scholarly journals Instrumental Analysis of Chlordiazepoxide in Different Matrices

2021 ◽  
pp. 1-10
Author(s):  
Lobna M. Abdel-Aziz ◽  
Ahmed A. Soror ◽  
Ahmed A. Hassan ◽  
Ahmed S. Ali ◽  
Ahmed A. Hafez ◽  
...  
Keyword(s):  
Literature Review ◽  
Biological Samples ◽  
Analytical Methods ◽  
Degradation Products ◽  
Electrochemical Techniques ◽  
Pharmacological Action ◽  
Pure Form ◽  
Instrumental Analysis ◽  
The World

Chlordiazepoxide is considered one of most important sedative and hypnotic benzodiazepines drugs which is currently used all over the world with the increased rate of anxiety drugs. In this literature review, we will introduce the pharmacological action of this drug in addition to most of up-to-date reported methods that have been developed for determination of chlordiazepoxide in its pure form, combined form with other drugs, combined form with degradation products, and in biological samples. Most of the reported analytical methods will focus on spectroscopic, chromatographic and electrochemical techniques.

scholarly journals MINI REVIEW: INSIGHTS ON INSTRUMENTAL ANALYSIS OF OMBITASVIR, PARITAPREVIR AND RITONAVIR

2021 ◽  
pp. 1-4
Author(s):  
ROSHDY E. SARAYA ◽  
MAGDA ELHENAWEE ◽  
HANAA SALEH ◽  
MAHMOUD M. SEBAIY
Keyword(s):  
Literature Review ◽  
Biological Samples ◽  
Degradation Products ◽  
Pure Form ◽  
Instrumental Analysis ◽  
Chromatographic Methods

In this literature review, we will introduce most of the up-to-date reported methods that have been developed for the determination of Ombitasvir, Paritaprevir and Ritonavir in their pure form, combined form with other drugs combined form with degradation products, and in biological samples. Most of reported methods includes spectrophotometric and chromatographic methods specially HPLC and HPTLC.

scholarly journals Instrumental analysis of some anti-ulcer drugs in different matrices

2020 ◽  
Vol 2 (1) ◽  
pp. 156-172
Author(s):  
Samar S. Elbaramawi ◽  
◽  
Mohamed E. El-Sadek ◽  
Mohamed M. Baraka ◽  
Lobna M. Abdel-Aziz ◽  
...  
Keyword(s):  
Literature Review ◽  
Biological Samples ◽  
Degradation Products ◽  
Pure Form ◽  
Instrumental Analysis ◽  
Doxycycline Hyclate ◽  
Ranitidine Hydrochloride

In this literature review, we will introduce most reported methods that have been developed for determination of certain anti-ulcer drugs such as Ranitidine hydrochloride, Famotidine, Omeprazole, Pantoprazole sodium, Tinidazole and Doxycycline hyclate in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples.

scholarly journals Analytical Methods for Determination of Salbutamol, Ambroxol and Fexofenadine

2020 ◽  
Vol 1 (1) ◽  
pp. 01-11
Author(s):  
Mahmoud Sebaiy
Keyword(s):  
Biological Samples ◽  
Analytical Methods ◽  
Degradation Products ◽  
Review Article ◽  
Pure Form

In this review article, we will introduce all reported methods that have been developed for determination of certain anti-tussive and anti-histaminic drugs such as salbutamol, ambroxol and fexofenadine in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples. We also will shed the light on the most important combination of drugs that are used for treatment of asthma and related diseases.

scholarly journals Review article on Analytical Techniques of Lamivudine Determination in Different Matrices

2021 ◽  
Vol 2 (3) ◽  
pp. 37-46
Author(s):  
Roshdy E. Saraya ◽  
Magda Elhenawee ◽  
Hanaa Saleh ◽  
Mahmoud M. Sebaiy Sebaiy
Keyword(s):  
Literature Review ◽  
Biological Samples ◽  
Degradation Products ◽  
Analytical Techniques ◽  
Review Article ◽  
Pure Form

In this literature review, we will introduce most of up-to-date reported methods that have been developed for determination of lamivudine in its pure form, combined form with other drugs, combined form with degradation products, and in biological samples.

Electroanalysis of Tricyclic Psychotropic Drugs using Modified Electrodes

2019 ◽  
Vol 15 (4) ◽  
pp. 423-442 ◽  
Author(s):  
Mona Habibi-Kool-Gheshlaghi ◽  
Farnoush Faridbod ◽  
Mahya Karami Mosammam ◽  
Mohammad Reza Ganjali
Keyword(s):  
Psychotropic Drugs ◽  
Analytical Methods ◽  
Electrochemical Techniques ◽  
Modified Electrodes ◽  
Electroanalytical Methods ◽  
Drug Assays ◽  
Medical Importance ◽  
Tricyclic Rings ◽  
Easy Operation

Background: Tricyclic psychotropic drugs are defined as a tricyclic rings of the dibenzazepine group with the presence of sulfur and nitrogen atoms. They have been prescribed for antidepressive therapy over the years. Due to their medical importance, many analytical methods have been developed for their monitoring. However, benefits of electrochemical techniques such as costeffectiveness, fast, easy operation and non-destructiveness make them appropriate analytical methods for drug assays. Electrochemical determinations of pharmaceuticals require suitable working electrodes. During years, many electrodes are modified by a variety of modifiers and several sensors were developed based on them. In this regard, nanomaterials, due to their remarkable properties, are one of the most important choices. Objective: Here, the application of electroanalytical methods in the determination of electroactive tricyclic psychotropic drugs will be reviewed and the nanomaterials which are used for improvements of the working electrodes will be considered.

scholarly journals Artistic dominant of the image of character of occupational novel

2020 ◽  
pp. 93-103
Author(s):  
Anna Anatolievna Gaganova
Keyword(s):  
Instrumental Analysis ◽  
Political Bias ◽  
Systemic Analysis ◽  
Stage Of Development ◽  
The World ◽  
Russian Literary ◽  
History Of ◽  
The Subject ◽  
Historical Periods

The object of this research is the genre of occupational novel. The subject is the image of character of occupational novel. The goal consists in determination of artistic specificity of the image of character in the process of development of the genre. Russian literary works for the period of 1920’s – 1970’s united by the image of a man of labor became the material for this study. The evolution of the image of character is viewed on the sampling of representational works. The conclusions are made that at the stage of formation of the genre of occupational novel (1920’s – 1930’s) dominates the image of the reformer of the world. The next stage (1940’s – 1950’s) marks the character of the defender of reformed world. Then, in the 1960’s, it is followed by the character-rationalizer. The final chronological stage of history of the genre (1970’s) personifies the image of a young hero-seeker, defined by the professional calling in life. The scientific novelty consists in reference to the genre of occupational novel in its entire evolution from the perspective of philological instrumental analysis, while the earlier studies were characterized by political bias. The genre of occupational novel is separated from the literary trends of the XX century, and is divided into historical periods. The article suggests a systemic analysis of the image of character of occupational novel within the framework of evolution of the genre. The author is firs to highlight the key artistic attributes that represent an artistic dominant for the image of character at each stage of development of the genre.

scholarly journals Fabrication of novel polymer-modified graphene-based electrochemical sensor for the determination of mercury and lead ions in water and biological samples

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Chenthattil Raril ◽  
Jamballi G. Manjunatha
Keyword(s):  
Heavy Metal ◽  
Detection Limit ◽  
Metal Ions ◽  
Biological Samples ◽  
Heavy Metal Ions ◽  
Electrochemical Techniques ◽  
Differential Pulse ◽  
Modified Graphene ◽  
Water And Biological Samples

Abstract Background This paper presents the application of polyglycine-modified graphene paste electrode (PGMGPE) for the electrochemical detection of Hg (II) and Pb (II) ions in the water and biological samples. Method The developed electrode was characterized by field emission scanning electron microscopy. Electrochemical techniques such as cyclic voltammetry and differential pulse voltammetry were used to study the behavior of metal ions. Results The modification process improves the electrochemical behavior of heavy metal ions. The peak current varied linearly with the increase of the concentration leading to a detection limit of 6.6 μM (Hg (II)) and 0.8 μM (Pb (II)), respectively. Conclusion The developed electrode exhibits good sensitivity, selectivity, stability, and lower detection limit, and was successfully applied to the determination of heavy metal ions in water and biological samples with a good recovery range.

Validated Chromatographic and Spectrofluorimetric Methods for Analysis of Silodosin: A Comparative Study with Application of RP-HPLC in the Kinetic Investigation of Silodosin Degradation

2020 ◽  
Author(s):  
Shereen A Boltia ◽  
Mohammed Abdelkawy ◽  
Taghreed A Mohamed ◽  
Nahla N Mostafa
Keyword(s):  
Analytical Methods ◽  
High Performance ◽  
Degradation Products ◽  
Reversed Phase ◽  
Array Detector ◽  
Kinetic Investigation ◽  
First Derivative ◽  
Rp Hplc ◽  
Significant Difference

Abstract Background Stability indicating determination of pharmaceuticals is crucial, especially for drugs which have few published official analytical methods. Silodosin (SLD) is an FDA approved α1A-adrenoceptor blocker. Objective Efficient analytical methods were suggested, based on different instrumental techniques for quantification of SLD, besides conducting kinetic investigation of its degradation. Methods The first method is based on Reversed Phase High Performance Liquid Chromatography with Photodiode Array Detector (RP-HPLC-PDAD). Detection is done at wavelength 225 nm. The second method is focused on using High Performance Thin Layer Chromatography (HPTLC) and eluting the drug by solvent mixture followed by scanning at wavelength 270 nm. The third method depends on the First Derivative Synchronous Fluorescence Spectroscopy (1DSFS) for analysis of solutions of SLD and its acid and oxidative induced degradation products at Δλ = 90 nm, then determining the first derivative of the spectra and measuring peak amplitudes at 360 nm. Results Acceptable linearities were found in the concentration range of 0.50–90 μg/mL, 0.10–3.0 μg/band, and 0.05–0.50 µg/mL, for RP-HPLC-PDAD, HPTLC, and spectrofluorimetric methods, respectively. Conclusion Statistical analysis showed no significant difference between the suggested and the reported method. In monitoring the kinetics of SLD degradation, the order of reactions was determined and effects of degrading agent concentration and temperature on reaction rate were studied. Highlights Three analytical methods were developed for the determination of SLD based on RP-HPLC-PDAD, HPTLC, and 1DSFS in bulk and capsule dosage form. In addition, kinetic investigation of SLD degradation was performed using the developed RP-HPLC-PDAD method.

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