scholarly journals MINI REVIEW: INSIGHTS ON INSTRUMENTAL ANALYSIS OF OMBITASVIR, PARITAPREVIR AND RITONAVIR

2021 ◽  
pp. 1-4
Author(s):  
ROSHDY E. SARAYA ◽  
MAGDA ELHENAWEE ◽  
HANAA SALEH ◽  
MAHMOUD M. SEBAIY
Keyword(s):  
Literature Review ◽  
Biological Samples ◽  
Degradation Products ◽  
Pure Form ◽  
Instrumental Analysis ◽  
Chromatographic Methods

In this literature review, we will introduce most of the up-to-date reported methods that have been developed for the determination of Ombitasvir, Paritaprevir and Ritonavir in their pure form, combined form with other drugs combined form with degradation products, and in biological samples. Most of reported methods includes spectrophotometric and chromatographic methods specially HPLC and HPTLC.

scholarly journals Instrumental Analysis of Chlordiazepoxide in Different Matrices

2021 ◽  
pp. 1-10
Author(s):  
Lobna M. Abdel-Aziz ◽  
Ahmed A. Soror ◽  
Ahmed A. Hassan ◽  
Ahmed S. Ali ◽  
Ahmed A. Hafez ◽  
...  
Keyword(s):  
Literature Review ◽  
Biological Samples ◽  
Analytical Methods ◽  
Degradation Products ◽  
Electrochemical Techniques ◽  
Pharmacological Action ◽  
Pure Form ◽  
Instrumental Analysis ◽  
The World

Chlordiazepoxide is considered one of most important sedative and hypnotic benzodiazepines drugs which is currently used all over the world with the increased rate of anxiety drugs. In this literature review, we will introduce the pharmacological action of this drug in addition to most of up-to-date reported methods that have been developed for determination of chlordiazepoxide in its pure form, combined form with other drugs, combined form with degradation products, and in biological samples. Most of the reported analytical methods will focus on spectroscopic, chromatographic and electrochemical techniques.

scholarly journals Instrumental analysis of some anti-ulcer drugs in different matrices

2020 ◽  
Vol 2 (1) ◽  
pp. 156-172
Author(s):  
Samar S. Elbaramawi ◽  
◽  
Mohamed E. El-Sadek ◽  
Mohamed M. Baraka ◽  
Lobna M. Abdel-Aziz ◽  
...  
Keyword(s):  
Literature Review ◽  
Biological Samples ◽  
Degradation Products ◽  
Pure Form ◽  
Instrumental Analysis ◽  
Doxycycline Hyclate ◽  
Ranitidine Hydrochloride

In this literature review, we will introduce most reported methods that have been developed for determination of certain anti-ulcer drugs such as Ranitidine hydrochloride, Famotidine, Omeprazole, Pantoprazole sodium, Tinidazole and Doxycycline hyclate in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples.

scholarly journals Review article on Analytical Techniques of Lamivudine Determination in Different Matrices

2021 ◽  
Vol 2 (3) ◽  
pp. 37-46
Author(s):  
Roshdy E. Saraya ◽  
Magda Elhenawee ◽  
Hanaa Saleh ◽  
Mahmoud M. Sebaiy Sebaiy
Keyword(s):  
Literature Review ◽  
Biological Samples ◽  
Degradation Products ◽  
Analytical Techniques ◽  
Review Article ◽  
Pure Form

In this literature review, we will introduce most of up-to-date reported methods that have been developed for determination of lamivudine in its pure form, combined form with other drugs, combined form with degradation products, and in biological samples.

scholarly journals Analytical Methods for Determination of Salbutamol, Ambroxol and Fexofenadine

2020 ◽  
Vol 1 (1) ◽  
pp. 01-11
Author(s):  
Mahmoud Sebaiy
Keyword(s):  
Biological Samples ◽  
Analytical Methods ◽  
Degradation Products ◽  
Review Article ◽  
Pure Form

In this review article, we will introduce all reported methods that have been developed for determination of certain anti-tussive and anti-histaminic drugs such as salbutamol, ambroxol and fexofenadine in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples. We also will shed the light on the most important combination of drugs that are used for treatment of asthma and related diseases.

Development and Validation of Two Robust Stability-Indicating Chromatographic Methods for Determination of Metolazone in Drug Substance and Pharmaceutical Dosage Form in the Presence of Its Degradation Products and Characterization of Main Degradation Products Based on LC-MS

2019 ◽  
Vol 58 (3) ◽  
pp. 251-261
Author(s):  
Hala E Zaazaa ◽  
Rasha Abdel-Ghany ◽  
M Abdelkawy ◽  
Mahmoud Sayed
Keyword(s):  
Dosage Form ◽  
Degradation Products ◽  
Hplc Method ◽  
Drug Substance ◽  
Design Parameters ◽  
Pharmaceutical Dosage Form ◽  
Stability Indicating ◽  
Chromatographic Methods ◽  
Hptlc Method

Abstract Two robust and selective stability-indicating chromatographic methods were developed and validated for the determination of metolazone in drug substance and pharmaceutical dosage form in the presence of its degradation products. The HPLC method employed a Kromasil C18 (250 × 4.6,5 μm) column and a mobile phase of acetonitrile: 0.2% orthophosphoric acid (32:68 v/v) at a flow rate 2 mL/min and detection at 238 nm. The separation was performed in HPLC isocratic mode. The robustness of the suggested method was assessed using the Plackett–Burman design, parameters affecting system suitability were established and non-significant intervals for the significant parameters were considered. The HPTLC method employed Nano-SIL-20 UV254 HPTLC plates as adsorbent, ethyl acetate: toluene: acetic acid solution (4:4:0.5, v/v/v), as a developing solvent system and densitometric detection at 238 nm. Metolazone was exposed to different stress conditions, including acid and alkaline hydrolysis and oxidative and photolytic degradation. The main degradation products obtained have been characterized and interpreted based on LC-MS. The linearity of the suggested methods was proved in the concentration range of 20–75 μg/mL for the HPLC method and 100–900 ng/spot for the HPTLC method. The suggested methods were validated according to international conference on harmonization guidelines. These methods were successfully dedicated for the estimation of metolazone in drug substance and pharmaceutical dosage form in the presence of its degradation products. The results of the suggested methods were evaluated and compared statistically with results obtained by an official method without finding any significant difference.

Rapid Thin-Layer-Chromatographic Methods for the Determination of Microbiological Degradation Products of Deoxynivalenol

1997 ◽  
Vol 25 (3) ◽  
pp. 361-362
Author(s):  
N. Ellend ◽  
E. M. Horvath ◽  
J. Binder ◽  
R. Braun ◽  
R. Krska
Keyword(s):  
Thin Layer ◽  
Degradation Products ◽  
Chromatographic Methods

scholarly journals Validated Stability Indicating Chromatographic Methods for Quantification of Imidocarb Dipropionate; Application for the Determination of Its Residues in Bovine Meat and Milk Samples

2020 ◽  
Vol 103 (4) ◽  
pp. 980-988
Author(s):  
Ghada AbdElHamid Sedik ◽  
Doha Mohamed Naguib ◽  
Fahima Morsy ◽  
Hala Elsayed Zaazaa
Keyword(s):  
Degradation Products ◽  
Reversed Phase ◽  
Hplc Method ◽  
Stability Indicating ◽  
Milk Samples ◽  
Chromatographic Methods ◽  
Ich Guidelines ◽  
Imidocarb Dipropionate ◽  
Tlc Plates

Abstract Background Imidocarb dipropionate (IMD) is an immunomodulator agent commonly used for treatment of anaplasmosis in cattle. Objective Thus, two sensitive, specific, and precise stability-indicating chromatographic methods have been developed, optimized, and validated for its determination in presence of its acid, alkaline, and oxidative stressed degradation products. Method The first method is based on separation of IMD and its forced induced degradation products on reversed phase cyano column using isocratic elution system consisted of sodium acetate buffer–methanol–acetonitrile (55: 30:15, v/v/v), pH 4.6 at a flow rate of 1.2 mL/min, and UV detection at 254 nm. The second method utilized TLC combined with densitometric determination of the separated bands at 254 nm. The separation was achieved using silica gel 60 F254 TLC plates with a mixture of ethyl acetate–methanol–ammonia–water (8.5:1:0.5:0.2, v/v/v/v) as a developing system. Results HPLC analysis was applied in range of 0.25–40 µg/mL with LOD of 0.073 µg/mL. While densitometric measurements showed linearity in the range of 0.1–1.8 µg/band with LOD of 0.02 µg/band. Conclusions The suggested methods were validated in compliance with the ICH guidelines and were successfully applied for determination of IMD in its commercial veterinary formulations with good recoveries. Furthermore, the proposed HPLC method was extended to the determination of IMD residues in bovine meat and milk samples Highlights Bovine meat, HPLC, Imidocarb dipropionate, Milk, TLC.

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