scholarly journals NATURAL ANTIMICROBIALS IN THE PIPELINE AND POSSIBLE SYNERGISM WITH ANTIBIOTICS TO OVERCOME MICROBIAL RESISTANCE

2019 ◽  
pp. 15-21
Author(s):  
EMTENAN M HANAFI ◽  
ENAS N DANIAL
Keyword(s):  
Quorum Sensing ◽  
Bioactive Compounds ◽  
Biofilm Formation ◽  
Bacterial Resistance ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Quorum Sensing Inhibitors ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant

The unresponsive use of antibiotics led to the appearance of multiple drug-resistant bacteria strains. Studying the mechanism by which bacteria can resist antibiotics, the so called quorum sensing and biofilm formation, enabled the researchers to find bioactive compounds, derived from eukaryotes and prokaryotes. The disrupt of this mechanism is called quorum sensing inhibitors or quorum quenchers. This article provides an overview on the current research done on such bioactive compounds, the possible use of them as antibiotic alternatives, what are the advantage and disadvantages, the source from which it has been extracted, and how it may succeed to overcome bacterial resistance. The recommendation of researchers is to use some of these natural antimicrobial compounds combined to lower doses of antibiotics for treatment, the fastest way to limit the adverse effects of the exploitation of antibiotics and to avoid bacterial resistance.

scholarly journals Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus

2012 ◽  
Vol 78 (8) ◽  
pp. 2768-2774 ◽  
Author(s):  
Ashley N. Brown ◽  
Kathryn Smith ◽  
Tova A. Samuels ◽  
Jiangrui Lu ◽  
Sherine O. Obare ◽  
...  
Keyword(s):  
Methicillin Resistant Staphylococcus Aureus ◽  
Enterobacter Aerogenes ◽  
Resistance Mechanisms ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Antibiotic Resistant ◽  
Gram Positive Bacteria ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant

ABSTRACTWe show here that silver nanoparticles (AgNP) were intrinsically antibacterial, whereas gold nanoparticles (AuNP) were antimicrobial only when ampicillin was bound to their surfaces. Both AuNP and AgNP functionalized with ampicillin were effective broad-spectrum bactericides against Gram-negative and Gram-positive bacteria. Most importantly, when AuNP and AgNP were functionalized with ampicillin they became potent bactericidal agents with unique properties that subverted antibiotic resistance mechanisms of multiple-drug-resistant bacteria.

scholarly journals A Simple Assay to Screen Antimicrobial Compounds Potentiating the Activity of Current Antibiotics

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Junaid Iqbal ◽  
Ruqaiyyah Siddiqui ◽  
Shahana Urooj Kazmi ◽  
Naveed Ahmed Khan
Keyword(s):  
Aqueous Extract ◽  
Bacterial Infections ◽  
Juglans Regia ◽  
Tree Bark ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Antimicrobial Compounds ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant

Antibiotic resistance continues to pose a significant problem in the management of bacterial infections, despite advances in antimicrobial chemotherapy and supportive care. Here, we suggest a simple, inexpensive, and easy-to-perform assay to screen antimicrobial compounds from natural products or synthetic chemical libraries for their potential to work in tandem with the available antibiotics against multiple drug-resistant bacteria. The aqueous extract ofJuglans regiatree bark was tested against representative multiple drug-resistant bacteria in the aforementioned assay to determine whether it potentiates the activity of selected antibiotics. The aqueous extract ofJ. regiabark was added to Mueller-Hinton agar, followed by a lawn of multiple drug-resistant bacteria,Salmonella typhior enteropathogenicE. coli. Next, filter paper discs impregnated with different classes of antibiotics were placed on the agar surface. Bacteria incubated with extract or antibiotics alone were used as controls. The results showed a significant increase (>30%) in the zone of inhibition around the aztreonam, cefuroxime, and ampicillin discs compared with bacteria incubated with the antibiotics/extract alone. In conclusion, our assay is able to detect either synergistic or additive action ofJ. regiaextract against multiple drug-resistant bacteria when tested with a range of antibiotics.

scholarly journals Potential of Herbal Antibacterials as an Alternative to Antibiotics for Multiple Drug Resistant Bacteria: An Analysis

2019 ◽  
Vol 13 (1) ◽  
pp. 1-8
Author(s):  
Bhoj Raj Singh ◽  
Akanksha Yadav ◽  
Dharmendra Kumar Sinh ◽  
Obli Rajendran Vinodh Kum
Keyword(s):  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant

scholarly journals Antibacterial activity of selected Dendrobium species against clinically isolated multiple drug resistant bacteria

2018 ◽  
Vol 12 (18) ◽  
pp. 426-432 ◽  
Author(s):  
Ram Paudel Mukti ◽  
Rajbanshi Neeta ◽  
Kumar Sah Anil ◽  
Acharya Sameer ◽  
Pant Bijaya
Keyword(s):  
Antibacterial Activity ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant
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