scholarly journals Nigella sativa (Black Seed) as a Natural Remedy against Viruses

2021 ◽  
Author(s):  
Rasha Saleh Basurra ◽  
Seok Mui Wang ◽  
Mohammed Abdelfatah Alhoot
Keyword(s):  
Adverse Effects ◽  
Nigella Sativa ◽  
Antiviral Agents ◽  
Viral Resistance ◽  
Research Attention ◽  
Beneficial Effects ◽  
Antiviral Efficacy ◽  
Black Seed ◽  
Natural Remedy ◽  
Natural Remedies

The currently available antiviral agents are associated with serious adverse effects, coupled with the increasing rate of viral resistance to the existing antiviral drugs. Hence, the search for alternative natural remedies is gaining momentum across the globe. Nigella sativa Linnen, also called Black seed, is a medicinal plant that is gaining worldwide recognition and has been extensively investigated. The present work is aimed to review the existing literature on the antiviral efficacy of Nigella sativa extracts (oil & bioactive compounds). The findings reveal that numerous articles have been published on Nigella sativa and its beneficial effects against different kinds of diseases. However, the antiviral efficacy of Nigella sativa is yet to be given the proper research attention it deserves.

scholarly journals NIGELLA SATIVA HAS BENEFICIAL EFFECT ON OSTEOPOROSIS AND BONE HEALING. IS IT FACT OR FICTION? A SYSTEMATIC REVIEW

2017 ◽  
Vol 10 (5) ◽  
pp. 41
Author(s):  
Muhamed T Osman
Keyword(s):  
Systematic Review ◽  
Bone Healing ◽  
Web Of Science ◽  
Nigella Sativa ◽  
Experimental Studies ◽  
Molecular Targets ◽  
The Elderly ◽  
Potential Effect ◽  
Beneficial Effects ◽  
Black Seed

Osteoporosis is the most common reason for a broken bone among the elderly. Several experimental studies have been reported that Nigella sativa(NS) and/or its major component thymoquinone (TQ) have good effects on osteoporosis and bone healing. We conducted this systematic review toevaluate these relevant studies to prove whether NS and/or TQ has potential effect on osteoporosis and can stop pathogenesis of this disease or thismatter still just a fiction. A search on published studies was done using databases including Scopus, PubMed, Google Scholar, Web of Science, andCINAHIL. Terms searched included “Nigella sativa, black seed, TQ, osteoporosis, bone healing.” Initially, 213 articles were extracted. After reviewing their titles and abstracts, 124 articles (Medline, 43; Scopus, 67; EBSCO, 14) were retrieved for further evaluation. However, after excluding the clinical trial studies, human reviews, removal of abstracts and unrelated studies, seven studies were considered finally as eligible for our review. Finally, seven studies were considered eligible for our review. The total number of animals used was 220 (150 rats and 70 rabbits) from different experimental study. Based on the results of this systematic review, we conclude that NS or TQ extract therapy for osteoporosis cannot be recommended yet and these data will not suffice to exclude the beneficial effects of NS on bone turnover reliably. Therefore, more studies are required to explore the specific cellular and molecular targets of NS or TQ using animal osteoporosis models. Once the anti-osteoporotic effectiveness of NS or TQ will be established, human studies can be carried out.Keywords: Nigella sativa, Black seed, Thymoquinone, Osteoporosis, Bone healing.

scholarly journals Evaluation of Prophylactic and Anticoccidial Effects of Black Seed and Garlic Extracts in Rabbits

2021 ◽  
Vol 11 (1) ◽  
pp. 124-137
Author(s):  
Huda Mohammed Mohammed Kuraa ◽  
Basem Refat Nageib ◽  
Abeer Hashem Mostafa El-Hendy ◽  
Ahmed Abdel-Fattah Ahmed Hassanin
Keyword(s):  
Histopathological Examination ◽  
Nigella Sativa ◽  
Seed Extract ◽  
Feed Additive ◽  
Economic Losses ◽  
Treatment Groups ◽  
Beneficial Effects ◽  
Black Seed ◽  
Significant Efficacy

The present study was carried out to discover the protective and curative effects of alcoholic extracts of garlic (Allium sativum) and black seeds (Nigella sativa) in rabbits experimentally infected by Eimeria magna using in vivo, in vitro, and histopathological examination. Overall oocysts number per gram was significantly lower in the garlic treatment and pretreatment groups, compared to the control positive, sulfadimidine treatment, and black seed treatment groups. At the end of the experiment, the oocyst disappeared in garlic pretreatment, garlic treatment, and black seed pretreatment groups. While oocyst counts of control positive and sulfadimidine groups were increasing oocysts similarly at the end of the experiment with repeated cycles. In vitro sporulation inhibition of garlic extract showed significant efficacy on E. magna oocysts in comparison with black seed extract and high significant efficacy of sporulation inhibition, compared to sulfadimidine. While black seed extract showed high significant efficacy of sporulation inhibition, compared to sulfadimidine. Body weight gain increased in control negative, garlic pretreatment, and garlic treatment groups in comparison with other groups. The results showed that there were no significant differences in erythrocytes counts in all experimental groups while leukocyte counts showed a significant decrease in control positive and sulfadimidine groups, compared to the other groups. Similarly, the histopathological examinations on days 14 and 28 post-infection revealed pathological changes in intestinal villi of the control positive group that appeared thickened and deformed with hypertrophied enterocytes containing numerous developmental stages of E. magna. Both garlic and black seed extract had beneficial effects on improving the lesions grossly and microscopically. The results obtained in the present study proved that garlic pretreatment had a better effect on a prophylaxis and treatment for coccidiosis than garlic treatment and both had more beneficial effects, compared to black seed extract. Therefore, it is recommended to use garlic as a natural feed additive in rabbit feeding as a prophylaxis and treatment for coccidiosis to minimize the economic losses caused by this parasite.

scholarly journals Dietary Black Seed Effects on Growth Performance, Proximate Composition, Antioxidant and Histo-Biochemical Parameters of a Culturable Fish, Rohu (Labeo rohita)

Animals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 48
Author(s):  
Maria Latif ◽  
Mehwish Faheem ◽  
Asmatullah ◽  
Seyed Hossein Hoseinifar ◽  
Hien Van Doan
Keyword(s):  
Growth Performance ◽  
Proximate Composition ◽  
Biochemical Parameters ◽  
Reduced Glutathione ◽  
Labeo Rohita ◽  
Nigella Sativa ◽  
Growth Promoter ◽  
Feeding Trial ◽  
Glutathione S Transferase ◽  
Black Seed

This feeding trial was conducted to investigate the effects of dietary black seed (Nigella sativa) supplementation on the growth performance, muscles proximate composition, antioxidant and histo-biochemical parameters of rohu (Labeo rohita). Fingerlings (8.503 ± 0.009 g) were fed on 0.0%, 1% and 2.5% black seed supplemented diets for 28 days. Fish sampling was done on the 7th, 14th, 21st and 28th day of experiment. The results of the present study indicated that black seed supplementation significantly increased growth performance and muscles protein contents of rohu over un-supplemented ones. Lipid peroxidation levels significantly decreased in all the studied tissues (liver, gills, kidney and brain) of black seed fed rohu, whereas the antioxidant enzymes (catalase, glutathione-S-transferase, glutathione peroxidase and reduced glutathione) activities were increased in all the studied tissues of black seed supplemented rohu at each sampling day. The hepatic-nephric marker enzymes levels were decreased for black seed fed rohu. The present study showed that tested black seed levels are safe for rohu. Black seed is cheaply available in local markets of Pakistan; therefore, based on the results of the present study, it is suggested that black seed has potential to be used as natural growth promoter and antioxidant in the diet of rohu.

scholarly journals Removal of sacral neuromodulation quadripolar tined-lead using a straight stylet: description of a surgical technique

2021 ◽  
Author(s):  
M. Agnello ◽  
M. Vottero ◽  
P. Bertapelle
Keyword(s):  
Adverse Effects ◽  
Sacral Neuromodulation ◽  
Pulse Generator ◽  
Lead Removal ◽  
Open Technique ◽  
Implantable Pulse Generator ◽  
Beneficial Effects ◽  
Tined Lead ◽  
Removal Technique ◽  
Sacral Bone

Abstract Background Up to 7.5% of tined-lead removals in patients having sacral neuromodulation (SNM) therapy are associated with a lead breakage. It is still unclear what adverse effects can be caused by unretrieved fragments. The aim of our study was to describe the lead removal technique we have been using for the last 2 years in our centre. Methods We retrospectively enrolled patients who had lead removal between January 2018 and January 2020 using our standardized technique. The novelty of the technique is in the use of the straight stylet, which is available in the quadripolar tined-lead kit. The stylet gives the electrode greater stiffness, reducing interactions with surrounding tissues and probability of damage or breakage during removal. Results In 59 patients (42 women, mean age 57.2 years [range 40–79 years]) the lead was removed using our standardized technique. In 44 of 59 patients, the tined-lead was removed within 2 months from the SNM-test, due to lack of beneficial effects. In 15 patients the electrode was removed because of failure of definitive implantation. Meantime from definitive implantable pulse generator (IPG) implantation to lead removal was 67.9 months. We recorded only 1 case of lead-breakage during removal: a female patient with a non-tined lead fixed on sacral bone, placed 18 years previously using an open technique. Conclusions Lead breakage during removal is not uncommon and adverse effects of retained fragments may occur. Our technique has been safely used for the last 2 years in our centre, with no episodes of lead breakage or retained fragments, except for one non-tined electrode.

Simple HPLC Method for the Determination of Thymoquinone in Black Seed Oil (Nigella Sativa Linn)

1995 ◽  
Vol 18 (5) ◽  
pp. 895-902 ◽  
Author(s):  
Hassan Y. Aboul-Enein ◽  
Laila I. Abou-Basha
Keyword(s):  
Seed Oil ◽  
Nigella Sativa ◽  
Hplc Method ◽  
Black Seed ◽  
Black Seed Oil

scholarly journals Antibacterial Effects of Mixtures of Press Oils of Laurel (Laurus nobilis) and Black Seed (Nigella sativa)

2017 ◽  
Vol 1 (1) ◽  
pp. 57-59
Author(s):  
Burhan SARIKAYA ◽  
Hatice Hüsna ALPEREN ◽  
Sadık AKGÜN
Keyword(s):  
Nigella Sativa ◽  
Antibacterial Effects ◽  
Laurus Nobilis ◽  
Black Seed ◽  
Press Oils

scholarly journals The effects of natural nano-sized clinoptilolite and Nigella sativa supplementation on serum bone markers in diabetic rats

Bioimpacts ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 173-178
Author(s):  
Yalda Salari Lak ◽  
Sirous Khorram ◽  
Mehran Mesgari Abbasi ◽  
Mohammad Asghari-Jafarabadi ◽  
Ali Tarighat-Esfanjani ◽  
...  
Keyword(s):  
Bone Markers ◽  
Nigella Sativa ◽  
Bone Mineralization ◽  
Serum Levels ◽  
Study Groups ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Model Assessment ◽  
Beneficial Effects

Introduction: Many studies confirm that diabetes mellitus is associated with higher risks of bone fracture. The beneficial effects of Nigella sativa (NS) and clinoptilolite in preventing/reducing some diabetes-related disorders have been shown. This study was conducted to examine the effects of separate and concurrent supplementation of natural nano-sized clinoptilolite (NCLN) and NS on serum bone markers in rats with type 2 diabetes. Methods: A total of 42 (case=36 and control=6) adult male Wistar rats were divided into 2 groups: diabetic and non-diabetic. An oral glucose tolerance test and a homeostatic model assessment of insulin resistance (HOMA-IR) test were conducted to confirm diabetes. Then, the diabetic group was divided into 4 subgroups: [1] control (n=9), [2] NS 1%/food (n=9), [3] NCLN 2%/food (n=9), [4] NS 1%/food + NCLN 2%/food (n=9). After 7 weeks, serum levels of bone markers were determined using ELISA kits. Results: Analysis showed that serum levels of alkaline phosphatase (ALP) in the NCLN group (1318.6 ± 217.5 U/L) was significantly (P<0.05) higher than other intervented groups. On the other hand, serum levels of calcium in NCLN+NS group (10.8 ± 2.6 mg/dL) were higher (P=0.027) compared to all other study groups. However, rats in the NS group had higher (535.8 ± 49.3 pg/mL) PTH (P<0.0001) compared to other supplementation groups. There were no significant differences in vitamin D and osteoprotegerin. Conclusion: The results of the current study suggest that bone mineralization may be affected by concurrent use of NS and NCLN through influencing calcium circulation. Moreover, dietary NS administration is strongly related to an augmented level of PTH.

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