scholarly journals PREVALENCE AND CLINICAL CONSEQUENCES OF POLYPHARMACY ON MEDICATION PROFILE AMONG THE ELDERLY IN A TERTIARY CARE TEACHING HOSPITAL

2020 ◽  
pp. 121-126 ◽  
Author(s):  
LAKSHMI PRASANNA MN ◽  
AZIZ UNNISA
Keyword(s):  
Drug Interactions ◽  
Older Adult ◽  
Teaching Hospital ◽  
Tertiary Care ◽  
Beers Criteria ◽  
Tertiary Care Teaching Hospital ◽  
Care Teaching ◽  
Clinical Consequences ◽  
The Mean ◽  
The Impact

Objective: A sharp increase in chronic diseases for elderly patients has been observed in recent years resulting in polypharmacy, which may lead to drug-drug interactions (DDI’s), drug-related problems, adverse drug reactions (ADR’s), and many more issues in these patients. The present study was conducted to assess the clinical consequences of polypharmacy and its prevalence in the older adult population. Methods: Our work is a prospective, observational study carried out in a tertiary care teaching hospital. The polypharmacy prescriptions were identified (taking at least five medications), and drug-drug interactions were detected by Micromedex® DrugReax® System 2.0 version. The medication profiles were also checked for inappropriate prescribing according to Beers Criteria 2015. Results: In the study, the mean age of patients was found to be 72.4±8.8 years. Most of the patients (81.8%) had more than two and less than five diseases. The mean number of drugs prescribed in all the prescriptions was found to be 7.4±2.6. According to Beers Criteria-2015, 3.83% of the total medications prescribed were inappropriate, 74.1% of moderate DDI’s were observed in patients, and 50.2% of the DDI’s observed theoretically were documented as fair. Conclusion: The impact of polypharmacy on consequences such as the length of stay, DDI’s, and DRP’s was also found to be significant. This study concludes that the medication profile of older adult patients should be assessed regularly for the rationality of drug therapy to maximize the therapeutic response positively with the lowest number of medications possible.

scholarly journals STUDY OF POTENTIAL DRUG INTERACTIONS AMONG EIGHT MAJOR DEPARTMENTS-GENERAL MEDICINE, ORTHOPEDICS, GYNECOLOGY, PULMONOLOGY, GENERAL SURGERY, PSYCHIATRY, OTOLARYNGOLOGY AND DERMATOLOGY OF A TERTIARY CARE TEACHING HOSPITAL IN SOUTHERN INDIA

2020 ◽  
pp. 59-67
Author(s):  
TALHA JABEEN ◽  
MOHD ABDUL KHADER ◽  
A. V. KISHORE BABU ◽  
A. SRINIVASA RAO
Keyword(s):  
Drug Interactions ◽  
Teaching Hospital ◽  
General Surgery ◽  
Tertiary Care ◽  
General Medicine ◽  
Potential Drug ◽  
Tertiary Care Teaching Hospital ◽  
Care Teaching ◽  
Study Population ◽  
The Mean

Objective: To identify frequency, type, severity and predictors of potential drug-drug interactions(pDDIs), potential drug-food interactions(pDFIs), potential drug-alcohol interactions(pDAIs) and potential drug-tobacco interactions(pDTIs) and most frequently interacting drug combination pairs in hospitalized patients from departments(depts) of General Medicine(GM), Orthopedic(Ortho), Gynecology(OBG), Pulmonology(Pulmo), General Surgery (GS), Psychiatry (Psych), Otolaryngology(ENT) and Dermatology (Derm) of study population. Methods: A Prospective Observational Study was conducted in eight major dept's of a tertiary care teaching hospital for a period of 6 mo. A sample size of 650 prescriptions reflecting admission no's for each department were used. Results: A total of 650 patients were included in the study. Among them, 282(43.4%) were males and 368(56.6%) were females. The mean age of the study population was 39.67±15.23. A total of 487 pDDIs, 734 pDFIs, 586 pDAIs and 159 pDTIs were found out of 650 hospitalized episodes. OBG showed the highest pDDIs and pDAIs. Highest pDFIs and pDTIs were seen in Pulmo. The majority of DDIs were minor, DFIs and DAIs were moderate and DTIs were of major in severity. Pharmacokinetic types of interactions were seen in the majority of the depts. Logistic regression analysis showed that Polypharmacy was associated with the occurrence of DIs. Most of the DIs repeated several times in particular depts and a list of these combinations was prepared. Conclusion: With the high occurrence of overall DIs and characteristic patterns of DIs combination pairs among different departments of the hospital, the presence of clinical pharmacists in hospitals can play a great role, especially in developing nations like India where their role in hospitalized settings is always controversial.

scholarly journals A STUDY ON THE PREVALENCE AND SEVERITY OF POSSIBLE DRUG-DRUG INTERACTIONS IN PEDIATRICS DEPARTMENT AT AN INDIAN TERTIARY CARE TEACHING HOSPITAL

2018 ◽  
Vol 10 (7) ◽  
pp. 52
Author(s):  
Ramam Sripada ◽  
S. V. Suresh Kumar ◽  
N. Devanna ◽  
Kandula Ravindra Reddy
Keyword(s):  
Drug Interactions ◽  
Pharmaceutical Care ◽  
Teaching Hospital ◽  
Medical Records ◽  
Pediatric Population ◽  
Tertiary Care ◽  
Moderate Severity ◽  
Tertiary Care Teaching Hospital ◽  
Care Teaching ◽  
Ambulatory Patients

Objective: To study the prevalence and severity of possible drug-drug interactions in the department of pediatrics.Methods: Case records of the in-patients of the pediatrics department from the medical records department were included and the records of the ambulatory patients were excluded from the study. All the collected cases were subjected to check for the drug-drug interactions by using the software micromedex 2.0 and the interactions were categorized based on the severity into minor, moderate and major.Results: A total of 142 cases were screened for possible drug-drug interactions (DDIs) and among them 76 cases were observed to be with possible DDIs.  The prevalence was found to be 53.5% in this study. Majority of the cases with possible DDIs were observed to be in females. Results of the age wise categorization revealed that majority of the possible DDIS were observed in children (2-12 y) followed by the infants (1 mo–2 y). The drug combinations amikacin+ampicillin, paracetamol+phenytoin and ofloxacin+ondansetron were found to be the frequently observed possible DDIs of minor, moderate and major severities respectively.Conclusion: Majority of the possible DDIs were of moderate severity followed by major. Clinical pharmacists should take the responsibility in assisting the pediatricians for screening the possible DDIs in the prescriptions there by preventing them and providing a better pharmaceutical care for the pediatric population.  

scholarly journals Assessment of the Impact of COVID-19 on Drug Store Management in a Tertiary Care Teaching Hospital of Central India

Cureus ◽  
2021 ◽  
Author(s):  
Srikanta Padhan ◽  
Pugazhenthan T ◽  
Ramesh Chandrakar ◽  
Abhiruchi Galhotra ◽  
Nitinkumar B Borkar
Keyword(s):  
Teaching Hospital ◽  
Tertiary Care ◽  
Central India ◽  
Drug Store ◽  
Tertiary Care Teaching Hospital ◽  
Care Teaching ◽  
Store Management ◽  
The Impact

scholarly journals Cognition, Comprehension and Application of Biostatistics in Research by Postgraduate Medical Students of a Tertiary Care Teaching Hospital: Pretest and Posttest Study Design

2016 ◽  
Vol 1 (1) ◽  
pp. 5-9
Author(s):  
Rajaat Vohra ◽  
Siddharth Pramod Dubhashi ◽  
Bhoopendra Nath Sharma ◽  
GN Saxena ◽  
Anusha Vohra
Keyword(s):  
Medical Students ◽  
Study Design ◽  
Teaching Hospital ◽  
Research Methodology ◽  
Tertiary Care ◽  
Knowledge Score ◽  
Postgraduate Students ◽  
Tertiary Care Teaching Hospital ◽  
Care Teaching ◽  
The Mean

ABSTRACT Introduction Biostatistics plays a key role in planning, conduct, analysis and reporting of a research. Teaching biostatistics and research methodology is often considered as a difficult task to medical students. The present study was undertaken to evaluate the cognition, comprehension and application of biostatistics in research in the 1st year postgraduate medical students. Materials and methods A predesigned and pretested questionnaire was used to collect data regarding knowledge and application of biostatistics from 65 postgraduate students registered. A series of 10 lectures were taken on various topics of biostatistics and research methodology. All students were subjected to Multiple Choice Questions covering all the topics before the 1st lecture and after the 10th lecture. Mean knowledge score was calculated and data were analyzed. Results Only 16.92% students had publication, 35.38% students have presented a paper/poster in any national or international conference while only 10.76% students have participated in any research methodology workshop. A total of 63.07% students said that they were aware of importance of biostatistics in research, 50.76% students said that they were having some knowledge of biostatistics. A total of 60% students have consulted statistician regarding the study while 23.07% students have attempted statistical analysis on their own. A total of 33.84% students are familiar with the use of MS-EXCEL spreadsheet. There was statistically significant improvement seen in the mean knowledge score of the students after the lectures in comparison to the mean knowledge score before the lectures. Conclusion Considering the fruitful outcome of structured training program in biostatistics, there is a need for provision of formal training in biostatistics to postgraduate students in all medical colleges. Capacity building initiative in this domain is the need of the hour. How to cite this article Vohra R, Dubhashi SP, Sharma BN, Saxena GN, Vohra A. Cognition, Comprehension and Application of Biostatistics in Research by Postgraduate Medical Students of a Tertiary care Teaching Hospital: Pretest and Posttest Study Design. J Mahatma Gandhi Univ Med Sci Tech 2016;1(1):5-9.

scholarly journals A Study on Detection of Drug-Laboratory interactions in Dermatology, in a Tertiary Care Teaching Hospital

2020 ◽  
Vol 13 (4) ◽  
pp. 350-355
Author(s):  
M. Sreenivasulu ◽  
K. Sivaiah ◽  
V.Jagadeesh Naik
Keyword(s):  
Drug Interactions ◽  
Teaching Hospital ◽  
Tertiary Care ◽  
American Psychological Association ◽  
Educational Interventions ◽  
Environmental Chemical ◽  
Dermatology Department ◽  
Tertiary Care Teaching Hospital ◽  
Care Teaching ◽  
Medical College

Background: An interaction is alleged to occur once the consequences of one drug is changed by the presence of another drug, herbal medicine, food, drink or by some environmental chemical agents. As per American psychological association drug interaction is defined as chemical or physiological reaction that can occur when two different drugs are taken together. Objective: This study was conducted for the detection of various drug interactions in dermatology in a tertiary care teaching hospital. Methods: An observational, prospective study was conducted for a period of six months (July 2017 to December 2017) among 108 patients in dermatology department of Santhiram Medical College and General Hospital, Nandyal. Results: A total of 108 patients were included in the study. Among them, 63 (58.3%) were males and 45(41.7%) were females. Of total 108 prescriptions, sever drug-drug interactions were present in 42 (38.9 %) prescriptions. Whereas, moderate drug-drug interactions were found in 14 (13%) and 52 prescriptions doesn’t have drug-drug interactions respectively. The study found the associations of potential drug interactions with age, sex, number of drugs per prescription. There was a direct link between polypharmacy and occurrence of drug interactions. To lower the frequency of potential interactions it could be necessary to make a careful selection of therapeutic alternatives, and in cases without other options, patients should be continuously monitored to identify adverse events. Conclusion: we concluded that educational interventions can minimize the incidence of drug interactions.

scholarly journals PREVALENCE OF POLYPHARMACY AND DRUG TO DRUG INTERACTIONS IN A TERTIARY CARE TEACHING HOSPITAL

2014 ◽  
Vol 5 (10) ◽  
pp. 778-782 ◽  
Author(s):  
Kumara Swamy RC ◽  
Jignesh U Ramani ◽  
Ramesh Bushipaka ◽  
Mehul Radadiya ◽  
Sowmya B ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Teaching Hospital ◽  
Tertiary Care ◽  
Tertiary Care Teaching Hospital ◽  
Care Teaching
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