Hyperglycemia among hospitalized cancer patients with coexisting diabetes mellitus

2015 ◽  
Vol 5 (6) ◽  
pp. 441-448 ◽  
Author(s):  
Nina J Karlin ◽  
Meng-Ru Cheng ◽  
Janna C Castro ◽  
Curtiss B Cook
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tianli Hui ◽  
Chao Shang ◽  
Liu Yang ◽  
Meiqi Wang ◽  
Ruoyang Li ◽  
...  

AbstractEarly reports indicate that metformin, a clinical drug administered to treat type 2 diabetes mellitus (T2DM), was found to be associated with a better prognosis of cancer. The objective of this study was retrospectively analyzed the effect of metformin on the outcomes of Chinese breast cancer patients with T2DM. A total of 3757 primary invasive breast cancer patients who underwent surgery from January 2010 to December 2013 were enrolled. According to the medication treatment, all the patients were divided as non-diabetes group, metformin group and insulin group. The follow-up data for disease-free survival (DFS) and overall survival (OS) were obtained from 3553 patients (median follow up of 85 months) and estimated with the Kaplan–Meier method followed by a log-rank test. Multivariate Cox proportional hazards regression model was applied. The results showed that there was a significant survival difference among non-diabetes group, metformin group and insulin group, 5-year DFS was 85.8%, 96.1%, 73.0%, and 5-year OS was 87.3%, 97.1%, 73.3% respectively (P < 0.05). Prognostic analysis showed metformin was significantly associated with better DFS and OS. Our results suggested that metformin may have a good effect on the survival of invasive breast cancer patients with T2DM.


Author(s):  
Livia Costa de Oliveira ◽  
Karla Santos da Costa Rosa ◽  
Ana Luísa Durante ◽  
Luciana de Oliveira Ramadas Rodrigues ◽  
Daianny Arrais de Oliveira da Cunha ◽  
...  

Background: Advanced cancer patients are part of a group likely to be more susceptible to COVID-19. Aims: To describe the profile of advanced cancer inpatients to an exclusive Palliative Care Unit (PCU) with the diagnosis of COVID-19, and to evaluate the factors associated with death in these cases. Design: Retrospective cohort study with data from advanced cancer inpatients to an exclusive PCU, from March to July 2020, with severe acute respiratory syndrome. Diagnostic of COVID-19 and death were the dependent variables. Logistic regression analyses were performed, with the odds ratio (OR) and 95% confidence interval (CI). Results: One hundred fifty-five patients were selected. The mean age was 60.9 (±13.4) years old and the most prevalent tumor type was breast (30.3%). Eighty-three (53.5%) patients had a diagnostic confirmation of COVID-19. Having diabetes mellitus (OR: 2.2; 95% CI: 1.1-6.6) and having received chemotherapy in less than 30 days before admission (OR: 3.8; 95% CI: 1.2-12.2) were associated factors to diagnosis of COVID-19. Among those infected, 81.9% died and, patients with Karnofsky Performance Status (KPS) < 30% (OR: 14.8; 95% CI 2.7-21.6) and C-reactive protein (CRP) >21.6mg/L (OR: 9.3; 95% CI 1.1-27.8), had a greater chance of achieving this outcome. Conclusion: Advanced cancer patients who underwent chemotherapy in less than 30 days before admission and who had diabetes mellitus were more likely to develop Coronavirus 2019 disease. Among the confirmed cases, those hospitalized with worse KPS and bigger CRP were more likely to die.


2014 ◽  
Vol 29 (1) ◽  
pp. 42-47
Author(s):  
Maria Luisa Cecilia Rivera-Arkoncel ◽  
◽  
Michael Sagun ◽  
Francis Raymond Arkoncel ◽  
Cecilia Jimeno ◽  
...  

1986 ◽  
Vol 19 (4) ◽  
pp. 828-831
Author(s):  
Yoshihiro KIDO ◽  
Yoshitaka OGAWA ◽  
Satoshi TANE ◽  
Michio OGAWA ◽  
Hitoshi SHIOZAKI ◽  
...  

2017 ◽  
Vol 12 (1) ◽  
pp. S373
Author(s):  
Milana Bergamino Sirvén ◽  
Aj Rullan ◽  
Maria Saigi ◽  
Inmaculada Peiró ◽  
Eduard Montanya ◽  
...  

2020 ◽  
Vol 9 (20) ◽  
pp. 7428-7439
Author(s):  
Minghua Cong ◽  
Wenjie Zhu ◽  
Chang Wang ◽  
Zhenming Fu ◽  
Chunhua Song ◽  
...  

2019 ◽  
Vol 9 (3) ◽  
pp. 902-911 ◽  
Author(s):  
Xianghua Zeng ◽  
Cheng Xu ◽  
Jianan Cheng ◽  
Chengdu Sun ◽  
Zhongyu Wang ◽  
...  

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