertensive patients (p<0.001) than in normotensive subjects.The logistic regression analysis indicates hypertensive were 1.2 times higher total cholesterol, 1.3 times higher triglyceride and 1.2 times higher LDL-C than normotensive and was statistically significant (p<0.001). HDL-C was 1.08 times lower in hypertensive than normotensive and statistically significant p<0.001). Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke.University Heart Journal Vol. 10, No. 2, July 2014; 73-77

scholarly journals Effects of Ethanolic Extract of Metracaria chamomela on Some Physiological Parameters in Male Rabbits

2015 ◽  
Vol 39 (2) ◽  
pp. 26-31
Author(s):  
Alia Hussein Ali
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Blood Cell Count

     The aim of this study is to explain the effect of Ethanolic extract 70% of Metracaria chamomella on some physiological parameters in male rabbits. Twelve adult male rabbits were used in this study and were divided equally into two groups: First group was control (C) and received normal saline for four weeks, the second group (Treated group) was intubated orally with ethanolic extract of Metracaria chamomella in a dose 70 mg/kg B.W. for four weeks. Blood samples were collected by heart puncture from each animal at the end of experiment. Blood sample was divided into a part for hematological study and a part for biochemical analysis. The value of serum urea, and creatinine were reduced in animals that received Metracaria chamomella extract at dose of 70 mg/ kg B.W. as compared with the control group. Significant decrease in serum activity of aspartate aminotransferase alanine aminotransferase and alkaline phosphatase activity was observed in Metracaria treated animal as compared with the control group. This study explained that there was significant increase in serum total protein, serum albumin and serum globulin in treated animals as compared with the control group. The value of total cholesterol, serum triacylglycerol, serum low density lipoprotein cholesterol and very low density lipoprotein cholesterol concentration were reduced significantly in animal received Metracaria chamomella extract while the high density lipoprotein cholesterol was elevated significantly as compared with control group. While the effect of Metracaria chamomella extract on blood picture showed no changes in red blood cell count, hemoglobin concentration and hematocrit value but showed significant decrease in platelet count, and significant   increase in white blood cell count as compared with control group. Over all this study explained that Metracaria chamomella extract had Reno protective and hypolipidimic effect in male rabbit.  

scholarly journals Assessment of Lipid and Atherogenic Profile of Scavengers at Refuse Dumpsites in Port Harcourt, Rivers State, Nigeria

2020 ◽  
pp. 52-58
Author(s):  
Happiness I. Nti ◽  
Holy Brown ◽  
Ebirien-Agana S. Bartimaeus
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Port Harcourt ◽  
Significant Difference

Aim: Scavengers are individuals who gather waste and recyclable materials from refuse dumpsites, and thus are exposed to varieties of deleterious substances that have the potential to modulate and affect human health. This study was designed to assess the lipid and atherogenic profile of scavengers utilising refuse dumpsites in Port Harcourt, Nigeria.  Methodology: Fifty (50) exposed (scavengers) aged 31.32±9.49 years and 50 non-exposed (control) aged 32.92 ±10.63 years (age-matched) male subjects were sampled. The blood pressure was measured and body mass index calculated from the height and weight of the subjects. Total cholesterol, high density lipoprotein, low density lipoprotein and triglycerides levels of the subjects were determined from fasting serum samples using standard spectrophotometric methods. Atheogenic ratios were also computed using established formulae. The data was analyzed using Statistical Package for Social Sciences (SPSS) version 21 and expressed as mean and standard deviations. Variations between parameters was considered significant at p<0.05. Results: The result obtained revealed that the mean ± SD of total cholesterol, triglycerides and low density lipoprotein showed no significant difference (p > 0.05) while the level of high density lipoprotein showed significant difference (p < 0.05) between exposed (scavengers) and non-exposed (control) individuals. Body mass index and blood pressure did not also vary significantly (p>0.05) between the two group of subjects. Conclusion: Cardiovascular disease risk exist among the study subjects as revealed by atherogenic profiling of the subjects indicating the need for life style changes and socio economic intervention among the subjects.

scholarly journals CLINICAL EVALUATION OF MANAGEMENT AND PREVALENCE OF TYPE TWO DIABETES MELLITUS COMPLICATIONS IN SOUTH INDIAN POPULATION

2018 ◽  
Vol 11 ◽  
Author(s):  
Geetha P
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Glycosylated Hemoglobin ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
South Indian Population ◽  
Low Density

Objective: The present study was aimed to assess the prevalence of complications and to assess the targets achieved during the management of diabetes mellitus type 2.Methods: The study was prospective and conducted out in a diabetes center, Chennai, ethical approval was obtained from the Institutional Ethics Committee, case records of the 300 patients diagnosed with type 2 diabetes mellitus and its complications were monitored during March 2017–April 2018. Major result actions are body weight, height, body mass index (BMI), blood pressure, fasting blood sugar (FBS), post-prandial blood sugar (PPBS) levels, glycosylated hemoglobin, serum lipids, and presence of complications of diabetes. Comparison of the average of various biochemical parameters was made in patients with and no diabetic complications.Results: The average age of 300 patients was found to be 55.006±13.04. The average BMI was 27.10±12.81 kg/m2. The average duration of diabetes was 10.48±7.53. The average of systolic (SBP) and diastolic blood pressure was 137±20.88 and 79.95±11.81. The mean glycated hemoglobin, FBS, PPBS, low-density lipoprotein, high-density lipoprotein, and triglyceride, and total cholesterol were found to be 8.5±3.99, 148.85±55.64 mg/dl, 200.98±72.63 mg/dl, 88.06±19.46 mg/dl, 36.20±8.27 mg/dl, 141.22±60.15 mg/dl, and 144.45±29.03 mg/dl, respectively. Among the microvascular complications; neuropathy, nephropathy, and retinopathy were documented in 8.33%, 23.66%, and 17.33% of patients, respectively. The prevalence of peripheral artery disease was 20.66%.Conclusion: The prevalence of diabetic complications is significantly increased with patients age, duration, SBP, low-density lipoprotein,total cholesterol, and post-prandial blood sugar levels. Knowledge concerning the supervision of target blood pressure and lipidparameters is need further than the glycemic manage among diabetes patients type two.

scholarly journals 10-YEAR RISK ESTIMATION OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN HYPERTENSIVE PATIENTS

2021 ◽  
Vol 9 (2) ◽  
pp. 145-150
Author(s):  
Olha M. Chernatska ◽  
Xaba Sibongumusa
Keyword(s):  
Cardiovascular Disease ◽  
Arterial Hypertension ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Cardiovascular Disease ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Hypertensive Patients

Arterial hypertension is one of the most common causes of atherosclerotic cardiovascular disease, which is still the reason of mortality for a lot of persons. Assessment of 10-year risk of atherosclerotic cardiovascular disease in hypertensive patients is very important for further treatment improvement. The aim is the absolute 10-year risk assessment of atherosclerotic cardiovascular disease in hypertensive patients for further correction of treatment. We included 61 patients with stage 1 to 2 arterial hypertension into our study. Most of them are women (70%). The patients were (56.84 ± 8.1) years old. The total cholesterol was (4.32 ± 1.0) mmol/l, high and low density lipoprotein cholesterol – (1.35 ± 0.2) mmol/l and (2.44 ± 0.7) mmol/l, respectively. Online calculator «ASCVD Risk Estimator Plus» was used. It included the assessment of age, sex, race, systolic and diastolic blood pressure, total cholesterol, high and low density lipoprotein cholesterol, presence of diabetes, smoking status, hypertension treatment, consumption of statins or aspirin. The risk was classified as low (< 5%), borderline (5% to < 7.5%), intermediate (≥ 7.5% to < 20%), or high (≥ 20%). The results were analyzed statistically using Microsoft Excel. For five persons it was not possible to calculate this risk using the online calculator because of too low values of total cholesterol and low density lipoprotein cholesterol. Low 10-year risk of atherosclerotic cardiovascular disease was confirmed in 30 (53.6%) people, borderline – in 2 (3.6 %), intermediate – in 11 (19.6%), high – in 13 (23.2%). Low absolute 10-year risk of atherosclerotic cardiovascular disease was determined in more than half (53.6%) of patients, high – in about quarter (23.2%), intermediate – in the fifth part (19.6%) of patients with arterial hypertension. For patients with borderline and intermediate risks, it is reasonable to continue therapy with moderate-intensity statins. For hypertensive patients with high risk, high-intensity statin therapy can be recommended and low-dose aspirin might be considered if bleeding risk is not increased. If the absolute 10-year risk of atherosclerotic cardiovascular disease is low, it is reasonable to assess additionally total cardiovascular risk categories and continue moderate-intensity statin therapy in the case of absence of low-density lipoprotein cholesterol goal levels with the next lipid profile assessment in 8 (± 4) weeks.

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