scholarly journals RECENT UPDATE ON PRONIOSOMAL GEL AS TOPICAL DRUG DELIVERY SYSTEM

2019 ◽  
Vol 12 (1) ◽  
pp. 54
Author(s):  
Jampala Rajkumar ◽  
Radha Gv ◽  
Trideva Sastri K ◽  
Sadhana Burada
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Minimal Amount ◽  
Hydrophilic Drugs ◽  
Drug Candidates ◽  
Gel Texture ◽  
Drug Delivery Carrier ◽  
Semi Solid

An existence of transdermal delivery tool, proniosomal gel, has established to showed remarkable development for lipophilic/hydrophilic drugs over additional formulations. Newer drugs of lipophilic nature emerge poor bioavailability, irregular absorption, and pharmacokinetic changes. Therefore, this novel drug delivery system has been proved advantageous over other oral and topical delivery of drug candidates to bypass such disruption. This proniosomal gel basically is a compact semi-solid liquid crystalline (gel) composed of non-ionic surfactants easily formed on dissolving the surfactant in a minimal amount of acceptable solvent and the least amount of aqueous phase and phosphate buffer. Topical application of gel under occlusive condition during which they are converted into nisomes due to hydration by water in the skin present itself. Proniosomal gels are typically present in transparent, translucent, or white semisolid gel texture, which makes them physically stable throughout storage and transport. This review provides an important overview of the preparation, formulation, evaluation, and application of proniosome gel as a drug delivery carrier.

scholarly journals RECENT UPDATE ON PRONIOSOMAL GEL AS TOPICAL DRUG DELIVERY SYSTEM

2019 ◽  
Vol 12 (1) ◽  
pp. 54
Author(s):  
Jampala Rajkumar ◽  
Radha Gv ◽  
Trideva Sastri K ◽  
Sadhana Burada
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Minimal Amount ◽  
Hydrophilic Drugs ◽  
Drug Candidates ◽  
Gel Texture ◽  
Drug Delivery Carrier ◽  
Semi Solid

An existence of transdermal delivery tool, proniosomal gel, has established to showed remarkable development for lipophilic/hydrophilic drugs over additional formulations. Newer drugs of lipophilic nature emerge poor bioavailability, irregular absorption, and pharmacokinetic changes. Therefore, this novel drug delivery system has been proved advantageous over other oral and topical delivery of drug candidates to bypass such disruption. This proniosomal gel basically is a compact semi-solid liquid crystalline (gel) composed of non-ionic surfactants easily formed on dissolving the surfactant in a minimal amount of acceptable solvent and the least amount of aqueous phase and phosphate buffer. Topical application of gel under occlusive condition during which they are converted into nisomes due to hydration by water in the skin present itself. Proniosomal gels are typically present in transparent, translucent, or white semisolid gel texture, which makes them physically stable throughout storage and transport. This review provides an important overview of the preparation, formulation, evaluation, and application of proniosome gel as a drug delivery carrier.

An Update on Recent Advances in Cubosome: A Novel Drug Delivery System

2021 ◽  
Vol 21 ◽  
Author(s):  
Madhukar Garg ◽  
Anju Goyal ◽  
Sapna Kumari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Lipid Bilayers ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Three Dimensional ◽  
Biologically Active ◽  
Potential Applications ◽  
Health Related ◽  
Novel Drug

: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three dimensional honeycombs like structure provided with two internal aqueous channels for incorporation of number of biologically active ingredients. In contrast liposomes they provide large surface area for incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as method of choice in the sustained release, controlled release and targeted release dosage forms as new drug delivery system for the better release of the drugs. As lot of advancement in the new form of dosage form has bring the novel avenues in drug delivery mechanisms so it was matter of worth to compile the latest updates on the various aspects of mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health related benefits.

The in vivo transformation and pharmacokinetic properties of a liquid crystalline drug delivery system

2017 ◽  
Vol 532 (1) ◽  
pp. 345-351 ◽  
Author(s):  
Andrew Otte ◽  
Yahira M. Báez-Santos ◽  
Ellina A. Mun ◽  
Bong-Kwan Soh ◽  
Young-nam Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Pharmacokinetic Properties

Semi-solid extrusion 3D printing ODFs: an individual drug delivery system for small scale pharmacy

2020 ◽  
Vol 46 (4) ◽  
pp. 531-538 ◽  
Author(s):  
Ting-Ting Yan ◽  
Zhu-Fen Lv ◽  
Pan Tian ◽  
Min-Mei Lin ◽  
Wei Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery System ◽  
Delivery System ◽  
Small Scale ◽  
Individual Drug ◽  
Semi Solid

scholarly journals A Review on - Fast Disintegrating Drug Delivery System

2019 ◽  
pp. 291-303
Author(s):  
Swapna Mane ◽  
Ritesh Bathe
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Forms ◽  
Drug Candidates ◽  
Pharmaceutical Ingredients ◽  
Mouth Cavity ◽  
Additional Water ◽  
Conventional Methods ◽  
Important Position

Now day's formulation research is breaking barriers of conventional methods. Recently, MDTs have take over an important position in the market by overcoming previously administration problems and contributing to extension of patient life, which have difficulty in swallowing tablets and capsules. Upon introduction into the mouth, these tablets dissolve/ disintegrate in the mouth without additional water for easy administration of pharmaceutical ingredients. These dosage forms are also used to attain instant a higher concentration of drug in body for immediate actions. These are novel dosage forms which dissolve in mouth cavity within a few seconds. This article attempts at discussing ideal properties, advantages, limitation, choice of drug candidates, need of formulation, approaches for preparation of MDTs, Patented technologies on MDTs and Evaluation tests of MDTs.

scholarly journals Construction of an exosome-functionalized graphene oxide based composite bionic smart drug delivery system and its anticancer activity

2022 ◽  
Author(s):  
Qi Chen ◽  
Chengchuan Che ◽  
Jinfeng Liu ◽  
Zhijin Gong ◽  
Meiru Si ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Functionalized Graphene Oxide ◽  
Ph Response ◽  
Drug Delivery Carrier ◽  
Cancer Tumor

Abstract Graphene oxide has covalently modified by chito oligosaccharides and γ-polyglutamic acid to form GO-CO-γ-PGA, which exhibits excellent performance as a drug delivery carrier, but this carrier did not have the ability to actively target. In this study, the targeting property of breast cancer tumor cell exosomes was exploited to give GO-CO-γ-PGA the ability to target breast tumor cells (MDA-MB-231), and the drug mitoxantrone (MIT) was loaded to finally form EXO-GO-CO-γ-PGA-MIT with a loading capacity of 1.39 mg/mg. The pH response of EXO-GO-CO-γ-PGA showed a maximum cumulative release rate of 56.59% (pH 5.0) and 6.73% (pH 7.4) for MIT at different pH conditions. pH 7.4). In vitro cellular assays showed that EXO-GO-CO-γ-PGA-MIT was more potent in killing MDA-MB-231 cells due to its targeting ability and had a significantly higher pro-apoptotic capacity compared to GO-CO-γ-PGA-MIT. The results showed that this bionic nano-intelligent drug delivery system has good drug slow release function, can increase the local drug concentration of tumor and enhance the pro-apoptotic ability of MIT, so this newly synthesized bionic drug delivery carriers (EXO-GO-CO-γ-PGA-MIT) has potential application in breast cancer treatment.

scholarly journals Advancement in Ocular Drug Delivery System to Overcome Ocular Barrier

2021 ◽  
Vol 71 (2) ◽  
Author(s):  
Supriya Nikam ◽  
Abhilasha Ghule ◽  
Akash Inde ◽  
Anjali Jambhulkar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ocular Drug Delivery ◽  
Direct Access ◽  
Ocular Delivery ◽  
Hydrophilic Drugs ◽  
Delivery Planning ◽  
Delivery Routes ◽  
Novel Drug

The Ocular drug delivery system (ODDS) is the prominently challenging system faced by pharmaceutical researchers. Ophthalmic preparations are available in buffered, sterile and isotonic solutions. For the ocular delivery of drugs, various types of dosage forms are prepared and dispensed. As the drops are easier for the administration likewise more prescribed dosage form is the eye drop solution. For obtaining prolonged therapeutic effect ointment, suspensions and gelled systems are also used. The presence of various barriers as anatomical, physiological and physiochemical barriers makes difficulties in delivery of drugs in at the intended sites. Scientists invented alternate delivery routes to direct access at intended target sites. Second invention involves development of novel drug delivery systems providing better permeability, treatability and controlled release at target site. The liposomal delivery is beneficial because they have the ability of envelopment and both hydrophobic and hydrophilic drugs are suitable for delivery to both the anterior and posterior segment of the eye. Therefore, the uses of this alternative approach become quite a necessary. This formulation of novel devices will definitely help to the overcome ocular barriers and side effects with conventional topical drops. Current reviews on the conventional formulations of ocular delivery and their advancements followed by current nanotechnology based on the formulation developments. The recent incident with other ocular drug delivery planning consists of in situ gels, implants, contact lens and nano wafers are discussed. Drug delivery at ophthalmic route has been proven significant advancement for the future perspectives.

scholarly journals A Brief Review on Topical Gels as Drug Delivery System

2021 ◽  
pp. 344-357
Author(s):  
Chinmoy Bhuyan ◽  
Dipankar Saha ◽  
Bipul Rabha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Topical Drug Delivery ◽  
Topical Gel ◽  
Semi Solid ◽  
Gel Formulations ◽  
Topical Gels

The method of applying prescription dosage forms to the skin for direct treatment of a cutaneous disorder is known as a topical drug delivery system. Topical gels are semisolid dosage forms in which a liquid phase is constrained within a three-dimensional polymeric matrix derived from natural or semi-synthetic sources with high physical or chemical cross-linking. Because of their intermediate behavior between solid and liquid materials, topical gels are an excellent candidate for transdermal drug delivery. Clinical evidence indicates that topical gel is a safe and effective treatment choice for the management of skin-related diseases, especially when used for local action to avoid the side effects of other conventional dosage forms. Gels, cream, ointment, and paste are the most commonly used semi-solid formulations for topical drug delivery. Gels are colloids in which the liquid medium has thickened to the extent that it behaves like a solid. Since topical gel formulations are less greasy and can be quickly removed from the skin, they offer better drug delivery. In comparison to cream, ointment, and paste, gel formulations have improved application properties and consistency. This article aims to review the principles and recent developments in topical gels, including classification, methods of preparation, applications, and so on.

Concepts on Smart Nano-Based Drug Delivery System

2021 ◽  
Vol 15 ◽  
Author(s):  
Shweta Rai ◽  
Neeraj Singh ◽  
Sankha Bhattacharya
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Specificity ◽  
Inorganic Nanoparticles ◽  
Information Storage ◽  
Passive Targeting ◽  
Hydrophilic Drugs

Nanomedicine is a branch of healthcare, which has many clinical applications. Nanoscale science has to presume an attractive slot for research in drug delivery as nanocarriers either through active or passive targeting approaches to the cell-specific drug delivery. Liposomes, solid-lipid nanoparticles, dendrimers, polymeric nanoparticles, mesoporous silica nanoparticles, inorganic nanoparticles, nanotubes, quantum dots, and nanofibers are nanocarriers that are proved too smart nano-based drug delivery system. The nanoparticulate system shows high stability, high specificity, high efficacy, liability to form in different dosage, used through different routes, as well as the ability to deliver hydrophobically as well as hydrophilic drugs. These nanoparticulate systems are showing wider applications to cure the disease through nanomedicines and biomedical applications viz. chemical and biological sensors, information storage systems, magneto-optic, optical devices, and fiber-optic systems. In this review article, the author describes the various smart nano-based drug delivery system along with their endocytic pathways used for the uptake of nanoparticles.

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