scholarly journals DRUG UTILIZATION PATTERN IN PREGNANCY AMONGST INPATIENT AND OUTPATIENT GROUPS IN A SPECIALIST HOSPITAL, NORTH-WESTERN NIGERIA

Author(s):  
Iyabo Adebisi ◽  
Tijjani Rabiu Giaze

Objective: Drugs prescribed in pregnancy may diffuse across the placenta to the fetus thereby posing a great risk of teratogenicity. In this study, drug utilization pattern in pregnancy amongst inpatient and outpatient groups was studied retrospectively in a specialist hospital in the North Western region of Nigerian.Methods: Drug prescription information was collected from case notes of 2634 patients that attended the antenatal clinic on an outpatient basis and those that were admitted due to complication(s) for a period of six months. Data collected were analyzed using Microsoft excel software and compared with FDA pregnancy categorization of drugs.Results: In the outpatient group, 215 patients had complaints that warranted the use of prescription drugs while in the inpatient group, 69 patients had complications that necessitated hospitalisation. In the outpatient group, prescribed drugs for the treatment of malaria (34%) and urinary tract infection (25%) were predominantly from FDA category B. In the inpatient group, drugs for malaria (18%), anemia (11.6%) and pre-eclampsia (11.6%) were the most prescribed. In the management of anemia, drugs prescribed were purely from FDA category A, while, in the case of pre-eclampsia, a significant amount of prescribed drugs were from FDA categories C and N.Conclusion: In both patient groups, no drug from FDA category X was prescribed. Therefore, it can be concluded that drugs prescribed in pregnancy in specialist hospital, Sokoto-Nigeria, were within a reasonable limit of safety. However, the use of drugs such as diazepam whose risks are yet to be classified should be avoided.

Author(s):  
Saswat Satapathy ◽  
Yajnesh P. Sahu ◽  
Ashok K. Panigrahi ◽  
Bhabagrahi Rath ◽  
Ananta N. Patra

Background: The intensive care unit is a setting where the multiple medications are prescribed to patients. Antimicrobials are heavily prescribed in the ICUs, which in turn enhance the risk of antimicrobial resistance, increase the side effects and increases the cost of treatment. Drug utilization study is a component of medical auditing that aims to monitor and evaluate the drug prescription patterns and to suggest necessary modifications in the prescribing practices to achieve rational therapeutic practice.Methods: A cross-sectional study was conducted in which data of patients admitted to ICU during the period from June 2019 to August 2019 was collected from the Medical Record Section of the hospital. Drug utilization pattern of antimicrobials in ICU was analyzed.Results: Out of 90 patients, 60 were males and 30 were females. The average duration of stay in ICU was 7.53 days. The most common antibiotic prescribed was ceftriaxone followed by piperacillin and tazobactam with DDD/100 bed days of 24.2 and 17.3 respectively.Conclusions: In this study, the results appeared to be similar to those reported in previous studies. However, prescription protocols need to be addressed to guide appropriate use of antimicrobials in the ICU setting. Therefore, it is necessary to conduct drug utilization research to understand the drug consumption and for implementation of protocols to improve the quality of healthcare. 


Author(s):  
Nitya Selvaraj ◽  
Anugraha Sekar ◽  
Ramya Gandhi ◽  
Nalinidevi Jayabalan ◽  
Suganya Ganesan ◽  
...  

Background: Drug utilization pattern in pregnancy population provide insights regarding drug profile and interventional measures and also minimizes the inherent risk occurring due to unethical prescription.Methods: It was a prospective cross sectional study where prescription slips were collected. Further drugs were categorized according to the classification defined by US Food and drug Administration for pregnancy. Using Pre validated questionnaire the pregnant women were interviewed and parameters regarding knowledge about antenatal visit and contraception, self-medication practices were noted.Results: Among the total 365 participants, 81.4% had finish their high schooling and were in reproductive age group of 22-25. Study revealed predominant usage category- A drugs in I (95.5%), II (97.8%), III (96.4%) trimester. None of them received Category D or X drugs. Almost 100% and 98.6% in III and II trimester respectively received iron. Other drugs prescribed were calcium, anti-emetics, anti-ulcer, NSAIDS and antimicrobial. The awareness about Intra Uterine Contraceptive Devices and Oral Contraceptive Pills were 48.2% and 31.5% respectively. Unfortunately only 4.9% felt that drug use could be dangerous to foetus. 58.9% were aware about antenatal examination during pregnancy.Conclusions: Evaluation of drug utilization pattern periodically will minimize incidence of risk to foetus and mother during pregnancy.


Author(s):  
D. Vijayalakshmi ◽  
Srinivas Rao Bendi ◽  
Motakatla Usharani ◽  
K. Swarna Latha

Background: Cancer is one among main causes of morbidity and mortality in developing and developed countries. The World Cancer Report 2014 of World Health Organization’s (WHO’s) International Agency for Research on Cancer (IARC), states that in 2012 the global incidence of cancer increased to a 14 million new cases, the figure expected to rise to an annual 19.3 million by 2025. The prescription pattern of anticancer drugs has evolved considerably in recent years because of better understanding of underlying pathophysiology of carcinomas as well as introduction of newer drugs. Methods: It was a hospital-based prospective, cross-sectional study conducted in Department of Oncology, GGH, Kakinada for a period of twelve months from February 2017 to January 2018. A total of 100 patients were enrolled using convenience sampling technique. Patient demographics like age, gender, educational level, employment status, marital status, smoking category, alcohol consumption, stage of cancer was collected. Drug utilization pattern was obtained from inpatient case reports, prescriptions and medication charts used during a chemotherapy cycle.Results: Among all anticancer drugs, cisplatin and 5-flurouracil were most commonly prescribed followed by Adriamycin. The most commonly used adjuvant drugs were B-complex, diclofenac, granisetron, ranitidine, dexamethasone. Antibiotic use was found to be very limited.Conclusions: Various anticancer drug prescription patterns are being used for treatment of patient with metastatic cancers. In this study, cisplatin and 5-flurouracil were commonly used. Injudicious antibiotic prescribing was not observed.  


2021 ◽  
pp. 20-23
Author(s):  
Giridhar Dasegowda ◽  
Girish M Bengalorkar ◽  
Salma Sadaf ◽  
Priyanka Prasanna Kumar Belaguthi ◽  
Sanjiti Mirmire ◽  
...  

Background: Stroke is not only one of the leading causes of morbidity and mortality worldwide but is also a topic of major public health concern in developing countries with a prevalence of 44 - 559 per 100,000 people. This study focuses on risk factors, socioeconomic distribution, drug utilization pattern, rehabilitation of patients and possible solutions to the encountered problems. Methods: Patients admitted to ESIC MC & PGIMSR, Bangalore were included in this cross-sectional study. A complete prole of patients diagnosed with stroke was obtained. On analysing the data obtained from 51 patients Results: under study, it was noted that ischemic stroke was the highest (84.31%), and stroke in males (70.59%) was higher than among females (29.41%) with highest occurrences between 55-70 years of age (41.18%). A large number of people were found to have >=3 risk factors (72.54%), including hypertension (78.43%), alcoholism (50.98%), diabetes mellitus (49.02%), smoking (47.05%), and dyslipidemia (27.45%). It was found that an average patient is prescribed 3.01 drugs in generic name and 4.68 in brand name (p<0.05). The study also highlighted the inadequacy of physiotherapy (39.21%), speech-therapy (11.76%) and occupational-therapy (0%). An understanding of risk factors and drug prescription strategies fol Conclusion: lowed by physicians across different socioeconomic groups helps to ne tune management strategies in accordance with guidelines, to provide a better quality of life to patients.


Author(s):  
Mahadeo P. Sawant ◽  
Sudhir L. Padwal ◽  
Rakesh R. Jadhav ◽  
Harshal N. Pise ◽  
Rucha Shinde

Background: Drug utilization pattern studies helps to screen, assess and propose appropriate modifications in prescription practices, this would help to make patient care rational and cost effective. Study was intended to analyse the drug prescribing pattern for treatment of Ischemic heart disease using WHO indicators.Methods: This is a cross sectional observational study conducted on ischemic heart disease patients admitted at inpatient department of medicine in a tertiary care teaching hospital. The study consisted of analysis of drug utilization pattern of prescribed drugs.Results: IHD was more commonly seen in males (70.06%) than females (29.94%). IHD was most commonly seen in patients of age group of 61-70 year. Drugs prescribed to patients belong to various therapeutic classes ranging from anti-platelets, anticoagulants, anti-anginal, antithrombin, thrombolytic, hypolipidemics. The most commonly prescribed therapeutic class of drugs was antiplatelet (86.26%) followed by hypolipidemic (82.25%) and ACE inhibitors drugs (46.60%). Average number of drugs per encounter was 7.70. Drugs were prescribed by their generic names were 29.99%. Out of total study group 22.06% patients were prescribed at least one antibiotic. Injections were prescribed only in 1392 (27.86%) out of 4995 drugs. Of total drugs 3270 (65.45%) of drugs were from National List of Essential Medicines-2016 (NLEM -2016) and 2774 (55.53%) drugs prescribed were from WHO-EML-2016.Conclusions: Risk of artery disease increased with increasing age. IHD was more common in males than females. The most commonly prescribed drug classes in Ischemic heart disease were anti-platelet drugs followed by hypolipidemic agents.


2020 ◽  
Vol 5 (3) ◽  
pp. 1191-1195
Author(s):  
Sushmita Shrestha ◽  
Navin Agrawal ◽  
Deependra Prasad Sarraf

Introduction: Irrational or inappropriate prescribing practice is common in developing countries that can lead to ineffective treatment, prolonged hospitalization, harm to the patient, increased treatment cost and development of drug-resistant organisms. The prescription of antibiotics and other drugs in endodontics is limited to patients with progressive and diffuse swelling and with systemic infection. However, antibiotics continue to be over-prescribed by more than 66% dentists without a rational justification.Therefore, the periodic assessment of drug utilization pattern is important to know the existing pattern of drug use, decrease adverse effects and provide feedback to the prescribers. Objective: To evaluate the drug utilization pattern in endodontics using the World Health Organization prescribing indicators. Methodology: A cross-sectional prospective study was conducted among the patients visiting the outpatient department of Conservative Dentistry and Endodontics. After obtaining the informed consent, the relevant data were collected on a self-designed proforma by reviewing the health cards of the patients. The WHO prescribing indicators were calculated. Descriptive statistics were calculated using SPSS version 11.0. Results: Out of 187 patients, 101 (54%) were female. Mean age was 38.9±16.6 years. Majority of the patients suffered from acute apical periodontitis (30.5%). A total of 281 drugs were prescribed to 187 patients. Paracetamol+Ibuprofen (44.1%) was the most frequently prescribed drugs. Most of the patients were prescribed one drug (78.6%).  Average drug per prescription was 1.5. Majority of the drugs (89.0%) were prescribed from Essential drug list of Nepal. Conclusions: Analgesics were the most frequently prescribed drug. The prescription practice was rational. There is need to increase the number of medicine prescribed from National List of Essential medicines.Educational initiatives should be undertaken to further strengthen the rational prescription among dental practitioners.


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