Developing innovation governance readiness in regenerative medicine: lessons learned from the Macchiarini crisis

2021 ◽  
Vol 16 (3) ◽  
pp. 283-294
Author(s):  
Maureen McKelvey ◽  
Rögnvaldur J Saemundsson
Keyword(s):  
Regenerative Medicine ◽  
Healthcare Systems ◽  
Fundamental Difference ◽  
Lessons Learned ◽  
Karolinska Institute ◽  
Gene Therapies ◽  
Conventional Drug ◽  
Innovation Governance ◽  
Clinical Adoption ◽  
Improve Health

The generation and clinical adoption of workable therapies in regenerative medicine has been slow, despite its alleged potential to relieve suffering and improve health outcomes. This has been explained by a fundamental difference between advanced cell and gene therapies and conventional drug- and device-based therapies, raising questions about how the readiness of existing healthcare systems to adopt such therapies can be evaluated and improved. In this paper, we use the lessons learned from the Macchiarini crisis at the Karolinska Institute in Sweden to take the first step in formulating the concept of innovation governance readiness. We propose it as a tool to help evaluate and improve the ability of private, public and civil society actors to work together to build and put into practice therapies based on emerging medical technologies such as regenerative medicine.

scholarly journals A public health perspective on mental health: lessons for population health in the 21st century

2021 ◽  
pp. 1-4
Author(s):  
James V. Lucey
Keyword(s):  
Public Health ◽  
Mental Health ◽  
Population Health ◽  
Royal College ◽  
Public Support ◽  
Healthcare Systems ◽  
Lessons Learned ◽  
Public Health Perspective ◽  
The World ◽  
Shared Commitment

In December 2019, clinicians and academics from the disciplines of public health and psychiatry met in Dublin at the Royal College of Surgeons in Ireland (RCSI), to restate their shared commitment to population health. The purpose of this review is to bring our discussion to a wider audience. The meeting could not have been more timely. Six weeks later, the COVID-19 emergency emerged in China and within 12 months it had swept the world. This paper, the contents of which were presented at that meeting in December recommended that future healthcare would be guided more by public health perspectives and informed by an understanding of health economics, population health and the lessons learned by psychiatry in the 20th century. Ultimately two issues are at stake in 21st century healthcare: the sustainability of our healthcare systems and the maintenance of public support for population health. We must plan for the next generation of healthcare. We need to do this now since it is clear that COVID-19 marks the beginning of 21st century medicine.

Innovative Technology – Enhancing Healthcare for All (Vol. 25, No. 5, Full Issue)

2021 ◽  
Vol 25 (05) ◽  
Keyword(s):  
Heart Failure ◽  
Health Outcomes ◽  
Digital Technology ◽  
Research Study ◽  
Intravenous Iron ◽  
Healthcare Systems ◽  
Innovative Technology ◽  
Heart Failure Patients ◽  
New Methods ◽  
Improve Health

For the month of May 2021, APBN discovers how the used of digital technology and innovative new methods can help treatment, prevention and management of diseases. In the Columns section, we have a contribution by Son Pham, Country Manager for GE Healthcare Vietnam and the CEO for GE Vietnam on how technology has helped healthcare systems in Vietnam during the COVID-19 pandemic. In the Spotlights section, read about a research study by the National Heart Centre Singapore (NHCS) and its international partners affirm the use of intravenous iron to help heart failure patients improve health outcomes.

scholarly journals Anticipating the clinical adoption of regenerative medicine: building institutional readiness in the UK

2018 ◽  
Vol 13 (1) ◽  
pp. 29-39 ◽  
Author(s):  
John Gardner ◽  
Andrew Webster ◽  
Jacqueline Barry
Keyword(s):  
Regenerative Medicine ◽  
The Uk ◽  
Clinical Adoption

scholarly journals Practical experience with SCIROCCO twinning and coaching- the perspective of a receiving region

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
J Txarramendieta Suarez
Keyword(s):  
Knowledge Transfer ◽  
Integrated Care ◽  
Basque Country ◽  
Practical Experience ◽  
Healthcare Systems ◽  
Voluntary Sector ◽  
Lessons Learned ◽  
Potential Benefits ◽  
Definition Of ◽  
Coaching Activities

Abstract One of the SCIROCCO twinning and coaching activities was conducted between two healthcare systems: Scotland and The Basque Country. The objective of this presentation is to describe the experience of the receiving region, the Basque Country. In particular, it will outline the role and engagement of the voluntary sector in the provision of integrated care in the Basque Country, in terms of: Organisation, including the definition of the voluntary sector, its size and stakeholders;Engagement of the voluntary sector with integration of careMotivation for the knowledge transfer activity with ScotlandObjectives of twinning, potential benefits of the knowledge transfer activityFeasibility and required adaptation for the transferPriority actions, main learningsConclusions, lessons learned

scholarly journals A blueprint for translational regenerative medicine

2020 ◽  
Vol 12 (572) ◽  
pp. eaaz2253
Author(s):  
James P. K. Armstrong ◽  
Timothy J. Keane ◽  
Anne C. Roques ◽  
P. Stephen Patrick ◽  
Claire M. Mooney ◽  
...  
Keyword(s):  
Immune Response ◽  
Regenerative Medicine ◽  
In Vivo Imaging ◽  
Imaging Modalities ◽  
Proof Of Concept ◽  
The Past ◽  
Valley Of Death ◽  
Clinical Adoption ◽  
Selection Of

The past few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to the so-called “valley of death.” Here, we present a proposed blueprint for translational regenerative medicine. We offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development. Last, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine.

scholarly journals (P1-4) Building Resilient Extended-Care Facilities during Natural Disasters – Lessons Learned From the 2007 Tulsa, Oklahoma Ice Storm

2011 ◽  
Vol 26 (S1) ◽  
pp. s100-s100
Author(s):  
C.E. Stewart ◽  
J. Gulden
Keyword(s):  
Natural Disasters ◽  
Healthcare Systems ◽  
Lessons Learned ◽  
Ice Storm ◽  
Power Outages ◽  
Public Health Response ◽  
System Failures ◽  
South Central ◽  
Extended Care ◽  
Care Facilities

Building Resilient Extended-Care Facilities During Natural Disasters – Lessons Learned from the 2007 Tulsa, Oklahoma Ice Storm. In the last decade, increasing importance has been placed on building resiliency into critical healthcare systems. This has meant shifting the paradigm from focusing on response to one of preparedness. In 2007, an ice storm as part of a series of winter storms occurred in the south central United States causing extensive power outages, in Tulsa, Oklahoma, for a period of up to 3 weeks. Five of the six tertiary care hospitals in Tulsa suffered power outages, phone system failures or oxygen and/or suctioning system failures. Local water treatment plants were without power for 48 hours. During this time, multiple extended-care (nursing home) patients were discharged to homes or transferred to hospitals because the nursing homes were not prepared to cope with an extended power outage. This paper is a retrospective analysis and discussion of lessons learned with respect to the vulnerability of these extended-care healthcare systems and the public health response during natural disasters.

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