scholarly journals MELOXICAM SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM: FORMULATION AND RELEASE KINETICS ANALYSIS

2021 ◽  
pp. 188-193
Author(s):  
SALMA AULIA ◽  
LINA WINARTI ◽  
YUDI WICAKSONO
Keyword(s):  
Sunflower Seed ◽  
Seed Oil ◽  
Release Kinetics ◽  
In Vitro Dissolution ◽  
Dissolution Study ◽  
Peg 400 ◽  
Sunflower Seed Oil ◽  
Release Model ◽  
Kinetics Of

Objective: This study aimed to find the best SNEDDS meloxicam formula and analyze the release kinetics of meloxicam SNEDDS and non-SNEDDS using DDSolver.  Methods: Meloxicam SNEDDS was prepared using sunflower seed oil, Cremophor RH 40 as a surfactant, and polyethylene glycol (PEG) 400 as a co-surfactant.  Results: The best formula obtained subjected to the in vitro dissolution study was analyzed using DDSolver. The study shows one selected formula consists of 10% sunflower seed oil, 70% cremophor RH 40, and 20% PEG 400 with a 20.5 nm±12 nm droplet size. The dissolution study showed that SNEDDS could significantly increase the meloxicam release compared to the non-SNEDDS formulation. The kinetics of meloxicam release from SNEDDS formulations follow the Weibull release model (β = 1.00).  Conclusion: This study concludes that SNEDDS best prepared in sunflower seeds oil: Chremophor RH 40: PEG 400 ratio of 1: 7: 2 and has the potency to increase the solubility and dissolution of meloxicam.

scholarly journals In vitro Release Kinetic Study of Esomeprazole Magnesium from Methocel K15M and Methocel K100 LVCR Matrix Tablets

1970 ◽  
Vol 7 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Bishyajit Kumar Biswas ◽  
Md Safiqul Islam ◽  
Farida Begum ◽  
Abu Shara Shamsur Rouf
Keyword(s):  
Release Rate ◽  
Release Kinetics ◽  
In Vitro Dissolution ◽  
Direct Compression ◽  
Medium Ph ◽  
Kinetic Order ◽  
Dissolution Study ◽  
Tablet Matrix ◽  
Kinetics Of

In the present study esomeprazole sustained release tablet matrix was prepared by utilizing different grades of hydroxypropyl methylcellulose (HPMC) polymers such as Methocel K15M & Methocel K100 LVCR by direct compression method. Different amount of Methocel K15M was used to develop matrix builder in the seven proposed formulations (F1-F7) for the study of release rate retardant effect at 20%, 25%, 30%, 35%, 40%, 45% and 50% of total weight of tablet matrix respectively. The dissolution study of Methocel K15M based tablet matrices of those proposed formulations were carried out in the simulated gastric medium (pH 1.3) for first two hours and then in the simulated intestinal medium (pH 6.8) for 8 hours using USP dissolution apparatus II. The formulation F-5 (40%) and F-6 (45%) met the optimum release rate of esomeprazole for 10h period of in vitro dissolution study. The release kinetics of formulation F-5 and F-6 very closely followed Higuchi kinetic order than first order and zero order kinetics. Similarly Methocel K100 LVCR was used to develop matrix builder in another seven proposed formulations (F8-F14). It was found that formulations F-11 (35%), F-12 (40%) and F-13 (45%) met the desired release rate of esomeprazole for 10h period. The release kinetics of formulation F-11, F-12 and F-13 followed Higuchi kinetic order. Between these two polymers, Methocel K100 LVCR showed better release retardant effect than Methocel K15M. Key words: Esomeprazole, Direct compression, Controlled release, Methocel K15M and Methocel K100 LVCRDOI = 10.3329/dujps.v7i1.1216 Dhaka Univ. J. Pharm. Sci. 7(1): 39-45, 2008 (June)  

Absorption and distribution of [l-14C]dolichol intubated into rats

1987 ◽  
Vol 65 (4) ◽  
pp. 317-320 ◽  
Author(s):  
Dean C. Crick ◽  
Kenneth K. Carroll
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Sunflower Seed ◽  
Seed Oil ◽  
High Density ◽  
High Density Lipoproteins ◽  
Sunflower Seed Oil ◽  
Layer Chromatography

[1-l4C]Dolichol was mixed in vitro with sunflower seed oil and intubated into rats. Radioactivity began to appear in the blood at 3 h and peaked after about 6 h. The absorbed radioactivity was rapidly cleared from the blood. At 7.5 h postintubation two thirds of the radioactivity in the serum was associated with chylomicrons and about one quarter with the high density lipoproteins. At 12 h the proportion of the radioactivity in the chylomicrons had fallen to one third and that in the high density lipoproteins had increased to one half of the total. Less than 0.02% of the dose was found in the tissues after 12 h. Liver and blood each contained about one third of the total, with smaller amounts in the lungs and spleen. The heart, testes, brain, and kidneys contained only traces of radioactivity. After 12 h most of the radioactivity in the tissues and feces was present as [1-l4C]dolichol. The radioactive compounds in the urine (about 0.05% of the dose) were more polar than [1-l4C]dolichol as determined by thin-layer chromatography.

scholarly journals Investigation of certain varieties of carbopol in ketorolac tromethamine hydrophilic matrix tablet formulations and evaluation of the kinetics of its in vitm release

2002 ◽  
Vol 70 (2) ◽  
pp. 189-198
Author(s):  
Genç Lütfi ◽  
Hegazy Nahed ◽  
Arica Betül
Keyword(s):  
Release Kinetics ◽  
In Vitro Release ◽  
Controlled Drug Release ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Matrix Tablet ◽  
Compression Technique ◽  
Tablet Formulations ◽  
Kinetics Of

Matrix tablets of ketorolac trometharnine (KT) were prepared by direct compression technique and Carbopol 934, 940 and 1342 have been used as polymers in different concentrations (5-15 % ). For the quality control of tablets; physical tests as crushing strength, diameter-height ratio and fkiability, KT amount assay and in vitro dissolution techniques were performed and dissolution profiles were plotted and evaluated kinetically. The in vitro release kinetics of ten different formulations of KT matrix tablet were studied at pH 1.2 and pH 7.0 using the USP dissolution technique and apparatus with basket assembly. Dissolution results were evaluated kinetically and statistically. According to our results, different types and concentrations of carbopol to tablet formulations may effect in controlled drug release.

A New Formulation Based on Ozonated Sunflower Seed Oil: In Vitro Antibacterial and Safety Evaluation

2017 ◽  
Vol 39 (3) ◽  
pp. 139-147 ◽  
Author(s):  
Francesca Serio ◽  
Graziano Pizzolante ◽  
Giuseppe Cozzolino ◽  
Maria D’Alba ◽  
Francesco Bagordo ◽  
...  
Keyword(s):  
Sunflower Seed ◽  
Seed Oil ◽  
Safety Evaluation ◽  
Sunflower Seed Oil ◽  
New Formulation

scholarly journals In-Vitro Comparative Dissolution Study of Commercially Available Paracetamol Tablet

2020 ◽  
Vol 10 (1) ◽  
pp. 18-23
Author(s):  
Ayan Kumar Kar ◽  
Banhishikha Kar
Keyword(s):  
Release Kinetics ◽  
Active Agent ◽  
Quality Standard ◽  
In Vitro Dissolution ◽  
Local Market ◽  
Dissolution Testing ◽  
Active Metabolites ◽  
Dissolution Study ◽  
Double Beam

Quality is the most important issue in the pharmaceutical field due to the presence of a drug which is considered as safe and therapeutically active agent. In-vitro evaluation ensures their quality, bioavailability as well as optimum therapeutic activity. Paracetamol (acetaminophen) which are the active metabolites of phenacetin is commonly used for the relief of headaches and pains, and is a major ingredient in numerous cold and flu remedies. Paracetamols are available in different brands in Indian market. The main objective of the present study was to conduct the comparative in-vitro dissolution studies of various brands collected from the local market to determine whether all the formulations used were equivalent or significantly different. The calibration curve was constructed covering the concentration range of 1 to 10 mcg/ml at 268 nm by UV spectrophotometer (UV 2203 Double beam spectrophotometer, Shimadzu).  Five different brands of Paracetamol of 500 mg conventional tablets from different manufacturers were selected in the study and dissolution testing in Phosphate buffer at pH 7.4 was conducted from each brands for 90 mins by using dissolution testing apparatus USP type-II. The dissolution rate was subjected to various mathematical models like zero order, first order, Higuchi and Hixson-Crowell equations to elucidate the kinetic behavior of drug release from the test samples. Different release kinetics model of all the selected brands was assuring the quality standard of manufacturing. Keywords: Paracetamol, Marketed Tablet, In-Vitro dissolution study, Release profile.

scholarly journals Pengaruh Penambahan Minyak Kelapa, Minyak Biji Bunga Matahari, dan Minyak Kelapa Sawit terhadap Penurunan Produksi Metan di dalam Rumen secara in Vitro (The Effect of Addition Coconut Oil, Sunflower Seed Oil, and Palm Olein on Reducing Ruminal Methane Pro

2012 ◽  
Vol 33 (2) ◽  
pp. 96
Author(s):  
Puput Diah Sitoresmi ◽  
Lies Mira Yusiati ◽  
Hari Hartadi
Keyword(s):  
Methane Production ◽  
Sunflower Seed ◽  
Protein Concentration ◽  
Palm Olein ◽  
Seed Oil ◽  
Coconut Oil ◽  
Microbial Protein ◽  
Sunflower Seed Oil ◽  
Oil Sunflower

<p>This experiment was conducted to determine the effect of vegetable oil, such as coconut oil, sunflower seed oil, and palm olein on methane production, number of protozoa, microbial protein concentration, ammonia (NH3) concentration and carboxymethyl cellulase (CMC-ase) activity in the vitro fermentation of king grass and rice bran by rumen microbial. The experiment consisted of two treatments (i.e.) the effect of coconut oil, sunflower seed oil, and palm olein and level of addition of vegetable oil i.e. 0%, 2.5%, 5.0%, and 7.5%. The fermentation was done using Hohenheim gas test (HGT) metode and incubated at 39°C for 72 hours with three replicates. At the end of the fermentation, methane concentration, number of protozoa, microbial protein concentration, NH3 concentration, CMC-<br />ase activity, and pH were observed. Data obtained were analyzed using analysis of variance and the design using factorial (3x4). The deferences of mean values were analyzed by Duncan’s new multiple range test (DMRT). The result showed that the number of protozoa decreased (P&lt;0.05) as much as 9.8%, 20.85%, and 23.95%, followed by methane supression (P&lt;0.01) much as 11.11%, 15.79%, and 18.51% with oil addition at level 2.5%, 5.0%, and 7.5% compared to control, but no effect on microbial protein concentration, ammonia (NH3) concentration and carboxymethyl cellulase (CMC-ase) activity. It can be concluded that coconut oil had the highest affect on methane production by inhibition of<br />protozoa growth and addition oil up to 5.0% reduced methane production as much as 15.80%.</p><p>(Key words : Coconut oil, Sunflower seed oil, Palm olein, Methane production, Protozoa count, In vitro fermentation)<br /><br /></p>

scholarly journals Formulation and Evaluation of Release Kinetics of Diltiazem Hydrochloride from Kollicoat SR 30 D Coated Pellets Prepared by Air Suspension Technique

1970 ◽  
Vol 43 (3) ◽  
pp. 321-332
Author(s):  
Afsana Akhter ◽  
Monzurul Amin Roni ◽  
Mohammad Shahriarul Absar ◽  
Golam Kibria ◽  
Reza-ul Jalil
Keyword(s):  
Polyvinyl Acetate ◽  
Release Kinetics ◽  
Methyl Cellulose ◽  
In Vitro Dissolution ◽  
Dissolution Time ◽  
Physical Parameters ◽  
Diltiazem Hydrochloride ◽  
Significant Difference ◽  
Kinetics Of

The purpose of the present study is to investigate the effect of polyvinyl acetate on the release kinetics of diltiazem hydrochloride from coated pellets prepared by solution and suspension layering technique. Kollicoat SR 30 D, an aqueous dispersion of polyvinyl acetate with different weight ratios was chosen to sustain the release of the drug. Drug was loaded with hydroxypropyl methyl cellulose on nonpareil seeds then coated with the Kollicoat SR 30 D. In vitro dissolution studies were carried out using USP dissolution apparatus Type-2. No significant difference was found in drug release from uncoated pellets and the pellets coated with 5% polymer load. With 10% polymer load, the initial release was minimized but from 2nd hour the release was quick-tempered. Better sustaining effect was found from 15- 20% polymer loaded pellets. The mean dissolution time was 2.5h and 4h while the polymer load was 15% and 20% respectively. Also these two cases 80% drug was released at 6h and 9h respectively. The physical parameters of the prepared pellets were also compared in this study. The release of drug from the coated pellets appeared to follow Higuchi's release kinetics.Key words: Diltiazem, Pellets, Kollicoat SR 30 D, Aqueous coating, Physical parameters, Release kinetics.DOI = 10.3329/bjsir.v43i3.1147Bangladesh J. Sci. Ind. Res. 43(3), 321-332, 2008

scholarly journals COMPARATIVE BIOEQUIVALENCE STUDIES OF CINNARIZINE AND ITS DIFFERENT AVAILABLE MARKETED FORMULATION DRUGS

2020 ◽  
pp. 209-215
Author(s):  
SANJEEV KUMAR ◽  
AMIN MIR M ◽  
SARVESH KUMAR ◽  
ANUJ KUMAR
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
In Vitro Dissolution ◽  
H1 Receptor ◽  
Disintegration Time ◽  
Standard Curve ◽  
Weight Variation ◽  
H1 Receptor Antagonist ◽  
Kinetics Of

Objective: The main focus of the study was to investigate the marketed formulations of cinnarizine and it is marketed analogous. Methods: The study involved the analysis of basic pre-formulation studies, namely, physical properties, melting point, Fourier-transform infrared, loss on drying, assay of cinnarizine, standard curve, and partition co-efficient of various marketed tablets of cinnarizine. Results: Cinnarizine is an H1-receptor antagonist drug which is widely used for the treatment of dynamical sickness, vomiting, and vertigo. In this study, five known marketed formulations of cinnarizine were evaluated for weight variation, hardness, drug content, friability, disintegration time, and in vitro dissolution as well as the drug release kinetics of the tablets. As per the study, the drugs show low disintegration time and good hardness, also in vitro dissolution studies have shown near about 90% drug release at the end of the first 10 min and then cumulative drug release of not less than 92% in the nearby 10 min. Hence, these formulations show lower friability, acceptable taste, and shorter disintegration time which make them suitable to be accepted. Thus, the tablets are good for the use, so allow them to be marketed for the wellbeing of humans. Conclusion: It had been found that all the tablets show acceptable limits for various parameters of analysis, in a sustained manner. Thus, all the tablets are effective for usage under standard conditions.

In Vitro Assessment of the Bioaccessibility of Tocopherol and Fatty Acids from Sunflower Seed Oil Bodies

2009 ◽  
Vol 57 (13) ◽  
pp. 5720-5726 ◽  
Author(s):  
Daniel A. White ◽  
Ian D. Fisk ◽  
Sakunkhun Makkhun ◽  
David A. Gray
Keyword(s):  
Fatty Acids ◽  
Sunflower Seed ◽  
Seed Oil ◽  
Oil Bodies ◽  
Sunflower Seed Oil ◽  
In Vitro Assessment
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